Optimal Design for an End Face Engagement Worm Gear with Multiple Worm-wheel Meshing

To solve the problem for lacking a special mechanical transmission that could provide multiple outputs with high transmission efficiency and good lubrication in the modem industrial, a novel worm gear, named end face engagement worm gear, with multiple worm-wheel meshing is proposed for the first time. The essential parameters for the worm gear are optimized to enhance lubrication and meshing properties. Moreover, analysis of variance（ANOVA） is applied to determine the optimum levels and to determine the influence of parameters. The ANOVA results show that the novel end face engagement worm gear with multiple worm wheels provides high lubrication（the lubrication angle is more than 89~） and meshing performance（the induce normal curvature is less than 0.0002 mm ＇）. The interaction between center distance and roller slant distance most strongly influences the lubrication angle（contributed 51.6%）, followed by the parameters of center distance（contributed 25.0%）, roller slant distance（contributed 16.4%）, tooth angle of gear, gear ratio, and roller radius. In addition, roller radius most strongly influences the induced normal curvature（contributed 39.4%）, followed by roller slant distance（contributed 15.2%）, tooth angle of the gear（contributed 9.0%）, center distance, and gear ratio. The proposed worm gear helps to enrich the no-backlash high precision worm drive and the optimal design method can provide a useful reference on performance improvement of other worm gear.

“三全育人”背景下“Web前端开发”课程思政教学内容设计--以“HTML5应用开发基础”课程为例

在新时代背景下,高校以“立德树人”为根本任务、以“三全育人”(全员育人、全过程育人和全方位育人)为教育理念,肩负起价值引领的责任,培养德智体美劳全面发展的人才。在课程教学过程中,通过融入思政教育内容,可以培养学生正确的价值观、道德观和社会责任感,提高学生的思想品德素养和综合能力。文章以“HTML5应用开发基础”课程为例,介绍了课程思政教学内容的设计方法。

Nε-(carboxymethyl)lysine promotes lipid uptake of macrophage via cluster of differentiation 36 and receptor for advanced glycation end products

BACKGROUND Advanced glycation end products(AGEs)are diabetic metabolic toxic products that cannot be ignored.Nε-(carboxymethyl)lysine(CML),a component of AGEs,could increase macrophage lipid uptake,promote foam cell formation,and thereby accelerate atherosclerosis.The receptor for AGEs(RAGE)and cluster of differentiation 36(CD36)were the receptors of CML.However,it is still unknown whether RAGE and CD36 play key roles in CML-promoted lipid uptake.AIM Our study aimed to explore the role of RAGE and CD36 in CML-induced macrophage lipid uptake.METHODS In this study,we examined the effect of CML on lipid uptake by Raw264.7 macrophages.After adding 10 mmol/L CML,the lipid accumulation in macrophages was confirmed by oil red O staining.Expression changes of CD36 and RAGE were detected with immunoblotting and quantitative real-time polymerase chain reaction.The interaction between CML with CD36 and RAGE was verified by immunoprecipitation.We synthesized a novel N-succinimidyl-4-18Ffluorobenzoate-CML radioactive probe.Radioactive receptor-ligand binding assays were performed to test the binding affinity between CML with CD36 and RAGE.The effects of blocking CD36 or RAGE on CML-promoting lipid uptake were also detected.RESULTS The study revealed that CML significantly promoted lipid uptake by macrophages.Immunoprecipitation and radioactive receptor-ligand binding assays indicated that CML could specifically bind to both CD36 and RAGE.CML had a higher affinity for CD36 than RAGE.ARG82,ASN71,and THR70 were the potential interacting amino acids that CD36 binds to CML Anti-CD36 and anti-RAGE could block the uptake of CML by macrophages.The lipid uptake promotion effect of CML was significantly attenuated after blocking CD36 or RAGE.CONCLUSION Our results suggest that the binding of CML with CD36 and RAGE promotes macrophage lipid uptake.

MATLAB App Designer在法布里-珀罗干涉实验中的应用

基于法布里-珀罗(F-P)多光束干涉原理,利用MATLAB设计了基于F-P干涉实验的可视化App仿真界面,不仅可复现F-P腔长、入射波长、透镜焦距等参数对F-P干涉图样的影响及实时动态展示,还可观察周围介质折射率、F-P腔折射率与干涉图样的关系,并能进行多波长分辨率和微小波长差测量实验的演示.这些直观形象的模拟结果展示,将有助于改善多光束干涉理论及实验教学效果.

基于Ant Design Pro的物流系统前端开发与用户体验优化研究

本文探讨了Ant Design Pro在物流系统开发中的应用,特别是其对用户体验和数据可视化的影响。通过采用案例研究方法,分析Ant Design Pro在构建企业级物流系统中的应用。研究发现,Ant Design Pro的一致性设计和丰富的组件库显著提升了开发效率和用户交互体验。此外,其数据可视化组件有效支持了复杂物流数据的呈现和分析。然而,其在性能优化和定制化需求方面面临着挑战。最终,本文提出了一系列基于Ant Design Pro的物流系统开发最佳实践,并对其潜在的改进方向进行了讨论。研究结果为物流行业的信息系统开发提供了实用的指导,并为Ant Design Pro社区贡献了宝贵的实践经验。

Endozepine-4 levels are increased in hepatic coma

AIM:To evaluate the serum levels of endozepine-4,their relation with ammonia serum levels,the grading of coma and the severity of cirrhosis,in patients with hepatic coma. METHODS:In this study we included 20 subjects with Hepatic coma,20 subjects with minimal hepatic encephalopathy(MHE) and 20 subjects control. All subjects underwent blood analysis,Child Pugh and Model for End- stage liver disease(MELD) assessment,endozepine-4 analysis. RESULTS:Subjects with hepatic coma showed significant difference in endozepine-4(P < 0.001) and NH3 levels(P < 0.001) compared both to MHE and controls patients. Between NH3 and endozepine-4 we observed a significant correlation(P = 0.009; Pearson correlation 0.570). There was a significant correlation between endozepine-4 and MELD(P = 0.017; Pearsoncorrelation = 0.529). In our study blood ammonia concentration was noted to be raised in patients with hepatic coma,with the highest ammonia levels being found in those who were comatose. We also found a high correlation between endozepine-4 and ammonia(P < 0.001). In patients with grade Ⅳ hepatic coma,endozepine levels were significantly higher compared to other groups. CONCLUSION:This study suggests that an increased level of endozepine in subjects with higher levels of MELD was observed. In conclusion,data concerning involvement of the GABA-ergic system in HE coma could be explained by stage-specific alterations.

Tool Wear Prediction in Micro-end-milling with Hard Material

The applications of micro-machining have increased drastically in the last ten years. However, tools with less than 1mm diameter using for micro-mills have very short and unpredictable life when they are used to cut hard metals. In this study, preliminary design of experiment (DOE) test program was conducted to investigate and identify the factors affecting tool wear at the micro-scale with hard material. Analysis of variance (ANOVA) and Taguchi method were efficient to determine appropriate cutting condition and the effect of parameters. A simple model was also developed to predict the width of slots on the workpiece along the cutting length. The obtained results can provide the basic guidelines for parameter setting of micro-end-milling with hard material.

Study On Pattern Design of Men's Tailored-suit Sleeve

Sleeve pattern design of men’ s tailored - suit is one of the most difficult problems of clothing pattern design. Based on the experimental studies of armhole girth, the difference of armhole width and crown height, crown angle, under sleeve curve’s diagonal line length, crown ease and its distribution rule, this paper mainly deals with the sleeve pattern design of tailored - suit for Chinese men. The influences of these factors are discussed and furthermore, some qualitative, quantifiable conclusions are drawn to design perfect pattern of men’ s tailored - suit sleeve.

SELECTING CLUSTER MODEL IN Sn - BASED SOLDER ALLOY DESIGN WITH DV - X_α CALCULATION METHOD

Applying calculation method in alloy design should be an important tendency due to its characters of inexpensive cost, high efficiency and prediction. DOS calculations of AuSn, AsSn and SbSn Sn- based alloys have been investigated by employing DV - Xa method, in which different cluster models were adopted to calculate electron structure.It is proved that some regulations must be taken into ac- count in order to carry out alloy design calculation successfully,which are described in this paper in detail.

Computer-aided Pattern Design of Multi-bar Warp Knitted Fabrics

To meet the development trend of multi-bar warp knit-ting machine towards high-speed,advanced technologyand computer control and the requirements of variousproducts with small quantity,there are many researcheson the computer-aided pattern design of multi-barwarp knitted fabrics.In terms of the special propertiesof the computer-aided pattern design of multi-barwarp knitted fabrics,the Object Oriented Program(OOP)programming-Object Windows class Library(OWL)programming is selected.According to thecharacters of the OWL programming,various functionsare defined.Pattern design and technical parameters canbe output,which offers a great convenience for the fac-tory.

Packaging Design and the Changing Needs of End Consumers

With the rapid development of China’s economy,the society has entered the era of big data intelligence,leading to tremendous changes in people’s shopping methods.From the original way of shopping via traditional channels from street vendors and farmer’s markets to shopping via WeChat,Douyin,Taobao,Pinduoduo,and other digital e-commerce channels,online shopping has become the norm and an integral part of people’s life in the post-pandemic era.The shift from traditional offline shopping to online shopping calls for a change in design thinking,integrating food packaging design,consumer needs,and brand stories,reflecting individual characters and regional cultures,as well as incorporating traditional Chinese style and cultural elements.

Creative Design Fulfills Brand and Fashion China Fashion Week A/W 2010-2011 Collection held in Beijing

March is a right party time for friends to get together to enjoy the smell of early spring. Moreover, people would like to take off the thick winter coat to showcase their colorful attitude towards the warm spring sunshine. Here, an annual fashion feast in Beijing not only could provide you a visual inspiration of trend, but also would tell you what’s the most "in" factors in the coming season.

Appraisal of Existing HIV/AIDs Prevention and Control Measures and Presentation of Innovative Strategies to End HIV/AIDS Epidemic by 2030

Background: Globally, UNAIDS report 2022 shows, there are 84.2 million people affected by HIV/AIDS and 40.1 million deaths from AIDS since the start of epidemic. In sub-Saharan Africa, women and girls accounted for 63% of all new HIV infections in 2021 with, six in seven new HIV infections among adolescents aged 15 - 19 years being girls. Key populations accounted for 70% of HIV infections globally in 2021, with 51% of these new HIV infections in sub-Saharan Africa. Reflecting on the 4 decades’ journey of HIV epidemic amidst local, national and international efforts, the UN target of ending AIDS as a public health threat by 2030 remains questionable unless new innovative ways are used. This study aimed at analyzing existing HIV/AIDS interventions, discuss UN interventions in line with ending HIV/AIDS by 2030 then, suggest and discuss new innovative ways of ending HIV scourge by 2030. Methods: Systematic literature review methodology was used to extract existing published information on HIV prevention strategies from 1981 to 2023. The articles were previewed by 2 experts for quality and grouped by intervention. Of the 637 articles accessed, on HIV prevention/control only 45 met the inclusion criteria. Data were synthesized using a narrative synthesis approach following standard guidelines on synthesis without meta-analysis. Descriptive analysis was done, strength and limitations were identified. UNAIDS recommendations for ending HIV/AIDS by 2030 identified and analyzed. New Innovations in HIV/AIDS were presented and discussed. The scope of the reviewed literature was limited to HIV preventive strategies practiced between 1981 and 2023. Results: Findings show that, Uganda’s HIV prevalence was at a peak in 1991 of 15% (30% among pregnant women in urban areas). ABC strategy is claimed to have turned sharply downward the prevalence through the mid-1990s and reached 5% (14% for pregnant urban women) by 2001. Analysis of the strategy showed that the achievements of the strategy could not be sustained, subsequently HIV prevalence rose again. This is because none of the ABC components can independently reduce HIV problem. In the real world, 100% abstinence has failed, condom use only reduces infection by 90% (WHO), and lifelong monogamy is impractical. Such limitations weaken ABC strategy. The study established that Post-exposure prophylaxis (PEP) i.e. taking HIV medicines within 72 hours (3 days) after a possible exposure to HIV infection is a safe, effective and a globally practiced HIV preventive intervention in emergency situations of HIV exposure. However, PEP is limited to care sought within 72 hours after exposure and yet timely access especially in rural areas and for key populations remains a big challenge. Oral PrEP was also identified as effective HIV preventive measure that can reduce HIV risk from sex by about 99% and from injection drug users by 74%. However, like PEP, timely access especially in rural areas and for key populations remains a big challenge. The UNAIDS 95-95-95 strategy (i.e. 95% of people know their HIV status, 95% with +HIV status be on sustained ART and 95% on ART get viral load suppression) formed the basis for setting the target of ending HIV/AIDS epidemic by 2030. However, our analysis shows that this target is unrealistic given the above highlighted limitations/ barriers in preventive measures and the unlikely perfect adherence (100%) to ART by all enrolled HIV positive persons. Conclusion: Ending HIV/AIDS by 2030 cannot be achieved by implementing the current preventing strategies and control measures. This study established that most of the existing HIV preventive strategies and control measures have a number of limitations. However, with sustained UN 95-95-95 strategy supplemented with additional innovative ways, there is hope that the UN dream of ending HIV/AIDS though not necessarily by 2030, can in the long run be achieved.

融与合——有感于Freedom in Design：The Architectnre of J．J．Pan and Partners．2000-2006

潘冀，1966年毕业于美国莱斯大学建筑学专业1967年获美国哥伦比亚大学城市建筑硕士学位主攻城市设计方向。在之后的几年内．先后为菲利普约翰逊和理查德-罗杰斯等建筑师事务所服务1972年取得美国职业建筑师资格．并于1981年回到台湾成立潘冀联合设计师事务所。在之后20多年内．该事务所逐渐成长为台湾最大的建筑师事务所之一．

基于端部绕组模块的定子励磁无刷电机冷却方法

为了提升定子励磁无刷电机的冷却能力,提出了一种基于端部绕组模块的定子励磁无刷电机冷却方法.在电机端部绕组和定子铁芯叠片端部的间隙中插入端部绕组冷却(EWC)模块,以减小定子绕组热点区域和冷却介质之间的间隙,从而提高端部绕组的冷却能力.对非重叠式集中绕组长度计算模型进行改进,评估采用EWC模块前后电机定子电枢绕组长度的变化,分析EWC模块的电导率对电机定子损耗的影响.采用计算流体动力学(CFD)模型,对比EWC模块在不同铜耗和励磁源损耗密度下的冷却性能.结果表明,采用EWC模块可以使端部绕组的稳态温升降低约50%,热态时的绕组电阻降低7.51%,从而改善了定子的冷却条件.

被动式木窗双端铣削加工定位夹紧装置的设计与研究

为满足欧式木窗定制化尺寸变化的需求,设计一种尺寸自适应定位夹紧装置,应用有限元软件对木窗夹紧过程进行静力学分析,在满足木窗夹紧的要求下,使木窗弹性变形在合理范围。同时为了满足轻量化设计要求对压辊连接架进行拓扑优化设计,根据拓扑优化结果改进压辊连接架结构,对优化后的模型进行静力学分析验证,最终得到优化后的工件。结果表明,优化后压辊连接架重量明显下降,满足相关使用要求。

木窗双端铣削加工中心关键机构的设计与研究

针对被动式欧式木窗外框铣削加工效率低、加工精度低和人工劳动强度大等问题,设计一种被动式欧式木窗的双端铣削加工中心,用于被动式欧式木窗外框高效率、高精度铣削加工。通过对木窗铣削工艺的分析,采用计算机辅助设计方法对加工中心结构进行详细设计,利用Solidworks软件对加工中心进行三维建模,基于有限元分析软件对关键支撑零件的强度、刚度进行分析,使用虚拟试验方法验证加工中心的加工效率。研究结果表明,加工中心理论加工效率约为400扇/d,相较于人工加工效率350扇/d,效率提升了14.28%,关键支撑零件的最大应力远小于材料的许用应力,满足使用要求。

机器人制孔末端执行器的设计及静动力学分析

提出了一种新型机器人制孔末端执行器的模块化结构设计方案,阐述了该末端执行器的主要模块结构设计、技术特点和技术参数。针对末端执行器整体和主要结构零件分别进行了有限元静力学及动力学分析计算,分析结果表明结构设计科学合理。同时,进一步揭示了高速制孔末端执行器与其匹配的机器人成本和制孔质量之间的关系,可以为其他类似机器人末端执行器设计提供参考。

基于多方数字签名和认证的毕业论文管理系统设计

为了使线上毕业论文指导意见及毕业答辩的成绩真实可靠,提出一种基于数字签名的毕业论文管理系统。本系统为注册的用户分发代表身份的密钥对,对每次毕业论文的任何修改都附加修改者本人的签名,并在其他用户在异地打开毕业论文的同时验证签名。本系统可以辅助完成在线答辩,保证答辩成绩的真实性和不可否认性。基于数字签名的认证用于毕业论文的管理对规范毕业论文管理过程、实现多方可信的毕业论文成果的共识能起到积极的促进作用。

C-NCAP(2018)行人保护对汽车设计开发的影响

C-NCAP将从2018年开始引入对行人保护的评价。与Eruo NCAP相比,C-NCAP(2018)虽然取消WAD 775 mm的上腿部碰撞测试,但是行人保护总得分率要求却明显提高,对行人保护的要求更加严格。根据行人保护的基本要求,从汽车前端造型、总布置以及结构设计3方面,阐述C-NCAP(2018)行人保护测试规程对汽车设计的影响,为旧车型的改造以及新车型的开发提供借鉴与参考。