The glacial history of Pico de Orizaba indicates that during the Last Glacial Maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m asl.The retracti...The glacial history of Pico de Orizaba indicates that during the Last Glacial Maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m asl.The retraction of the glacier has left behind an intense climatic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geomorphological processes are represented by the fragmentation of the bedrock that occupies the upper parts of the mountain.There is a notable lack of studies regarding the fragmentation and erosion occurring in tropical high mountains,and the associated geomorphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m asl,through continuous monitoring of surface ground temperature.The results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and proglacial.It was found that the paraglacial zone presents an intense drop of temperature,of up to~9℃ in only sixty minutes.The rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the main factor of the constant slope dynamics that occur at the site.This activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the temperature presents a certain degree of stability,until reaching the proglacial zone,where cycles are almost non-existent,and therefore there is no gelifraction activity.The geomorphological processes have resulted in significant alterations to the mountain slopes,which can have severe consequences in terms of risk and water.展开更多
A Pickering emulsion based on sodium starch octenyl succinate(SSOS)was prepared and its effects on the physicochemical properties of hairtail myofibrillar protein gels(MPGs)subjected to multiple freeze-thaw(F-T)cycles...A Pickering emulsion based on sodium starch octenyl succinate(SSOS)was prepared and its effects on the physicochemical properties of hairtail myofibrillar protein gels(MPGs)subjected to multiple freeze-thaw(F-T)cycles were investigated.The whiteness,water-holding capacity,storage modulus(G')and texture properties of the MPGs were significantly improved by adding 1%-2%Pickering emulsion(P<0.05).Meanwhile,Raman spectral analysis demonstrated that Pickering emulsion promoted the transformation of secondary structure,enhanced hydrogen bonds and hydrophobic interactions,and promoted the transition of disulfide bond conformation from g-g-g to g-g-t and t-g-t.At an emulsion concentration of 2%,theα-helix content decreased by 10.37%,while theβ-sheet content increased by 7.94%,compared to the control.After F-T cycles,the structure of the MPGs was destroyed,with an increase in hardness and a decrease in whiteness and water-holding capacity,however,the quality degradation of MPGs was reduced with 1%-2%Pickering emulsion.These findings demonstrated that SSOS-Pickering emulsions,as potential fat substitutes,can enhance the gel properties and the F-T stability of MPGs.展开更多
As a widely-applied engineering material in cold regions, the frozen subgrade soils are usually subjected to seismic loading, which are also dramatically influenced by the freeze-thaw(F-T)cycles due to the varying tem...As a widely-applied engineering material in cold regions, the frozen subgrade soils are usually subjected to seismic loading, which are also dramatically influenced by the freeze-thaw(F-T)cycles due to the varying temperature. A series of dynamic cyclic triaxial experiments were conducted through a cryogenic triaxial apparatus for exploring the influences of F-T cycles on the dynamic mechanical properties of frozen subgrade clay.According to the experimental results of frozen clay at the temperature of-10℃, the dynamic responses and microstructure variation at different times of F-T cycles(0, 1, 5, and 20 cycles) were explored in detail.It is experimentally demonstrated that the dynamic stress-strain curves and dynamic volumetric strain curves of frozen clay are significantly sparse after 20F-T cycles. Meanwhile, the cyclic number at failure(Nf) of the frozen specimen reduces by 89% after 20freeze-thaw cycles at a low ratio of the dynamic stress amplitude. In addition, with the increasing F-T cycles,the axial accumulative strain, residual deformation,and the value of damage variable of frozen clay increase, while the dynamic resilient modulus and dynamic strength decrease. Finally, the influence of the F-T cycles on the failure mechanisms of frozen clay was discussed in terms of the microstructure variation. These studies contribute to a better understanding of the fundamental changes in the dynamic mechanical of frozen soils exposed to F-T cycles in cold and seismic regions.展开更多
With the emphasis on environmental issues,the recycling of waste concrete,even recycled concrete,has become a hot spot in the field of architecture.But the repeated recycling of waste concrete used in harsh environmen...With the emphasis on environmental issues,the recycling of waste concrete,even recycled concrete,has become a hot spot in the field of architecture.But the repeated recycling of waste concrete used in harsh environments is still a complex problem.This paper discusses the durability and recyclability of recycled aggregate concrete(RAC)as a prefabricated material in the harsh environment,the effect of high-temperature curing(60℃,80℃,and 100℃)on the frost resistance of RAC and physical properties of the second generation recycled coarse aggregate(RCA_(2))of RAC after 300 freeze-thaw cycles were studied.The frost resistance of RAC was characterized by compressive strength,relative dynamic elastic modulus,and mass loss.As the physical properties of RCA_(2),the apparent density,water absorption,and crushing value were measured.And the SEM images of RAC after 300 freeze-thaw cycles were shown.The results indicated that the frost resistance of RAC cured at 80℃ for 7 days was comparable to that cured in the standard condition(cured for 28 days at 20℃±2℃ and 95%humidity),and the RAC cured at 100℃ was slightly worse.However,the frost resistance of RAC cured at 60℃ deteriorated seriously.The RAC cured at 80℃ for 7 days is the best.Whether after the freeze-thaw cycle or not,the RCA that curd at 60℃,80℃,and 100℃ for 7 days can also meet the requirements of Grade III RCA and be used as the aggregate of non-bearing part of prefabricated concrete components.RCA_(2) which is cured at 80℃ for 7 days had the best physical properties.展开更多
Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic character...Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic characteristics of EICP-treated specimens against the impact of drying-wetting(D-W)cycles is under-explored yet.This study investigates the evolution of mechanical behavior and pore charac-teristics of EICP-treated sea sand subjected to D-W cycles.The uniaxial compressive strength(UCS)tests,synchrotron radiation micro-computed tomography(micro-CT),and three-dimensional(3D)recon-struction of CT images were performed to study the multiscale evolution characteristics of EICP-reinforced sea sand under the effect of D-W cycles.The potential correlations between microstructure characteristics and macro-mechanical property deterioration were investigated using gray relational analysis(GRA).Results showed that the UCS of EICP-treated specimens decreases by 63.7% after 15 D-W cycles.The proportion of mesopores gradually decreases whereas the proportion of macropores in-creases due to the exfoliated calcium carbonate with increasing number of D-W cycles.The micro-structure in EICP-reinforced sea sand was gradually disintegrated,resulting in increasing pore size and development of pore shape from ellipsoidal to columnar and branched.The gray relational degree suggested that the weight loss rate and UCS deterioration were attributed to the development of branched pores with a size of 100-1000 m m under the action of D-W cycles.Overall,the results in this study provide a useful guidancee for the long-term stability and evolution characteristics of EICP-reinforced sea sand under D-W weathering conditions.展开更多
A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the mol...A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power system.This model considers the impact of thermal properties of fluid variation on accuracy and has been validated with Simulink.This study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet parameters.Meanwhile,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also analyzed.The results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial values.This simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.展开更多
This paper deals with the problem of limit cycles for the whirling pendulum equation x=y,y=sin x(cosx-r)under piecewise smooth perturbations of polynomials of cos x,sin x and y of degree n with the switching line x=0....This paper deals with the problem of limit cycles for the whirling pendulum equation x=y,y=sin x(cosx-r)under piecewise smooth perturbations of polynomials of cos x,sin x and y of degree n with the switching line x=0.The upper bounds of the number of limit cycles in both the oscillatory and the rotary regions are obtained using the Picard-Fuchs equations,which the generating functions of the associated first order Melnikov functions satisfy.Furthermore,the exact bound of a special case is given using the Chebyshev system.At the end,some numerical simulations are given to illustrate the existence of limit cycles.展开更多
The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to ...The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to still be observable today. Since Jupiter orbits the Sun with a period of approximately 12 years, it has always been thought that this could be connected to the nearly 11-year periodic peak in the number of sunspots observed. In this paper, the Sun and planets are considered to be moving about a center of mass point as the different planets orbit the Sun. This is the action of gravity that holds the solar system together. The center of mass for the Jupiter-Sun system actually lies outside the Sun. The four gas giant planets dominate such effects and the four gas giant Jovian planets can be projected together to determine an effective distance from the Sun’s center. Taken together these effects do seem to function as a sunspot forcing factor with a periodicity very close to 11 years. These predictions are made without consideration of any details of what is happening in the interior of the Sun. From these estimates, sunspot cycle 25 will be expected to peak in about September-October of 2025. Sunspot cycle 26 should peak in the year March of 2037.展开更多
Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induce...Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induced by the large radius of K+ions.Here,we explore high-performance K-ion half/full batteries with high rate capability,high specific capacity,and extremely durable cycle stability based on carbon nanosheets with tailored N dopants,which can alleviate the change of volume,increase electronic conductivity,and enhance the K+ion adsorption.The as-assembled K-ion half-batteries show an excellent rate capability of 468 mA h g^(−1) at 100 mA g^(−1),which is superior to those of most carbon materials reported to date.Moreover,the as-assembled half-cells have an outstanding life span,running 40,000 cycles over 8 months with a specific capacity retention of 100%at a high current density of 2000 mA g^(−1),and the target full cells deliver a high reversible specific capacity of 146 mA h g^(−1) after 2000 cycles over 2 months,with a specific capacity retention of 113%at a high current density of 500 mA g^(−1),both of which are state of the art in the field of K-ion batteries.This study might provide some insights into and potential avenues for exploration of advanced K-ion batteries with durable stability for practical applications.展开更多
In order to study the effect of PVA fiber on the dynamic and static mechanical properties of low-temperature freeze-thaw concrete under the saturated surface dry state,different contents of PVA fiber were added to pre...In order to study the effect of PVA fiber on the dynamic and static mechanical properties of low-temperature freeze-thaw concrete under the saturated surface dry state,different contents of PVA fiber were added to prepare concrete in this experiment.The concrete was subjected to compression,flexural and SHPB impact tests combined with scanning electron microscopy for microstructure analysis,after different times of freeze-thaw cycles in the temperature range of 20-70℃.The experimental results show that the compressive strength of the PVA fiber reinforced concrete first increases and then decreases after freeze and thaw cycles,and the compressive strength is positively correlated with the fiber content.The flexural strength gradually decreases with freeze-thaw cycles.The flexural strength of the concrete with 1.2 kg/m^(3) of PVA fiber presents the lowest strength loss after 45 freeze and thaw cycles,which is about 14%.The dynamic failure strength gradually decreases with the increase of freeze-thaw times,and the reduction amplitude decreases with the increase of PVA fiber content.The best impact resistance is achieved when the PVA fiber dosage is 1.2 kg/m^(3).展开更多
To study the damage mechanisms of anhydrite rock under freeze-thaw cycles, the physicalmechanical properties and the microcracking activities of anhydrite rock were investigated through mass variation, nuclear magneti...To study the damage mechanisms of anhydrite rock under freeze-thaw cycles, the physicalmechanical properties and the microcracking activities of anhydrite rock were investigated through mass variation, nuclear magnetic resonance, scanning electron microscope tests, and uniaxial compression combined with acoustic emission(AE) tests. Results show that with the increase of freeze-thaw processes,the mass, uniaxial compression strength, and elastic modulus of the anhydrite specimens decrease while the porosity and plasticity characteristics increase.For example, after 120 cycles, the uniaxial compression strength and elastic modulus decrease by 46.54% and 60.16%, and the porosity increase by 75%. Combined with the evolution trend of stressstrain curves and the detected events, three stages were labeled to investigate the AE characteristics in freeze-thaw weathered anhydrite rock. It is found that with the increase of freeze-thaw cycles, the proportions of AE counts in stage Ⅰ and stage Ⅱ show a decaying exponential trend. Contrarily, the proportion of AE counts in stage Ⅲ displays an exponential ascending trend. Meanwhile, as the freeze-thaw cycles increase, the low-frequency AE signals increase while the intermediate-frequency AE signals decrease. After 120 cycles, the proportion of low-frequency AE signals increases by 168.95%, and the proportion of intermediate-frequency AE signals reduces by 81.14%. It is concluded that the microtensile cracking events occupy a dominant position during the loading process. With the increase of freeze-thaw cycles, the b value of samples decreases.After 120 cycles, b value decreases by 27.2%, which means that the proportion of cracking events in rocks with small amplitude decreases. Finally, it is proposed that the freeze-thaw damage mechanism of anhydrite is also characterized by the water chemical softening effect.展开更多
Objective:To examine the inhibitory effect of Hydrangea serrata extract against hepatocellular carcinoma HepG2 cells and its underlying mechanisms.Methods:The effects of Hydrangea serrata extract on growth inhibition ...Objective:To examine the inhibitory effect of Hydrangea serrata extract against hepatocellular carcinoma HepG2 cells and its underlying mechanisms.Methods:The effects of Hydrangea serrata extract on growth inhibition of tumor cells and spheroids were assessed using MTT and 3D culture assays.Quantitative real-time PCR and Western blot analyses were employed to investigate the changes in mRNA and protein expression levels of molecules related to cell cycle and apoptosis.Results:Hydrangea serrata extract effectively inhibited the growth of both tumor cells and spheroids.The extract also significantly upregulated p27 mRNA expression and downregulated CDK2 mRNA expression,leading to cell cycle arrest.Moreover,increased BAX/Bcl-2 ratio as well as caspase-9 and-3 were observed after treatment with Hydrangea serrata extract,indicating the induction of tumor cell apoptosis.Conclusions:Hydrangea serrata extract has the potential to alleviate tumors by effectively modulating cell-cycle-related gene expressions and inducing apoptosis,thereby inhibiting tumor growth.展开更多
Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Alt...Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.展开更多
The Miller cycle is a program that effectively reduces NOx emissions from marine diesel engines by lowering the maximum combustion temperature in the cylinder,thereby reducing NOx emissions.To effectively investigate ...The Miller cycle is a program that effectively reduces NOx emissions from marine diesel engines by lowering the maximum combustion temperature in the cylinder,thereby reducing NOx emissions.To effectively investigate the impact of Miller cycle optimum combustion performance and emission capability under high load conditions,this study will perform a one-dimensional simulation of the performance of a marine diesel engine,as well as a threedimensional simulation of the combustion in the cylinder.A 6-cylinder four-stroke single-stage supercharged diesel engine is taken as the research object.The chassis dynamometer and other related equipment are used to build the test system,carry out the diesel engine bench test,and collect experimental data.The simulation results are compared with the test results,and the error is less than 5%.In this study,the authors will use simulation software to simulate several Miller cycle scenarios designed for early inlet valve closure and analyze the impact of the Miller cycle on combustion and emissions at 100%load conditions.By comparing the flow field distribution of the engine at 1500 r/min condition,it was found that proper EIVC can prolong the ignition latency period and homogeneous fuel-air mixture combustion acceleration,but it can reduce pressure and temperature within the piston chamber and NOx emission.However,the Miller cycle reduces end-of-compression temperatures,which increases combustion duration and exhaust temperatures,making it difficult to improve fuel economy at the optimum fuel consumption point,and closing the intake valves prematurely leads to excessive fuel expenditure.Furthermore,temperature and heat release rate within the piston chamber,NOx,and SOOT generation were significantly enhanced.展开更多
Two different freeze-thaw cycles(FTC)are considered in this study to assess the related impact on gas permeability and micro-pore structure of a mortar.These are the water-freezing/water-thawing(WF-WT)and the air-free...Two different freeze-thaw cycles(FTC)are considered in this study to assess the related impact on gas permeability and micro-pore structure of a mortar.These are the water-freezing/water-thawing(WF-WT)and the air-freezing/air-thawing(AF-AT)cycles.The problem is addressed experimentally through an advanced nuclear magnetic resonance(NMR)technique able to provide meaningful information on the relationships among gas permeability,pore structure,mechanical properties,and the number of cycles.It is shown that the mortar gas permeability increases with the number of FTCs,the increase factor being 20 and 12.83 after 40 cycles for the WF-WT and AF-AT,respectively.The results also confirm that gas permeability hysteresis phenomena occur during the confining pressure loading and unloading process.展开更多
Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent...Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent thoracoscopic lung cancer radical surgery in our hospital from June 2022 to February 2023 were randomly divided into control group and intervention group, with 52 cases in each group. The control group implemented evidence-based ERAS clinical pathway management, while the intervention group implemented evidence-based PDCA cycle quality management. The postoperative recovery of the two groups of patients was compared. Results: The postoperative recovery of the intervention group was significantly better than that of the control group. The first time to get out of bed, the first time to eat, the duration of chest drainage tube placement, and the length of hospital stay were significantly shorter than those of the control group. The incidence of postoperative chest complications and hospitalization costs were significantly lower than those of the control group, and patient satisfaction was significantly higher than that of the control group (P Conclusion: Evidence-based PDCA cycle quality management mode can effectively improve the implementation quality of accelerated rehabilitation nursing for patients undergoing thoracoscopic lung cancer radical surgery, and it is worthy of clinical promotion.展开更多
Upon infecting a host cell,the reticulate body(RB)form of the Chlamydia bacteria simply proliferates by binary fission for an extended period.Available data show only RB units in the infected cells 20 hours post infec...Upon infecting a host cell,the reticulate body(RB)form of the Chlamydia bacteria simply proliferates by binary fission for an extended period.Available data show only RB units in the infected cells 20 hours post infection(hpi),spanning nearly half way through the development cycle.With data collected every 4 hpi,conversion to the elementary body(EB)form begins abruptly at a rapid rate sometime around 24 hpi.By modeling proliferation and conversion as simple birth and death processes,it has been shown that the optimal strategy for maximizing the total(mean)EB population at host cell lysis time is a bang-bang control qualitatively replicating the observed conversion activities.However,the simple birth and death model for the RB proliferation and conversion to EB deviates in a significant way from the available data on the evolution of the RB population after the onset of RB-to-EB conversion.By working with a more refined model that takes into account a small size threshold eligibility requirement for conversion noted in the available data,we succeed in removing the deficiency of the previous models on the evolution of the RB population without affecting the optimal bang-bang conversion strategy.展开更多
Bentonite,consisting of clay minerals of the montmorillonite group,has been widely used as an adsorbent and backfill material in nuclear waste disposal and groundwater remediation.It is challenging to use bentonite as...Bentonite,consisting of clay minerals of the montmorillonite group,has been widely used as an adsorbent and backfill material in nuclear waste disposal and groundwater remediation.It is challenging to use bentonite as a filling material in cold regions since bentonite is highly sensitive to thermal environmental changes,during which its bulk volume and microstructure change significantly.In this study,a series of one-dimensional and three-dimensional freeze-thaw tests were carried out within a closed system to investigate the influencing factors of the deformation of bentonite under freeze-thaw cycles.Results show that the initial soil water content greatly impacts bentonite's deformation during freeze-thaw cycles.For an initial higher degree of saturation(Sr),the expansion caused by the formation of ice lenses has a greater impact than the shrinkage induced by dehydration,ice-cementation,and so on.Conversely,bentonite tends to shrink at a lower degree of saturation during freezing.And the critical degree of saturation that determines bentonite's behavior of frost heave or frost shrinkage seems to be roughly 0.8.As the number of freeze-thaw cycles rises,initially uncompacted bentonite clay becomes more compacted,and initially compacted bentonite clay remains unchanged.展开更多
This research aims to investigate the effect of frost damage on chloride transportation mechanism in ordinary andfiber concrete with both theoretical and experimental methods.The proposed theoretical model takes into a...This research aims to investigate the effect of frost damage on chloride transportation mechanism in ordinary andfiber concrete with both theoretical and experimental methods.The proposed theoretical model takes into account the varying damage levels caused by concrete cover depth and freeze-thaw cycles,which are the two primary parameters affecting the expression of the chloride diffusion coefficient.In the experiment,three types of concrete were prepared:ordinary Portland concrete(OPC),polypropylenefiber concrete(PFC),and steelfiber concrete(SFC).These were then immersed in NaCl solution for 120 days after undergoing 10,25,and 50 freeze-thaw cycles.The damage coefficient of the tested concrete was determined by measuring the dynamic elas-tic modulus.The results indicated that the relative dynamic elasticity modulus of the specimens decreased with each freeze-thaw cycle,and the chloride diffusion coefficient of the specimens increased as the degree of frost degradation increased.Samples containing steel and polypropylenefibers exhibited greater resistance to cyclic water freezing compared to the controlled concrete withoutfibers.A model has been also developed that takes into account the damage caused by freezing-thawing cycles and the depth of the concrete,which can predict variations in free chloride concentration at different depths.The calculated values were in good agreement with the test results for depths between 10 to 30 mm.This new damage-induced diffusion model can helpfill the gap in research on the effects of freeze-thaw cycles on chloride diffusion.展开更多
基金part of the SIREI project num 531062023178 developed at CCT-UV.
文摘The glacial history of Pico de Orizaba indicates that during the Last Glacial Maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m asl.The retraction of the glacier has left behind an intense climatic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geomorphological processes are represented by the fragmentation of the bedrock that occupies the upper parts of the mountain.There is a notable lack of studies regarding the fragmentation and erosion occurring in tropical high mountains,and the associated geomorphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m asl,through continuous monitoring of surface ground temperature.The results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and proglacial.It was found that the paraglacial zone presents an intense drop of temperature,of up to~9℃ in only sixty minutes.The rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the main factor of the constant slope dynamics that occur at the site.This activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the temperature presents a certain degree of stability,until reaching the proglacial zone,where cycles are almost non-existent,and therefore there is no gelifraction activity.The geomorphological processes have resulted in significant alterations to the mountain slopes,which can have severe consequences in terms of risk and water.
基金supported by the National Natural Science Foundation of China(U20A2067,32272360)。
文摘A Pickering emulsion based on sodium starch octenyl succinate(SSOS)was prepared and its effects on the physicochemical properties of hairtail myofibrillar protein gels(MPGs)subjected to multiple freeze-thaw(F-T)cycles were investigated.The whiteness,water-holding capacity,storage modulus(G')and texture properties of the MPGs were significantly improved by adding 1%-2%Pickering emulsion(P<0.05).Meanwhile,Raman spectral analysis demonstrated that Pickering emulsion promoted the transformation of secondary structure,enhanced hydrogen bonds and hydrophobic interactions,and promoted the transition of disulfide bond conformation from g-g-g to g-g-t and t-g-t.At an emulsion concentration of 2%,theα-helix content decreased by 10.37%,while theβ-sheet content increased by 7.94%,compared to the control.After F-T cycles,the structure of the MPGs was destroyed,with an increase in hardness and a decrease in whiteness and water-holding capacity,however,the quality degradation of MPGs was reduced with 1%-2%Pickering emulsion.These findings demonstrated that SSOS-Pickering emulsions,as potential fat substitutes,can enhance the gel properties and the F-T stability of MPGs.
基金the National Natural Science Foundation of China (NSFC)(Grant Nos.U22A20596 and 41771066)the Science and Technology Project of Qinghai-Tibet Railway Company (QZ2021-G03)。
文摘As a widely-applied engineering material in cold regions, the frozen subgrade soils are usually subjected to seismic loading, which are also dramatically influenced by the freeze-thaw(F-T)cycles due to the varying temperature. A series of dynamic cyclic triaxial experiments were conducted through a cryogenic triaxial apparatus for exploring the influences of F-T cycles on the dynamic mechanical properties of frozen subgrade clay.According to the experimental results of frozen clay at the temperature of-10℃, the dynamic responses and microstructure variation at different times of F-T cycles(0, 1, 5, and 20 cycles) were explored in detail.It is experimentally demonstrated that the dynamic stress-strain curves and dynamic volumetric strain curves of frozen clay are significantly sparse after 20F-T cycles. Meanwhile, the cyclic number at failure(Nf) of the frozen specimen reduces by 89% after 20freeze-thaw cycles at a low ratio of the dynamic stress amplitude. In addition, with the increasing F-T cycles,the axial accumulative strain, residual deformation,and the value of damage variable of frozen clay increase, while the dynamic resilient modulus and dynamic strength decrease. Finally, the influence of the F-T cycles on the failure mechanisms of frozen clay was discussed in terms of the microstructure variation. These studies contribute to a better understanding of the fundamental changes in the dynamic mechanical of frozen soils exposed to F-T cycles in cold and seismic regions.
基金This research was funded by the National Natural Science Foundation of China(52078068)Practice Innovation Program of Jiangsu Province(KYCX22_3082).
文摘With the emphasis on environmental issues,the recycling of waste concrete,even recycled concrete,has become a hot spot in the field of architecture.But the repeated recycling of waste concrete used in harsh environments is still a complex problem.This paper discusses the durability and recyclability of recycled aggregate concrete(RAC)as a prefabricated material in the harsh environment,the effect of high-temperature curing(60℃,80℃,and 100℃)on the frost resistance of RAC and physical properties of the second generation recycled coarse aggregate(RCA_(2))of RAC after 300 freeze-thaw cycles were studied.The frost resistance of RAC was characterized by compressive strength,relative dynamic elastic modulus,and mass loss.As the physical properties of RCA_(2),the apparent density,water absorption,and crushing value were measured.And the SEM images of RAC after 300 freeze-thaw cycles were shown.The results indicated that the frost resistance of RAC cured at 80℃ for 7 days was comparable to that cured in the standard condition(cured for 28 days at 20℃±2℃ and 95%humidity),and the RAC cured at 100℃ was slightly worse.However,the frost resistance of RAC cured at 60℃ deteriorated seriously.The RAC cured at 80℃ for 7 days is the best.Whether after the freeze-thaw cycle or not,the RCA that curd at 60℃,80℃,and 100℃ for 7 days can also meet the requirements of Grade III RCA and be used as the aggregate of non-bearing part of prefabricated concrete components.RCA_(2) which is cured at 80℃ for 7 days had the best physical properties.
基金The authors gratefully acknowledge the financial support of National NaturalScience Foundation of China(Grant No.41972276)Natural Science Foundation of Fujian Province,China(Grant No.2020J06013)"Foal Eagle Program"Youth Top-notch Talent Project of Fujian Province,China(Grant No.00387088).
文摘Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic characteristics of EICP-treated specimens against the impact of drying-wetting(D-W)cycles is under-explored yet.This study investigates the evolution of mechanical behavior and pore charac-teristics of EICP-treated sea sand subjected to D-W cycles.The uniaxial compressive strength(UCS)tests,synchrotron radiation micro-computed tomography(micro-CT),and three-dimensional(3D)recon-struction of CT images were performed to study the multiscale evolution characteristics of EICP-reinforced sea sand under the effect of D-W cycles.The potential correlations between microstructure characteristics and macro-mechanical property deterioration were investigated using gray relational analysis(GRA).Results showed that the UCS of EICP-treated specimens decreases by 63.7% after 15 D-W cycles.The proportion of mesopores gradually decreases whereas the proportion of macropores in-creases due to the exfoliated calcium carbonate with increasing number of D-W cycles.The micro-structure in EICP-reinforced sea sand was gradually disintegrated,resulting in increasing pore size and development of pore shape from ellipsoidal to columnar and branched.The gray relational degree suggested that the weight loss rate and UCS deterioration were attributed to the development of branched pores with a size of 100-1000 m m under the action of D-W cycles.Overall,the results in this study provide a useful guidancee for the long-term stability and evolution characteristics of EICP-reinforced sea sand under D-W weathering conditions.
基金This work was supported by the Chinese TMSR Strategic Pioneer Science and Technology Project(No.XDA02010300).
文摘A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power system.This model considers the impact of thermal properties of fluid variation on accuracy and has been validated with Simulink.This study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet parameters.Meanwhile,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also analyzed.The results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial values.This simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.
基金supported by the Natural Science Foundation of Ningxia(2022AAC05044)the National Natural Science Foundation of China(12161069)。
文摘This paper deals with the problem of limit cycles for the whirling pendulum equation x=y,y=sin x(cosx-r)under piecewise smooth perturbations of polynomials of cos x,sin x and y of degree n with the switching line x=0.The upper bounds of the number of limit cycles in both the oscillatory and the rotary regions are obtained using the Picard-Fuchs equations,which the generating functions of the associated first order Melnikov functions satisfy.Furthermore,the exact bound of a special case is given using the Chebyshev system.At the end,some numerical simulations are given to illustrate the existence of limit cycles.
文摘The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to still be observable today. Since Jupiter orbits the Sun with a period of approximately 12 years, it has always been thought that this could be connected to the nearly 11-year periodic peak in the number of sunspots observed. In this paper, the Sun and planets are considered to be moving about a center of mass point as the different planets orbit the Sun. This is the action of gravity that holds the solar system together. The center of mass for the Jupiter-Sun system actually lies outside the Sun. The four gas giant planets dominate such effects and the four gas giant Jovian planets can be projected together to determine an effective distance from the Sun’s center. Taken together these effects do seem to function as a sunspot forcing factor with a periodicity very close to 11 years. These predictions are made without consideration of any details of what is happening in the interior of the Sun. From these estimates, sunspot cycle 25 will be expected to peak in about September-October of 2025. Sunspot cycle 26 should peak in the year March of 2037.
基金National Natural Science Foundation of China,Grant/Award Numbers:51972178,52202061Hunan Provincial Nature Science Foundation,Grant/Award Number:2022JJ40068。
文摘Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induced by the large radius of K+ions.Here,we explore high-performance K-ion half/full batteries with high rate capability,high specific capacity,and extremely durable cycle stability based on carbon nanosheets with tailored N dopants,which can alleviate the change of volume,increase electronic conductivity,and enhance the K+ion adsorption.The as-assembled K-ion half-batteries show an excellent rate capability of 468 mA h g^(−1) at 100 mA g^(−1),which is superior to those of most carbon materials reported to date.Moreover,the as-assembled half-cells have an outstanding life span,running 40,000 cycles over 8 months with a specific capacity retention of 100%at a high current density of 2000 mA g^(−1),and the target full cells deliver a high reversible specific capacity of 146 mA h g^(−1) after 2000 cycles over 2 months,with a specific capacity retention of 113%at a high current density of 500 mA g^(−1),both of which are state of the art in the field of K-ion batteries.This study might provide some insights into and potential avenues for exploration of advanced K-ion batteries with durable stability for practical applications.
基金Funded by the National Natural Science Foundation of China (No.51972214)the Innovation Team of Higher Education Institutions in Liaoning Province (No.LT2019012)。
文摘In order to study the effect of PVA fiber on the dynamic and static mechanical properties of low-temperature freeze-thaw concrete under the saturated surface dry state,different contents of PVA fiber were added to prepare concrete in this experiment.The concrete was subjected to compression,flexural and SHPB impact tests combined with scanning electron microscopy for microstructure analysis,after different times of freeze-thaw cycles in the temperature range of 20-70℃.The experimental results show that the compressive strength of the PVA fiber reinforced concrete first increases and then decreases after freeze and thaw cycles,and the compressive strength is positively correlated with the fiber content.The flexural strength gradually decreases with freeze-thaw cycles.The flexural strength of the concrete with 1.2 kg/m^(3) of PVA fiber presents the lowest strength loss after 45 freeze and thaw cycles,which is about 14%.The dynamic failure strength gradually decreases with the increase of freeze-thaw times,and the reduction amplitude decreases with the increase of PVA fiber content.The best impact resistance is achieved when the PVA fiber dosage is 1.2 kg/m^(3).
基金the Fundamental Research Funds for the Central Universities(Project No.2022CDJKYJH037)the National Key R&D Program of China(Grant No.2021YFB3901402)。
文摘To study the damage mechanisms of anhydrite rock under freeze-thaw cycles, the physicalmechanical properties and the microcracking activities of anhydrite rock were investigated through mass variation, nuclear magnetic resonance, scanning electron microscope tests, and uniaxial compression combined with acoustic emission(AE) tests. Results show that with the increase of freeze-thaw processes,the mass, uniaxial compression strength, and elastic modulus of the anhydrite specimens decrease while the porosity and plasticity characteristics increase.For example, after 120 cycles, the uniaxial compression strength and elastic modulus decrease by 46.54% and 60.16%, and the porosity increase by 75%. Combined with the evolution trend of stressstrain curves and the detected events, three stages were labeled to investigate the AE characteristics in freeze-thaw weathered anhydrite rock. It is found that with the increase of freeze-thaw cycles, the proportions of AE counts in stage Ⅰ and stage Ⅱ show a decaying exponential trend. Contrarily, the proportion of AE counts in stage Ⅲ displays an exponential ascending trend. Meanwhile, as the freeze-thaw cycles increase, the low-frequency AE signals increase while the intermediate-frequency AE signals decrease. After 120 cycles, the proportion of low-frequency AE signals increases by 168.95%, and the proportion of intermediate-frequency AE signals reduces by 81.14%. It is concluded that the microtensile cracking events occupy a dominant position during the loading process. With the increase of freeze-thaw cycles, the b value of samples decreases.After 120 cycles, b value decreases by 27.2%, which means that the proportion of cracking events in rocks with small amplitude decreases. Finally, it is proposed that the freeze-thaw damage mechanism of anhydrite is also characterized by the water chemical softening effect.
基金funded by the GRRC Program of Gyeonggi province[GRRC-KyungHee2023(B01)],Republic of Korea.
文摘Objective:To examine the inhibitory effect of Hydrangea serrata extract against hepatocellular carcinoma HepG2 cells and its underlying mechanisms.Methods:The effects of Hydrangea serrata extract on growth inhibition of tumor cells and spheroids were assessed using MTT and 3D culture assays.Quantitative real-time PCR and Western blot analyses were employed to investigate the changes in mRNA and protein expression levels of molecules related to cell cycle and apoptosis.Results:Hydrangea serrata extract effectively inhibited the growth of both tumor cells and spheroids.The extract also significantly upregulated p27 mRNA expression and downregulated CDK2 mRNA expression,leading to cell cycle arrest.Moreover,increased BAX/Bcl-2 ratio as well as caspase-9 and-3 were observed after treatment with Hydrangea serrata extract,indicating the induction of tumor cell apoptosis.Conclusions:Hydrangea serrata extract has the potential to alleviate tumors by effectively modulating cell-cycle-related gene expressions and inducing apoptosis,thereby inhibiting tumor growth.
基金supported by the National Natural Science Foundation of China(52173143 and 82371108)Natural Science Foundation of Henan Province(232300421176)Basic Science Key Project of Henan Eye Hospital(20JCZD002 and 23JCZD003).
文摘Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.
基金funded by the National Natural Science Foundation of China under Grant No.51505275.
文摘The Miller cycle is a program that effectively reduces NOx emissions from marine diesel engines by lowering the maximum combustion temperature in the cylinder,thereby reducing NOx emissions.To effectively investigate the impact of Miller cycle optimum combustion performance and emission capability under high load conditions,this study will perform a one-dimensional simulation of the performance of a marine diesel engine,as well as a threedimensional simulation of the combustion in the cylinder.A 6-cylinder four-stroke single-stage supercharged diesel engine is taken as the research object.The chassis dynamometer and other related equipment are used to build the test system,carry out the diesel engine bench test,and collect experimental data.The simulation results are compared with the test results,and the error is less than 5%.In this study,the authors will use simulation software to simulate several Miller cycle scenarios designed for early inlet valve closure and analyze the impact of the Miller cycle on combustion and emissions at 100%load conditions.By comparing the flow field distribution of the engine at 1500 r/min condition,it was found that proper EIVC can prolong the ignition latency period and homogeneous fuel-air mixture combustion acceleration,but it can reduce pressure and temperature within the piston chamber and NOx emission.However,the Miller cycle reduces end-of-compression temperatures,which increases combustion duration and exhaust temperatures,making it difficult to improve fuel economy at the optimum fuel consumption point,and closing the intake valves prematurely leads to excessive fuel expenditure.Furthermore,temperature and heat release rate within the piston chamber,NOx,and SOOT generation were significantly enhanced.
基金supported by the National Natural Science Foundation of China(Grant No.51709097).
文摘Two different freeze-thaw cycles(FTC)are considered in this study to assess the related impact on gas permeability and micro-pore structure of a mortar.These are the water-freezing/water-thawing(WF-WT)and the air-freezing/air-thawing(AF-AT)cycles.The problem is addressed experimentally through an advanced nuclear magnetic resonance(NMR)technique able to provide meaningful information on the relationships among gas permeability,pore structure,mechanical properties,and the number of cycles.It is shown that the mortar gas permeability increases with the number of FTCs,the increase factor being 20 and 12.83 after 40 cycles for the WF-WT and AF-AT,respectively.The results also confirm that gas permeability hysteresis phenomena occur during the confining pressure loading and unloading process.
文摘Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent thoracoscopic lung cancer radical surgery in our hospital from June 2022 to February 2023 were randomly divided into control group and intervention group, with 52 cases in each group. The control group implemented evidence-based ERAS clinical pathway management, while the intervention group implemented evidence-based PDCA cycle quality management. The postoperative recovery of the two groups of patients was compared. Results: The postoperative recovery of the intervention group was significantly better than that of the control group. The first time to get out of bed, the first time to eat, the duration of chest drainage tube placement, and the length of hospital stay were significantly shorter than those of the control group. The incidence of postoperative chest complications and hospitalization costs were significantly lower than those of the control group, and patient satisfaction was significantly higher than that of the control group (P Conclusion: Evidence-based PDCA cycle quality management mode can effectively improve the implementation quality of accelerated rehabilitation nursing for patients undergoing thoracoscopic lung cancer radical surgery, and it is worthy of clinical promotion.
文摘Upon infecting a host cell,the reticulate body(RB)form of the Chlamydia bacteria simply proliferates by binary fission for an extended period.Available data show only RB units in the infected cells 20 hours post infection(hpi),spanning nearly half way through the development cycle.With data collected every 4 hpi,conversion to the elementary body(EB)form begins abruptly at a rapid rate sometime around 24 hpi.By modeling proliferation and conversion as simple birth and death processes,it has been shown that the optimal strategy for maximizing the total(mean)EB population at host cell lysis time is a bang-bang control qualitatively replicating the observed conversion activities.However,the simple birth and death model for the RB proliferation and conversion to EB deviates in a significant way from the available data on the evolution of the RB population after the onset of RB-to-EB conversion.By working with a more refined model that takes into account a small size threshold eligibility requirement for conversion noted in the available data,we succeed in removing the deficiency of the previous models on the evolution of the RB population without affecting the optimal bang-bang conversion strategy.
基金supported by the National Natural Science Foundation of China(Nos.42072316,51979002).
文摘Bentonite,consisting of clay minerals of the montmorillonite group,has been widely used as an adsorbent and backfill material in nuclear waste disposal and groundwater remediation.It is challenging to use bentonite as a filling material in cold regions since bentonite is highly sensitive to thermal environmental changes,during which its bulk volume and microstructure change significantly.In this study,a series of one-dimensional and three-dimensional freeze-thaw tests were carried out within a closed system to investigate the influencing factors of the deformation of bentonite under freeze-thaw cycles.Results show that the initial soil water content greatly impacts bentonite's deformation during freeze-thaw cycles.For an initial higher degree of saturation(Sr),the expansion caused by the formation of ice lenses has a greater impact than the shrinkage induced by dehydration,ice-cementation,and so on.Conversely,bentonite tends to shrink at a lower degree of saturation during freezing.And the critical degree of saturation that determines bentonite's behavior of frost heave or frost shrinkage seems to be roughly 0.8.As the number of freeze-thaw cycles rises,initially uncompacted bentonite clay becomes more compacted,and initially compacted bentonite clay remains unchanged.
基金supported by the Graduate Research Innovation Program of Jiangsu University(Si Y.D.,SJCX21_1689)the Foundation from the National Natural Science Foundation of China(Yan Y.D.,51608233).
文摘This research aims to investigate the effect of frost damage on chloride transportation mechanism in ordinary andfiber concrete with both theoretical and experimental methods.The proposed theoretical model takes into account the varying damage levels caused by concrete cover depth and freeze-thaw cycles,which are the two primary parameters affecting the expression of the chloride diffusion coefficient.In the experiment,three types of concrete were prepared:ordinary Portland concrete(OPC),polypropylenefiber concrete(PFC),and steelfiber concrete(SFC).These were then immersed in NaCl solution for 120 days after undergoing 10,25,and 50 freeze-thaw cycles.The damage coefficient of the tested concrete was determined by measuring the dynamic elas-tic modulus.The results indicated that the relative dynamic elasticity modulus of the specimens decreased with each freeze-thaw cycle,and the chloride diffusion coefficient of the specimens increased as the degree of frost degradation increased.Samples containing steel and polypropylenefibers exhibited greater resistance to cyclic water freezing compared to the controlled concrete withoutfibers.A model has been also developed that takes into account the damage caused by freezing-thawing cycles and the depth of the concrete,which can predict variations in free chloride concentration at different depths.The calculated values were in good agreement with the test results for depths between 10 to 30 mm.This new damage-induced diffusion model can helpfill the gap in research on the effects of freeze-thaw cycles on chloride diffusion.