AIM:To evaluate the efficacy and safety of paclitaxelnedaplatin combination as a front-line regimen in Chinese patients with metastatic esophageal squamous cell carcinoma(ESCC).METHODS:A two-center,open-label,single-a...AIM:To evaluate the efficacy and safety of paclitaxelnedaplatin combination as a front-line regimen in Chinese patients with metastatic esophageal squamous cell carcinoma(ESCC).METHODS:A two-center,open-label,single-arm phaseⅡstudy was designed.Thirty-nine patients were enrolled and included in the intention-to-treat analysis of efficacy and adverse events.Patients received 175mg/m2of paclitaxel over a 3 h infusion on 1 d,followed by nedaplatin 80 mg/m2in a 1 h infusion on 2 d every3 wk until the documented disease progression,unac-ceptable toxicity or patient’s refusal.RESULTS:Of the 36 patients assessable for efficacy,there were 2 patients(5.1%)with complete response and 16 patients(41.0%)with partial response,giving an overall response rate of 46.1%.The median progression-free survival and median overall survival for all patients were 7.1 mo(95%CI:4.6-9.7)and 12.4 mo(95%CI:9.5-15.3),respectively.Toxicities were moderate and manageable.Grade 3/4 toxicities included neutropenia(15.4%),nausea(10.3%),anemia(7.7%),thrombocytopenia(5.1%),vomiting(5.1%)and neutropenia fever(2.6%).CONCLUSION:The combination of paclitaxel and nedaplatin is active and well tolerated as a first-line therapy for patients with metastatic ESCC.展开更多
The study was designed to evaluate the therapeutic and side effects of Bevacizumab plus FOLFIRI regimen as front-line therapy for Chinese patients with advanced colorectal cancer. A total of 15 previously untreated pa...The study was designed to evaluate the therapeutic and side effects of Bevacizumab plus FOLFIRI regimen as front-line therapy for Chinese patients with advanced colorectal cancer. A total of 15 previously untreated patients with advanced colorectal cancer received Bevacizumab plus FOLFIRI regimen as font-line therapy, in detail, irinotecan 180 mg/m2 was given intravenously on day1, then calcium folinate (CF) 200 mg/m2, F-fluorouracil (5-Fu) 400 mg/m2 given in bolus immediately after CF, day 1 - 2;5-Fu 600 mg/2 given continuously after bolus for 22 hours on day1, day2;Bevacizumab was given intravenously at dosage of 5 mg/kg, on day-1. Therapeutic and side effects were evaluated at least after four cycles of treatment. The results showed that all the cases among the group were valid for response evaluation, with CR 0, PR 10, SD 3, and PD 2. The response rate is 66.7% and median time to progression (mTTP) was 10.6 months. The main toxicities were bone marrow suppression, nausea and vomiting, stomach pain and diarrhea;there was no chemotherapy-related death. The data suggested that the combination regimen with Bevacizumab plus FOLFIRI regimen was effective as front-line therapy for Chinese patients with advanced colorectal cancer, and the side effects were tolerable and manageable.展开更多
The conventional and intensive observational data of the China Heavy Rain Experiment and Study (CHeRES) are used to specially analyze the heavy rainfall process in the mei-yu front that occurred during 20-21 June 2002...The conventional and intensive observational data of the China Heavy Rain Experiment and Study (CHeRES) are used to specially analyze the heavy rainfall process in the mei-yu front that occurred during 20-21 June 2002, focusing on the meso-β system. A mesoscale convective system (MCS) formed in the warm-moist southwesterly to the south of the shear line over the Dabie Mountains and over the gorge between the Dabie and Jiuhua Mountains. The mei-yu front and shear line provide a favorable synoptic condition for the development of convection. The GPS observation indicates that the precipitable water increased obviously about 2-3 h earlier than the occurrence of rainfall and decreased after that. The abundant moisture transportation by southwesterly wind was favorable to the maintenance of convective instability and the accumulation of convective available potential energy (CAPE). Radar detection reveals that meso-β and -γ systems were very active in the MaCS. Several convection lines developed during the evolution of the MaCS, and these are associated with surface convergence lines. The boundary outflow of the convection line may have triggered another convection line. The convection line moved with the mesoscale surface convergence line, but the convective cells embedded in the convergence line propagated along the line. On the basis of the analyses of the intensive observation data, a multi-scale conceptual model of heavy rainfall in the mei-yu front for this particular case is proposed.展开更多
基金Supported by Natural Science Foundation of Anhui Province No.070413256XMedical Research Foundation of Anhui Provincial Health Department No.2010B001 and No.13zc012
文摘AIM:To evaluate the efficacy and safety of paclitaxelnedaplatin combination as a front-line regimen in Chinese patients with metastatic esophageal squamous cell carcinoma(ESCC).METHODS:A two-center,open-label,single-arm phaseⅡstudy was designed.Thirty-nine patients were enrolled and included in the intention-to-treat analysis of efficacy and adverse events.Patients received 175mg/m2of paclitaxel over a 3 h infusion on 1 d,followed by nedaplatin 80 mg/m2in a 1 h infusion on 2 d every3 wk until the documented disease progression,unac-ceptable toxicity or patient’s refusal.RESULTS:Of the 36 patients assessable for efficacy,there were 2 patients(5.1%)with complete response and 16 patients(41.0%)with partial response,giving an overall response rate of 46.1%.The median progression-free survival and median overall survival for all patients were 7.1 mo(95%CI:4.6-9.7)and 12.4 mo(95%CI:9.5-15.3),respectively.Toxicities were moderate and manageable.Grade 3/4 toxicities included neutropenia(15.4%),nausea(10.3%),anemia(7.7%),thrombocytopenia(5.1%),vomiting(5.1%)and neutropenia fever(2.6%).CONCLUSION:The combination of paclitaxel and nedaplatin is active and well tolerated as a first-line therapy for patients with metastatic ESCC.
文摘The study was designed to evaluate the therapeutic and side effects of Bevacizumab plus FOLFIRI regimen as front-line therapy for Chinese patients with advanced colorectal cancer. A total of 15 previously untreated patients with advanced colorectal cancer received Bevacizumab plus FOLFIRI regimen as font-line therapy, in detail, irinotecan 180 mg/m2 was given intravenously on day1, then calcium folinate (CF) 200 mg/m2, F-fluorouracil (5-Fu) 400 mg/m2 given in bolus immediately after CF, day 1 - 2;5-Fu 600 mg/2 given continuously after bolus for 22 hours on day1, day2;Bevacizumab was given intravenously at dosage of 5 mg/kg, on day-1. Therapeutic and side effects were evaluated at least after four cycles of treatment. The results showed that all the cases among the group were valid for response evaluation, with CR 0, PR 10, SD 3, and PD 2. The response rate is 66.7% and median time to progression (mTTP) was 10.6 months. The main toxicities were bone marrow suppression, nausea and vomiting, stomach pain and diarrhea;there was no chemotherapy-related death. The data suggested that the combination regimen with Bevacizumab plus FOLFIRI regimen was effective as front-line therapy for Chinese patients with advanced colorectal cancer, and the side effects were tolerable and manageable.
基金This project was supported by the National Key Basic Research and Development Project 2004CB418301the National Natural Science Foundation of China under Grant No.40405008.
文摘The conventional and intensive observational data of the China Heavy Rain Experiment and Study (CHeRES) are used to specially analyze the heavy rainfall process in the mei-yu front that occurred during 20-21 June 2002, focusing on the meso-β system. A mesoscale convective system (MCS) formed in the warm-moist southwesterly to the south of the shear line over the Dabie Mountains and over the gorge between the Dabie and Jiuhua Mountains. The mei-yu front and shear line provide a favorable synoptic condition for the development of convection. The GPS observation indicates that the precipitable water increased obviously about 2-3 h earlier than the occurrence of rainfall and decreased after that. The abundant moisture transportation by southwesterly wind was favorable to the maintenance of convective instability and the accumulation of convective available potential energy (CAPE). Radar detection reveals that meso-β and -γ systems were very active in the MaCS. Several convection lines developed during the evolution of the MaCS, and these are associated with surface convergence lines. The boundary outflow of the convection line may have triggered another convection line. The convection line moved with the mesoscale surface convergence line, but the convective cells embedded in the convergence line propagated along the line. On the basis of the analyses of the intensive observation data, a multi-scale conceptual model of heavy rainfall in the mei-yu front for this particular case is proposed.
