BACKGROUND Peptic ulcer disease(PUD)remains a significant healthcare burden,contributing to morbidity and mortality worldwide.Despite advancements in therapies,its prevalence persists,particularly in regions with wide...BACKGROUND Peptic ulcer disease(PUD)remains a significant healthcare burden,contributing to morbidity and mortality worldwide.Despite advancements in therapies,its prevalence persists,particularly in regions with widespread nonsteroidal antiinflammatory drugs(NSAIDs)use and Helicobacter pylori infection.AIM To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal(GI)bleeding in Pakistani population.METHODS This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December 2022.Data on demographics,symptoms,length of stay,mortality,re-bleed,and Forrest classification was collected.RESULTS The mean age of patients was 53 years,and the majority was men(68.3%).Hematemesis(82.4%)and epigastric pain(75.4%)were the most common presenting symptoms.Most patients(73.2%)were discharged within five days.The mortality rates at one week and one month were 10.6%and 14.8%,respectively.Re-bleed within 24 h and seven days occurred in 14.1%and 18.3%of patients,respectively.Most ulcers were Forrest class(FC)Ⅲ(72.5%).Antiplatelet use was associated with higher mortality at 7 and 30 d,while alternative medications were linked to higher 24-hour re-bleed rates.NSAID use was associated with more FCⅢulcers.Re-bleed at 24 h and 7 d was strongly associated with one-week or one-month mortality.CONCLUSION Antiplatelet use and rebleeding increase the risk of early mortality in PUD-related upper GI bleeding,while alternative medicines are associated with early rebleeding.展开更多
Based on the homonymy novel,the film Forrest Gump adapted several parts of the original works and appeal to American optimism instead of cynicism.The film reflected the general social background of America in late 20t...Based on the homonymy novel,the film Forrest Gump adapted several parts of the original works and appeal to American optimism instead of cynicism.The film reflected the general social background of America in late 20th century,revealed the negative portrayal of the counterculture,and offers an ultimately positive perspective by the theme of humanity,respect,tolerance and unconditional love.展开更多
The movie Forrest Gump has always been the topic of discussion and research,mainly on the American dreams typically represented by the character.Specially intended to discuss the individual struggle,the cruel reality ...The movie Forrest Gump has always been the topic of discussion and research,mainly on the American dreams typically represented by the character.Specially intended to discuss the individual struggle,the cruel reality is to be illustrated and the survival of the fittest in the struggle is to be analyzed.The study is aim to find the appealing elements in the movie and lead people get some enlightenment from it.展开更多
文摘BACKGROUND Peptic ulcer disease(PUD)remains a significant healthcare burden,contributing to morbidity and mortality worldwide.Despite advancements in therapies,its prevalence persists,particularly in regions with widespread nonsteroidal antiinflammatory drugs(NSAIDs)use and Helicobacter pylori infection.AIM To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal(GI)bleeding in Pakistani population.METHODS This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December 2022.Data on demographics,symptoms,length of stay,mortality,re-bleed,and Forrest classification was collected.RESULTS The mean age of patients was 53 years,and the majority was men(68.3%).Hematemesis(82.4%)and epigastric pain(75.4%)were the most common presenting symptoms.Most patients(73.2%)were discharged within five days.The mortality rates at one week and one month were 10.6%and 14.8%,respectively.Re-bleed within 24 h and seven days occurred in 14.1%and 18.3%of patients,respectively.Most ulcers were Forrest class(FC)Ⅲ(72.5%).Antiplatelet use was associated with higher mortality at 7 and 30 d,while alternative medications were linked to higher 24-hour re-bleed rates.NSAID use was associated with more FCⅢulcers.Re-bleed at 24 h and 7 d was strongly associated with one-week or one-month mortality.CONCLUSION Antiplatelet use and rebleeding increase the risk of early mortality in PUD-related upper GI bleeding,while alternative medicines are associated with early rebleeding.
文摘Based on the homonymy novel,the film Forrest Gump adapted several parts of the original works and appeal to American optimism instead of cynicism.The film reflected the general social background of America in late 20th century,revealed the negative portrayal of the counterculture,and offers an ultimately positive perspective by the theme of humanity,respect,tolerance and unconditional love.
文摘The movie Forrest Gump has always been the topic of discussion and research,mainly on the American dreams typically represented by the character.Specially intended to discuss the individual struggle,the cruel reality is to be illustrated and the survival of the fittest in the struggle is to be analyzed.The study is aim to find the appealing elements in the movie and lead people get some enlightenment from it.
