Objective:The fruit stalk of Schisandra chinensis(Turcz.)Baill.(S.chinensis)has been found to contain bioactive components similar to the fruit of S.chinensis.Here,we report a recent discovery about new nortriterpenoi...Objective:The fruit stalk of Schisandra chinensis(Turcz.)Baill.(S.chinensis)has been found to contain bioactive components similar to the fruit of S.chinensis.Here,we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity,which were isolated from the fruit stalk of S.chinensis.Methods:The chemical components of ethyl acetate extract from 70%ethanol extract from S.chinensis fruit stalk were separated,purified,and identified by liquid chromatography methods(silica gel,ODS,HPLC)and extensive spectroscopic analyses(NMR,IR,UV,MS,CD).Results:Two new nortriterpenoids,schilancitrilactone M and 25-hydroxyl schindilactone D(1 and 2),along with ten known nortriterpenoids(3-12)were isolated from the fruit stalk of S.chinensis.The isolated compounds were tested for their cytotoxic activities against MGC-803 cells,and the results showed that compounds 6-8 possessed significant activities with IC50 of 9.01,11.77,and 2.74μmol/L,respectively.Conclusion:Twelve nortriterpenoids including two new compounds were isolated from the fruit stalk of S.chinensis for the first time.Among them,compounds 6-8 showed significant anti-gastric cancer activities.We postulated that the fruit stalk of S.chinensis could be used as an anti-gastric cancer drug.展开更多
The collection of wild kiwifruit germplasms has already proved its worth with the development of valuable new kiwifruit cultivars.Through field investigation and consulting the existing literature,this paper illustrat...The collection of wild kiwifruit germplasms has already proved its worth with the development of valuable new kiwifruit cultivars.Through field investigation and consulting the existing literature,this paper illustrates that Jiugongshan region in China is a unique gene bank of excellent wild kiwifruit germplasm resources on the boundary between Hubei and Jiangxi provinces.It is also one of the important birthplaces of breeding materials for new kiwifruit cultivars in China.The paper introduces the main characteristics of two wild red-fleshed kiwifruit germplasms discovered in this region,and one of them is a new large-fruited variant of wild red-fleshed kiwifruit.The main fruit qualities of the large-fruited form are that short fruit stalk,large fruit(the maximum fresh fruit mass of about 81.2 g),moderate sweetness and sourness,reddish to red inner pericarp,the ripe fruit soluble solids content 14.10%,total sugar 8.84%,total acid 1.18%,vitamin C 644.3 mg/kg.It is expected to be cultivated into a new edible cultivar(line)or ornamental and edible cultivar(line)of Actinidia chinensis,which has a broad prospect of development and utilization.展开更多
基金This study was supported by the National Nature Science Foundation(81973440)National Key Research and Development Project(2018YFC1707100+1 种基金2018YFC1707103)Heilongjiang Touyan Innovation Team Program.
文摘Objective:The fruit stalk of Schisandra chinensis(Turcz.)Baill.(S.chinensis)has been found to contain bioactive components similar to the fruit of S.chinensis.Here,we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity,which were isolated from the fruit stalk of S.chinensis.Methods:The chemical components of ethyl acetate extract from 70%ethanol extract from S.chinensis fruit stalk were separated,purified,and identified by liquid chromatography methods(silica gel,ODS,HPLC)and extensive spectroscopic analyses(NMR,IR,UV,MS,CD).Results:Two new nortriterpenoids,schilancitrilactone M and 25-hydroxyl schindilactone D(1 and 2),along with ten known nortriterpenoids(3-12)were isolated from the fruit stalk of S.chinensis.The isolated compounds were tested for their cytotoxic activities against MGC-803 cells,and the results showed that compounds 6-8 possessed significant activities with IC50 of 9.01,11.77,and 2.74μmol/L,respectively.Conclusion:Twelve nortriterpenoids including two new compounds were isolated from the fruit stalk of S.chinensis for the first time.Among them,compounds 6-8 showed significant anti-gastric cancer activities.We postulated that the fruit stalk of S.chinensis could be used as an anti-gastric cancer drug.
文摘The collection of wild kiwifruit germplasms has already proved its worth with the development of valuable new kiwifruit cultivars.Through field investigation and consulting the existing literature,this paper illustrates that Jiugongshan region in China is a unique gene bank of excellent wild kiwifruit germplasm resources on the boundary between Hubei and Jiangxi provinces.It is also one of the important birthplaces of breeding materials for new kiwifruit cultivars in China.The paper introduces the main characteristics of two wild red-fleshed kiwifruit germplasms discovered in this region,and one of them is a new large-fruited variant of wild red-fleshed kiwifruit.The main fruit qualities of the large-fruited form are that short fruit stalk,large fruit(the maximum fresh fruit mass of about 81.2 g),moderate sweetness and sourness,reddish to red inner pericarp,the ripe fruit soluble solids content 14.10%,total sugar 8.84%,total acid 1.18%,vitamin C 644.3 mg/kg.It is expected to be cultivated into a new edible cultivar(line)or ornamental and edible cultivar(line)of Actinidia chinensis,which has a broad prospect of development and utilization.
