Objective: To discuss the effect of intensity modulated radiation therapy combined with paclitaxel + endostar chemotherapy on serum malignant molecule levels in patients with locally advanced non-small cell lung cance...Objective: To discuss the effect of intensity modulated radiation therapy combined with paclitaxel + endostar chemotherapy on serum malignant molecule levels in patients with locally advanced non-small cell lung cancer. Methods: Patients with locally advanced NSCLC who were treated in the hospital between February 2015 and January 2017 were collected and divided into control group (n=59) and research group (n=59) by random number table. Control group received the routine paclitaxel + endostar chemotherapy after the operation, and research group underwent intensity modulated radiation therapy combined with paclitaxel +endostar chemotherapy after the operation. The differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were compared between the two groups before and after treatment. Results: Before treatment, the differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were not statistically significant between the two groups. After treatment, serum TK1, CYFRA21-1, Pro-GRP, CEA, CA125 and SCC-Ag levels of research group were lower than those of control group;serum EGFR, COX-2, VEGF, HIF-1 and MMP-2 levels of research group were lower than those of control group. Conclusion:Postoperative intensity modulated radiation therapy combined with paclitaxel + endostar chemotherapy can effectively reduce the serum malignant molecule levels and optimize the illness in patients with local advanced NSCLC.展开更多
Miniature optical fiber sensors with thin films as sensitive elements could open new fields for optical fiber sensor applications. Thin films work as sensitive elements and a transducer to get response and feedback fr...Miniature optical fiber sensors with thin films as sensitive elements could open new fields for optical fiber sensor applications. Thin films work as sensitive elements and a transducer to get response and feedback from environments, in which optical fibers act as a signal carrier. A novel Ag coated intensity modulated optical fiber sensor based on refractive index changes using IR and UV-Vis （UV-visible） light sources is proposed. The sensor with an IR light source has higher sensitivity compared to a UV-Vis source. When the refractive index is en- hanced to 1.38, the normalized intensity of IR and UV-Vis light diminishes to 0.2 and 0.8. respectively.展开更多
We report the observation of spectral broadening induced by 200 femtosecond laser pulses with the repetition rate of 1 kHz at the wavelength of 532 nm in semi-insulating 4H–SiC single crystals.It is demonstrated that...We report the observation of spectral broadening induced by 200 femtosecond laser pulses with the repetition rate of 1 kHz at the wavelength of 532 nm in semi-insulating 4H–SiC single crystals.It is demonstrated that the full width at half maximum of output spectrum increases linearly with the light propagation length and the peak power density,reaching a maximum 870 cm-1on a crystal of 19 mm long under an incident laser with a peak power density of 60.1 GW/cm2.Such spectral broadening can be well explained by the self-phase modulation model which correlates time-dependent phase change of pulses to intensity-dependent refractive index.The nonlinear refractive index n2 is estimated to be1.88×10-15cm2/W.The intensity-dependent refractive index is probably due to both the nonlinear optical polarizability of the bound electrons and the increase of free electrons induced by the two-photon absorption process.Super continuum spectra could arise as crystals are long enough to induce the self-focusing effect.The results show that SiC crystals may find applications in spectral broadening of high power lasers.展开更多
目的探讨调强放疗(IMRT)及化疗对胸部肿瘤患者心率变异性(HRV)频域指标的影响。方法 3组分别接受不同治疗方法的胸部肿瘤患者(单纯放疗组、序贯放化组、同步放化组),每组36例,均于治疗前、中、后进行24 h HRV监测,比较其监测结果。结果 ...目的探讨调强放疗(IMRT)及化疗对胸部肿瘤患者心率变异性(HRV)频域指标的影响。方法 3组分别接受不同治疗方法的胸部肿瘤患者(单纯放疗组、序贯放化组、同步放化组),每组36例,均于治疗前、中、后进行24 h HRV监测,比较其监测结果。结果 3组患者标化低频功率(nLF)、标化高频功率(nHF)随治疗时间的增加呈下降趋势(P<0.01),3组患者nLF、nHF、低频功率/高频功率差异均无统计学意义(P>0.05)。结论胸部肿瘤患者HRV改变与照射剂量相关,随着照射剂量增加,HRV频域指标显著下降;紫杉类化疗药对HRV可能无显著性影响。展开更多
文摘Objective: To discuss the effect of intensity modulated radiation therapy combined with paclitaxel + endostar chemotherapy on serum malignant molecule levels in patients with locally advanced non-small cell lung cancer. Methods: Patients with locally advanced NSCLC who were treated in the hospital between February 2015 and January 2017 were collected and divided into control group (n=59) and research group (n=59) by random number table. Control group received the routine paclitaxel + endostar chemotherapy after the operation, and research group underwent intensity modulated radiation therapy combined with paclitaxel +endostar chemotherapy after the operation. The differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were compared between the two groups before and after treatment. Results: Before treatment, the differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were not statistically significant between the two groups. After treatment, serum TK1, CYFRA21-1, Pro-GRP, CEA, CA125 and SCC-Ag levels of research group were lower than those of control group;serum EGFR, COX-2, VEGF, HIF-1 and MMP-2 levels of research group were lower than those of control group. Conclusion:Postoperative intensity modulated radiation therapy combined with paclitaxel + endostar chemotherapy can effectively reduce the serum malignant molecule levels and optimize the illness in patients with local advanced NSCLC.
基金supported by the Universiti Teknologi Malaysia,AMTEC(No.R.J130000.7609.4C112)the Frontier Material Research Alliance
文摘Miniature optical fiber sensors with thin films as sensitive elements could open new fields for optical fiber sensor applications. Thin films work as sensitive elements and a transducer to get response and feedback from environments, in which optical fibers act as a signal carrier. A novel Ag coated intensity modulated optical fiber sensor based on refractive index changes using IR and UV-Vis （UV-visible） light sources is proposed. The sensor with an IR light source has higher sensitivity compared to a UV-Vis source. When the refractive index is en- hanced to 1.38, the normalized intensity of IR and UV-Vis light diminishes to 0.2 and 0.8. respectively.
基金Project supported by the National High Technology Research and Development Program of China(Grant No.2014AA041402)the National Natural Science Foundation of China(Grant Nos.51272276 and 51322211)
文摘We report the observation of spectral broadening induced by 200 femtosecond laser pulses with the repetition rate of 1 kHz at the wavelength of 532 nm in semi-insulating 4H–SiC single crystals.It is demonstrated that the full width at half maximum of output spectrum increases linearly with the light propagation length and the peak power density,reaching a maximum 870 cm-1on a crystal of 19 mm long under an incident laser with a peak power density of 60.1 GW/cm2.Such spectral broadening can be well explained by the self-phase modulation model which correlates time-dependent phase change of pulses to intensity-dependent refractive index.The nonlinear refractive index n2 is estimated to be1.88×10-15cm2/W.The intensity-dependent refractive index is probably due to both the nonlinear optical polarizability of the bound electrons and the increase of free electrons induced by the two-photon absorption process.Super continuum spectra could arise as crystals are long enough to induce the self-focusing effect.The results show that SiC crystals may find applications in spectral broadening of high power lasers.
文摘目的:比较在胸部上中段食管癌术后预防性放射治疗中调强放射治疗(IMRT)与三维适形放射治疗(3D-CRT)剂量分布差异。方法:采用CMS治疗计划系统,对10例胸部上中段食管癌术后病理为T3/T4和/或淋巴结阳性患者分别设定3D-CRT 54Gy/27f照射和IMRT 54Gy/27f照射,比较两者相关靶区和危及器官的剂量体积直方图参数及靶区适形指数(CI)。结果:在相同靶区相同剂量模式下,10例患者在肺、脊髓、胃等组织器官受量近似一致的情况下,IMRT等剂量线的剂量分布(95%CTV、95%PTV和100%PTV)及靶区适形指数(CI)(0.93 vs 0.79)均优于3D-CRT。结论:相同靶区相同剂量模式下,胸部上中段食管癌术后预防性照射治疗时,调强放疗技术(IMRT)靶区剂量分布优于三维适形放疗(3D-CRT)。
文摘目的探讨调强放疗(IMRT)及化疗对胸部肿瘤患者心率变异性(HRV)频域指标的影响。方法 3组分别接受不同治疗方法的胸部肿瘤患者(单纯放疗组、序贯放化组、同步放化组),每组36例,均于治疗前、中、后进行24 h HRV监测,比较其监测结果。结果 3组患者标化低频功率(nLF)、标化高频功率(nHF)随治疗时间的增加呈下降趋势(P<0.01),3组患者nLF、nHF、低频功率/高频功率差异均无统计学意义(P>0.05)。结论胸部肿瘤患者HRV改变与照射剂量相关,随着照射剂量增加,HRV频域指标显著下降;紫杉类化疗药对HRV可能无显著性影响。
