The Protective Effects of Flavonoids from Scutellaria Baicalensis Georgi Stems and Leaves on Oligodendrocyte Damage Induced by Aβ1-42

Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ1-42-induced oligodendrocytes (OL) damage. Methods: Immunofluorescence was used for the detection of myelin-associated glycoprotein (MAG), a characteristic protein of rat oligodendrocytes (OLN-93 cells). To evaluate the potential protective effects of SSFs on OLN-93 cells injured by Aβ1-42, an injury model was established by subjecting OLN-93 cells to Aβ1-42 exposed. Cell morphology was examined using an inverted microscope, while cell viability was assessed using the colorimetric method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Additionally, lactate dehydrogenase (LDH) was measured using the pyruvic acid reduction assay. The Ginkgo biloba leaf extract (GBE) injection was used as a positive control. Results: A total of >95% of the MAG immunofluorescence-positive cells were identified as oligodendrocytes. Gradually increasing concentrations of SSFs impaired the cells, and the maximum nondetrimental dose for OLN-93 cells was 75 mg/L. This study assessed the effects of SSFs on OLN-93 cells damaged by Aβ1-42. The results indicated that SSFs significantly improved OLN-93 cell morphological abnormal changes, increased the OLN-93 cell survival rate, and reduced LDH release. Conclusion: SSFs can alleviate Aβ1-42-induced damage of OL.

Unveiling the planar deformation mechanisms for improved formability in pre-twinned AZ31 Mg alloy sheet at warm temperature

To investigate the role of pre-twins in Mg alloy sheets during warm planar deformation,the stretch forming is conducted at 200℃.Results suggest the formability of the pre-twinned AZ31 Mg alloy sheet is enhanced to 11.30 mm.The mechanisms for the improved formability and the deformation behaviors during the planar stretch forming are systematically investigated based on the planar stress states.The Schmid factor for deformation mechanisms are calculated,the results reveal that planar stress states extremely affect the Schmid factor for{10-12}twinning.The detwinning is activated and the prismatic slip is enhanced in the pre-twinned sheet,especially under the planar extension stress state in the outer region.Consequently,the thickness-direction strain is accommodated better.The dynamic recrystallization(DRX)type is continuous DRX(CDRX)regardless of the planar stress state.However,the CDRX degree is greater under the planar extension stress state.Some twin lattices deviate from the perfect{10-12}twinning relation due to the planar compression stress state and the CDRX.The basal texture is weakened when the planar stress state tends to change the texture components.

Protection Performance of Plasma Sprayed Al_(2)O_(3)-13 wt%TiO_(2) Coating Sealed with an Organic-inorganic Hybrid Agent

An organic-inorganic hybrid sealing agent was fabricated and used in the plasma sprayed Al_(2)O_(3)-13 wt%TiO_(2)coating,and conventional silicone agent was also used for comparison.Protection performance of the coatings was comprehensively evaluated based on both anti-corrosion and anti-biofouling properties.The results reveal that the sealing treatment is remarkably useful to decrease the porosity of the coating,and the porosity of the coating sealed with the hybrid agent is only 0.035%.Immersion corrosion test and Tafel polarization test reveal that the sealed coating with the hybrid agent exhibits a better corrosion resistance by compared with the coating sealed with silicone agent.The corrosion current density i_(corr) of the hybrid agent sealed coating is only 0.7×10^(-6)A·cm^(-2).Moreover,anti-biofouling tests both in the outdoor analogue hydraulic environment and in the natural marine environment prove that the mentioned novel coating presents a better combination of corrosion resistance and anti-biofouling property by compared with the other coatings,and it could be used as a protection of metal components in the marine environment.

Wrinkling prediction in rubber forming of Ti-15-3 alloy

Wrinkling is a common failure in the sheet metal forming of titanium owing to the relatively poor ability to shrink. It is important to predict wrinkling accurately in the sheet metal forming without costly trials. The ABAQUS/Explicit code was utilized to predict the wrinkling behavior in the sheet metal forming of Ti-15-3 alloy sheets. In terms of the comparison of wrinkling behavior between the simulation and experiment of the Fukui＇s conical cup tests at room temperature, the sensitivities of wrinkling simulation to various input parameters were evaluated comprehensively and quantitatively. Prediction of wrinkling and influence of rubber hardness on the winkling behavior in the rubber forming of convex flange were investigated quantitatively and validated by the rubber forming experiments. The excellent agreements between the simulations and the experiments conIirmed the accuracy of the prediction.

Friction coefficient in rubber forming process of Ti-15-3 alloy

The forming limit diagram of Ti-15-3 alloy sheet was constituted at room temperature. The effects of different punch and rubber hardness on the limit principal strain distributions were investigated experimentally. Finite element analysis models of the samples with dimensions of 180 mm×180 mm were established to analyze the friction coefficients of different interfaces. Effects of various friction coefficients on the strain distributions were studied in detail. Finally, the friction coefficients in the cold forming were determined by contrasting the strain results between the experimental data and the simulated ones.

Microstructure and properties of Al-0.70Fe-0.24Cu alloy conductor prepared by horizontal continuous casting and subsequent continuous extrusion forming

A novel process for manufacturing A1-0.70Fe-0.24Cu alloy conductor was proposed, which includes horizontal continuous casting and subsequent continuous extrusion forming （Conform）. The mechanical properties, electrical conductivity and the compressed creep behaviour of the alloy were studied. The results indicate that the Conform process induces obvious grain refinement, strain-induced precipitation of AI7CuzFe phase and the transformation of crystal orientation distribution. The processed alloy has good comprehensive mechanical properties and electrical conductivity. Moreover, a better creep resistance under the conditions of 90 ~C and 76 MPa is shown compared with pure A1 and annealed copper, and the relationship between primary creep strain and time may comply with the logarithmic law. The enhanced properties are attributed to the grain refinement as well as the fine and homogeneously distributed thermally stable A1Fe and A17Cu2Fe precipitation phases.

Superplastic Forming and Diffusion Bonding for Sandwich Structure of Ti-6Al-4V Alloy

Superplastic forming and diffusion bonding (SPF/DB) is a well-established process for the manufacture of components almost exclusively from Ti-6AI-4V sheet material. The sandwich structure of Ti-6AI-4V alloy is investigated. The effects of the microstructure on the SPF/DB process were discussed. The microstructure at the interfaces and the distribution of thickness were researched.

The Evolutionary History of Ore-forming Processes of Metallic Ore Deposits in Northern Guangxi

The northern Guangxi region is an important rare metal, rare earth metal and polymetallic metallogenic province. In the region there exist five metallogenic series and two metallogenic subseries, whose metallogenesis shows features of polycyclic spiral evolution throughout the geological history. As far as various cycles are concerned, mantle-derived ore substances were reduced while crust-derived ore substances increased from early to late timesfin the whole geological evolutionary history, mantle-derived substances decreased gradually while crust-derived ones increased. Meanwhile ore element associations became more and more varied. In terms of space, mineralization migrated from the old basement outwards, i.e. from west to east during the Precambrian, and from north to south during the Phanerozoic, and again from east to west during the Yanshanian.

The Forming Conditions of and Ore-searching Direction for B, Mg,Pb, Zn and Au Deposits in the Liaoji Proterozoic Rift

The Liaoji Proterozoic rift is an inter-intracontinenatl rift developed from Archean granite-greenstone tectonic regime and contains many important mineral deposits of U, B, magnesite, Pb-Zn, Au, Ag, Co and P. These deposits were formed as the result of late mobilization, transportation and concentfation of the previously enriched ore-forming mate- rials in several ore-bearing formations formed during the rift stage. So the metallogeny of these deposits in the rift shows both inheritance and new generation of the ore-forming materials. In future ore-searching practice, attentions should be paid on the studies of the ore-bearing formations in the rift, on the multiple stages of metallogeny and and on multiple derivations of the ore-forming materials.

间歇式四边封气动自动制袋-充填-包装机的研制

本文介绍了间歇式四边封气动自动制袋充填包装机的结构及工作原理 ,分析了该机的动力传输及各部件之间的动作配合。

袋成型-充填-封口机产品质量行业状况分析

本文对我国袋成型-充填-封口机的现状、存在的主要问题作了分析,对产品发展提出建议。

40Cr13环件径-轴向环轧工艺参数优化

结合客户订单中40Cr13环件的实际规格及技术要求,建立三维模型,在之前方式设置参数的基础上选取了环件初始轧制温度、驱动辊摩擦系数和驱动辊转速三个轧制工艺参数,通过数值模拟,并利用单一变量对其进行优化。实际验证结果表明:成品环件的精度和机械性能均比未优化参数下环轧的环件高。

重包装膜(FFS)应用现状及发展综述

从全球范围内和中国国内两个层面探讨了重包装膜(Form Fill Seal Films)的应用现状及发展趋势。探讨了市场竞争、技术创新和可持续发展等方面的问题。

如何申领和使用原产地证书Form E

在2010年10月29日越南河内举行的第十三次中国-东盟领导人会议上,我国商务部陈德铭部长与东盟各国经贸部长共同签署了《〈中国-东盟全面经济合作框架协议货物贸易协议〉第二议定书》（以下简称《第二议定书》）。该议定书于2011年1月1日起生效实施，

Novel AC Servo Rotating and Linear Composite Driving Device for Plastic Forming Equipment

The existing plastic forming equipment are mostly driven by traditional AC motors with long trans- mission chains, low efficiency, large size, low precision and poor dynamic response are the common disadvantages. In order to realize high performance forming processes, the driving device should be improved, especially for com- plicated processing motions. Based on electric servo direct drive technology, a novel AC servo rotating and linear composite driving device is proposed, which features implementing both spindle rotation and feed motion with- out transmission, so that compact structure and precise control can be achieved. Flux switching topology is employed in the rotating drive component for strong robustness, and fractional slot is employed in the linear direct drive component for large force capability. Then the mechanical structure for compositing rotation and linear motion is designed. A device prototype is manufactured, machining of each component and the whole assembly are presented respectively. Commercial servo amplifiers are utilized to construct the control system of the proposed device. To validate the effectiveness of the proposed composite driving device, experimental study on thedynamic test benches are conducted. The results indicate that the output torque can attain to 420 N-m and the dynamic tracking errors are less than about 0.3 rad in the rotating drive, the dynamic tracking errors are less than about 1.6 mm in the linear feed. The proposed research provides a method to construct high efficiency and accu- racy direct driving device in plastic forming equipment.

STUDY ON CRYSTAL STRUCTURE OF DESHEPTAPEPTIDE(B24-30) INSULIN——FINDING OF A NEW CRYSTAL FORM

The structure-function relationship of insulin to be understood at three-dimensional level has already been a challenging problem since the elucidation of fine crystal structures of insulin. Of course, it is a better experimental approach to such a problem that certain insulin-receptor complexes were prepared and their structures were

不同填充形式断层垂向封闭性研究方法及其应用

为了研究不同填充形式断层垂向封闭性,将断层分为砂质填充和泥质填充2种类型。通过不同填充形式断层断裂带特征分析,对其垂向封闭机理进行了研究,得到泥质填充断层主要是通过泥岩塑性变形流动堵塞断层紧闭后遗留下来的渗漏空间形成垂向封闭,而砂质填充断层则主要是通过SiO2和CaCO3沉淀胶结形成垂向封闭。通过断层面压力是否达到泥岩塑性变形极限和SiO2和CaCO3是否发生沉淀,分别建立了一套不同填充形式断层垂向封闭性的研究方法,并将其应用于海拉尔盆地乌尔逊凹陷Wu39号断层在南一段和大一段的垂向封闭性研究中,结果表明Wu39号断层在大一段内具较好的垂向封闭性,而在南一段垂向封闭性差。这一研究结果与该断裂附近油气分布有较好的吻合关系,表明该方法用于不同填充形式断层垂向封闭性研究是可行的。

FFS袋用吹塑薄膜原料的性能研究

本工作研究了茂金属线型低密度聚乙烯(mLLDPE)/低密度聚乙烯(LDPE)共混物的流变性能及所制薄膜性能。结果表明:mLLDPE的加工性能较差,w(LDPE)为20%即可明显改善mLLDPE的加工性能,随着LDPE用量的增加,mLLDPE/LDPE共混物的加工性能改善更为明显;随着w(mLLDPE)的增加,用mLLDPE/LDPE共混物制得的薄膜力学性能有较大幅度提高。

基于模块化技术的袋装机设计方案评价系统

在对袋装机模块化设计分析的基础上,通过对各种分析评价方法的比较,构建了设计方案模糊综合评价模型。基于该模型,分析了设计方案评价的软件设计流程。最后采用BorlandC++Builder平台开发了袋装机设计方案评价系统,该系统可对袋装机方案进行成本、结构、适用范围等各方面的评估,帮助设计人员进行袋装机方案模拟、方案决策。

热成型充填封口机故障分析与维护

对热成型充填封口机的常见故障进行了分析 ,并介绍了维护和保养方面的知识 ,对于使用该类机器的用户具有一定的参考价值。