Due to the presence of ice and unfrozen water in pores of frozen rock,the rock fracture behaviors are susceptible to temperature.In this study,the potential thawing-induced softening effects on the fracture behaviors ...Due to the presence of ice and unfrozen water in pores of frozen rock,the rock fracture behaviors are susceptible to temperature.In this study,the potential thawing-induced softening effects on the fracture behaviors of frozen rock is evaluated by testing the tension fracture toughness(KIC)of frozen rock at different temperatures(i.e.-20℃,-15℃,-12℃,-10℃,-8℃,-6℃,-4℃,-2℃,and 0℃).Acoustic emission(AE)and digital image correlation(DIC)methods are utilized to analyze the microcrack propagation during fracturing.The melting of pore ice is measured using nuclear magnetic resonance(NMR)method.The results indicate that:(1)The KIC of frozen rock decreases moderately between-20℃ and-4℃,and rapidly between-4℃ and 0℃.(2)At-20℃ to-4℃,the fracturing process,deduced from the DIC results at the notch tip,exhibits three stages:elastic deformation,microcrack propagation and microcrack coalescence.However,at-4℃e0℃,only the latter two stages are observed.(3)At-4℃e0℃,the AE activities during fracturing are less than that at-20℃ to-4℃,while more small events are reported.(4)The NMR results demonstrate a reverse variation trend in pore ice content with increasing temperature,that is,a moderate decrease is followed by a sharp decrease and-4℃ is exactly the critical temperature.Next,we interpret the thawing-induced softening effect by linking the evolution in microscopic structure of frozen rock with its macroscopic fracture behaviors as follow:from-20℃ to-4℃,the thickening of the unfrozen water film diminishes the cementation strength between ice and rock skeleton,leading to the decrease in fracture parameters.From-4℃ to 0℃,the cementation effect of ice almost vanishes,and the filling effect of pore ice is reduced significantly,which facilitates microcrack propagation and thus the easier fracture of frozen rocks.展开更多
The soil freezing and thawing process affects soil physical properties,such as heat conductivity,heat capacity,and hydraulic conductivity in frozen ground regions,and further affects the processes of soil energy,hydro...The soil freezing and thawing process affects soil physical properties,such as heat conductivity,heat capacity,and hydraulic conductivity in frozen ground regions,and further affects the processes of soil energy,hydrology,and carbon and nitrogen cycles.In this study,the calculation of freezing and thawing front parameterization was implemented into the earth system model of the Chinese Academy of Sciences(CAS-ESM)and its land component,the Common Land Model(CoLM),to investigate the dynamic change of freezing and thawing fronts and their effects.Our results showed that the developed models could reproduce the soil freezing and thawing process and the dynamic change of freezing and thawing fronts.The regionally averaged value of active layer thickness in the permafrost regions was 1.92 m,and the regionally averaged trend value was 0.35 cm yr–1.The regionally averaged value of maximum freezing depth in the seasonally frozen ground regions was 2.15 m,and the regionally averaged trend value was–0.48 cm yr–1.The active layer thickness increased while the maximum freezing depth decreased year by year.These results contribute to a better understanding of the freezing and thawing cycle process.展开更多
Since the 1990s,the Qinghai–Tibetan Plateau(QTP)has experienced a strikingly warming and wetter climate that alters the thermal and hydrological properties of frozen ground.A positive correlation between the warming ...Since the 1990s,the Qinghai–Tibetan Plateau(QTP)has experienced a strikingly warming and wetter climate that alters the thermal and hydrological properties of frozen ground.A positive correlation between the warming and thermal degradation in permafrost or seasonally frozen ground(SFG)has long been recognized.Still,a predictive relationship between historical wetting under warming climate conditions and frozen ground has not yet been well demonstrated,despite the expectation that it will become even more important because precipitation over the QTP has been projected to increase continuously in the near future.This study investigates the response of the thermal regime to historical wetting in both permafrost and SFG areas and examines their relationships separately using the Community Land Surface Model version 4.5.Results show that wetting before the 1990s across the QTP mainly cooled the permafrost body in the arid and semiarid zones,with significant correlation coefficients of 0.60 and 0.48,respectively.Precipitation increased continually at the rate of 6.16 mm decade–1 in the arid zone after the 1990s but had a contrasting warming effect on permafrost through a significant shortening of the thawing duration within the active layer.However,diminished rainfall in the humid zone after the 1990s also significantly extended the thawing duration of SFG.The relationship between the ground thawing index and precipitation was significantly negatively correlated(−0.75).The dual effects of wetting on the thermal dynamics of the QTP are becoming critical because of the projected increases in future precipitation.展开更多
Using a new low-temperature dynamic triaxial apparatus, the influence law of freezing-thawing cycles on clay shear strength is studied. In this research, the concept of correction coefficients of freezing-thawing cycl...Using a new low-temperature dynamic triaxial apparatus, the influence law of freezing-thawing cycles on clay shear strength is studied. In this research, the concept of correction coefficients of freezing-thawing cycles on clay static strength, cohesion and internal friction angles is proposed, and the change patterns, correction curves and regressive formulae of clay static strength, cohesion and internal friction angles under freezing-thawing cycles are given. The test results indicate that with increasing numbers of freezing-thawing cycles, the clay static strength and cohesion decrease exponentially but the internal friction angle increases exponentially. The performance of static strength, cohesion and internal friction angles are different with increasing numbers of freezing-thawing cycles, i.e., the static strength decreases constantly until about 30% of the initial static strength prior to the freezing-thawing cycling and then stays basically stable. After 5-7 freezing-thawing cycles, the cohesion decreases gradually to about 70% of the initial cohesion. The internal friction angle increases about 20% after the first freezing-thawing cycle, then increases gradually close to a stable value which is an increase of about 40% of the internal friction angle. The freezing-thawing process can increase the variation of the density of the soil samples; therefore, strict density discreteness standards of frozen soil sample preparation should be established to ensure the reliability of the test results.展开更多
The aim was to discuss the optimal storage environment and proper insemination time after thawing of 0.25 mL straw frozen semen. Straw frozen semen was thawed at 40 ℃ for 20 s, and then stored at 0 -4 ℃, 14 - 16 ℃,...The aim was to discuss the optimal storage environment and proper insemination time after thawing of 0.25 mL straw frozen semen. Straw frozen semen was thawed at 40 ℃ for 20 s, and then stored at 0 -4 ℃, 14 - 16 ℃, 25 -27 ℃ for 2, 4, 6, 8 and 10 h, respectively. The sperm motility was detected. After thawing, semen was stored at 0 - 4 ℃ and 14 - 16 ℃ for 10 h. Their sperm motilities (0.434 ±0. 016 7 and 0.423 ±0.019 6) had no significant differences (P 〉 0.05) with initial thawing motility (0.441 ± 0.030). Sperm motility reduced as the storage time prolonged at 25 -27 ℃. Sperm motility after 6 h had signifi- cant differences with that of initial thawing motility (P 〈 O. 05 ), and sperm motilities after 8 and 10 h showed extremely significant differences (P 〈 0.01 ). Thus, sperm motility after thawing was still very high after stored at 0 -4 ℃ and 14 - 16 ℃ within 10 h, which met the requirements for insemination. Under this temperature and time ranges, sperm could be carried over long distances, which had small effects on sperm quality and reached the expected insemination effects. However, under the temperature of 25 - 27 ℃, semen should be used for insemination within 6 h after thawing.展开更多
Research on the stability of soil slopes in seasonally frozen regions has mainly focused on slope failures during the thawing window.There are few studies on slope stability during the freezing window and its subseque...Research on the stability of soil slopes in seasonally frozen regions has mainly focused on slope failures during the thawing window.There are few studies on slope stability during the freezing window and its subsequent influence on slope failure in the next thawing window.In this paper,soil strength was tested during freezing and thawing to obtain temperature-dependent strength parameters for the simulation of slope stability.Then,the slope's temperature field over an entire year was accurately simulated so that characteristics of the frozen layer could be determined at any time.Based on the above results,the progressive failure modes of frozen soil slopes are discussed.The results show that:1)during the freezing window,depth of the frozen soil layer increases,as does the slope's safety factor,while a yield zone propagates towards the slope shoulder.(2)During the thawing window,the frozen soil layer shrinks in depth while the yield zone continuously expands,which decreases the safety factor.Comprehensive analysis of these results indicate that the frozen layer provides a“toe-locking effect”that increases the safety factor during the freezing window,while it also provides a“dragging effect”that propagates the yield zone towards the slope shoulder.During the thawing window,the“toe-locking effect”gradually diminishes;a continuous sliding surface is formed,which lead to a landslide.The frozen soil layer of the freezing window accelerates the slope sliding in the thawing window.展开更多
The impact of the anomalous thawing of frozen soil in the late spring on the summer precipitation in China and its possible mechanism are analyzed in the context of the frozen soil thawing date data of the 50 meteorol...The impact of the anomalous thawing of frozen soil in the late spring on the summer precipitation in China and its possible mechanism are analyzed in the context of the frozen soil thawing date data of the 50 meteorological stations in the Tibetan Plateau, and the NCEP/NCAR monthly average reanalysis data. Results show that the thawing dates of the Tibetan Plateau gradually become earlier from 1980 to 1999, which is consistent with the trend of global warming in the 20th century. Because differences in the thermal capacity and conductivity between frozen and unfrozen soils are larger, changes in the freezing/thawing process of soil may change the physical properties of the underlying surface, thus affecting exchanges of sensible and latent heat between the ground surface and air. The thermal state change of the plateau ground surface must lead to the thermal anomalies of the atmosphere over and around the plateau, and then further to the anomalies of the general atmospheric circulation. A possible mechanism for the impact of the thawing of the plateau on summer (July) precipitation may be as follows. When the frozen soil thaws early (late) in the plateau, the thermal capacity of the ground surface is large (small), and the thermal conductivity is small (large), therefore, the thermal exchanges between the ground surface and the air are weak (strong). The small (large) ground surface sensible and latent heat fluxes lead to a weak (strong) South Asian high, a weak (strong) West Pacific subtropical high and a little to south (north) of its normal position. Correspondingly, the ascending motion is strengthened (weakened) and precipitation increases (decreases) in South China, while in the middle and lower reaches of the Changjiang River, the ascending motion and precipitation show the opposite trend.展开更多
A frozen soil parameterization coupling of thermal and hydrological processes is used to investigate how frozen soil processes affect water and energy balances in seasonal frozen soil. Simulation results of soil liqui...A frozen soil parameterization coupling of thermal and hydrological processes is used to investigate how frozen soil processes affect water and energy balances in seasonal frozen soil. Simulation results of soil liquid water content and temperature using soil model with and without the inclusion of freezing and thawing processes are evaluated against observations at the Rosemount field station. By comparing the simulated water and heat fluxes of the two cases, the role of phase change processes in the water and energy balances is analyzed. Soil freezing induces upward water flow towards the freezing front and increases soil water content in the upper soil layer. In particular, soil ice obviously prevents and delays the infiltration during rain at Rosemount. In addition, soil freezingthawing processes alter the partitioning of surface energy fluxes and lead the soil to release more sensible heat into the atmosphere during freezing periods.展开更多
Prediction on the coupled thermal-hydraulic fields of embankment and cutting slopes is essential to the assessment on evolution of melting zone and natural permafrost table, which is usually a key factor for permafros...Prediction on the coupled thermal-hydraulic fields of embankment and cutting slopes is essential to the assessment on evolution of melting zone and natural permafrost table, which is usually a key factor for permafrost embankment design in frozen ground regions. The prediction may be further complicated due to the inherent uncertainties of material properties. Hence, stochastic analyses should be conducted. Firstly, Karhunen-Loeve expansion is applied to attain the random fields for hydraulic and thermal conductions. Next, the mixed-form modified Richards equation for mass transfer (i.e., mass equation) and the heat transport equation for heat transient flow in a variably saturated frozen soil are combined into one equation with temperature unknown. Furthermore, the finite element formulation for the coupled thermal-hydraulic fields is derived. Based on the random fields, the stochastic finite element analyses on stability of embankment are carried out. Numerical results show that stochastic analyses of embankment stability may provide a more rational picture for the distribution of factors of safety (FOS), which is definitely useful for embankment design in frozen ground regions.展开更多
Adopting the quasi-three-dimensional (Quasi-3D) numerical method to optimize the anti-freeze design parameters of an underground pipeline usually involves heavy numerical calculations. Here, the fitting formulae bet...Adopting the quasi-three-dimensional (Quasi-3D) numerical method to optimize the anti-freeze design parameters of an underground pipeline usually involves heavy numerical calculations. Here, the fitting formulae between the safe con-veyance distance (SCD) of a water pipeline and six influencing factors are established based on the lowest water temper-ature (LWT) along the pipeline axis direction. With reference to the current widely used anti-freeze design approaches for underground pipelines in seasonally frozen areas, this paper first analyzes the feasibility of applying the maximum frozen penetration (MFP) instead of the mean annual ground surface temperature (MAGST) and soil water content (SWC) to calculate the SCD. The results show that the SCD depends on the buried depth if the MFP is fixed and the variation of the MAGST and SWC combination does not significantly change the SCD. A comprehensive formula for the SCD is estab-lished based on the relationships between the SCD and several primary influencing factors and the interaction among them. This formula involves five easy-to-access parameters: the MFP, buried depth, pipeline diameter, flow velocity, and inlet water temperature. A comparison between the analytical method and the numerical results based on the Quasi-3D method indicates that the two methods are in good agreement overall. The analytic method can be used to optimize the anti-freeze design parameters of underground water pipelines in seasonally frozen areas under the condition of a 1.5 safety coefficient.展开更多
The Freeze-Sealing Pipe-Roof(FSPR)method,which has been applied for the first time in the Gongbei Tunnel of the Hong Kong-Zhuhai-Macao Bridge,is a new approach of tunnel pre-support that allows flexible adjustment of ...The Freeze-Sealing Pipe-Roof(FSPR)method,which has been applied for the first time in the Gongbei Tunnel of the Hong Kong-Zhuhai-Macao Bridge,is a new approach of tunnel pre-support that allows flexible adjustment of freeze tube arrangement and can be adapted to different environmental conditions.When the FSPR method is used to construct shallow burial submerged tunnels,the frozen wall to hold back groundwater during excavation will be weakened by air and water flows inside and outside the tunnel,and its waterproof performance needs to be further investigated.In this paper,a two-dimensional numerical model of the temperature field considering excavation and moving water boundary is established based on the preliminary design scheme and in-situ conditions and is used to analyze the variation in frozen curtain properties with various active freezing times during excavation.The results show that excavation has a weakening effect on both sides of the frozen wall,with a greater effect on the inner side,and a positive temperature appears in the local area inside the jacked pipe.The concrete fill in the jacked pipe obviously improves the freezing efficiency,and the tunnel excavation after 60 days of active freezing in the interval filling mode can ensure that the frozen soil thickness at the thinnest segment exceeds 2 m,i.e.,the design requirement.In practice,the active freezing time can be extended appropriately to reduce the influence of river water flow above the tunnel.The study serves as a technical reference for the design and implementation of similar projects.展开更多
The clinical outcomes of five groups of infertility patients receiving frozen- thawed, cleavage-stage embryo transfers with exogenous hormone protocols with or without a depot gonadotropin-releasing hormone (GnRH) a...The clinical outcomes of five groups of infertility patients receiving frozen- thawed, cleavage-stage embryo transfers with exogenous hormone protocols with or without a depot gonadotropin-releasing hormone (GnRH) agonist were assessed. A retrospective cohort analysis was performed on 1003 cycles undergoing frozen-thawed, cleavage-stage embryo transfers from January 1, 2012 to June 31, 2015 in the Reproductive Medicine Center of Wuhan General Hospital of Guangzhou Military Region. Based on the infertility etiologies of the patients, the 1003 cycles were divided into five groups: tubal infertility, polycystic ovary syndrome (PCOS), endometriosis, male infertility, and unexplained infertility. The main outcome was the live birth rate. Two groups were set up based on the intervention: group A was given a GnRH agonist with exogenous estrogen and progesterone, and group B (control group) was given exogenous estrogen and progesterone only. The results showed that the baseline serum hormone levels and basic characteristics of the patients were not significantly different between groups A and B. The live birth rates in groups A and B were 41.67% and 29.29%, respectively (P〈0.05). The live birth rates in patients with PCOS in groups A and B were 56.25% and 30.61%, respectively (P〈0.05). The clinical pregnancy, implantation and on-going pregnancy rates showed the same trends as the live birth rates between groups A and B. The ectopic pregnancy rate was significantly lower in group A than in group B. We concluded that the live birth rate was higher and other clinical outcomes were more satisfactory with GnRH agonist co- treatment than without GnRH agonist co-treatment for frozen-thawed embryo transfer. The GnRH agonist combined with exogenous estrogen and progesterone worked for all types of infertility tested, especially for women with PCOS.展开更多
In order to determine the changing rule of long-term frozen soil strength and elucidate the connection between long-term strength and soil physical properties,frozen loess was subjected to 4,6,8,10,and 50 freeze-thaw ...In order to determine the changing rule of long-term frozen soil strength and elucidate the connection between long-term strength and soil physical properties,frozen loess was subjected to 4,6,8,10,and 50 freeze-thaw cycles,under closed-state conditions in a constant-temperature box.The frozen samples were tested on a spherical template indenter,and the results show that under the effect of repeated freeze-thaw cycles,the long-term strength of frozen loess decreased; changes in the mechanical property indices were highly unstable during the first 10 cycles; the soil strength and density were the greatest at the eighth cycle while the void ratio was the smallest; and after eight cycles all of the indices had less fluctuation and certain rising or falling tendencies.By converting the number of freeze-thaw cycles into elapsed time in the tests,three different forecasting methods of long-term soil strength could be assessed and the soil equivalent cohesive force after 10 years,20 years,or 30 years could be estimated.展开更多
Objective: In this study, the influence and response relationship between the seasonal freezing-thawing process of soil and the spatial factor changes in the management and utilization of water resource processes were...Objective: In this study, the influence and response relationship between the seasonal freezing-thawing process of soil and the spatial factor changes in the management and utilization of water resource processes were explored. Methods: The monitoring equipment in this study was arranged at different altitudes, gradients, and slope directions, such as the typical forest sample area in the Dayekou Basin of the Qilian Mountains. The spatial variation characteristics of the seasonal freezing-thawing process of the soil were analyzed, and a regression model was established. Results: 1) The results of this study determined that the rate of the soil’s freezing increased with the altitude in a trend of volatility. However, the rate of the thawing of the frozen soil was found to have an opposite trend. The variation degree of the freezing-thawing process increased with the altitude in a trend of volatility. The end time of the approximate soil freezing with altitude increased in a volatility trend ahead of schedule. However, the opposite was observed in the thawing rate of the frozen soil;2) The rate of the soil’s freezing under the mosses of the spruce forest at an altitude of 3028 m was found to be the lowest. However, in the sub-alpine scrub forest at an altitude of 3300 m, a maximum in the spatial ordering was observed, with an average of 1.9 cm·d-1. The thawing rate of the frozen soil in scrub-spruce forest at an altitude of 3300 m was found to be minimal. However, in the sunny slope grassland at an altitude of 2946 m, a maximum in the spatial ordering was observed, with an average of 1.5 cm·d-1. In the spatial ordering of the variation degree of the process of freezing-thawing with an average of 1.2, the scrub-grassland at an altitude of 2518 m was found to be the lowest, and the scrub-spruce forest at an altitude of 3195 m was also low;3) The soil freezing began on approximately October 20th, and the rate of soil freezing gradually became reduced. The arrival time of the frozen soil of up to 150 cm in depth in sub-alpine scrub forest was first observed at an altitude of 3028 m. However, the scrub-spruce forest at an altitude of 3100 m did not become frozen until approximately January 12th on average. Then, the thawing rate of the frozen soil increased gradually. The end time of the thawing was earliest observed in the sunny slope grassland at an altitude of 2946 m. However, the scrub-spruce forest at an altitude of 3100 m was found to be the last to thaw, and averaged approximately July 27th. The average durations of the freezing and thawing of the soil were 77 and 121 days, respectively, and the average duration of the entire process of freezing-thawing was 199 days;4) This study’s established regression models of the duration time of frozen soil’s thaw, and the rate of frozen soil’s thaw, all passed the R test of goodness of fit, F test of variance, and t test. Conclusions: The characteristics of the seasonal freezing-thawing process of the soil with the spatial changes were seasonal. However, the characteristics under the different spatial factor influences were not the same.展开更多
Freezing and thawing during the winter season change soil properties such as density. The density change in the particulate media influences soil stiffness. In addition, freezing of partially or fully saturated soils ...Freezing and thawing during the winter season change soil properties such as density. The density change in the particulate media influences soil stiffness. In addition, freezing of partially or fully saturated soils changes the soil matrix from a particulate media to a continuum. The goal of this study is to investigate the cyclic freezing and thawing effects on elastic waves. Sand-silt mixtures with 10% silt fraction in weight and 40% saturation are prepared. The sand-silt mixtures are placed in a nylon cell, onto which a pair of bender elements and a pair of piezoelectric disk elements are installed for the measurement of shear and compressional waves, respectively. The temperature of the mixtures decreases from 20 ℃ to -10 ℃ to freezing. The frozen sample is gradually thawed at room temperature (20 ℃), These freezing-thawing processes are repeated three times. The test result shows that the shear and compressional wave velocities significantly increase when the specimen is frozen. When the temperature is greater than 0 ℃, the elastic wave velocities are lower during thawing than during freezing due to soil structure change. This study demonstrates that soil strucre change during the winter season may be effectively estimated from elastic waves.展开更多
Objective To analyse factors influencing the outcome of frozen-thawed embryo transfer (FET). Method A retrospective analysis was performed in our center on 129 thawing cycles from March 2001 to April 2003. The relat...Objective To analyse factors influencing the outcome of frozen-thawed embryo transfer (FET). Method A retrospective analysis was performed in our center on 129 thawing cycles from March 2001 to April 2003. The related parameters were compared between conceived and non-conceived cycles. Results There were totally 129 clinical pregnancies in these transfers (pregnancy rate: 27.1%). Frozen-thawed embryos were transferred to natural cycles and CC cycling and hormone replacement treatment had equal success. Groups of IVF and ICSI did not differ significantly in pregnancy rates (P〉0.05). The pregnancy rates for one, two, three and four pre-embryos transfer were 0, 20.0%,44.1% and 75.0%, respectively (P〈0.05). There were statistical differences between pregnancy group or non- pregnancy group in the endometrial thickness, CES, CES/No. of embryo. A higher pregnancy rate was observed in embryo transfers which had at least one 4-cell grade I embryo (d 2)(P〈0.01). Conclusions The most important factors influencing the implantation rate and pregnancy rate of frozen-thawed embryo transfer are age, endometrium thickness, and the number, morphology and growth rate of transferred frozen embryos of women participants.展开更多
The endometrial condition is a significant factor for successful pregnancy. To regulate endometrial function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells...The endometrial condition is a significant factor for successful pregnancy. To regulate endometrial function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells and stimulation of endometrium embryo transfer (SEET) to enhance communication between embryo and maternal tissues. We attempted to improve the endometrial condition by PSL administration and SEET during frozen–thawed blastocyst transfer (FBT). Patients took PSL (5 mg) 3 times daily for 3 days after ovulation during the FBT cycle. To analyse effects of PSL combined with SEET, we determined rates of chemical pregnancy, clinical pregnancy, foetal heart movement (FHM) and live birth. Rates of chemical pregnancy, clinical pregnancy and FHM were significantly higher in the PSL(+)/SEET(+) (57.7%, 50.0% and 46.2%, respectively) and PSL(+)/SEET(-) (53.3%, 46.7% and 46.7%, respectively) groups than in the PSL(-)/SEET(+) (30.3%, 18.2% and 18.2%, respectively) and PSL(-)/SEET(-) (22.4%, 22.4% and 18.4%;P = 0.0043, 0.0081 and 0.0055, respectively) groups. The live birth rate was significantly higher in the PSL(+)/SEET(+) group than in the PSL(+)/SEET(-), PSL(-)/SEET(+) and PSL(-)/SEET(-) groups (42.3%, 26.7%, 18.2% and 12.2%, respectively;P = 0.0237). PSL combined with SEET may be a useful adjunct to assisted reproductive technology in women who repeatedly fail to conceive by infertility treatment.展开更多
Objectives:To assess the clinical outcomes of frozen-thawed blastocysts transfer in natural and hormonally controlled cycles.Methods:A retrospective analysis of natural and hormonally controlled cycle for 246 frozen-t...Objectives:To assess the clinical outcomes of frozen-thawed blastocysts transfer in natural and hormonally controlled cycles.Methods:A retrospective analysis of natural and hormonally controlled cycle for 246 frozen-thawed blastocyst transfer cycles,the clinical pregnancy rate,implantation rate,early abortion rate were compared.Results:Of the 192 hormonally controlled cycles,the cancel rate,clinical pregnancy rate per ET,implantation rate and abortion rate were 7.3%(14/192),53.9%(96/178),38.8%(131/338)and 11.5%(11/96)respectively,whereas in 54 natural cycles,these rates were 16.7%(9/54),68.9%(31/45),52.9%(45/85)and 16.1%(5/31)respectively.There was no significant difference between the two groups with regard to the clinical pregnancy and abortion rate per ET,but the cancel rate and implantation rate were higher in natural cycles.However,the pregnancy and implantation rates of patients without PCOS in hormonal control cycles(57.2%,40.9%)were similar with those in natural cycles(P>0.05).Conclusion:These findings suggested that both hormonally controlled and natural cycles had similar pregnancy outcomes in frozen-thawed blastocysts transfer.展开更多
In permafrost regions with warm frozen soil,subgrade thaw-collapse phenomenon commonly occurs,facing thaw collapse problems of the existed frozen soil subgrade,thus it is difficult to use traditional methods such as a...In permafrost regions with warm frozen soil,subgrade thaw-collapse phenomenon commonly occurs,facing thaw collapse problems of the existed frozen soil subgrade,thus it is difficult to use traditional methods such as active cooling and passive protection technology to stabilize the existed warm frozen soil subgrade.This study derives a novel stabilizer method,a long-short(L-S)cement-mixed batter pile composite foundation to stabilize the existed warm frozen soil subgrade.To solve the thawcollapse problems in warm frozen soil subgrade,high water content and large compressibility characteristics were compared between soft soil and warm frozen soils.Theoretical analysis of heat conduction and numerical simulation of finite element model were used to study the freeze–thaw process and evaluate the stabilized effects of the L-S cement-mixed batter piles on the warm frozen soil foundation of the Qinghai-Tibet Highway.Furthermore,the thaw process and mechanical properties of foundation and piles were analyzed by introducing the hydration heat factor in the thermodynamic control equation.The results indicate that the thawing displacement of the existed warm frozen soil subgrade was reduced owing to the“support”and“grasp”effects of the L-S cement-mixed batter piles on the surrounding soil.The composite ground formed by strengthening the warm frozen ground with batter piles could considerably improve the bearing capacity of the existed warm frozen ground,effectively restrain the deformation of the upper embankment,and improve the strength of the ground.The analysis can provide method for the construction design of cement mixing batter pile foundation in cold regions.展开更多
基金We acknowledge the funding support from the National Natural Science Foundation of China(Grant No.42271148).
文摘Due to the presence of ice and unfrozen water in pores of frozen rock,the rock fracture behaviors are susceptible to temperature.In this study,the potential thawing-induced softening effects on the fracture behaviors of frozen rock is evaluated by testing the tension fracture toughness(KIC)of frozen rock at different temperatures(i.e.-20℃,-15℃,-12℃,-10℃,-8℃,-6℃,-4℃,-2℃,and 0℃).Acoustic emission(AE)and digital image correlation(DIC)methods are utilized to analyze the microcrack propagation during fracturing.The melting of pore ice is measured using nuclear magnetic resonance(NMR)method.The results indicate that:(1)The KIC of frozen rock decreases moderately between-20℃ and-4℃,and rapidly between-4℃ and 0℃.(2)At-20℃ to-4℃,the fracturing process,deduced from the DIC results at the notch tip,exhibits three stages:elastic deformation,microcrack propagation and microcrack coalescence.However,at-4℃e0℃,only the latter two stages are observed.(3)At-4℃e0℃,the AE activities during fracturing are less than that at-20℃ to-4℃,while more small events are reported.(4)The NMR results demonstrate a reverse variation trend in pore ice content with increasing temperature,that is,a moderate decrease is followed by a sharp decrease and-4℃ is exactly the critical temperature.Next,we interpret the thawing-induced softening effect by linking the evolution in microscopic structure of frozen rock with its macroscopic fracture behaviors as follow:from-20℃ to-4℃,the thickening of the unfrozen water film diminishes the cementation strength between ice and rock skeleton,leading to the decrease in fracture parameters.From-4℃ to 0℃,the cementation effect of ice almost vanishes,and the filling effect of pore ice is reduced significantly,which facilitates microcrack propagation and thus the easier fracture of frozen rocks.
基金This work was jointly funded by the National Natural Science Foundation of China(Grant Nos.42205168,41830967,and 42175163)the Youth Innovation Promotion Association CAS(2021073)the National Key Scientific and Technological Infrastructure project“Earth System Science Numerical Simulator Facility”(EarthLab).
文摘The soil freezing and thawing process affects soil physical properties,such as heat conductivity,heat capacity,and hydraulic conductivity in frozen ground regions,and further affects the processes of soil energy,hydrology,and carbon and nitrogen cycles.In this study,the calculation of freezing and thawing front parameterization was implemented into the earth system model of the Chinese Academy of Sciences(CAS-ESM)and its land component,the Common Land Model(CoLM),to investigate the dynamic change of freezing and thawing fronts and their effects.Our results showed that the developed models could reproduce the soil freezing and thawing process and the dynamic change of freezing and thawing fronts.The regionally averaged value of active layer thickness in the permafrost regions was 1.92 m,and the regionally averaged trend value was 0.35 cm yr–1.The regionally averaged value of maximum freezing depth in the seasonally frozen ground regions was 2.15 m,and the regionally averaged trend value was–0.48 cm yr–1.The active layer thickness increased while the maximum freezing depth decreased year by year.These results contribute to a better understanding of the freezing and thawing cycle process.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41905008, 41975007, and 42075081)the Innovation and Entrepreneurship Training Program for College Students of Chengdu University of Information Technology (CUIT) (202210621003, 202210621039, 202110621015)provided by the Scientific Research Foundation of CUIT (KYTZ202126)
文摘Since the 1990s,the Qinghai–Tibetan Plateau(QTP)has experienced a strikingly warming and wetter climate that alters the thermal and hydrological properties of frozen ground.A positive correlation between the warming and thermal degradation in permafrost or seasonally frozen ground(SFG)has long been recognized.Still,a predictive relationship between historical wetting under warming climate conditions and frozen ground has not yet been well demonstrated,despite the expectation that it will become even more important because precipitation over the QTP has been projected to increase continuously in the near future.This study investigates the response of the thermal regime to historical wetting in both permafrost and SFG areas and examines their relationships separately using the Community Land Surface Model version 4.5.Results show that wetting before the 1990s across the QTP mainly cooled the permafrost body in the arid and semiarid zones,with significant correlation coefficients of 0.60 and 0.48,respectively.Precipitation increased continually at the rate of 6.16 mm decade–1 in the arid zone after the 1990s but had a contrasting warming effect on permafrost through a significant shortening of the thawing duration within the active layer.However,diminished rainfall in the humid zone after the 1990s also significantly extended the thawing duration of SFG.The relationship between the ground thawing index and precipitation was significantly negatively correlated(−0.75).The dual effects of wetting on the thermal dynamics of the QTP are becoming critical because of the projected increases in future precipitation.
基金Scientific Research Fund of Institute of Engineering Mechanics,China Earthquake Administration under Grant No.2018D12National Natural Science Foundation of Heilongjiang Province under Grant No.E 2016045+1 种基金National Natural Science Foundation of China under Grant No.5137816451508140
文摘Using a new low-temperature dynamic triaxial apparatus, the influence law of freezing-thawing cycles on clay shear strength is studied. In this research, the concept of correction coefficients of freezing-thawing cycles on clay static strength, cohesion and internal friction angles is proposed, and the change patterns, correction curves and regressive formulae of clay static strength, cohesion and internal friction angles under freezing-thawing cycles are given. The test results indicate that with increasing numbers of freezing-thawing cycles, the clay static strength and cohesion decrease exponentially but the internal friction angle increases exponentially. The performance of static strength, cohesion and internal friction angles are different with increasing numbers of freezing-thawing cycles, i.e., the static strength decreases constantly until about 30% of the initial static strength prior to the freezing-thawing cycling and then stays basically stable. After 5-7 freezing-thawing cycles, the cohesion decreases gradually to about 70% of the initial cohesion. The internal friction angle increases about 20% after the first freezing-thawing cycle, then increases gradually close to a stable value which is an increase of about 40% of the internal friction angle. The freezing-thawing process can increase the variation of the density of the soil samples; therefore, strict density discreteness standards of frozen soil sample preparation should be established to ensure the reliability of the test results.
基金Supported by the Technology Research and Demonstrational Popularization Project of Beijing Vocational College of Agriculture(XY-YF-15-07)(XY-YF-14-21)
文摘The aim was to discuss the optimal storage environment and proper insemination time after thawing of 0.25 mL straw frozen semen. Straw frozen semen was thawed at 40 ℃ for 20 s, and then stored at 0 -4 ℃, 14 - 16 ℃, 25 -27 ℃ for 2, 4, 6, 8 and 10 h, respectively. The sperm motility was detected. After thawing, semen was stored at 0 - 4 ℃ and 14 - 16 ℃ for 10 h. Their sperm motilities (0.434 ±0. 016 7 and 0.423 ±0.019 6) had no significant differences (P 〉 0.05) with initial thawing motility (0.441 ± 0.030). Sperm motility reduced as the storage time prolonged at 25 -27 ℃. Sperm motility after 6 h had signifi- cant differences with that of initial thawing motility (P 〈 O. 05 ), and sperm motilities after 8 and 10 h showed extremely significant differences (P 〈 0.01 ). Thus, sperm motility after thawing was still very high after stored at 0 -4 ℃ and 14 - 16 ℃ within 10 h, which met the requirements for insemination. Under this temperature and time ranges, sperm could be carried over long distances, which had small effects on sperm quality and reached the expected insemination effects. However, under the temperature of 25 - 27 ℃, semen should be used for insemination within 6 h after thawing.
基金supported by the National Natural Science Foundation of China (Grant No. 42271148)Open foundation of State Key Laboratory of Frozen Soil Engineering (Grant No. SKLFSE201807)
文摘Research on the stability of soil slopes in seasonally frozen regions has mainly focused on slope failures during the thawing window.There are few studies on slope stability during the freezing window and its subsequent influence on slope failure in the next thawing window.In this paper,soil strength was tested during freezing and thawing to obtain temperature-dependent strength parameters for the simulation of slope stability.Then,the slope's temperature field over an entire year was accurately simulated so that characteristics of the frozen layer could be determined at any time.Based on the above results,the progressive failure modes of frozen soil slopes are discussed.The results show that:1)during the freezing window,depth of the frozen soil layer increases,as does the slope's safety factor,while a yield zone propagates towards the slope shoulder.(2)During the thawing window,the frozen soil layer shrinks in depth while the yield zone continuously expands,which decreases the safety factor.Comprehensive analysis of these results indicate that the frozen layer provides a“toe-locking effect”that increases the safety factor during the freezing window,while it also provides a“dragging effect”that propagates the yield zone towards the slope shoulder.During the thawing window,the“toe-locking effect”gradually diminishes;a continuous sliding surface is formed,which lead to a landslide.The frozen soil layer of the freezing window accelerates the slope sliding in the thawing window.
基金This work was supported jointly by the Key Innovation Project of the Chinese Academy of Sciences(Grant No.ZKCX2-SW-210)the National Natural Science Foundation of the China(Grant Nos.40375033 and 40175020)the Key National Natural Science Foundation of China(Grant Nos.40231005).
文摘The impact of the anomalous thawing of frozen soil in the late spring on the summer precipitation in China and its possible mechanism are analyzed in the context of the frozen soil thawing date data of the 50 meteorological stations in the Tibetan Plateau, and the NCEP/NCAR monthly average reanalysis data. Results show that the thawing dates of the Tibetan Plateau gradually become earlier from 1980 to 1999, which is consistent with the trend of global warming in the 20th century. Because differences in the thermal capacity and conductivity between frozen and unfrozen soils are larger, changes in the freezing/thawing process of soil may change the physical properties of the underlying surface, thus affecting exchanges of sensible and latent heat between the ground surface and air. The thermal state change of the plateau ground surface must lead to the thermal anomalies of the atmosphere over and around the plateau, and then further to the anomalies of the general atmospheric circulation. A possible mechanism for the impact of the thawing of the plateau on summer (July) precipitation may be as follows. When the frozen soil thaws early (late) in the plateau, the thermal capacity of the ground surface is large (small), and the thermal conductivity is small (large), therefore, the thermal exchanges between the ground surface and the air are weak (strong). The small (large) ground surface sensible and latent heat fluxes lead to a weak (strong) South Asian high, a weak (strong) West Pacific subtropical high and a little to south (north) of its normal position. Correspondingly, the ascending motion is strengthened (weakened) and precipitation increases (decreases) in South China, while in the middle and lower reaches of the Changjiang River, the ascending motion and precipitation show the opposite trend.
基金supported by the National Basic Research Program of China under Grant No 2006CB400504National Natural Science Foundation of China under Grant Nos 40605027 and 40775050
文摘A frozen soil parameterization coupling of thermal and hydrological processes is used to investigate how frozen soil processes affect water and energy balances in seasonal frozen soil. Simulation results of soil liquid water content and temperature using soil model with and without the inclusion of freezing and thawing processes are evaluated against observations at the Rosemount field station. By comparing the simulated water and heat fluxes of the two cases, the role of phase change processes in the water and energy balances is analyzed. Soil freezing induces upward water flow towards the freezing front and increases soil water content in the upper soil layer. In particular, soil ice obviously prevents and delays the infiltration during rain at Rosemount. In addition, soil freezingthawing processes alter the partitioning of surface energy fluxes and lead the soil to release more sensible heat into the atmosphere during freezing periods.
基金supported by the National 973 Project of China (No. 2012CB026104)the National Natural Science Foundation of China (No. 51378057)
文摘Prediction on the coupled thermal-hydraulic fields of embankment and cutting slopes is essential to the assessment on evolution of melting zone and natural permafrost table, which is usually a key factor for permafrost embankment design in frozen ground regions. The prediction may be further complicated due to the inherent uncertainties of material properties. Hence, stochastic analyses should be conducted. Firstly, Karhunen-Loeve expansion is applied to attain the random fields for hydraulic and thermal conductions. Next, the mixed-form modified Richards equation for mass transfer (i.e., mass equation) and the heat transport equation for heat transient flow in a variably saturated frozen soil are combined into one equation with temperature unknown. Furthermore, the finite element formulation for the coupled thermal-hydraulic fields is derived. Based on the random fields, the stochastic finite element analyses on stability of embankment are carried out. Numerical results show that stochastic analyses of embankment stability may provide a more rational picture for the distribution of factors of safety (FOS), which is definitely useful for embankment design in frozen ground regions.
基金financially supported by the National Basic Research Program of China (No. 2013CBA01803)the National Natural Science Foundation of China (No. 41101065)and the CAS "Equipment Development Project for Scientific Research" (No. YZ201523)
文摘Adopting the quasi-three-dimensional (Quasi-3D) numerical method to optimize the anti-freeze design parameters of an underground pipeline usually involves heavy numerical calculations. Here, the fitting formulae between the safe con-veyance distance (SCD) of a water pipeline and six influencing factors are established based on the lowest water temper-ature (LWT) along the pipeline axis direction. With reference to the current widely used anti-freeze design approaches for underground pipelines in seasonally frozen areas, this paper first analyzes the feasibility of applying the maximum frozen penetration (MFP) instead of the mean annual ground surface temperature (MAGST) and soil water content (SWC) to calculate the SCD. The results show that the SCD depends on the buried depth if the MFP is fixed and the variation of the MAGST and SWC combination does not significantly change the SCD. A comprehensive formula for the SCD is estab-lished based on the relationships between the SCD and several primary influencing factors and the interaction among them. This formula involves five easy-to-access parameters: the MFP, buried depth, pipeline diameter, flow velocity, and inlet water temperature. A comparison between the analytical method and the numerical results based on the Quasi-3D method indicates that the two methods are in good agreement overall. The analytic method can be used to optimize the anti-freeze design parameters of underground water pipelines in seasonally frozen areas under the condition of a 1.5 safety coefficient.
基金This research was supported by the National Natural Science Foundation of China(No.52108386)。
文摘The Freeze-Sealing Pipe-Roof(FSPR)method,which has been applied for the first time in the Gongbei Tunnel of the Hong Kong-Zhuhai-Macao Bridge,is a new approach of tunnel pre-support that allows flexible adjustment of freeze tube arrangement and can be adapted to different environmental conditions.When the FSPR method is used to construct shallow burial submerged tunnels,the frozen wall to hold back groundwater during excavation will be weakened by air and water flows inside and outside the tunnel,and its waterproof performance needs to be further investigated.In this paper,a two-dimensional numerical model of the temperature field considering excavation and moving water boundary is established based on the preliminary design scheme and in-situ conditions and is used to analyze the variation in frozen curtain properties with various active freezing times during excavation.The results show that excavation has a weakening effect on both sides of the frozen wall,with a greater effect on the inner side,and a positive temperature appears in the local area inside the jacked pipe.The concrete fill in the jacked pipe obviously improves the freezing efficiency,and the tunnel excavation after 60 days of active freezing in the interval filling mode can ensure that the frozen soil thickness at the thinnest segment exceeds 2 m,i.e.,the design requirement.In practice,the active freezing time can be extended appropriately to reduce the influence of river water flow above the tunnel.The study serves as a technical reference for the design and implementation of similar projects.
文摘The clinical outcomes of five groups of infertility patients receiving frozen- thawed, cleavage-stage embryo transfers with exogenous hormone protocols with or without a depot gonadotropin-releasing hormone (GnRH) agonist were assessed. A retrospective cohort analysis was performed on 1003 cycles undergoing frozen-thawed, cleavage-stage embryo transfers from January 1, 2012 to June 31, 2015 in the Reproductive Medicine Center of Wuhan General Hospital of Guangzhou Military Region. Based on the infertility etiologies of the patients, the 1003 cycles were divided into five groups: tubal infertility, polycystic ovary syndrome (PCOS), endometriosis, male infertility, and unexplained infertility. The main outcome was the live birth rate. Two groups were set up based on the intervention: group A was given a GnRH agonist with exogenous estrogen and progesterone, and group B (control group) was given exogenous estrogen and progesterone only. The results showed that the baseline serum hormone levels and basic characteristics of the patients were not significantly different between groups A and B. The live birth rates in groups A and B were 41.67% and 29.29%, respectively (P〈0.05). The live birth rates in patients with PCOS in groups A and B were 56.25% and 30.61%, respectively (P〈0.05). The clinical pregnancy, implantation and on-going pregnancy rates showed the same trends as the live birth rates between groups A and B. The ectopic pregnancy rate was significantly lower in group A than in group B. We concluded that the live birth rate was higher and other clinical outcomes were more satisfactory with GnRH agonist co- treatment than without GnRH agonist co-treatment for frozen-thawed embryo transfer. The GnRH agonist combined with exogenous estrogen and progesterone worked for all types of infertility tested, especially for women with PCOS.
基金This project is supported in part by the Natural Science Foundation of China (Nos.41301070,41301071)the West Light Program for Talent Cultivation of the Chinese Academy of Sciences (2013-03)the project sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry,granted to Dr.Ze Zhang
文摘In order to determine the changing rule of long-term frozen soil strength and elucidate the connection between long-term strength and soil physical properties,frozen loess was subjected to 4,6,8,10,and 50 freeze-thaw cycles,under closed-state conditions in a constant-temperature box.The frozen samples were tested on a spherical template indenter,and the results show that under the effect of repeated freeze-thaw cycles,the long-term strength of frozen loess decreased; changes in the mechanical property indices were highly unstable during the first 10 cycles; the soil strength and density were the greatest at the eighth cycle while the void ratio was the smallest; and after eight cycles all of the indices had less fluctuation and certain rising or falling tendencies.By converting the number of freeze-thaw cycles into elapsed time in the tests,three different forecasting methods of long-term soil strength could be assessed and the soil equivalent cohesive force after 10 years,20 years,or 30 years could be estimated.
文摘Objective: In this study, the influence and response relationship between the seasonal freezing-thawing process of soil and the spatial factor changes in the management and utilization of water resource processes were explored. Methods: The monitoring equipment in this study was arranged at different altitudes, gradients, and slope directions, such as the typical forest sample area in the Dayekou Basin of the Qilian Mountains. The spatial variation characteristics of the seasonal freezing-thawing process of the soil were analyzed, and a regression model was established. Results: 1) The results of this study determined that the rate of the soil’s freezing increased with the altitude in a trend of volatility. However, the rate of the thawing of the frozen soil was found to have an opposite trend. The variation degree of the freezing-thawing process increased with the altitude in a trend of volatility. The end time of the approximate soil freezing with altitude increased in a volatility trend ahead of schedule. However, the opposite was observed in the thawing rate of the frozen soil;2) The rate of the soil’s freezing under the mosses of the spruce forest at an altitude of 3028 m was found to be the lowest. However, in the sub-alpine scrub forest at an altitude of 3300 m, a maximum in the spatial ordering was observed, with an average of 1.9 cm·d-1. The thawing rate of the frozen soil in scrub-spruce forest at an altitude of 3300 m was found to be minimal. However, in the sunny slope grassland at an altitude of 2946 m, a maximum in the spatial ordering was observed, with an average of 1.5 cm·d-1. In the spatial ordering of the variation degree of the process of freezing-thawing with an average of 1.2, the scrub-grassland at an altitude of 2518 m was found to be the lowest, and the scrub-spruce forest at an altitude of 3195 m was also low;3) The soil freezing began on approximately October 20th, and the rate of soil freezing gradually became reduced. The arrival time of the frozen soil of up to 150 cm in depth in sub-alpine scrub forest was first observed at an altitude of 3028 m. However, the scrub-spruce forest at an altitude of 3100 m did not become frozen until approximately January 12th on average. Then, the thawing rate of the frozen soil increased gradually. The end time of the thawing was earliest observed in the sunny slope grassland at an altitude of 2946 m. However, the scrub-spruce forest at an altitude of 3100 m was found to be the last to thaw, and averaged approximately July 27th. The average durations of the freezing and thawing of the soil were 77 and 121 days, respectively, and the average duration of the entire process of freezing-thawing was 199 days;4) This study’s established regression models of the duration time of frozen soil’s thaw, and the rate of frozen soil’s thaw, all passed the R test of goodness of fit, F test of variance, and t test. Conclusions: The characteristics of the seasonal freezing-thawing process of the soil with the spatial changes were seasonal. However, the characteristics under the different spatial factor influences were not the same.
基金supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2012-0005729)
文摘Freezing and thawing during the winter season change soil properties such as density. The density change in the particulate media influences soil stiffness. In addition, freezing of partially or fully saturated soils changes the soil matrix from a particulate media to a continuum. The goal of this study is to investigate the cyclic freezing and thawing effects on elastic waves. Sand-silt mixtures with 10% silt fraction in weight and 40% saturation are prepared. The sand-silt mixtures are placed in a nylon cell, onto which a pair of bender elements and a pair of piezoelectric disk elements are installed for the measurement of shear and compressional waves, respectively. The temperature of the mixtures decreases from 20 ℃ to -10 ℃ to freezing. The frozen sample is gradually thawed at room temperature (20 ℃), These freezing-thawing processes are repeated three times. The test result shows that the shear and compressional wave velocities significantly increase when the specimen is frozen. When the temperature is greater than 0 ℃, the elastic wave velocities are lower during thawing than during freezing due to soil structure change. This study demonstrates that soil strucre change during the winter season may be effectively estimated from elastic waves.
文摘Objective To analyse factors influencing the outcome of frozen-thawed embryo transfer (FET). Method A retrospective analysis was performed in our center on 129 thawing cycles from March 2001 to April 2003. The related parameters were compared between conceived and non-conceived cycles. Results There were totally 129 clinical pregnancies in these transfers (pregnancy rate: 27.1%). Frozen-thawed embryos were transferred to natural cycles and CC cycling and hormone replacement treatment had equal success. Groups of IVF and ICSI did not differ significantly in pregnancy rates (P〉0.05). The pregnancy rates for one, two, three and four pre-embryos transfer were 0, 20.0%,44.1% and 75.0%, respectively (P〈0.05). There were statistical differences between pregnancy group or non- pregnancy group in the endometrial thickness, CES, CES/No. of embryo. A higher pregnancy rate was observed in embryo transfers which had at least one 4-cell grade I embryo (d 2)(P〈0.01). Conclusions The most important factors influencing the implantation rate and pregnancy rate of frozen-thawed embryo transfer are age, endometrium thickness, and the number, morphology and growth rate of transferred frozen embryos of women participants.
文摘The endometrial condition is a significant factor for successful pregnancy. To regulate endometrial function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells and stimulation of endometrium embryo transfer (SEET) to enhance communication between embryo and maternal tissues. We attempted to improve the endometrial condition by PSL administration and SEET during frozen–thawed blastocyst transfer (FBT). Patients took PSL (5 mg) 3 times daily for 3 days after ovulation during the FBT cycle. To analyse effects of PSL combined with SEET, we determined rates of chemical pregnancy, clinical pregnancy, foetal heart movement (FHM) and live birth. Rates of chemical pregnancy, clinical pregnancy and FHM were significantly higher in the PSL(+)/SEET(+) (57.7%, 50.0% and 46.2%, respectively) and PSL(+)/SEET(-) (53.3%, 46.7% and 46.7%, respectively) groups than in the PSL(-)/SEET(+) (30.3%, 18.2% and 18.2%, respectively) and PSL(-)/SEET(-) (22.4%, 22.4% and 18.4%;P = 0.0043, 0.0081 and 0.0055, respectively) groups. The live birth rate was significantly higher in the PSL(+)/SEET(+) group than in the PSL(+)/SEET(-), PSL(-)/SEET(+) and PSL(-)/SEET(-) groups (42.3%, 26.7%, 18.2% and 12.2%, respectively;P = 0.0237). PSL combined with SEET may be a useful adjunct to assisted reproductive technology in women who repeatedly fail to conceive by infertility treatment.
文摘Objectives:To assess the clinical outcomes of frozen-thawed blastocysts transfer in natural and hormonally controlled cycles.Methods:A retrospective analysis of natural and hormonally controlled cycle for 246 frozen-thawed blastocyst transfer cycles,the clinical pregnancy rate,implantation rate,early abortion rate were compared.Results:Of the 192 hormonally controlled cycles,the cancel rate,clinical pregnancy rate per ET,implantation rate and abortion rate were 7.3%(14/192),53.9%(96/178),38.8%(131/338)and 11.5%(11/96)respectively,whereas in 54 natural cycles,these rates were 16.7%(9/54),68.9%(31/45),52.9%(45/85)and 16.1%(5/31)respectively.There was no significant difference between the two groups with regard to the clinical pregnancy and abortion rate per ET,but the cancel rate and implantation rate were higher in natural cycles.However,the pregnancy and implantation rates of patients without PCOS in hormonal control cycles(57.2%,40.9%)were similar with those in natural cycles(P>0.05).Conclusion:These findings suggested that both hormonally controlled and natural cycles had similar pregnancy outcomes in frozen-thawed blastocysts transfer.
基金supported by the National Natural Science Foundation of China(Grant No.41971086)Natural Science Foundation of Shanxi Province(Grant No.2023-JC-QN-0626,2022JQ-467).
文摘In permafrost regions with warm frozen soil,subgrade thaw-collapse phenomenon commonly occurs,facing thaw collapse problems of the existed frozen soil subgrade,thus it is difficult to use traditional methods such as active cooling and passive protection technology to stabilize the existed warm frozen soil subgrade.This study derives a novel stabilizer method,a long-short(L-S)cement-mixed batter pile composite foundation to stabilize the existed warm frozen soil subgrade.To solve the thawcollapse problems in warm frozen soil subgrade,high water content and large compressibility characteristics were compared between soft soil and warm frozen soils.Theoretical analysis of heat conduction and numerical simulation of finite element model were used to study the freeze–thaw process and evaluate the stabilized effects of the L-S cement-mixed batter piles on the warm frozen soil foundation of the Qinghai-Tibet Highway.Furthermore,the thaw process and mechanical properties of foundation and piles were analyzed by introducing the hydration heat factor in the thermodynamic control equation.The results indicate that the thawing displacement of the existed warm frozen soil subgrade was reduced owing to the“support”and“grasp”effects of the L-S cement-mixed batter piles on the surrounding soil.The composite ground formed by strengthening the warm frozen ground with batter piles could considerably improve the bearing capacity of the existed warm frozen ground,effectively restrain the deformation of the upper embankment,and improve the strength of the ground.The analysis can provide method for the construction design of cement mixing batter pile foundation in cold regions.