Coronary artery disease(CAD) is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism(SNP) profiling provi...Coronary artery disease(CAD) is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism(SNP) profiling provides an effective technique to unravel these underlying genetic interplays or their functional involvements for CAD. This study aimed to identify the susceptible pathways and modules for CAD based on SNP omics. First, the Wellcome Trust Case Control Consortium(WTCCC) SNP datasets of CAD and control samples were used to assess the jointeffect of multiple genetic variants at the pathway level, using logistic kernel machine regression model. Then, an expanded genetic network was constructed by integrating statistical gene–gene interactions involved in these susceptible pathways with their protein–protein interaction(PPI)knowledge. Finally, risk functional modules were identified by decomposition of the network. Of 276 KEGG pathways analyzed, 6 pathways were found to have a significant effect on CAD. Other than glycerolipid metabolism, glycosaminoglycan biosynthesis, and cardiac muscle contraction pathways, three pathways related to other diseases were also revealed, including Alzheimer's disease, non-alcoholic fatty liver disease, and Huntington's disease. A genetic epistatic network of 95 genes was further constructed using the abovementioned integrative approach. Of 10 functional modules derived from the network, 6 have been annotated to phospholipase C activity and cell adhesion molecule binding, which also have known functional involvement in Alzheimer's disease.These findings indicate an overlap of the underlying molecular mechanisms between CAD and Alzheimer's disease, thus providing new insights into the molecular basis for CAD and its molecular relationships with other diseases.展开更多
DM642 is a DSP chip specially used for video processing that offered by TI company,it adds a lot of peripheral devices and inter faces based on C6000 series of chips,with the high speed computing ability,it has a wide...DM642 is a DSP chip specially used for video processing that offered by TI company,it adds a lot of peripheral devices and inter faces based on C6000 series of chips,with the high speed computing ability,it has a wide range of applications in multimedia field.This pa per analyzes and describes the works and the main functional modules of two-way video synthesis hardware system based on DM642.展开更多
Multispectral microscopy enables information enhancement in the study of specimens because of the large spectral band used in this technique. A low cost multimode multispectral microscope using a camera and a set of q...Multispectral microscopy enables information enhancement in the study of specimens because of the large spectral band used in this technique. A low cost multimode multispectral microscope using a camera and a set of quasi-monochromatic Light Emitting Diodes (LEDs) ranging from ultraviolet to near-infrared wavelengths as illumination sources was constructed. But the use of a large spectral band provided by non-monochromatic sources induces variation of focal plan of the imager due to chromatic aberration which rises up the diffraction effects and blurs the images causing shadow around them. It results in discrepancies between standard spectra and extracted spectra with microscope. So we need to calibrate that instrument to be a standard one. We proceed with two types of images comparison to choose the reference wavelength for image acquisition where diffraction effect is more reduced. At each wavelength chosen as a reference, one image is well contrasted. First, we compare the thirteen well contrasted images to identify that presenting more reduced shadow. In second time, we determine the mean of the shadow size over the images from each set. The correction of the discrepancies required measurements on filters using a standard spectrometer and the microscope in transmission mode and reflection mode. To evaluate the capacity of our device to transmit information in frequency domain, its modulation transfer function is evaluated. Multivariate analysis is used to test its capacity to recognize properties of well-known sample. The wavelength 700 nm was chosen to be the reference for the image acquisition, because at this wavelength the images are well contrasted. The measurement made on the filters suggested correction coefficients in transmission mode and reflection mode. The experimental instrument recognized the microsphere’s properties and led to the extraction of the standard transmittance and reflectance spectra. Therefore, this microscope is used as a conventional instrument.展开更多
The association between miRNA and disease has attracted more and more attention.Until now,existing methods for identifying miRNA related disease mainly rely on top-ranked association model,which may not provide a full...The association between miRNA and disease has attracted more and more attention.Until now,existing methods for identifying miRNA related disease mainly rely on top-ranked association model,which may not provide a full landscape of association between miRNA and disease.Hence there is strong need of new computational method to identify the associations from miRNA group view.In this paper,we proposed a framework,MDA-TOEPGA,to identify miRNAdisease association based on two-objective evolutionary programming genetic algorithm,which identifies latent miRNAdisease associations from the view of functional module.To understand the miRNA functional module in diseases,the case study is presented.We have been compared MDA-TOEPGA with several state-of-the-art functional module algorithm.Experimental results showed that our method cannot only outperform classical algorithms,such as K-means,IK-means,MCODE,HC-PIN,and ClusterONE,but can also achieve an ideal overall performance in terms of a composite score consisting of f1,Sensitivity,and Accuracy.Altogether,our study showed that MDA-TOEPGA is a promising method to investigate miRNA-disease association from the landscapes of functional module.展开更多
Reverse logistics are playing more and more important role with the development of competition and the social responsibility of enterprises.It could be divided into commission acceptance,recycling and returned goods h...Reverse logistics are playing more and more important role with the development of competition and the social responsibility of enterprises.It could be divided into commission acceptance,recycling and returned goods handling.Reverse logistics information system consists of the database establishment,network structure and logic structure design.The collection,storage,processing,transmission and output functions of the reverse logistics information system were discussed in the thesis.Eventually,it established seven modules for the reverse logistics information system including the system management module,oriented module,returning goods processing module,reverse transportation management module,information sharing module,statistical analysis module and cost control module.展开更多
Considering research on multi-objective optimization for reliability and performance suffering cost constraints in digital circuits,an improved multi-objective optimization algorithm based on performance and reliabili...Considering research on multi-objective optimization for reliability and performance suffering cost constraints in digital circuits,an improved multi-objective optimization algorithm based on performance and reliability was proposed to solve the problem of discrete system resources configuration in this paper. This algorithm used the particle-swarm optimization( PSO) to evaluate the tradeoffs configuration of the system resources between reliability and performance and proved the feasibility through the simulation.Finally, the information of resources configuration from optimization algorithm was used to effectively guide the system design so as to mitigate soft errors caused by single event effect( SEE).展开更多
The key difficulty of restoring a fuzzy image is to estimate its point spread function( PSF). In the paper,PSF is modelled based on modulation transfer function( MTF). The first step is calculating the image MTF. In t...The key difficulty of restoring a fuzzy image is to estimate its point spread function( PSF). In the paper,PSF is modelled based on modulation transfer function( MTF). The first step is calculating the image MTF. In the traditional slanted-edge method,a sub-block is always manually extracted from original image and its MTF will be viewed as the result of the whole image. However,handcraft extraction is inefficient and will lead to inaccurate results. Given this,an automatic MTF computation algorithm is proposed,which extracts and screens out all the effective sub-blocks and calculates their average MTF as the final result. Then,a two-dimensional MTF restoration model is constructed by multiplying the horizontal and vertical MTF,and it is combined with conventional image restoration methods to restore fuzzy image. Experimental results indicate the proposed method implementes a fast and accurate MTF computation and the MTF model improves the performance of conventional restoration methods significantly.展开更多
Purpose: Children are sometimes examined with Computed Tomography protocols designed for adults, leading to radiation doses higher than necessary. Lack of optimisation could lead to image quality higher than what is n...Purpose: Children are sometimes examined with Computed Tomography protocols designed for adults, leading to radiation doses higher than necessary. Lack of optimisation could lead to image quality higher than what is needed for diagnostic purposes with associated high doses to patients. Optimising the protocols for paediatric head trauma CT imaging will reduce radiation dose. Objective: The study aimed to optimise radiation dose and assess the image quality for a set of protocols by evaluating noise, a contrast to noise ratio, modulation transfer function and noise power spectrum. Methods: Somaton Sensation 64 was used to scan the head of an anthropomorphic phantom with a set of protocols. ImageJ software was used to analyse the paediatric head image from the scanner. IMPACTSCAN dosimeter software was used to evaluate the radiation dose to the various organs in the head. MATLAB was used to analyse the Modulation Transfer Function and the Noise Power. Results: The estimated Computed Tomography Dose Index volume (CTDI<sub>vol</sub>) increased with increasing tube current and tube voltage. The high pitch of 0.9 gave a lower dose than the 0.5 pitch. The eye lens received the highest radiation dose (39.2 mGy) whiles the thyroid received the least radiation dose (13.7 mGy). There was an increase in noise (62.46) when the H60 kernel was used and a lower noise (8.829) was noticed when the H30 kernel was used. Conclusion: The results obtained show that the H30 kernel (smooth kernel) gave higher values for noise and contrast to noise ratio (CNR) than the H60 kernel (sharp kernel). The H60 kernel produced high values for the modulation transfer function (MTF) and noise power spectrum (NPS). The eye lens received the highest radiation dose.展开更多
Background: The aim of this review is to summarize the optical quality results in patients following theimplantation of the V4c implantable collamer lens with a central port (ICL, STAAR Surgical Inc.).Main text: A lit...Background: The aim of this review is to summarize the optical quality results in patients following theimplantation of the V4c implantable collamer lens with a central port (ICL, STAAR Surgical Inc.).Main text: A literature search in several databases was carried out to identify those publications, both prospective,retrospective and/or comparative with other refractive surgery procedures, reporting optical outcomes of patientswho were implanted with the V4c ICL model. A total of 17 clinical studies published between 2012 and 2021 wereincluded in this review. A detailed analysis of the available data was performed including number of eyes, follow-upand preoperative spherical equivalent. Specifically, the review focused on several optical parameters includinghigher-order aberrations (HOAs), modulation transfer function (MTF) cut-off frequency and Strehl ratio. This reviewencompassed a total of 817 eyes measured using different optical devices based on Hartmann-Shack, retinal imagequality measurement and ray-tracing technologies at different follow-ups.Conclusions: The outcomes found in this review lead us to conclude that the ICL V4c model provides good opticalquality, by means of different metrics, when implanted.展开更多
Background:The aim of this review is to summarize the optical quality results in patients following the implantation of the V4c implantable collamer lens with a central port(ICL,STAAR Surgical Inc.).Main text:A litera...Background:The aim of this review is to summarize the optical quality results in patients following the implantation of the V4c implantable collamer lens with a central port(ICL,STAAR Surgical Inc.).Main text:A literature search in several databases was carried out to identify those publications,both prospective,retrospective and/or comparative with other refractive surgery procedures,reporting optical outcomes of patients who were implanted with the V4c ICL model.A total of 17 clinical studies published between 2012 and 2021 were included in this review.A detailed analysis of the available data was performed including number of eyes,follow-up and preoperative spherical equivalent.Specifically,the review focused on several optical parameters including higher-order aberrations(HOAs),modulation transfer function(MTF)cut-off frequency and Strehl ratio.This review encompassed a total of 817 eyes measured using different optical devices based on Hartmann-Shack,retinal image quality measurement and ray-tracing technologies at different follow-ups.Conclusions:The outcomes found in this review lead us to conclude that the ICL V4c model provides good optical quality,by means of different metrics,when implanted.展开更多
A piezoelectric platform using function module actuator is presented to achieve nano-positioning and high frequency scanning in large working range. A function module actuator is designed to produce a pair of orthogon...A piezoelectric platform using function module actuator is presented to achieve nano-positioning and high frequency scanning in large working range. A function module actuator is designed to produce a pair of orthogonal bending deformations and a longitudinal deformation through partition exciting. The bending deformations are used to actuate the planar motion,while the longitudinal deformation is utilized to dynamically adjust the driving force and broaden the scanning frequency. The dynamic model of the platform system is developed. The open-loop performances of a prototype are first tested: a scan frequency of 308 Hz in a scanning range of 3.368 μm×3.396 μm is measured in direct actuation mode,and the displacement resolution is measured to be 16 nm;maximum speed is measured to be 3.38 mm s^-1 in the inertial actuation mode. Furthermore,the closedloop experiments are carried out and a switching strategy is proposed to obtain the switching of the inertial and direct actuation modes automatically;the platform achieves the scanning with frequency of 300 Hz at the set position.展开更多
In optical scanning holography, one pupil produces a spherical wave and another produces a plane wave. They interfere with each other and result in a fringe pattern for scanning a three-dimensional object. The resolut...In optical scanning holography, one pupil produces a spherical wave and another produces a plane wave. They interfere with each other and result in a fringe pattern for scanning a three-dimensional object. The resolution of the hologram reconstruction is affected by the point spread function(PSF) of the optical system. In this paper, we modulate the PSF by a spiral phase plate, which significantly enhances the lateral and depth resolution. We explain the theory for such resolution enhancement and show simulation results to verify the efficacy of the approach.展开更多
基金supported in part by the National Natural Science Foundation of China(Grant Nos.31071166 and 81373085)Natural Science Foundation of Guangdong Province,China(Grant No.8251008901000007)+2 种基金Science and Technology Planning Project of Guangdong Province(Grant No.2009A030301004)Dongguan Science and Technology Project,Guangdong,China(Grant No.2011108101015)the funds from Guangdong Medical College,China(Grant Nos.XG1001,JB1214,XZ1105,STIF201122,M2011024,and M2011010)
文摘Coronary artery disease(CAD) is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism(SNP) profiling provides an effective technique to unravel these underlying genetic interplays or their functional involvements for CAD. This study aimed to identify the susceptible pathways and modules for CAD based on SNP omics. First, the Wellcome Trust Case Control Consortium(WTCCC) SNP datasets of CAD and control samples were used to assess the jointeffect of multiple genetic variants at the pathway level, using logistic kernel machine regression model. Then, an expanded genetic network was constructed by integrating statistical gene–gene interactions involved in these susceptible pathways with their protein–protein interaction(PPI)knowledge. Finally, risk functional modules were identified by decomposition of the network. Of 276 KEGG pathways analyzed, 6 pathways were found to have a significant effect on CAD. Other than glycerolipid metabolism, glycosaminoglycan biosynthesis, and cardiac muscle contraction pathways, three pathways related to other diseases were also revealed, including Alzheimer's disease, non-alcoholic fatty liver disease, and Huntington's disease. A genetic epistatic network of 95 genes was further constructed using the abovementioned integrative approach. Of 10 functional modules derived from the network, 6 have been annotated to phospholipase C activity and cell adhesion molecule binding, which also have known functional involvement in Alzheimer's disease.These findings indicate an overlap of the underlying molecular mechanisms between CAD and Alzheimer's disease, thus providing new insights into the molecular basis for CAD and its molecular relationships with other diseases.
文摘DM642 is a DSP chip specially used for video processing that offered by TI company,it adds a lot of peripheral devices and inter faces based on C6000 series of chips,with the high speed computing ability,it has a wide range of applications in multimedia field.This pa per analyzes and describes the works and the main functional modules of two-way video synthesis hardware system based on DM642.
文摘Multispectral microscopy enables information enhancement in the study of specimens because of the large spectral band used in this technique. A low cost multimode multispectral microscope using a camera and a set of quasi-monochromatic Light Emitting Diodes (LEDs) ranging from ultraviolet to near-infrared wavelengths as illumination sources was constructed. But the use of a large spectral band provided by non-monochromatic sources induces variation of focal plan of the imager due to chromatic aberration which rises up the diffraction effects and blurs the images causing shadow around them. It results in discrepancies between standard spectra and extracted spectra with microscope. So we need to calibrate that instrument to be a standard one. We proceed with two types of images comparison to choose the reference wavelength for image acquisition where diffraction effect is more reduced. At each wavelength chosen as a reference, one image is well contrasted. First, we compare the thirteen well contrasted images to identify that presenting more reduced shadow. In second time, we determine the mean of the shadow size over the images from each set. The correction of the discrepancies required measurements on filters using a standard spectrometer and the microscope in transmission mode and reflection mode. To evaluate the capacity of our device to transmit information in frequency domain, its modulation transfer function is evaluated. Multivariate analysis is used to test its capacity to recognize properties of well-known sample. The wavelength 700 nm was chosen to be the reference for the image acquisition, because at this wavelength the images are well contrasted. The measurement made on the filters suggested correction coefficients in transmission mode and reflection mode. The experimental instrument recognized the microsphere’s properties and led to the extraction of the standard transmittance and reflectance spectra. Therefore, this microscope is used as a conventional instrument.
基金This work was supported in part by the National Natural Science Foundation of China under Grants 61873089,62032007the Key Project of the Education Department of Hunan Province under Grant 20A087the Innovation Platform Open Fund Project of Hunan Provincial Education Department under Grant 20K025.
文摘The association between miRNA and disease has attracted more and more attention.Until now,existing methods for identifying miRNA related disease mainly rely on top-ranked association model,which may not provide a full landscape of association between miRNA and disease.Hence there is strong need of new computational method to identify the associations from miRNA group view.In this paper,we proposed a framework,MDA-TOEPGA,to identify miRNAdisease association based on two-objective evolutionary programming genetic algorithm,which identifies latent miRNAdisease associations from the view of functional module.To understand the miRNA functional module in diseases,the case study is presented.We have been compared MDA-TOEPGA with several state-of-the-art functional module algorithm.Experimental results showed that our method cannot only outperform classical algorithms,such as K-means,IK-means,MCODE,HC-PIN,and ClusterONE,but can also achieve an ideal overall performance in terms of a composite score consisting of f1,Sensitivity,and Accuracy.Altogether,our study showed that MDA-TOEPGA is a promising method to investigate miRNA-disease association from the landscapes of functional module.
基金Course Construction of Customs Practice,China(No.z201308003)
文摘Reverse logistics are playing more and more important role with the development of competition and the social responsibility of enterprises.It could be divided into commission acceptance,recycling and returned goods handling.Reverse logistics information system consists of the database establishment,network structure and logic structure design.The collection,storage,processing,transmission and output functions of the reverse logistics information system were discussed in the thesis.Eventually,it established seven modules for the reverse logistics information system including the system management module,oriented module,returning goods processing module,reverse transportation management module,information sharing module,statistical analysis module and cost control module.
文摘Considering research on multi-objective optimization for reliability and performance suffering cost constraints in digital circuits,an improved multi-objective optimization algorithm based on performance and reliability was proposed to solve the problem of discrete system resources configuration in this paper. This algorithm used the particle-swarm optimization( PSO) to evaluate the tradeoffs configuration of the system resources between reliability and performance and proved the feasibility through the simulation.Finally, the information of resources configuration from optimization algorithm was used to effectively guide the system design so as to mitigate soft errors caused by single event effect( SEE).
基金Supported by the National High Technology Research and Development Programme of China(No.2012AA12A305)the National Key Technology R&D Program of the Ministry of Science and Technology(No.2013BAH03B01)+1 种基金Fundamental Research Funds for the Central Universities of China(No.2042015kf0059)China Postdoctoral Science Foundation(No.2015M582277)
文摘The key difficulty of restoring a fuzzy image is to estimate its point spread function( PSF). In the paper,PSF is modelled based on modulation transfer function( MTF). The first step is calculating the image MTF. In the traditional slanted-edge method,a sub-block is always manually extracted from original image and its MTF will be viewed as the result of the whole image. However,handcraft extraction is inefficient and will lead to inaccurate results. Given this,an automatic MTF computation algorithm is proposed,which extracts and screens out all the effective sub-blocks and calculates their average MTF as the final result. Then,a two-dimensional MTF restoration model is constructed by multiplying the horizontal and vertical MTF,and it is combined with conventional image restoration methods to restore fuzzy image. Experimental results indicate the proposed method implementes a fast and accurate MTF computation and the MTF model improves the performance of conventional restoration methods significantly.
文摘Purpose: Children are sometimes examined with Computed Tomography protocols designed for adults, leading to radiation doses higher than necessary. Lack of optimisation could lead to image quality higher than what is needed for diagnostic purposes with associated high doses to patients. Optimising the protocols for paediatric head trauma CT imaging will reduce radiation dose. Objective: The study aimed to optimise radiation dose and assess the image quality for a set of protocols by evaluating noise, a contrast to noise ratio, modulation transfer function and noise power spectrum. Methods: Somaton Sensation 64 was used to scan the head of an anthropomorphic phantom with a set of protocols. ImageJ software was used to analyse the paediatric head image from the scanner. IMPACTSCAN dosimeter software was used to evaluate the radiation dose to the various organs in the head. MATLAB was used to analyse the Modulation Transfer Function and the Noise Power. Results: The estimated Computed Tomography Dose Index volume (CTDI<sub>vol</sub>) increased with increasing tube current and tube voltage. The high pitch of 0.9 gave a lower dose than the 0.5 pitch. The eye lens received the highest radiation dose (39.2 mGy) whiles the thyroid received the least radiation dose (13.7 mGy). There was an increase in noise (62.46) when the H60 kernel was used and a lower noise (8.829) was noticed when the H30 kernel was used. Conclusion: The results obtained show that the H30 kernel (smooth kernel) gave higher values for noise and contrast to noise ratio (CNR) than the H60 kernel (sharp kernel). The H60 kernel produced high values for the modulation transfer function (MTF) and noise power spectrum (NPS). The eye lens received the highest radiation dose.
文摘Background: The aim of this review is to summarize the optical quality results in patients following theimplantation of the V4c implantable collamer lens with a central port (ICL, STAAR Surgical Inc.).Main text: A literature search in several databases was carried out to identify those publications, both prospective,retrospective and/or comparative with other refractive surgery procedures, reporting optical outcomes of patientswho were implanted with the V4c ICL model. A total of 17 clinical studies published between 2012 and 2021 wereincluded in this review. A detailed analysis of the available data was performed including number of eyes, follow-upand preoperative spherical equivalent. Specifically, the review focused on several optical parameters includinghigher-order aberrations (HOAs), modulation transfer function (MTF) cut-off frequency and Strehl ratio. This reviewencompassed a total of 817 eyes measured using different optical devices based on Hartmann-Shack, retinal imagequality measurement and ray-tracing technologies at different follow-ups.Conclusions: The outcomes found in this review lead us to conclude that the ICL V4c model provides good opticalquality, by means of different metrics, when implanted.
文摘Background:The aim of this review is to summarize the optical quality results in patients following the implantation of the V4c implantable collamer lens with a central port(ICL,STAAR Surgical Inc.).Main text:A literature search in several databases was carried out to identify those publications,both prospective,retrospective and/or comparative with other refractive surgery procedures,reporting optical outcomes of patients who were implanted with the V4c ICL model.A total of 17 clinical studies published between 2012 and 2021 were included in this review.A detailed analysis of the available data was performed including number of eyes,follow-up and preoperative spherical equivalent.Specifically,the review focused on several optical parameters including higher-order aberrations(HOAs),modulation transfer function(MTF)cut-off frequency and Strehl ratio.This review encompassed a total of 817 eyes measured using different optical devices based on Hartmann-Shack,retinal image quality measurement and ray-tracing technologies at different follow-ups.Conclusions:The outcomes found in this review lead us to conclude that the ICL V4c model provides good optical quality,by means of different metrics,when implanted.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.U1913215&51975162)。
文摘A piezoelectric platform using function module actuator is presented to achieve nano-positioning and high frequency scanning in large working range. A function module actuator is designed to produce a pair of orthogonal bending deformations and a longitudinal deformation through partition exciting. The bending deformations are used to actuate the planar motion,while the longitudinal deformation is utilized to dynamically adjust the driving force and broaden the scanning frequency. The dynamic model of the platform system is developed. The open-loop performances of a prototype are first tested: a scan frequency of 308 Hz in a scanning range of 3.368 μm×3.396 μm is measured in direct actuation mode,and the displacement resolution is measured to be 16 nm;maximum speed is measured to be 3.38 mm s^-1 in the inertial actuation mode. Furthermore,the closedloop experiments are carried out and a switching strategy is proposed to obtain the switching of the inertial and direct actuation modes automatically;the platform achieves the scanning with frequency of 300 Hz at the set position.
基金supported in part by the Research Grants Council of the Hong Kong Special Administrative Region,China, under project 7131–12Ethe NSFC RGC grant under project N–HKU714–13
文摘In optical scanning holography, one pupil produces a spherical wave and another produces a plane wave. They interfere with each other and result in a fringe pattern for scanning a three-dimensional object. The resolution of the hologram reconstruction is affected by the point spread function(PSF) of the optical system. In this paper, we modulate the PSF by a spiral phase plate, which significantly enhances the lateral and depth resolution. We explain the theory for such resolution enhancement and show simulation results to verify the efficacy of the approach.