Invasive fractional fl ow reserve(FFR)measurement is currently the gold standard for coronary intervention.FFR measurement by coronary computed tomography angiography(FFRCT)is a novel and promising imaging technology ...Invasive fractional fl ow reserve(FFR)measurement is currently the gold standard for coronary intervention.FFR measurement by coronary computed tomography angiography(FFRCT)is a novel and promising imaging technology that permits noninvasive assessment of physiologically signifi cant coronary lesions.FFRCT is capable of combining the anatomic information provided by coronary computed tomography angiography with computational fl uid dynamics to compute FFR.To date,several studies have reported the diagnostic performance of FFRCT compared with invasive FFR measurement as the reference standard.Further studies are now being implemented to determine the clinical feasibility and economic implications of FFRCT techniques.This article provides an overview and discusses the available evidence as well as potential future directions of FFRCT.展开更多
Hemodynamical evaluation of a coronary artery lesion is an important diagnostic step to assess its functional impact.Fractional flow reserve(FFR)received a class IA recommendation from the European Society of Cardiolo...Hemodynamical evaluation of a coronary artery lesion is an important diagnostic step to assess its functional impact.Fractional flow reserve(FFR)received a class IA recommendation from the European Society of Cardiology for the assessment of angiographically moderate stenosis.FFR evaluation of coronary artery disease offers improvement of the therapeutic strategy,deferring unnecessary procedures for lesions with a FFR>0.8,improving patients'management and clinical outcome.Post intervention,an optimal FFR>0.9 post stenting should be reached and>0.8 post drug eluting balloons.Non-hyperemic pressure ratio measurements have been validated in previous studies with a common threshold of 0.89.They might overestimate the hemodynamic significance of some lesions but remain useful whenever hyperemic agents are contraindicated.FFR remains the gold standard reference for invasive assessment of ischemia.We illustrate this review with two cases introducing the possibility to estimate also non-invasively FFR from reconstructed 3-D angiograms by quantitative flow ratio.We conclude introducing a hybrid approach to intermediate lesions(DFR 0.85-0.95)potentially maximizing clinical decision from all measurements.展开更多
Objective To study the relationgship and the clinical significance between plasma fibrinogen and fractional flow reserve(FFR)in coronary intermediate lesions.Methods The patients were from The Department of Cardiovasc...Objective To study the relationgship and the clinical significance between plasma fibrinogen and fractional flow reserve(FFR)in coronary intermediate lesions.Methods The patients were from The Department of Cardiovascular of Affiliated Hospital of Xuzhou Medical College.Their coronary artery lesions were assessed by展开更多
文摘Invasive fractional fl ow reserve(FFR)measurement is currently the gold standard for coronary intervention.FFR measurement by coronary computed tomography angiography(FFRCT)is a novel and promising imaging technology that permits noninvasive assessment of physiologically signifi cant coronary lesions.FFRCT is capable of combining the anatomic information provided by coronary computed tomography angiography with computational fl uid dynamics to compute FFR.To date,several studies have reported the diagnostic performance of FFRCT compared with invasive FFR measurement as the reference standard.Further studies are now being implemented to determine the clinical feasibility and economic implications of FFRCT techniques.This article provides an overview and discusses the available evidence as well as potential future directions of FFRCT.
文摘Hemodynamical evaluation of a coronary artery lesion is an important diagnostic step to assess its functional impact.Fractional flow reserve(FFR)received a class IA recommendation from the European Society of Cardiology for the assessment of angiographically moderate stenosis.FFR evaluation of coronary artery disease offers improvement of the therapeutic strategy,deferring unnecessary procedures for lesions with a FFR>0.8,improving patients'management and clinical outcome.Post intervention,an optimal FFR>0.9 post stenting should be reached and>0.8 post drug eluting balloons.Non-hyperemic pressure ratio measurements have been validated in previous studies with a common threshold of 0.89.They might overestimate the hemodynamic significance of some lesions but remain useful whenever hyperemic agents are contraindicated.FFR remains the gold standard reference for invasive assessment of ischemia.We illustrate this review with two cases introducing the possibility to estimate also non-invasively FFR from reconstructed 3-D angiograms by quantitative flow ratio.We conclude introducing a hybrid approach to intermediate lesions(DFR 0.85-0.95)potentially maximizing clinical decision from all measurements.
文摘Objective To study the relationgship and the clinical significance between plasma fibrinogen and fractional flow reserve(FFR)in coronary intermediate lesions.Methods The patients were from The Department of Cardiovascular of Affiliated Hospital of Xuzhou Medical College.Their coronary artery lesions were assessed by
文摘心血管疾病是危害人类生命健康最严重的疾病之一,中国每5人中就有2人死于心血管疾病。心肌缺血是重要的心血管疾病之一。心肌血流储备分数(fractional flow reserve,FFR)用于量化心外膜下冠状动脉狭窄是否产生心肌缺血;微血管阻力指数(index of microcirculatory resistance,IMR)是定量评价冠脉微循环状态的有创指标。传统FFR和IMR测量临床上依靠导丝,在最大充血态下进行介入测量,临床上辅助心肌缺血的诊断。基于冠脉造影的caFFR和caIMR(coronary angiography-derived FFR and IMR)无需介入操作、无需血管扩张药物、无禁忌症限制,可以快速同步计算FFR和IMR,进而辅助冠脉介入手术的诊疗。本文总结了近年来基于冠脉造影的caFFR和caIMR以及其他冠脉生理学检测技术的研究进展。进一步开展基于造影的FFR和IMR组合研究,从宏观到微观开展冠脉功能学研究具有重要的临床价值。
