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Observer-based robust high-order fully actuated attitude autopilot design for spinning glide-guided projectiles 被引量:1
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作者 Wei Wang Yuchen Wang +2 位作者 Shiwei Chen Yongcang Guo Zhongjiao Shi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第4期282-294,共13页
This paper investigates the design of an attitude autopilot for a dual-channel controlled spinning glideguided projectile(SGGP),addressing model uncertainties and external disturbances.Based on fixed-time stable theor... This paper investigates the design of an attitude autopilot for a dual-channel controlled spinning glideguided projectile(SGGP),addressing model uncertainties and external disturbances.Based on fixed-time stable theory,a disturbance observer with integral sliding mode and adaptive techniques is proposed to mitigate total disturbance effects,irrespective of initial conditions.By introducing an error integral signal,the dynamics of the SGGP are transformed into two separate second-order fully actuated systems.Subsequently,employing the high-order fully actuated approach and a parametric approach,the nonlinear dynamics of the SGGP are recast into a constant linear closed-loop system,ensuring that the projectile's attitude asymptotically tracks the given goal with the desired eigenstructure.Under the proposed composite control framework,the ultimately uniformly bounded stability of the closed-loop system is rigorously demonstrated via the Lyapunov method.Validation of the effectiveness of the proposed attitude autopilot design is provided through extensive numerical simulations. 展开更多
关键词 Spinning glide-guided projectile Attitude control Sliding mode disturbance observer Fixed-time stable theory High-order fully actuated approach
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Not in Control,but Liable?Attributing Human Responsibility for Fully Automated Vehicle Accidents
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作者 Siming Zhai Lin Wang Peng Liu 《Engineering》 SCIE EI CAS CSCD 2024年第2期121-132,共12页
Human agency has become increasingly limited in complex systems with increasingly automated decision-making capabilities.For instance,human occupants are passengers and do not have direct vehicle control in fully auto... Human agency has become increasingly limited in complex systems with increasingly automated decision-making capabilities.For instance,human occupants are passengers and do not have direct vehicle control in fully automated cars(i.e.,driverless cars).An interesting question is whether users are responsible for the accidents of these cars.Normative ethical and legal analyses frequently argue that individuals should not bear responsibility for harm beyond their control.Here,we consider human judgment of responsibility for accidents involving fully automated cars through three studies with seven experiments(N=2668).We compared the responsibility attributed to the occupants in three conditions:an owner in his private fully automated car,a passenger in a driverless robotaxi,and a passenger in a conventional taxi,where none of these three occupants have direct vehicle control over the involved vehicles that cause identical pedestrian injury.In contrast to normative analyses,we show that the occupants of driverless cars(private cars and robotaxis)are attributed more responsibility than conventional taxi passengers.This dilemma is robust across different contexts(e.g.,participants from China vs the Republic of Korea,participants with first-vs third-person perspectives,and occupant presence vs absence).Furthermore,we observe that this is not due to the perception that these occupants have greater control over driving but because they are more expected to foresee the potential consequences of using driverless cars.Our findings suggest that when driverless vehicles(private cars and taxis)cause harm,their users may face more social pressure,which public discourse and legal regulations should manage appropriately. 展开更多
关键词 fully automated vehicle accidents Responsibility attribution CONTROLLABILITY Foreseeability
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Enhancing efficiency and stability of organic solar cells through a simplified four-step synthesis of fully non-fused ring electron acceptor
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作者 Chenyang Han Huanhuan Gao +7 位作者 Yanna Sun Yuanyuan Kan Zhaozhao Bi Wei Ma Yani Zhang Juan Antonio Zapien Yingguo Yang Ke Gao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期601-608,I0015,共9页
Design and synthesis of superior cost-effective non-fullerene acceptors(NFAs)are still big challenges for facilitating the commercialization of organic solar cells(OSCs),yet to be realized.Herein,two medium bandgap fu... Design and synthesis of superior cost-effective non-fullerene acceptors(NFAs)are still big challenges for facilitating the commercialization of organic solar cells(OSCs),yet to be realized.Herein,two medium bandgap fully non-fused ring electron acceptors(NFREAs,medium bandgap,i,e.,1,3-1,8 eV),namely PTR-2Cl and PTR-4Cl are synthesized with only four steps by using intramolecular noncovalent interaction central core,structured alkyl side chain orientation linking units and flanking with different electron-withdrawing end group.Among them,PTR-4C1 exhibits increased average electrostatic potential(ESP)difference with polymer donor,enhanced crystallinity and compactπ-πstacking compared with the control molecule PTR-2CI.As a result,the PTR-4Cl-based OSC achieved an impressive power conversion efficiency(PCE)of 14.72%,with a much higher open-circuit voltage(V_(OC))of 0.953 V and significantly improved fill factor(FF)of 0.758,demonstrating one of the best acceptor material in the top-performing fully NFREA-based OSCs with both high PCE and V_(OC).Notably,PTR-4Cl-based cells maintain a good T_80lifetime of its initial PCE after over 936 h under a continuous thermal annealing treatment and over1300 h T_(80)lifetime without encapsulation.This work provides a cost-effective design strategy for NFREAs on obtaining high V_(OC),efficient exciton dissociation,and ordered molecular packing and thus high-efficiency and stable OSCs. 展开更多
关键词 Organic solar cells fully non-fused ring acceptors End group engineering Morphology regulation High efficiency
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Design of Fully Automatic Specification Selection System for Resistance Welding Equipment
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作者 Xiangkun Lu Zengtai Tian +1 位作者 Hao Xu Yue Guo 《Journal of Harbin Institute of Technology(New Series)》 CAS 2024年第1期64-68,共5页
A system for fully automatic selection of welding specifications in resistance welding equipment has been developed to address the problem of workers frequently choosing the wrong specifications during manual welding ... A system for fully automatic selection of welding specifications in resistance welding equipment has been developed to address the problem of workers frequently choosing the wrong specifications during manual welding of multiple parts on a single machine in automobile factories. The system incorporates an automatic recognition system for different workpiece materials using the added machine fixture,visual detection system for nuts and bolts,and secondary graphical confirmation to ensure the correctness of specification calling. This system achieves reliable,fully automatic selection of welding specifications in resistance welding equipment and has shown significant effects in improving welding quality for massproduced workpieces,while solving the problem of specification calling errors that can occur with traditional methods involving process charts and code adjustments. This system is particularly suitable for promoting applications in manual welding of multiple parts on a single machine in automobile factories,ensuring correct specification calling and welding quality. 展开更多
关键词 seat spot welding welding specifications fully automatic
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Optimal Cooperative Secondary Control for Islanded DC Microgrids via a Fully Actuated Approach
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作者 Yi Yu Guo-Ping Liu +1 位作者 Yi Huang Peng Shi 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第2期405-417,共13页
DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately por... DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately portray the electrical characteristics of actual MGs while is controller design-friendly has kept the issue active. To this end, this paper establishes a large-signal model containing the comprehensive dynamical behavior of the DC MGs based on the theory of high-order fully actuated systems, and proposes distributed optimal control based on this. The proposed secondary control method can achieve the two goals of voltage recovery and current sharing for multi-bus DC MGs. Additionally, the simple structure of the proposed approach is similar to one based on droop control, which allows this control technique to be easily implemented in a variety of modern microgrids with different configurations. In contrast to existing studies, the process of controller design in this paper is closely tied to the actual dynamics of the MGs. It is a prominent feature that enables engineers to customize the performance metrics of the system. In addition, the analysis of the stability of the closed-loop DC microgrid system, as well as the optimality and consensus of current sharing are given. Finally, a scaled-down solar and battery-based microgrid prototype with maximum power point tracking controller is developed in the laboratory to experimentally test the efficacy of the proposed control method. 展开更多
关键词 DC microgrids distributed control high-order fully actuated system approach linear quadratic regulator microgrid modeling secondary control
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GRU-integrated constrained soft actor-critic learning enabled fully distributed scheduling strategy for residential virtual power plant
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作者 Xiaoyun Deng Yongdong Chen +2 位作者 Dongchuan Fan Youbo Liu Chao Ma 《Global Energy Interconnection》 EI CSCD 2024年第2期117-129,共13页
In this study,a novel residential virtual power plant(RVPP)scheduling method that leverages a gate recurrent unit(GRU)-integrated deep reinforcement learning(DRL)algorithm is proposed.In the proposed scheme,the GRU-in... In this study,a novel residential virtual power plant(RVPP)scheduling method that leverages a gate recurrent unit(GRU)-integrated deep reinforcement learning(DRL)algorithm is proposed.In the proposed scheme,the GRU-integrated DRL algorithm guides the RVPP to participate effectively in both the day-ahead and real-time markets,lowering the electricity purchase costs and consumption risks for end-users.The Lagrangian relaxation technique is introduced to transform the constrained Markov decision process(CMDP)into an unconstrained optimization problem,which guarantees that the constraints are strictly satisfied without determining the penalty coefficients.Furthermore,to enhance the scalability of the constrained soft actor-critic(CSAC)-based RVPP scheduling approach,a fully distributed scheduling architecture was designed to enable plug-and-play in the residential distributed energy resources(RDER).Case studies performed on the constructed RVPP scenario validated the performance of the proposed methodology in enhancing the responsiveness of the RDER to power tariffs,balancing the supply and demand of the power grid,and ensuring customer comfort. 展开更多
关键词 Residential virtual power plant Residential distributed energy resource Constrained soft actor-critic fully distributed scheduling strategy
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Fuzzy Inventory Model under Selling Price Dependent Demand and Variable Deterioration with Fully Backlogged Shortages
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作者 Tanzim S. Shaikh Santosh P. Gite 《American Journal of Operations Research》 2024年第2期87-103,共17页
The objective is to develop a model considering demand dependent on selling price and deterioration occurs after a certain period of time, which follows two-parameter Weibull distribution. Shortages are allowed and fu... The objective is to develop a model considering demand dependent on selling price and deterioration occurs after a certain period of time, which follows two-parameter Weibull distribution. Shortages are allowed and fully backlogged. Fuzzy optimal solution is obtained by considering hexagonal fuzzy numbers and for defuzzification Graded Mean Integration Representation Method. A numerical example is provided for the illustration of crisp and fuzzy, both models. To observe the effect of changes in parameters, sensitivity analysis is carried out. 展开更多
关键词 DETERIORATION Selling Price Dependent Demand fully Backlogged Hexagonal Fuzzy Numbers Graded Mean Integration Representation Method
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Orlicz空间的Fully k凸 被引量:1
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作者 王廷辅 张云峰 王保祥 《哈尔滨师范大学自然科学学报》 CAS 1989年第3期19-21,共3页
赋Orlicz范数的Orlicz空间当且仅当自反严格凸时具有Fully k凸(k≥z)
关键词 fully k凸 ORLICZ空间
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Realization of Fully Differential Fourth-Order Bessel Filter with Accurate Group Delay 被引量:1
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作者 江金光 何怡刚 吴杰 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2003年第9期927-932,共6页
A fully differential R-MOSFET-C fourth-order Bessel active lowpass filter employing fully differential operational amplifier,passive resistors,and current-steering MOS transistors as a variable resistor is proposed.T... A fully differential R-MOSFET-C fourth-order Bessel active lowpass filter employing fully differential operational amplifier,passive resistors,and current-steering MOS transistors as a variable resistor is proposed.This proposed implementation relies on the tunability of current-steering MOS transistors operating in the triode region counteracting the concert deviation of resistor in the integrated circuit manufacturing technology in orde r that the group delay of Bessel active filter could be designed accurately.The amplifier is not only with voltage common-mode negative feedback,but also with current common-mode negative feedback,which will benefit for the stability of its D C operating point.0.75μs group delay fourth-order Bessel lowpass filter,whic h is synthesized according to passive doubly terminated RLC prototype lowpass filter,demonstrates better than -65dB THD using 100kHz,2.5V pp signal in Taiwan UMC 2P2M(2-poly,2-metal)5.0V,0.5μm CMOS technology. 展开更多
关键词 fully differential voltage and curr ent common-mode negative feedback frequency tunable R-MOSFET-C filter Bessel filter
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程度副词TOTALLY和FULLY的语义韵对比分析——一项基于BNC和CLEC语料库的研究 被引量:4
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作者 韩亚华 《南阳理工学院学报》 2014年第4期68-70,共3页
本研究以CLEC和BNC语料库为基础,通过检索软件AntConc对程度副词totally和fully进行语义韵对比分析,揭示了中国英语学习者和英语本族语使用者在使用这两个词时产生的不同语义韵特征,分析了产生差异的原因并对英语教学尤其是词汇教学提... 本研究以CLEC和BNC语料库为基础,通过检索软件AntConc对程度副词totally和fully进行语义韵对比分析,揭示了中国英语学习者和英语本族语使用者在使用这两个词时产生的不同语义韵特征,分析了产生差异的原因并对英语教学尤其是词汇教学提出了积极的建议。本研究的结果将有助于促进学习者对词语搭配和语义韵的习得,加深学习者对语言现象的理解并将在一定程度上拓展词汇教学的内容和词汇教学的方法。 展开更多
关键词 totally fully 语料库 语义韵 对比分析
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Threshold Voltage Model for a Fully Depleted SOI-MOSFET with a Non-Uniform Profile
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作者 张国和 邵志标 周凯 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2007年第6期842-847,共6页
A novel approximation of the two-dimensional (2D) potential function perpendicular to the channel is proposed,and then an analytical threshold voltage model for a fully depleted SOI-MOSFET with a non-uniform Gaussia... A novel approximation of the two-dimensional (2D) potential function perpendicular to the channel is proposed,and then an analytical threshold voltage model for a fully depleted SOI-MOSFET with a non-uniform Gaussian distribution doping profile is given based on this approximation. The model agrees well with numerical simulation by MEDICI. The result represents a new way and some reference points in analyzing and controlling the threshold voltage of non-uniform fully depleted (FD) SOI devices in practice. 展开更多
关键词 fully depleted SOI-MOSFET NON-UNIFORM surface potential threshold voltage
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An Analytical Threshold Voltage Model for Fully Depleted SOI MOSFETs
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作者 李瑞贞 韩郑生 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2005年第12期2303-2308,共6页
A new two-dimensional (2D) analytical model for the threshold-voltage of fully depleted SOI MOSFETs is derived. The 2D potential distribution functions in the active layer of the devices are obtained through solving... A new two-dimensional (2D) analytical model for the threshold-voltage of fully depleted SOI MOSFETs is derived. The 2D potential distribution functions in the active layer of the devices are obtained through solving the 2D Poisson's equation. The minimum of the potential at the oxide-Si layer interface is used to monitor the threshold voltage of the SOI MOSFETs. This model is verified by its excellent agreement with MEDICI simulation using SOI MOSFETs with different gate lengths,gate oxide thicknesses,silicon film thicknesses,and channel doping concentrations. 展开更多
关键词 fully depleted SOI MOSFETs surface potential threshold voltage
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full well还是fully well?
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作者 顾祖良 《英语知识》 2006年第4期48-48,共1页
关键词 “full well” fully well” 用法 英语 例句 习惯用法 副词
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Review of fully coherent free-electron lasers 被引量:19
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作者 Chao Feng Hai-Xiao Deng 《Nuclear Science and Techniques》 SCIE CAS CSCD 2018年第11期214-228,共15页
Generation of intense, fully coherent radiation with wide spectral coverage has been a long-standing challenge for laser technologies. Several techniques have been developed in recent years to extend the spectral cove... Generation of intense, fully coherent radiation with wide spectral coverage has been a long-standing challenge for laser technologies. Several techniques have been developed in recent years to extend the spectral coverage in optical physics, but none of them hold the potential to produce X-ray laser pulses with very high-peak power. Urgent demands for intense X-ray light sources have prompted the development of free-electron lasers(FELs), which have been proved to be very useful tools in many scientific areas. In this paper, we give an overview of the basic principle of FELs, techniques for realizing fully coherent FELs, and the development of fully coherent FEL facilities in China. 展开更多
关键词 Free-electron LASER fully COHERENT Seeded FEL FEL OSCILLATOR
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Laboratory pull-out tests on fully grouted rock bolts and cable bolts:Results and lessons learned 被引量:19
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作者 Isabelle Thenevin Laura Blanco-Martín +3 位作者 Faouzi Hadj-Hassen Jacques Schleifer Zbigniew Lubosik Aleksander Wrana 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2017年第5期843-855,共13页
Laboratory pull-out tests were conducted on the following rock bolts and cable bolts:steel rebars,smooth steel bars,fiberglass reinforced polymer threaded bolts,flexible cable bolts,IR5/IN special cable bolts and Mini... Laboratory pull-out tests were conducted on the following rock bolts and cable bolts:steel rebars,smooth steel bars,fiberglass reinforced polymer threaded bolts,flexible cable bolts,IR5/IN special cable bolts and Mini-cage cable bolts.The diameter of the tested bolts was between 16 mm and 26 mm.The bolts were grouted in a sandstone sample using resin or cement grouts.The tests were conducted under either constant radial stiffness or constant confining pressure boundary conditions applied on the outer surface of the rock sample.In most tests,the rate of displacement was about 0.02 mm/s.The tests were performed using a pull-out bench that allows testing a wide range of parameters.This paper provides an extensive database of laboratory pull-out test results and confirms the influence of the confining pressure and the embedment length on the pull-out response(rock bolts and cable bolts).It also highlights the sensitivity of the results to the operating conditions and to the behavior of the sample as a whole,which cannot be neglected when the test results are used to assess the bolt-grout or the grouterock interface. 展开更多
关键词 Pull-out test fully grouted bolts Laboratory-scale Confining pressure Embedment length Bolt-grout interface
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Development and prospect on fully mechanized mining in Chinese coal mines 被引量:104
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作者 Jinhua Wang 《International Journal of Coal Science & Technology》 EI CAS 2014年第3期253-260,共8页
Fully mechanized mining(FMM)technology has been applied in Chinese coal mines for more than 40 years.At present,the output of a FMM face has reached 10-million tons with Chinese-made equipment.In this study,the new de... Fully mechanized mining(FMM)technology has been applied in Chinese coal mines for more than 40 years.At present,the output of a FMM face has reached 10-million tons with Chinese-made equipment.In this study,the new developments in FMM technology and equipment in Chinese coal mines during past decades are introduced.The automatic FMM technology for thin seams,complete sets of FMM technology with ultra large shear height of 7 m for thick seams,complete sets of fully mechanized top coal caving technology with large shear height for ultra-thick seams of 20 m,complete sets of FMM technology for complex and difficult seams,including steeply inclined seams,soft coal seams with large inclination angle,and the mechanized filling mining technology and equipment are presented.Some typical case studies are also introduced.Finally,the existing problems with the FMM technology are discussed,and prospect of FMM technology and equipment applied in Chinese coal mines is put forward. 展开更多
关键词 fully mechanized mining Mining with large shear height fully mechanized top coal caving Steeply inclined seam Back filling mining PROSPECT
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Mining pressure monitoring and analysis in fully mechanized backfilling coal mining face-A case study in Zhai Zhen Coal Mine 被引量:14
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作者 张强 张吉雄 +2 位作者 康涛 孙强 李伟康 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第5期1965-1972,共8页
Fully mechanized solid backfill mining(FMSBM) technology adopts dense backfill body to support the roof. Based on the distinguishing characteristics and mine pressure control principle in this technology, the basic pr... Fully mechanized solid backfill mining(FMSBM) technology adopts dense backfill body to support the roof. Based on the distinguishing characteristics and mine pressure control principle in this technology, the basic principles and methods for mining pressure monitoring were analyzed and established. And the characteristics of overburden strata movement were analyzed by monitoring the support resistance of hydraulic support, the dynamic subsidence of immediate roof, the stress of backfill body, the front abutment pressure, and the mass ratio of cut coal to backfilled materials. On-site strata behavior measurements of 7403 W solid backfilling working face in Zhai Zhen Coal Mine show that the backfill body can effectively support the overburden load, obviously control the overburden strata movement, and weaken the strata behaviors distinctly. Specific performances are as follows. The support resistance decreases obviously; the dynamic subsidence of immediate roof keeps consistent to the variation of backfill body stress, and tends to be stable after the face retreating to 120-150 m away from the cut. The peak value of front abutment pressure arises at 5-12 m before the operating face, and mass ratio is greater than the designed value of 1.15, which effectively ensures the control of strata movement. The research results are bases for intensively studying basic theories of solid backfill mining strata behaviors and its control, and provide theoretical guidance for engineering design in FMSBM. 展开更多
关键词 fully mechanized solid backfill mining(FMSBM) strata movement strata behavior mining pressure monitoring
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Evaluation of fully covered self-expanding metal stents in benign biliary strictures and bile leaks 被引量:9
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作者 David Lalezari Inder Singh +1 位作者 Sofiya Reicher Viktor Ernst Eysselein 《World Journal of Gastrointestinal Endoscopy》 CAS 2013年第7期332-339,共8页
AIM: To investigate the use of fully covered metal stents in benign biliary strictures (BBS) and bile leaks. METHODS: We studied 17 patients, at Harbor-UCLA Medical center (Los Angeles), with BBS (n=12) and bile leaks... AIM: To investigate the use of fully covered metal stents in benign biliary strictures (BBS) and bile leaks. METHODS: We studied 17 patients, at Harbor-UCLA Medical center (Los Angeles), with BBS (n=12) and bile leaks (n=5) from July 2007 to February 2012 that had received placement of fully covered self-expanding metal stents (FCSEMs). Fourteen patients had endoscopic placement of VIABIL (Conmed, Utica, New York, United States) stents and three had Wallflex (Boston Scientific, Mass) stents. FCSEMS were 8 mm or 10 mm in diameter and 4 cm to 10 cm in length. Patients were followed at regular intervals to evaluate for symptoms and liver function tests. FCSEMS were removed after 4 or more weeks. Resolution of BBS and leak was documented cholangiographically following stent removal. Stent patency can be defined as adequate bile and contrast flow from the stent and into the ampulla during endoscopic retrograde cholangiopancreatography (ERCP) without clinical signs and/or symptoms of biliary obstruction. Criterion for bile leak resolution at ERCP is defined as absence of contrast extravasation from the common bile duct, cystic duct remanent, or gall blad-der fossa. Rate of complications such as migration, and instent occlusion were recorded. Failure of endoscopic therapy was defined as persistent biliary stenosis or continuous biliary leakage after 12 mo of stent placement. RESULTS: All 17 patients underwent successful FC- SEMS placement and removal. Etiologies of BBS included: cholecystectomies (n=8), cholelithiasis (n=2), hepatic artery compression (n=1), pancreatitis (n=2), and Whipple procedure (n=1). All bile leaks occurred following cholecystectomy. The anatomic location of BBS varied: distal common bile duct (n=7), common hepatic duct (n=1), hepaticojejunal anastomosis (n=2), right intrahepatic duct (n=1), and choledochoduo-denal anastomatic junction (n=1). All bile leaks were found to be at the cystic duct. Twelve of 17 patients had failed prior stent placement or exchange. Resolution of the biliary strictures and bile leaks was achieved in 16 of 17 patients (94%). The overall median stent time was 63 d (range 27-251 d). The median stent time for the BBS group and bile leak group was 62 ± 58 d (range 27-199 d) and 92 ± 81 d (range 48-251 d), respectively. All 17 patients underwent successful FCSEMS removal. Long term follow-up was obtained for a median of 575 d (range 28-1435 d). Complications occurred in 5 of 17 patients (29%) and included: migration (n=2), stent clogging (n=1), cholangitis (n=1), and sepsis with hepatic abscess (n=1). CONCLUSION: Placement of fully covered self-expanding metal stents may be used in the management of benign biliary strictures and bile leaks with a low rate of complications. 展开更多
关键词 BILE LEAKS Benign BILIARY STRICTURE fully COVERED metal STENTS BILIARY disease
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Drug-eluting fully covered self-expanding metal stent for dissolution of bile duct stones in vitro 被引量:8
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作者 Chao Huang Xiao-Bo Cai +3 位作者 Li-Li Guo Xiao-Sheng Qi Qiang Gao Xin-Jian Wan 《World Journal of Gastroenterology》 SCIE CAS 2019年第26期3370-3379,共10页
BACKGROUND The treatment of difficult common bile duct stones(CBDS)remains a big challenge around the world.Biliary stenting is a widely accepted rescue method in patients with failed stone extraction under endoscopic... BACKGROUND The treatment of difficult common bile duct stones(CBDS)remains a big challenge around the world.Biliary stenting is a widely accepted rescue method in patients with failed stone extraction under endoscopic retrograde cholangiopancreatography.Fully covered self-expanding metal stent(FCSEMS)has gained increasing attention in the management of difficult CBDS.AIM To manufacture a drug-eluting FCSEMS,which can achieve controlled release of stone-dissolving agents and speed up the dissolution of CBDS.METHODS Customized covered nitinol stents were adopted.Sodium cholate(SC)and disodium ethylene diamine tetraacetic acid(EDTA disodium,EDTA for short)were used as stone-dissolving agents.Three different types of drug-eluting stents were manufactured by dip coating(Stent I),coaxial electrospinning(Stent II),and dip coating combined with electrospinning(Stent III),respectively.The drugrelease behavior and stone-dissolving efficacy of these stents were evaluated in vitro to sort out the best manufacturing method.And the selected stonedissolving stents were further put into porcine CBD to evaluate their biosecurity.RESULTS Stent I and Stent II had obvious burst release of drugs in the first 5 d while Stent III presented controlled and sustainable drug release for 30 d.In still buffer,the final stone mass-loss rate of each group was 5.19%±0.69%for naked FCSEMS,20.37%±2.13%for Stent I,24.57%±1.45%for Stent II,and 33.72%±0.67%for Stent III.In flowing bile,the final stone mass-loss rate of each group was 5.87%±0.25%for naked FCSEMS,6.36%±0.48%for Stent I,6.38%±0.37%for Stent II,and 8.15%±0.27%for Stent III.Stent III caused the most stone mass-loss no matter in still buffer or in flowing bile,which was significantly higher than those of other groups(P<0.05).In vivo,Stent III made no difference from naked FCSEMS in serological analysis(P>0.05)and histopathological examination(P>0.05).CONCLUSION The novel SC and EDTA-eluting FCSEMS is efficient in diminishing CBDS in vitro.When conventional endoscopic techniques fail to remove difficult CBDS,SC and EDTA-eluting FCSEMS implantation may be considered a promising alternative. 展开更多
关键词 Common BILE duct stone DRUG-ELUTING STENT fully COVERED self-expanding metal STENT Electrospinning NANOFIBER film
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Segmentation of retinal fluid based on deep learning:application of three-dimensional fully convolutional neural networks in optical coherence tomography images 被引量:3
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作者 Meng-Xiao Li Su-Qin Yu +4 位作者 Wei Zhang Hao Zhou Xun Xu Tian-Wei Qian Yong-Jing Wan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第6期1012-1020,共9页
AIM: To explore a segmentation algorithm based on deep learning to achieve accurate diagnosis and treatment of patients with retinal fluid.METHODS: A two-dimensional(2D) fully convolutional network for retinal segment... AIM: To explore a segmentation algorithm based on deep learning to achieve accurate diagnosis and treatment of patients with retinal fluid.METHODS: A two-dimensional(2D) fully convolutional network for retinal segmentation was employed. In order to solve the category imbalance in retinal optical coherence tomography(OCT) images, the network parameters and loss function based on the 2D fully convolutional network were modified. For this network, the correlations of corresponding positions among adjacent images in space are ignored. Thus, we proposed a three-dimensional(3D) fully convolutional network for segmentation in the retinal OCT images.RESULTS: The algorithm was evaluated according to segmentation accuracy, Kappa coefficient, and F1 score. For the 3D fully convolutional network proposed in this paper, the overall segmentation accuracy rate is 99.56%, Kappa coefficient is 98.47%, and F1 score of retinal fluid is 95.50%. CONCLUSION: The OCT image segmentation algorithm based on deep learning is primarily founded on the 2D convolutional network. The 3D network architecture proposed in this paper reduces the influence of category imbalance, realizes end-to-end segmentation of volume images, and achieves optimal segmentation results. The segmentation maps are practically the same as the manual annotations of doctors, and can provide doctors with more accurate diagnostic data. 展开更多
关键词 optical COHERENCE tomography IMAGES FLUID segmentation 2D fully convolutional NETWORK 3D fully convolutional NETWORK
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