In this review,we introduce some chip-based waveguide biosensing and imaging techniques,which significantly reduce the complexity of the entire system.These techniques use a well-confined evanescent field to interact ...In this review,we introduce some chip-based waveguide biosensing and imaging techniques,which significantly reduce the complexity of the entire system.These techniques use a well-confined evanescent field to interact with the surrounding materials and achieve high sensitivity sensing and high signal-to-noise ratio(SNR)super-resolution imaging.The fabrication process of these chips is simple and compatible with conventional semiconductor fabrication methods,allowing high-yield production.Combined with recently developed chip-based light sources,these techniques offer the possibility of biosensing and super-resolution imaging based on integrated circuits.展开更多
基金the National Natural Science Foundation of China(Nos.61735017,61822510,and 51672245)the Zhejiang Provincial Natural Science Foundation of China(No.R17F050003)+4 种基金the National Key Basic Research Program of China(No.2015CB352003)the Fundamental Research Funds for the Central Universities,Chinathe Program for Zhejiang Leading Team of S&T Innovationthe Cao Guangbiao Advanced Technology Programthe First-Class Universities and Academic Programs。
文摘In this review,we introduce some chip-based waveguide biosensing and imaging techniques,which significantly reduce the complexity of the entire system.These techniques use a well-confined evanescent field to interact with the surrounding materials and achieve high sensitivity sensing and high signal-to-noise ratio(SNR)super-resolution imaging.The fabrication process of these chips is simple and compatible with conventional semiconductor fabrication methods,allowing high-yield production.Combined with recently developed chip-based light sources,these techniques offer the possibility of biosensing and super-resolution imaging based on integrated circuits.
