The determination of material formula needs try-and-error experiment,and consumes large amount of time and fund.In order to solve the problem,a comprehensive method is established,via the experiment of artificial-simi...The determination of material formula needs try-and-error experiment,and consumes large amount of time and fund.In order to solve the problem,a comprehensive method is established,via the experiment of artificial-similar material formula of a mine slope.We controlled the samples by the compactness,and arranged the formula of the test group with the method of the uniform formula experiment.The physical and mechanical parameters of these samples were analyzed using the method of the partial least-squares regression(PLS).And a mathematical model of the indexes of physical and mechanics parameters relating to the factors of formulation constituents was established eventually.We used the model to analyze the effect of each formulation constituent on physical and mechanics parameters of samples.The experiment results and analysis illustrates that1)in the formulation of similar material,the effect of raw materials on the internal friction angleφand cohesion C is opposite;2)The method can highly facilitate the process of the of preparing artificial-similar materials,more economic and effective.展开更多
Laboratory experiments are performed to explore the response rule of a sandy beach profile under plunging wave on a non-uniform sediment-bed slope. The initial beach slope of combination of 1/10 and 1/20 is exposed to...Laboratory experiments are performed to explore the response rule of a sandy beach profile under plunging wave on a non-uniform sediment-bed slope. The initial beach slope of combination of 1/10 and 1/20 is exposed to regular waves and cnoidal waves respectively. The free surface elevation, process of wave propagation, wave breaking, uprush and backwash and the change of a cross-shore beach profile are measured and recorded. The beach profile under the regular waves action exhibits two parts： a sandbar profile and a beach berm profile, and only one typical profile transformation under the cnoidal waves action is obtained, which is the beach berm profile. In the laboratory experiments, it is found that the beach states under wave action related to the previous factors. In addition, they are related to the characteristic of breaking waves such as the breaking intensity of the plunging wave. A concept about the characteristic angle of the plunging wave has been put forward through the observation and analysis of the phenomenon of the laboratory experiment. A qualitative analysis about the sediment transport carrying by currents generated from the plunging wave and the state of beach profile under the wave action has been done. The quantitative analysis about the relationship between the characteristic angle and Irribarren number has been done. An available formula of equilibrium states for the sandy beach induced by the plunging wave has been established based on the relationship between Irribarren number and the beach profile. By fitting these experimental results and others＇ experimental results to three lines, the three fitting coefficients can be calculated in their formula respectively. The recommended empirical formulas can divide three states of a beach morphology profile obviously, which include a depositive beach, an erosive beach and an intermediate beach.展开更多
目的基于质量源于设计(QbD)理念,优化板蓝根配方颗粒喷雾干燥工艺。方法结合信息熵赋值法,以喷干粉得粉率及尿苷、腺苷、鸟苷和(R,S)-告依春含量作为关键质量属性(CQAs),利用Plackett-Burman试验设计对进风温度、雾化压力、药液温度、...目的基于质量源于设计(QbD)理念,优化板蓝根配方颗粒喷雾干燥工艺。方法结合信息熵赋值法,以喷干粉得粉率及尿苷、腺苷、鸟苷和(R,S)-告依春含量作为关键质量属性(CQAs),利用Plackett-Burman试验设计对进风温度、雾化压力、药液温度、进液速度和药液相对密度进行考察,筛选出关键工艺参数(CPPs),再运用中心点复合设计(Center Point Composite design,CCD)试验对筛出的CPPs进行优化,在二次多项式回归模型的基础上建立板蓝根配方颗粒喷雾干燥工艺设计空间,并加以验证。结果Plackett-Burman试验结果显示,药液相对密度和进液速度为该研究的关键工艺参数。CCD试验方差分析结果显示构建的模型具有显著性差异(P<0.01),失拟项不显著(P>0.05),表明模型预测能力良好。构建的CPPs优化设计空间为药液相对密度1.05-1.08,进液速度30%-40%。结论基于QbD理念建立的板蓝根配方颗粒喷雾干燥工艺设计空间,可提高其工艺的稳定性,有利于保障产品质量的一致性。展开更多
基金Projects(41372312,51379194)supported by the National Natural Science Foundation of ChinaProject(CUGL140817)supported by the Fundamental Research Funds for the Central Universities of China University of Geosciences(Wuhan)+1 种基金Project(2014CFB894)supported by the Natural Science Foundation of Hubei Province of ChinaProject(2014M552113)supported by the China Postdoctoral Science Foundation
文摘The determination of material formula needs try-and-error experiment,and consumes large amount of time and fund.In order to solve the problem,a comprehensive method is established,via the experiment of artificial-similar material formula of a mine slope.We controlled the samples by the compactness,and arranged the formula of the test group with the method of the uniform formula experiment.The physical and mechanical parameters of these samples were analyzed using the method of the partial least-squares regression(PLS).And a mathematical model of the indexes of physical and mechanics parameters relating to the factors of formulation constituents was established eventually.We used the model to analyze the effect of each formulation constituent on physical and mechanics parameters of samples.The experiment results and analysis illustrates that1)in the formulation of similar material,the effect of raw materials on the internal friction angleφand cohesion C is opposite;2)The method can highly facilitate the process of the of preparing artificial-similar materials,more economic and effective.
基金The National Natural Science Foundation of China under contract Nos 51239001,51179015,51409022 and 51509023the Hunan Provincial Innovation Foundation for Postgraduate under contract No.CX2015B348
文摘Laboratory experiments are performed to explore the response rule of a sandy beach profile under plunging wave on a non-uniform sediment-bed slope. The initial beach slope of combination of 1/10 and 1/20 is exposed to regular waves and cnoidal waves respectively. The free surface elevation, process of wave propagation, wave breaking, uprush and backwash and the change of a cross-shore beach profile are measured and recorded. The beach profile under the regular waves action exhibits two parts： a sandbar profile and a beach berm profile, and only one typical profile transformation under the cnoidal waves action is obtained, which is the beach berm profile. In the laboratory experiments, it is found that the beach states under wave action related to the previous factors. In addition, they are related to the characteristic of breaking waves such as the breaking intensity of the plunging wave. A concept about the characteristic angle of the plunging wave has been put forward through the observation and analysis of the phenomenon of the laboratory experiment. A qualitative analysis about the sediment transport carrying by currents generated from the plunging wave and the state of beach profile under the wave action has been done. The quantitative analysis about the relationship between the characteristic angle and Irribarren number has been done. An available formula of equilibrium states for the sandy beach induced by the plunging wave has been established based on the relationship between Irribarren number and the beach profile. By fitting these experimental results and others＇ experimental results to three lines, the three fitting coefficients can be calculated in their formula respectively. The recommended empirical formulas can divide three states of a beach morphology profile obviously, which include a depositive beach, an erosive beach and an intermediate beach.
文摘目的基于质量源于设计(QbD)理念,优化板蓝根配方颗粒喷雾干燥工艺。方法结合信息熵赋值法,以喷干粉得粉率及尿苷、腺苷、鸟苷和(R,S)-告依春含量作为关键质量属性(CQAs),利用Plackett-Burman试验设计对进风温度、雾化压力、药液温度、进液速度和药液相对密度进行考察,筛选出关键工艺参数(CPPs),再运用中心点复合设计(Center Point Composite design,CCD)试验对筛出的CPPs进行优化,在二次多项式回归模型的基础上建立板蓝根配方颗粒喷雾干燥工艺设计空间,并加以验证。结果Plackett-Burman试验结果显示,药液相对密度和进液速度为该研究的关键工艺参数。CCD试验方差分析结果显示构建的模型具有显著性差异(P<0.01),失拟项不显著(P>0.05),表明模型预测能力良好。构建的CPPs优化设计空间为药液相对密度1.05-1.08,进液速度30%-40%。结论基于QbD理念建立的板蓝根配方颗粒喷雾干燥工艺设计空间,可提高其工艺的稳定性,有利于保障产品质量的一致性。
