Elevated heart rate is a major risk factor for cardiovascular diseases. The inhibitor of funny current （I （f） ）, a hyperpolarization-activated cyclic nucleotide-gated channel current, ivabradine is a new agent sel...Elevated heart rate is a major risk factor for cardiovascular diseases. The inhibitor of funny current （I （f） ）, a hyperpolarization-activated cyclic nucleotide-gated channel current, ivabradine is a new agent selectively reducing heart rate devoid of other cardiovascular effects, which has come into the market in Europe for more than 3 years. It has been approved that pure heart rate reduction by ivabradine can improve myocardial ischernia, endothelial function and myocardial contractile function. Long-term administration will not increase all-cause mortality. Its therapeutic value in stable coronary artery disease has been verified in clinical practice, while in other fields of cardiovascular diseases still needs more evidence-based medical research. This article is a review about its recent research advances in experimental and clinical studies.展开更多
文摘Elevated heart rate is a major risk factor for cardiovascular diseases. The inhibitor of funny current （I （f） ）, a hyperpolarization-activated cyclic nucleotide-gated channel current, ivabradine is a new agent selectively reducing heart rate devoid of other cardiovascular effects, which has come into the market in Europe for more than 3 years. It has been approved that pure heart rate reduction by ivabradine can improve myocardial ischernia, endothelial function and myocardial contractile function. Long-term administration will not increase all-cause mortality. Its therapeutic value in stable coronary artery disease has been verified in clinical practice, while in other fields of cardiovascular diseases still needs more evidence-based medical research. This article is a review about its recent research advances in experimental and clinical studies.
