Ultrahigh-Speed Lattice-Matched In_(0.53)Ga_(0.47)As/In_(0.52)Al_(0.48)As HEMTs with 218GHz Cutoff Frequency

Lattice-matched In0.5 Ga0.47 As/In0.52 Al 0.48 As high electron mobility transistors （HEMTs） with a cutoff frequency （ft） as high as 218GHz are reported. This fT is the highest value ever reported for HEMTs in China. These devices also demonstrate excellent DC characteristics：the extrinsic transconductance is 980mS/mm and the maximum current density is 870mA/mm. The material structure and all the device fabrication technology in this work were developed by our group.

FEV_(1)%pred、FEV_(1)/VC_(max)%在不同年龄哮喘患儿临床诊断中的应用价值

目的:研究FEV_(1)%pred(第1秒用力呼气容积占预测值的百分比)、FEV_(1)/VC_(max)%(第1秒用力呼气体积与最大肺活量的百分比)在不同年龄哮喘患儿临床诊断中的应用价值。方法:选取佛山市妇幼保健院2022年5月—2023年5月就诊的哮喘患儿,并按照年龄阶段不同分为学龄前组(5~6岁)、早学龄组(7~8岁)、中学龄组(9~10岁)、晚学龄组(11~12岁)、青春初期组(13~14岁),各30例,另外选取同期在医院进行体检的健康儿童90例作为学龄前对照组、早学龄对照组、中学龄对照组、晚学龄对照组、青春初期对照组,各18例。检测不同组别患儿的FEV_(1)%pred、FEV_(1)/FVC_(max)%,同时用受试者操作特征(ROC)曲线界定出不同组患儿诊断哮喘的FEV_(1)%pred、FEV_(1)/VC_(max)%的最佳界值,比较不同组FEV_(1)%pred、FEV_(1)/VC_(max)%切点值的敏感度及特异度。结果:五组哮喘患儿FEV_(1)%pred、FEV_(1)/VC_(max)%均低于对照组,差异均有统计学意义(P<0.05);以85.67%、84.11%为界点鉴别诊断在早学龄组患儿FEV_(1)%pred、FEV_(1)/VC_(max)%的AUC值最大,敏感度和特异度分别为83.3%、94.4%及76.7%、94.4%。结论:FEV_(1)%pred和FEV_(1)/VC_(max)%作为哮喘诊断指标,在不同年龄段哮喘患儿中显示出差异化的敏感度和特异度,其最佳切点值能有效指导临床诊断,对早期识别和治疗哮喘具有重要应用价值。

轧制应变速率对Mg-1%Al合金组织、阻尼和力学性能的影响

在不同应变速率下轧制Mg-1%Al合金板材,研究了轧制应变速率对Mg-1%Al合金显微组织、力学性能和阻尼性能的影响。随着轧制应变速率增加,Mg-1%Al合金的平均晶粒尺寸和再结晶体积分数增加;抗拉强度、屈服强度和织构强度减小;延伸率先升高后降低,在应变速率20 s^(-1)时达到最高,为25.33%。随着应变速率增加,室温阻尼性能增加,应变速率30 s^(-1)下应变振幅0.1%时阻尼值为0.061,是应变速率15 s^(-1)时的1.5倍。应变速率一定时,阻尼性能随着频率增加而降低。

1%粉唑醇颗粒剂对玉米不同生育期生长性状及产量的影响

为了切实践行高工效植保的理念,采用地表撒施的方法施用1%粉唑醇颗粒剂后进行全田漫灌,以不施药为对照(CK),研究了不同施药量(6、12、18、24、30、36和42 kg/hm^(2))处理对玉米不同生育期生长性状及产量的影响。结果表明:与CK相比,不同施药量处理不仅对各生育期玉米生长性状(株高、茎秆直径、叶面积、叶绿素含量)的影响存在一定差异,且对成熟期玉米穗部性状和产量的影响也存在一定差异,其中施药量为30 kg/hm^(2)时增产显著,施药量为24 kg/hm^(2)时略有增产。研究结果实现了一次施药即可促进玉米生长、改善穗部性状、提高产量,符合当前我们植保工作的发展方向。

精准脉冲光联合1%吡美莫司乳膏治疗红斑毛细血管扩张型玫瑰痤疮的临床观察

目的 观察精准脉冲光(DPL)联合1%吡美莫司乳膏治疗红斑毛细血管扩张型玫瑰痤疮的临床效果。方法 选取2022年1月至2022年12月在漯河市第二人民医院皮肤科确诊的80例红斑毛细血管扩张型玫瑰痤疮患者,随机分为观察组(41例)与对照组(39例)。观察组采用DPL治疗,每4周1次,3次1个疗程,同时联合外用1%吡美莫司乳膏,2次/d,共12周;对照组仅外用1%吡美莫司乳膏2次/d,共12周。比较两组治疗后的疗效及不良反应。结果 治疗后第4、8、12周,观察组的皮损评分分别为9.26±1.86、7.91±1.87、5.95±1.46,明显低于对照组的11.38±1.36、10.67±1.64、8.67±1.35,差异有统计学意义(t值分为3.26、3.69、4.12,P值分别为0.002、0.001、0.001)。观察组有效率分别为29.27%、56.10%、73.17%,明显高于对照组的10.26%、28.21%、38.46%,差异有统计学意义(χ^(2)值分别为4.52、6.36、9.79,P值分别为0.034、0.012、0.002)。两组均未发生明显不良反应。结论 DPL联合1%吡美莫司乳膏治疗红斑毛细血管扩张型玫瑰痤疮临床疗效好,无明显不良反应,是一种有效、安全的方法。

ENSO Frequency Asymmetry and the Pacific Decadal Oscillation in Observations and 19 CMIP5 Models

Using observational data and the pre-industrial simulations of 19 models from the Coupled Model Intercomparison Project Phase 5（CMIP5）, the El Ni o（EN） and La Ni a（LN） events in positive and negative Pacific Decadal Oscillation（PDO） phases are examined. In the observational data, with EN（LN） events the positive（negative） SST anomaly in the equatorial eastern Pacific is much stronger in positive（negative） PDO phases than in negative（positive） phases. Meanwhile,the models cannot reasonably reproduce this difference. Besides, the modulation of ENSO frequency asymmetry by the PDO is explored. Results show that, in the observational data, EN is 300% more（58% less） frequent than LN in positive（negative）PDO phases, which is significant at the 99% confidence level using the Monte Carlo test. Most of the CMIP5 models exhibit results that are consistent with the observational data.

Similarities and differences in inherent mechanism and characteristic frequency between the one-dimensional poroelastic model and the layered White model

The similarities and differences in inherent mechanism and characteristic frequency between the onedimensional(1D)poroelastic model and the layered White model were investigated.This investigation was conducted under the assumption that the rock was homogenous and isotropic at the mesoscopic scale.For the inherent mechanism,both models resulted from quasi-static flow in a slow P-wave diffusion mode,and the differences between them originated from saturated fluids and boundary conditions.On the other hand,for the characteristic frequencies of the models,the characteristic frequency of the 1D poroelastic model was first modified because the elastic constant and formula for calculating it were misused and then compared to that of the layered White model.Both of them moved towards higher frequencies with increasing permeability and decreasing viscosity and diffusion length.The differences between them were due to the diffusion length.The diffusion length for the 1D poroelastic model was determined by the sample length,whereas that for the layered White model was determined by the length of the representative elementary volume(REV).Subsequently,a numerical example was presented to demonstrate the similarities and differences between the models.Finally,published experimental data were interpreted using the 1D poroelastic model combined with the Cole-Cole model.The prediction of the combined model was in good agreement with the experimental data,thereby validating the effectiveness of the 1D poroelastic model.Furthermore,the modified characteristic frequency in our study was much closer to the experimental data than the previous prediction,validating the effectiveness of our modification of the characteristic frequency of the 1D poroelastic model.The investigation provided insight into the internal relationship between wave-induced fluid flow(WIFF)models at macroscopic and mesoscopic scales and can aid in a better understanding of the elastic modulus dispersion and attenuation caused by the WIFF at different scales.

Relations among High-frequency Magnetic Properties and Frequency in Nanocrystalline Fe_(72.5)Cu_1Nb_2V_2Si_(13.5)B_9 Alloy

High-frequency magnetic properties, such as core loss, coercivity and amplitude permeabilityof a newly-developed nanocrystalline Fe72.5Cu1Nb2V2Si13.5B9 alloy in the wide ranges of f =20-103 kHz, Bm = 0.01~0.6 T and Bmf = 10~40 (T.kHz) have been measured. A largeamount of experimental data have been fitted by a computer, thus obtaining several expressionsrepresenting the influence of frequency on high-frequency magnetic properties, that are useful inpractical applications.

Effects of routine rehabilitation therapy combined with low frequency electrical stimulation on monoamine neurotransmitters, NSE, ET-1 and cerebral hemodynamics in children with cerebral palsy

Objective:To investigate the effects of routine rehabilitation therapy combined with low frequency head stimulation on monoamine neurotransmitters, neuron-specific enolase (NSE), endothelin-1 (ET-1) and cerebral hemodynamics in children with cerebral palsy.Methods:From January 2017 to June 2018, 110 children with cerebral palsy were randomly divided into observation group (55 cases) and control group (55 cases). The control group received routine rehabilitation treatment, while the observation group received low-frequency head stimulation on the basis of routine rehabilitation treatment. The changes of dopamine (DA), norepinephrine (NE), serotonin (5-HT), NSE, ET-1 levels and mean blood flow velocity of anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA) were compared in two groups.Results:Before treatment, there was no significant difference in DA, NE and 5-HT levels in two groups. After treatment, DA, NE and 5-HT levels in the observation group were (192.23±22.71) ng/mL, (98.02±11.71) ng/L, (210.07±25.03) ng/L, and in the control group. the DA, NE, 5-HT levels were (147.06±17.02) ng/mL, (83.07±11.15) ng/L, and (171.88±20.45) ng/L, respectively. The DA, NE and 5-HT levels in two groups were higher than those before treatment, and DA, NE and 5-HT levels in the observation group were higher than those in the control group. Before treatment, there was no significant difference in NSE and ET-1 levels between the two groups. After treatment, the NSE and ET-1 levels in the observation group were (7.97±2.07) μg/L and (41.01±10.07) pg/mL, and the NSE and ET-1 levels in the control group were (10.38±3.02) μg/L, (58.46±15.02) pg/mL, respectively. the NSE and ET-1 in two groups were lower than those before treatment, and the NSE and ET-1 of the observation group were lower than the control group. Before treatment, there was no significant difference in mean blood flow velocity between ACA, MCA and PCA. After treatment, the mean blood flow velocities of ACA, MCA, and PCA in the observation group were (46.88±7.72) cm/s, (59.85±10.18) cm/s, and (49.15±7.02) cm/s, respectively, which was significantly higher than before treatment and higher than that of the control group in the same period.Conclusion: Conventional rehabilitation combined with low-frequency electrical stimulation of the head can effectively increase the content of monoamine neurotransmitters in children with cerebral palsy, enhance cerebral blood circulation, and reduce brain damage.

l_(1)-norm Based GWLP for Robust Frequency Estimation

In this work,we address the frequency estimation problem of a complex single-tone embedded in the heavy-tailed noise.With the use of the linear prediction(LP)property and l_(1)-norm minimization,a robust frequency estimator is developed.Since the proposed method employs the weighted l_(1)-norm on the LP errors,it can be regarded as an extension of the l_(1)-generalized weighted linear predictor.Computer simulations are conducted in the environment of α-stable noise,indicating the superiority of the proposed algorithm,in terms of its robust to outliers and nearly optimal estimation performance.

Frequency Structures Vibration Identified by an Adaptative Filtering Techiques Applied on GPS L1 Signal

This paper is part of a research under enhancement since 2001, in which the main objective is to measure small dynamic displacements by analysis of L1 GPS carrier frequency with 1575.42 MHz—wavelength 19.05 cm, under an adaptive method for collecting data and filtering techniques. This method, named Phase Residual Method (PRM) is based on the frequency domain analysis of the phase residuals resulted from the L1 double difference static data processing of two satellites in almost orthogonal elevation angle. In this work it is proposed to obtain the phase residuals directly from the raw phase observable collected in a short baseline during a limited time span, in lieu of obtaining the residual data file from regular GPS processing programs. In order to improve the ability to detect millimetric displacements, two filtering techniques are introduced. The first one is the autocorrelation that reduces the phase noise with random time behavior. The other one is the running mean to separate low frequency from the high frequency phase sources. Two trials are presented to verify the proposed method and filtering techniques applied. One simulates a 2.5 millimeter vertical GPS antenna displacement and the second using the data collected during a bridge dynamic load test. The results show a good consistency to detect millimetric oscillations from L1 frequency and filtering techniques.

高频超声联合血清CA125、CA199、CYFRA21-1对乳腺肿块的鉴别诊断价值

目的:探讨高频超声联合血清糖类抗原125(CA125)、糖类抗原199(CA199)、细胞角蛋白19片段(CYFRA21-1)对乳腺肿块的鉴别诊断价值。方法:选取2021年6月—2023年4月信阳市妇幼保健院收治的120例乳腺肿块患者作为研究对象,根据手术或病理活检结果将其分为恶性组(86例)、良性组(34例)。比较两组患者高频超声诊断乳腺肿块结果,血清CA125、CA199、CYFRA21-1水平及其联合诊断结果,并分析其单独及联合诊断价值。结果:相较于良性组,恶性组患者乳腺肿块多呈不规则形状,且存在钙化现象,肿块内部呈不均匀回声,边界不清晰,纵横比>1,差异均有统计学意义(χ^(2)=91.962、79.099、53.861、72.881、90.133,P<0.05)。恶性组患者CA125、CA199、CYFRA21-1均明显高于良性组,差异均有统计学意义(t=27.986、18.877、15.019,P<0.05)。相较于单独检测,联合诊断的灵敏度、准确度均较高,漏诊率较低,差异均有统计学意义(χ^(2)=17.425、21.217、17.425,P<0.05)。结论:高频超声、CA125、CA199、CYFRA21-1联合诊断可显著提升诊断灵敏度,降低漏诊率,可为临床诊断乳腺肿块提供可靠依据。

Treatment time influences the effects of a low-frequency pulsed electric field on synthesis of tyrosine hydroxylase and dopamine in PC12 cells

BACKGROUND： Electromagnetic radiation can influence dopamine （DA） synthesis in brain tissues or ceils, but electromagnetic frequencies, intensities, and radiation time can produce different effects. In addition, the signal pathway by which electromagnetic radiation influences DA synthesis remains controversial. OBJECTIVE： To determine tyrosine hydroxylase （TH） expression in PC12 cells and DA levels in cell culture media after different periods of low-frequency pulsed electric field （LF-PEF） stimulation, and to determine how LF-PEF signaling stimulates TH synthesis using inhibitors. DESIGN, TIME AND SETTING： A parallel, controlled, cell experiment was performed at the Laboratory of Cell Biology, School of Life Science, East China Normal University, between January and October 2006. MATERIALS： PC12 cells were purchased from the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China. Nerve growth factor was purchased from PeproTech, USA. The protein kinase A inhibitor, H-89, and mitogen-activated protein kinase kinase inhibitor, U0126, were purchased from Sigma, USA. METHODS： （1） Following routine culture in Dulbecco＇s modified eagle medium, primary PC12 cells were stimulated under LF-PEF （pulse frequency 50.Hz, pulse width 20 μs, peak field strength 1 V/m） for 5, 10, 15, 20, and 30 minutes. （2） Inhibitors （H-89 or U0126, 1 μmol/L） were added 30 minutes before LF-PEF stimulation for 10 minutes. MAIN OUTCOME MEASURES： （1） TH expression was determined by Western blot in PC12 cells at 0.5, 1,2, 3, and 4 days after LF-PEF stimulation. Similarly, DA was measured by high-performance liquid chromatography in media at 2, 3, 4, or 5 days after LF-PEE （2） TH expression was detected 1 day after H-89 or U0126 treatment and LF-PEE RESULTS： （1） Short-term LF-PEF stimulation （5 and 10 minutes） increased TH expression and media DA levels after short-term culture （2 days） （P 〈 0.01）, but both parameters decreased with longer culture （3 4 days） （P 〈 0.01）. Long-term LF-PEF stimulation （15, 20, or 30 minutes） decreased TH and DA synthesis, followed by a rapid increase （P 〈 0.01）. （2） H89 could completely inhibit TH expression in PC12 cells stimulated by LF-PEF for 10 minutes, while the inhibition rate of U0126 was 53.2%. CONCLUSION： Short-term LF-PEF first promotes then inhibits, while long-term LF-PEF first inhibits then promotes, TH and DA synthesis. LF-PEF stimulation regulates TH expression primarily by activating protein kinase A to regulate DA synthesis.

1%盐酸特比萘芬软膏治疗浅部真菌病随机双盲对照多中心临床试验

1％盐酸特比萘芬软膏治疗手足癣的临床治愈率 69.8％，有效率 97.7％，真菌清除率 100％；对体股癣分别为 97.0％、 100％和 100％；对花斑癣分别为 90.0％、 100％和 100％。不良反应发生率 1.87％，表现为局部刺激。在体外特比萘芬对皮肤癣菌的 MIC范围为 0.00125～ 0.02mg/L,MIC50为 0.0025mg/L， MIC90为 0.005mg/L。

1%双硫磷砂粒剂现场灭蚊幼效果研究

目的研究1%双硫磷砂粒剂对大容器和河流孳生的淡色库蚊、废旧轮胎和雨水井中孳生的白纹伊蚊幼虫的现场杀灭效果,以及该药物控制不同类型孳生地蚊虫孳生的持效期和适宜浓度。方法用不同浓度1%双硫磷砂粒剂处理淡色库蚊和白纹伊蚊孳生地,观察2种蚊幼密度变化及持效期。结果投放0.25mg/L 1%双硫磷砂粒剂28 d后,容器内淡色库蚊幼虫密度下降率达到80%以上,持效期接近1个月,而投放2g/m2剂量于河流中,淡色库蚊幼虫密度下降80%以上的时间为11 d,持效期为12 d;对白纹伊蚊而言,1 mg/L剂量投放20 d后,对废旧轮胎和雨水井蚊幼的杀灭效果差不多,蚊幼密度下降率都接近100%。结论1%双硫磷砂粒剂对河流中淡色库蚊的有效控制时间在2周左右,1 mg/L剂量对其他孳生地的淡色库蚊和白纹伊蚊的有效控制时间均在28 d左右。

0.1%洗必泰口腔冲洗在气管插管患者中的应用

目的探讨使用0.1%洗必泰进行口腔冲洗在气管插管患者中的临床效果。方法选择120例气管插管患者随机分为观察组和对照组,各60例,对照组采用生理盐水纱布进行口腔擦洗,观察组在使用0.1%洗必泰进行口腔擦洗的基础上进行口腔冲洗。比较两组患者口腔定植菌及VAP等并发症的发生情况。结果观察组痰细菌图片培养阳性率降低16.67%;痰培养阳性率降低28.3%;发生VAP风险降低28.33%;呼吸机相关肺炎等护理并发症的发生率明显低于对照组(P<0.05)。结论使用0.1%洗必泰进行口腔冲洗可以降低患者VAP及其他并发症的风险,改善患者预后。

我国省属高校ESI世界前1%学科分布特征及发展策略

以ESI数据库2015年7月更新的数据为依据,对我国省属高校入围ESI世界前1%学科的来源机构、高等院校、学科指标、来源地域、学科领域及排名位次等特征进行分析,发现省属高校ESI学科存在若干问题:校际分布严重不均,学科指标差距明显,地域分布聚集显著,学科领域高度集中,排名位次普遍靠后。为促进省属高校ESI学科的合理分布,高校应提高对ESI学科建设的重视程度,抢抓国家"双一流"建设机遇,深化学科内涵发展,推进学科协同创新,服务区域经济发展。

1%安备双硫磷颗粒剂控制城市内河蚊幼效果研究

目的了解1%安备双硫磷颗粒剂对城市内河孳生的致倦库蚊蚊幼虫的现场杀灭效果和该药物控制缓慢流动水型孳生地蚊虫孳生的持效期。方法将1%安备双硫磷颗粒剂用纱布包好,按2～5 g/m2投放在城市内河的缓流区河岸边的水体中,观察内河致倦库蚊蚊幼密度变化及药效持效期。结果 按2～5 g/m2剂量投放于河流后的1～11 d河道中的致倦库蚊蚊幼虫密度下降率均达到100%;3条试验的内河灭效大于80%的持效期为17 d。结论 1%安备双硫磷颗粒剂2～5 g/m2剂量可持续控制城市内河缓慢流动的水体中致倦库蚊幼虫,有效控制时间在2.5周左右;第19天控制效果明显下降,3条内河的控制效果也出现了差异,RPI值分别为:18.30、59.295、4.65;第25天时密度下降率分别为:42.3%、23.2%、9.7%;表明药物浓度降低后,由于内河水流速度和水质混浊的影响,使得后期药效存在较大差异。

退火温度对高纯Al-1% Si-0.5% Cu合金晶粒、异常长大的影响

介绍了在同一变形条件下,退火温度对高纯Al-1%Si-0.5%Cu(质量分数,下同)合金的再结晶晶粒尺寸的影响。实验证明纯度达到99.999%以上的Al-1%Si-0.5%Cu合金锭坯,经过均匀化处理、多向锻造、中间退火及冷轧、再结晶退火后,在420～450℃时即可形成均匀、细小的等轴晶粒,但当退火温度≥480℃时,局部区域出现晶粒异常长大现象,最大晶粒异常长大温度约为480℃。研究认为退火温度较高时,改变了局部区域第二相的溶解析出行为,造成局部区域第二相减少、粗化,所提供的阻力不足以克服晶界移动的驱动力,则在一些晶界阻力不均匀的地方会发生个别晶粒异常长大。因此在该变形条件下,应控制再结晶退火温度低于480℃,在420～450℃时可得到平均晶粒尺寸近50μm的锭坯。

1.8%复硝酚钠胁迫对五味子木脂素类成分含量的影响

以五味子为试材,研究了不同浓度的1.8%复硝酚钠水剂胁迫对五味子果实木脂素类成分含量的影响。结果表明:五味子醇甲、五味子醇乙、五味子丙素含量最高的是1.8%复硝酚钠的3 000倍稀释液配施底肥处理组,分别为9.57、2.68、1.13mg/g,显著高于其它处理组。五味子甲素、五味子乙素含量最高的是空白对照组,含量分别为3.14、3.30mg/g,其中空白对照组五味子甲素的含量显著高于其它处理,但空白对照组的五味子乙素的含量与3 000倍稀释液配施底肥处理组之间差异不显著,与其它处理组差异显著。1.8%复硝酚钠水剂的2 000倍稀释液配施底肥处理组的五味子酯甲的含量显著高于其它处理组,含量为1.90mg/g。