Essential genes are indispensable for the survival of an organism in optimal conditions.Rapid and accurate identifications of new essential genes are of great theoretical and practical significance.Exploring features ...Essential genes are indispensable for the survival of an organism in optimal conditions.Rapid and accurate identifications of new essential genes are of great theoretical and practical significance.Exploring features with predictive power is fundamental for this.Here,we calculate six fractal features from primary gene and protein sequences and then explore their relationship with gene essentiality by statistical analysis and machine learning-based methods.The models are applied to all the currently available identified genes in 27 bacteria from the database of essential genes(DEG).It is found that the fractal features of essential genes generally differ from those of non-essential genes.The fractal features are used to ascertain the parameters of two machine learning classifiers:Na¨?ve Bayes and Random Forest.The area under the curve(AUC) of both classifiers show that each fractal feature is satisfactorily discriminative between essential genes and non-essential genes individually.And,although significant correlations exist among fractal features,gene essentiality can also be reliably predicted by various combinations of them.Thus,the fractal features analyzed in our study can be used not only to construct a good essentiality classifier alone,but also to be significant contributors for computational tools identifying essential genes.展开更多
Dear Sir,Iam Dr.Kavitha S,from the Department of Electronics and Communication Engineering,Nandha Engineering College,Erode,Tamil Nadu,India.I write to present the detection of glaucoma using extreme learning machine(...Dear Sir,Iam Dr.Kavitha S,from the Department of Electronics and Communication Engineering,Nandha Engineering College,Erode,Tamil Nadu,India.I write to present the detection of glaucoma using extreme learning machine(ELM)and fractal feature analysis.Glaucoma is the second most frequent cause of permanent blindness in industrial展开更多
The structural features of soil in debris flow-triggering region play an important role in the formation and evolution of debris flow. In this paper, a case study on the fractal of soil particle-size distribution (PS...The structural features of soil in debris flow-triggering region play an important role in the formation and evolution of debris flow. In this paper, a case study on the fractal of soil particle-size distribution (PSDFs) and pore-solid (PSFs) in Jiangjia Ravine was conducted. The results revealed that the soil in Jiangjia Ravine had significant fractal features and its PSDF and PSF had the same variation trend despite different type of soils in debris flow-triggering region: residual soil (RS) 〉 debris flow deposit (DFD)~clinosol (CL), their fractal dimension of PSDFs are respectively between 2.62 and 2.96, 2.52 and 2.68, 2.37 and 2.52; and the fractal dimension of PSFs are respectively between 2. 75 and 2.95, 2. 57 and 2. 72, 2.59 and 2.64. The fractal dimension of soil reflected its complexity as a self-organizing system and was closely related to the evolution of soil in debris flow- triggering region.展开更多
Shales from the Lower Cambrian Niutitang Formation of Yangtze Platform have been widely investigated due to its shale gas potential.To better illustrate the pore structure and fractal characteristics of shale,a series...Shales from the Lower Cambrian Niutitang Formation of Yangtze Platform have been widely investigated due to its shale gas potential.To better illustrate the pore structure and fractal characteristics of shale,a series of experiments were conducted on outcrop samples from the Lower Cambrian Niutitang Formation on Yangtze Platform,including X-ray diffraction(XRD),field-emission scanning electron microscopy(FE-SEM) and low-temperature nitrogen adsorption.Frenkel-Halsey-Hill(FHH) model was adopted to calculate the fractal dimensions.Furthermore,the relationships between fractal dimensions and pore structure parameters and mineral composition are discussed.FE-SEM observation results show that interparticle pores are most developed in shale,followed by intraparticle pores.This study identified the fractal dimensions D1(ranging from 2.558 0 to 2.710 2) and D2(ranging from 2.541 5 to 2.765 2).The pore structure of the Niutitang Formation shale is primarily controlled by quartz and clay content.Fractal dimensions are able to characterize the pore structure complexity of Niutitang Formation shale because D1 and D2 correlate well with average pore diameter and quartz content.展开更多
基金Project supported by the Shandong Provincial Natural Science Foundation,China(Grant No.ZR2014FM022)
文摘Essential genes are indispensable for the survival of an organism in optimal conditions.Rapid and accurate identifications of new essential genes are of great theoretical and practical significance.Exploring features with predictive power is fundamental for this.Here,we calculate six fractal features from primary gene and protein sequences and then explore their relationship with gene essentiality by statistical analysis and machine learning-based methods.The models are applied to all the currently available identified genes in 27 bacteria from the database of essential genes(DEG).It is found that the fractal features of essential genes generally differ from those of non-essential genes.The fractal features are used to ascertain the parameters of two machine learning classifiers:Na¨?ve Bayes and Random Forest.The area under the curve(AUC) of both classifiers show that each fractal feature is satisfactorily discriminative between essential genes and non-essential genes individually.And,although significant correlations exist among fractal features,gene essentiality can also be reliably predicted by various combinations of them.Thus,the fractal features analyzed in our study can be used not only to construct a good essentiality classifier alone,but also to be significant contributors for computational tools identifying essential genes.
文摘Dear Sir,Iam Dr.Kavitha S,from the Department of Electronics and Communication Engineering,Nandha Engineering College,Erode,Tamil Nadu,India.I write to present the detection of glaucoma using extreme learning machine(ELM)and fractal feature analysis.Glaucoma is the second most frequent cause of permanent blindness in industrial
文摘The structural features of soil in debris flow-triggering region play an important role in the formation and evolution of debris flow. In this paper, a case study on the fractal of soil particle-size distribution (PSDFs) and pore-solid (PSFs) in Jiangjia Ravine was conducted. The results revealed that the soil in Jiangjia Ravine had significant fractal features and its PSDF and PSF had the same variation trend despite different type of soils in debris flow-triggering region: residual soil (RS) 〉 debris flow deposit (DFD)~clinosol (CL), their fractal dimension of PSDFs are respectively between 2.62 and 2.96, 2.52 and 2.68, 2.37 and 2.52; and the fractal dimension of PSFs are respectively between 2. 75 and 2.95, 2. 57 and 2. 72, 2.59 and 2.64. The fractal dimension of soil reflected its complexity as a self-organizing system and was closely related to the evolution of soil in debris flow- triggering region.
基金supported by the National Natural Science Foundation of China(Nos41690131,41572327,41273001)the Program of Introducing Talents of Discipline to Universities(No.B14031)
文摘Shales from the Lower Cambrian Niutitang Formation of Yangtze Platform have been widely investigated due to its shale gas potential.To better illustrate the pore structure and fractal characteristics of shale,a series of experiments were conducted on outcrop samples from the Lower Cambrian Niutitang Formation on Yangtze Platform,including X-ray diffraction(XRD),field-emission scanning electron microscopy(FE-SEM) and low-temperature nitrogen adsorption.Frenkel-Halsey-Hill(FHH) model was adopted to calculate the fractal dimensions.Furthermore,the relationships between fractal dimensions and pore structure parameters and mineral composition are discussed.FE-SEM observation results show that interparticle pores are most developed in shale,followed by intraparticle pores.This study identified the fractal dimensions D1(ranging from 2.558 0 to 2.710 2) and D2(ranging from 2.541 5 to 2.765 2).The pore structure of the Niutitang Formation shale is primarily controlled by quartz and clay content.Fractal dimensions are able to characterize the pore structure complexity of Niutitang Formation shale because D1 and D2 correlate well with average pore diameter and quartz content.