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Galvanic Skin Response—Extinction Biofeedback Training for Psychogenic Abdominal Pain: A Validation Protocol
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作者 Maddalena Castelletti Enrico Berné +2 位作者 Erasmo Dionigio Carlo Castagnoli Alberto Montagna Giorgio Tonon 《Journal of Biosciences and Medicines》 2024年第5期190-201,共12页
Abdominal and pelvic pain of psychogenic origin is a widespread, disabling, difficult to identify, and often inadequately treated medical condition. This condition is often associated with poor quality of life due to ... Abdominal and pelvic pain of psychogenic origin is a widespread, disabling, difficult to identify, and often inadequately treated medical condition. This condition is often associated with poor quality of life due to high pain interference with daily activities. Cognitive behavioral psychological therapy and neuromodulation with biofeedback are validated therapies for the treatment of this condition. Aim of the present research work is the validation of a therapeutic protocol that involves the use of both techniques in combination. 20 patients diagnosed with psychogenic abdominal pain, of both sexes, aged between 18 and 60 years who had not benefited from pharmacological therapies were enrolled. 10 patients were randomly assigned to the control group (psychological treatment only), another 10 patients were assigned to the study group (neuromodulation with biofeedback-Galvanic skin response-extinction in combination with psychological therapy). For both groups, the pain score, interference of pain with daily living activities, pain relief, and the share of anxiety associated with the pain condition were evaluated (pre- and post-treatment). The patients who underwent the combined treatment achieved statistically significant better scores than patients in the control group, respectively −4.9 ± 0.9 vs −1.0 ± 0.4 for Pain;−5.1 ± 1.1 vs −0.9 ± 0.3 for Interference with life;−7.2 ± 3.7 vs −2.2 ± 2.1 for HAMA;4.6 ± 1.2 vs 1.1 ± 0.6 for Relief. 展开更多
关键词 Chronic Abdominal and Pelvic Psychogenic Pain (PAP) Biofeedback Training Pain Management Galvanic skin response (GSR)
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Optimization of Microwave Extraction of Flavonoids from Water Chestnut Skin Dregs with Response Surface Method
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作者 黄利华 《Agricultural Science & Technology》 CAS 2015年第1期187-191,共5页
[Objective] In order to take full advantage of processing by-product of water chestnut, the microwave extraction method of flavonoids from water chestnut skin dregs was optimized. The extracted flavonoids had a relati... [Objective] In order to take full advantage of processing by-product of water chestnut, the microwave extraction method of flavonoids from water chestnut skin dregs was optimized. The extracted flavonoids had a relatively high yield. [Method] The Box-Behnken design-based response surface method was adopted to optimize the microwave extraction of flavonoids from water chestnut skin dregs, a by-product of water chestnut starch. The mathematical relationships between various influencing factors and flavonoids yield were established. [Result] The optimum extraction conditions of flavonoids from water chestnut skin dregs were as follows: ethanol concentration of 55.4%, solid/liquid ratio of 1:30 g/ml, microwave power of 320 W, microwave time of 3 min and microwave time of 2 times. Under the optimum extraction conditions, the theoretical flavonoids yield was 2.376%. However, the actual flavonoids yield under the optimum extraction conditions was 2.365%. The relative error between actual values and theoretically predicted values was 0.461%. [Conclusion] The results showed the optimized extraction method is reliable, and it can provide a reference for the comprehensive and highly efficient utilization of water chestnut processing wastes. 展开更多
关键词 Water chestnut skin dregs FLAVONOIDS response surface methodology (RSM) MICROWAVE
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Olfactory ensheathing cell transplantation improves sympathetic skin responses in chronic spinal cord injury 被引量:6
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作者 Zuncheng Zheng Guifeng Liu +1 位作者 Yuexia Chen Shugang Wei 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第30期2849-2855,共7页
Forty-three patients with chronic spinal cord injury for over 6 months were transplanted with bryonic olfactory ensheathing cells, 2-4 × 106, into multiple sites in the injured area under the sur-gical microscope... Forty-three patients with chronic spinal cord injury for over 6 months were transplanted with bryonic olfactory ensheathing cells, 2-4 × 106, into multiple sites in the injured area under the sur-gical microscope. The sympathetic skin response in patients was measured with an electromyo-graphy/evoked potential instrument 1 day before transplantation and 3-8 weeks after trans-tion. Spinal nerve function of patients was assessed using the American Spinal Injury Association impairment scale. The sympathetic skin response was elicited in 32 cases before olfactory en-sheathing celltransplantation, while it was observed in 34 cases after transplantation. tantly, sympathetic skin response latency decreased significantly and amplitude increased cantly after transplantation. Transplantation of olfactory ensheathing cells also improved American Spinal Injury Association scores for movement, pain and light touch. Our findings indicate that factory ensheathing celltransplantation improves motor, sensory and autonomic nerve functions in patients with chronic spinal cord injury. 展开更多
关键词 neural regeneration spinal cord injury clinical practice olfactory ensheathing cells cell transplan-tation olfactory ensheathing cell transplantation sympathetic skin response neurological function autonomic nerve PARALYSIS NEUROREGENERATION
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The Effects of the Enriched Environment on Sympathetic Skin Response in Pentylenetetrazol-Kindled Rats 被引量:2
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作者 Nazan DOLU Seval KELOGLAN +1 位作者 Soner BITIKTAS Setenay CUG 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第5期394-397,共4页
Epilepsy is a neurodegenerative disease that interrupts the normal electrical activity of the brain and promotes abnormal wiring in this organ.Epileptic seizures are often associated with significant changes in the fu... Epilepsy is a neurodegenerative disease that interrupts the normal electrical activity of the brain and promotes abnormal wiring in this organ.Epileptic seizures are often associated with significant changes in the functioning of the autonomic nervous system(ANS). 展开更多
关键词 The Effects of the Enriched Environment on Sympathetic skin response in Pentylenetetrazol-Kindled Rats CAGE
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Numerical Model of Thermal Responses in Human Skin under Low-Level Radiant Exposure 被引量:1
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作者 ZHANG Wenhuan LI Jun 《Journal of Donghua University(English Edition)》 CAS 2022年第4期408-412,共5页
For improving the evaluative accuracy of thermal protective clothing performance,the estimated methods of thermal response of skin and the human body were comprehensively described and analyzed.This study reviewed the... For improving the evaluative accuracy of thermal protective clothing performance,the estimated methods of thermal response of skin and the human body were comprehensively described and analyzed.This study reviewed the one-dimensional(1D)and multi-dimensional heat transfer models of the skin heat transfer model,including the corresponding heat and moisture transfer.Further,it investigated the influence of moisture transfer in vivo heat transfer.Moreover,the thermo-physiological model with active regulation was analyzed,especially in the local extremes,such as fingers and toes.Additionally,future research trends are discussed in estimating thermal protective performance.In developing the thermal protective model,it is essential to consider the geometric structure,local heat thermoregulation of extremities,and mass transfer inside the skin. 展开更多
关键词 thermal response thermo-physiological model human skin bioheat model mass transfer
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Sympathetic skin response in patients with myasthenia gravis: A comparative analysis
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作者 Hongning Zhao Xiaoming Wang Junqiang Zhang Deben Yang Xiaoqiong Zhao Xin Liu HuiHuang Jianxiu Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2007年第11期675-677,共3页
BACKGROUND: The examination of sympathetic skin response is an important index for assessing the autonomic nerve function, and patients with myasthenia gravis are always accompanied by dysautonomia. Therefore, it wil... BACKGROUND: The examination of sympathetic skin response is an important index for assessing the autonomic nerve function, and patients with myasthenia gravis are always accompanied by dysautonomia. Therefore, it will be important to know whether sympathetic skin response can be used as the index for the clinical evaluation of myasthenia gravis. OBJECTIVE: To investigate the diagnostic value of sympathetic skin response in the damage of autonomic nerve function of patients with myasthenia gravis. DESIGN: A case-controlled comparative observation. SETTING: Department of Neurology and Room of Nerve Electromyogram, the Affiliated Hospital of North Sichuan Medical College. PARTICIPANTS: Thirty outpatients or inpatients with myasthenia gravis were selected from the Department of Neurology, the Affiliated Hospital of North Sichuan Medical College from May 2006 to May 2007, including 9 males and 21 females, aged 8 - 72 years with a mean age of (28 ± 5) years old. They were all accorded with the diagnostic standards of myasthenia gravis, accompanied by different severity of autonomic nerve symptoms, including poor skin nutrition, sweating of hands and feet, pyknocardia, persistent hypotension, abdominal pain, constipation, etc. They all had not taken any drug affecting the autonomic nerve function before the examination. Informed consents were obtained from all the patients. Meanwhile, 30 healthy physical examinees were enrolled as the normal control group, including 10 males and 20 females, aged 10 - 75 years with a mean age of (31 ±5) years old. Approval was obtained from the hospital ethic committee. METHODS: After admission, the patients were examined with sympathetic skin response using DANTEC keypoint 2.0 electromyography evoked potential apparatus (Danmark). The changes of the latency and wave amplitude of sympathetic skin response were observed. The subjects in the normal control group were examined with the same methods at physical examination. Abnormality was judged by the disappearance of wave form, latency longer than that in the normal control group by Mean+2.5SD, or wave amplitude lower than the average value in the normal control group by 50%. MAIN OUTCOME MEASURES: The results of the latency and wave amplitude of sympathetic skin response were compared between the patients with myasthenia gravis and normal controls. RESULTS: All the 30 patients with myasthenia gravis and 30 healthy physical examinees were involved in the final analysis of results. There were no significant differences between the left and right upper and lower limbs in both the myasthenia gravis group and normal control group (P 〉 0.05). In the myasthenia gravis group, the abnormal rate of sympathetic skin response was 37% (11/30), the latency was prolonged and the wave amplitude was decreased as compared with those in the normal control group, and there were significant differences (P 〈 0.01). CONCLUSION: Sympathetic skin response can be used as an electrophysiological index for judging the damages of autonomic nerve function in patients with myasthenia gravis. 展开更多
关键词 myasthenia gravis sympathetic skin response autonomic nerve function
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Numerical Estimation of the Thermal Response of Thermal Protective Clothing-Air Gap-Human Skin Micro-system 被引量:1
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作者 田明伟 王祯 +5 位作者 刘康炜 胡馨之 朱士凤 曲丽君 陈韶娟 周泉 《Journal of Donghua University(English Edition)》 EI CAS 2016年第4期569-573,共5页
Thermal protective clothing has been recognized as the primary shielding against emergency fire hazard and inflammable gas leakage. Therefore,the thermal response of human covered with thermal protective clothing unde... Thermal protective clothing has been recognized as the primary shielding against emergency fire hazard and inflammable gas leakage. Therefore,the thermal response of human covered with thermal protective clothing under high temperature is the key work to investigate the thermal insulation of thermal protective clothing. A coupling model composed of thermal protective clothing,air gap and human skin is established and the temperature of the micro-system is numerically solved via the finite element method( FEM).Especially,the heat transfer of air gap located between clothing and human skin considering conduction and radiation is established while the human skin layers involve the effect of blood perfusion. Then the effect of thermophysical properties( thermal conductivity and volumetric capacity) of fabric and thickness of fabric and air on the thermal response of the micro-system is elucidated and compared.The results indicate that the volumetric heat capacity of fabric is the key parameter to affect the thermal shielding performance of thermal protective clothing,and the thicker fabric thickness and air gap thickness can improve the thermal protective properties of the micro-system. 展开更多
关键词 clothing fabric protective volumetric shielding perfusion insulation conduction elucidated skin
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Transcriptomic analysis of regenerated skins reveals key genes involved in skin immune response and air-breathing of loach(Paramisgurnus dabryanus)
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作者 Rongyun Li Jian Gao +2 位作者 Yunbang Zhang Bing Sun Xiaojuan Cao 《Aquaculture and Fisheries》 CSCD 2024年第5期753-762,共10页
Fish skin acts as the first immune barrier against pathogens from external environments.Recently,fish skin immunity research has gradually become a hot topic in aquaculture disease control.Interestingly,the skin can d... Fish skin acts as the first immune barrier against pathogens from external environments.Recently,fish skin immunity research has gradually become a hot topic in aquaculture disease control.Interestingly,the skin can do air-breathing in some bimodal respiration fish.However,there is no comprehensive understanding of these two functions.In this study,the skin regeneration of loach(Paramisgurnus dabryanus)was investigated through morphological and histological observations.Then,original skins(OS)and the regenerated skins(RS)when their capillaries were the most abundant during healing,were collected for transcriptomic analysis.285,899,386 clean reads with a total length of 42.34 Gb were obtained.A total of 1282 differentially expressed genes(DEGs)were detected,including 1030 DEGs up-regulated and 252 DEGs down-regulated in the comparison of RS vs.OS.Fc gamma R-mediated phagocytosis(containing gelsolin(Gsn)),chemokine signaling pathway(containing C-C motif chemokine ligand 28(Ccl28)),and B cell receptor signaling pathway(containing CD80 molecule(Cd81))were closely related to skin immune response of the loach.PI3K-Akt signaling pathway[containing fibronectin 1(Fn1)and lysyl oxidase-like 2b(Loxl2b)],TGF-beta signaling pathway[containing thrombospondin 1(Thbs1)],ECM-receptor interaction[containing integrin alpha 7(Itga7),Itgb8,Itgb10 and Itgb5],and dilated cardiomyopathy[containing laminin subunit alpha1(Lama1)]were closely associated with skin air-breathing of the loach.This study is conducive to explore the molecular mechanisms of skin immune response during its regeneration and air-breathing of bimodal respiration fish.This study will benefit for the aquaculture of P.dabryanus and its related species. 展开更多
关键词 Paramisgurnus dabryanus skin regeneration Transcriptomic analysis skin air-breathing skin immune response
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Impact of cold indoor thermal environmental conditions on human thermal response 被引量:6
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作者 刘红 谭青 +2 位作者 李百战 谈美兰 马小磊 《Journal of Central South University》 SCIE EI CAS 2011年第4期1285-1292,共8页
To explore the thermal responses under the non-thermal equilibrium cold environmental conditions,a laboratory study was conducted in climate chamber.The local skin temperatures and thermal sensation of 20 subjects wer... To explore the thermal responses under the non-thermal equilibrium cold environmental conditions,a laboratory study was conducted in climate chamber.The local skin temperatures and thermal sensation of 20 subjects were recorded at 10 min intervals for 90 min under air temperatures of 7.4,9.1,11 and 15 °C.The results show that both local skin temperatures and mean skin temperature decrease not only with the drop of ambient air temperature but also with the exposure time.Local thermal sensation and overall the thermal sensation have the similar temperature-varying and time-varying characteristics.Predicted mean vote(PMV) model cannot correctly predict the thermal sensation under non-thermal equilibrium cold environment.The correlation between local thermal sensation and local skin temperatures shows that thermal sensation is closely related to skin temperature.Skin temperature is an effective indicator of thermal sensation.A linear relationship model between overall thermal sensation and mean skin temperature,considering both ambient temperature and exposure time,was established in the non-thermal equilibrium cold environment,which makes the evaluation of thermal sensation more objective. 展开更多
关键词 indoor thermal environment thermal comfort thermal sensation skin temperature human thermal response
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Sustained complete response to erlotinib in squamous cell carcinoma of the head and neck:A case report 被引量:1
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作者 Mie Mie Thinn Chung-Tzu Hsueh Chung-Tsen Hsueh 《World Journal of Clinical Cases》 SCIE 2019年第5期616-622,共7页
BACKGROUND Squamous cell carcinoma of head and neck(SCCHN) is the fifth most common cancer worldwide. Inhibition of epidermal growth factor receptor signaling has been shown to be a critical component of therapeutic o... BACKGROUND Squamous cell carcinoma of head and neck(SCCHN) is the fifth most common cancer worldwide. Inhibition of epidermal growth factor receptor signaling has been shown to be a critical component of therapeutic option. Herein, we report a case of durable complete response to erlotinib.CASE SUMMARY An 81-year-old Caucasian male who presented with metastatic poorly differentiated squamous cell carcinoma of right cervical lymph nodes(levels 2 and 3). Imaging studies including(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(CT) and contrast-enhanced CT scan of neck and chest did not reveal any other disease elsewhere. Panendoscopic examination with random biopsy did not reveal malignant lesion in nasopharynx,oropharynx, and larynx. He underwent modified neck dissection and postoperative radiation. Within 2 mo after completion of radiation, he developed local recurrence at right neck, which was surgically removed. Two mo after the salvage surgery, he developed a second recurrence at right neck. Due to suboptimal performance status and his preference, he started erlotinib treatment.He achieved partial response after first 2 mo of erlotinib treatment, then complete response after total 6 mo of erlotinib treatment. He developed sever skin rash and diarrhea including Clostridium difficile infection during the course of erlotinib treatment requiring dose reduction and eventual discontinuation. He remained in complete remission for more than two years after discontinuation of erlotinib.CONCLUSION We report a case of metastatic SCCHN achieving durable complete response from erlotinib. Patient experienced skin rash and diarrhea toxicities which were likely predictors of his treatment response. 展开更多
关键词 SQUAMOUS cell carcinoma of head and NECK EPIDERMAL growth factor receptor ERLOTINIB Complete response skin RASH TYROSINE kinase inhibitor Case report
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Minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing
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作者 Xiao‑Xuan Lei Liu Hang‑Hang Cheng +8 位作者 Hai‑Yan Lin Yu Yang Yun‑Yu Lu Meng‑Ru Pang Yun‑Qing Dong Floris J.Bikker Tymour Forouzanfar Biao Cheng Gang Wu 《Military Medical Research》 SCIE CAS CSCD 2023年第4期563-566,共4页
Dear Editor,The skin barrier can be impaired by acute skin wounds,which may lead to a series of complications.It is essential to accelerate wound healing and rapidly restore the structural integrity and functionality ... Dear Editor,The skin barrier can be impaired by acute skin wounds,which may lead to a series of complications.It is essential to accelerate wound healing and rapidly restore the structural integrity and functionality of skin.One of the promising bioactive agents is human salivary histatin 1(Hst1),a 38-amino acid histidine-rich peptide that functions to maintain the homeostasis of oral mucosa with a cellular mechanism of promoting the adhesion,spreading,migration of epithelial cells and thus re-epithelialization[1].In recent years,Hst1 has been shown to be effective against various skin-related cell types,such as fibroblasts,myo-fibroblasts,keratinocytes and endothelial cells.In our latest in-vivo study,Hst1 not only promotes angiogenesis,re-epithelialization and collagen production,but also suppresses inflammation,thereby significantly accelerating acute skin wound healing in mice[2].All these studies show that Hst1 is a potent bioactive agent for accelerating acute skin wound healing. 展开更多
关键词 Histatin 1 Minimal active domain Acute skin wound Inflammatory response Oxidative stress
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黄芩苷调节cAMP/PKA/CREB信号通路对湿疹大鼠皮肤屏障功能的影响 被引量:3
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作者 王首帆 徐宜厚 +1 位作者 徐爱琴 朱立宏 《天津医药》 CAS 2024年第2期148-153,共6页
目的探讨黄芩苷(BA)调节环磷酸腺苷(cAMP)/蛋白激酶A(PKA)/cAMP反应元件结合蛋白(CREB)通路对湿疹大鼠皮肤屏障功能的影响。方法将SD大鼠随机分为对照组(NC组)、Model组、低剂量BA组(BA-L组,25 mg/kg)、中剂量BA组(BA-M组,50 mg/kg)、... 目的探讨黄芩苷(BA)调节环磷酸腺苷(cAMP)/蛋白激酶A(PKA)/cAMP反应元件结合蛋白(CREB)通路对湿疹大鼠皮肤屏障功能的影响。方法将SD大鼠随机分为对照组(NC组)、Model组、低剂量BA组(BA-L组,25 mg/kg)、中剂量BA组(BA-M组,50 mg/kg)、高剂量BA组(BA-H组,100 mg/kg)、泼尼松组(PNS组,25 mg/kg)、BAH+cAMP抑制剂(SQ22536)组(100 mg/kg+2.13 mg/kg)、BA-H+PKA抑制剂(H-89)组(100 mg/kg+5 mg/kg),每组12只。除NC组外,其余组大鼠均构建湿疹大鼠模型。建模成功2 d后,分组进行给药处理。检测湿疹面积及严重度指数(EASI)评分、经皮肤水分流失量(TEWL)、角质层含水量(WCSC)变化;酶联免疫吸附试验(ELISA)检测大鼠血清中免疫球蛋白E(IgE)、干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)水平及大鼠背部受试区皮损组织中c AMP蛋白表达;HE染色检测大鼠背部受试区皮损组织病理变化;Western blot检测大鼠背部受试区皮损组织中水通道蛋白3(AQP3)、cathelicidin相关抗菌肽(CRAMP)、p-PKA、p-CREB蛋白表达。结果与NC组比较,Model组大鼠背部受试区皮损组织病理损伤严重,EASI评分、TEWL、IgE、IL-4水平升高,WCSC、IFN-γ水平、AQP3、CRAMP、cAMP、p-PKA、p-CREB蛋白水平降低(P<0.05)。与Model组比较,BA-L组、BA-M组、BA-H组、PNS组大鼠背部受试区皮损组织病理损伤减轻,EASI评分、TEWL、IgE、IL-4水平降低,WCSC、IFN-γ水平、AQP3、CRAMP、cAMP、p-PKA、p-CREB蛋白水平升高(P<0.05);且BA-L组、BA-M组、BA-H组上述指标变化呈剂量依赖性。SQ22536或H-89减弱了高剂量BA对湿疹大鼠皮肤屏障功能的改善作用。结论BA可能通过激活cAMP/PKA/CREB信号通路改善湿疹大鼠皮肤屏障功能。 展开更多
关键词 湿疹 黄芩苷 环磷酸腺苷/蛋白激酶A/cAMP反应元件结合蛋白通路 皮肤屏障功能
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心理性勃起功能障碍患者的阴茎交感皮肤反应表现分析
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作者 韩友峰 孙国海 +1 位作者 戴玉田 石亮 《中国性科学》 2024年第1期8-11,共4页
目的探讨心理性勃起功能障碍(ED)患者的阴茎交感皮肤反应(PSSR)的变化。方法选取因非创伤性ED收住院分别进行夜间阴茎胀大试验(NPT)及阴茎神经电生理检查的患者96例作为研究对象,将NPT结果显示有单次阴茎勃起头部硬度≥60%的时间≥10 mi... 目的探讨心理性勃起功能障碍(ED)患者的阴茎交感皮肤反应(PSSR)的变化。方法选取因非创伤性ED收住院分别进行夜间阴茎胀大试验(NPT)及阴茎神经电生理检查的患者96例作为研究对象,将NPT结果显示有单次阴茎勃起头部硬度≥60%的时间≥10 min的有效勃起患者68例纳入心理性ED组,以至少连续两晚均未出现有效勃起患者28例纳入非创伤性器质性ED组。比较两组年龄、身高、体重、病程、检查天数、有效勃起总次数、第一天有效勃起次数、第二天有效勃起次数、第三天有效勃起次数、阴茎头部硬度≥60%的维持时间、阴茎根部硬度≥60%的维持时间、头部膨大周径、根部膨大周径、阴茎神经电生理检查结果PSSR潜伏期及波幅。结果两组身高、体重、病程、检查天数、PSSR波幅比较,差异均无统计学意义(P>0.05)。心理性ED组年龄小于非创伤性器质性ED组(P<0.01),而有效勃起总次数、第一天有效勃起次数、第二天有效勃起次数、第三天有效勃起次数、阴茎头部硬度≥60%的维持时间、阴茎根部硬度≥60%的维持时间、头部膨大周径、根部膨大周径均高于非创伤性器质性ED组(P<0.01),PSSR潜伏期短于非创伤性器质性ED组(P<0.01)。结论心理性ED患者PSSR潜伏期缩短,交感神经兴奋性可能偏高,PSSR检测可作为一种辅助方法用于心理性ED的评估。 展开更多
关键词 心理性勃起功能障碍 阴茎夜间胀大试验 阴茎交感皮肤反应 交感神经高兴奋性
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纳布啡对行切痂植皮术烧伤患者氧化应激及全麻苏醒期躁动的影响
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作者 程南 郑卫国 沈迎雁 《中国中西医结合外科杂志》 CAS 2024年第1期81-85,共5页
目的:探究纳布啡对烧伤患者行切痂植皮术后全麻苏醒期躁动及氧化应激反应的影响。方法:选取2021年3月-2022年3月我院收治并行切痂植皮术的烧伤患者72例,采用随机数字法分为纳布啡组(n=36)和对照组(n=36)。纳布啡组患者在全身麻醉诱导前1... 目的:探究纳布啡对烧伤患者行切痂植皮术后全麻苏醒期躁动及氧化应激反应的影响。方法:选取2021年3月-2022年3月我院收治并行切痂植皮术的烧伤患者72例,采用随机数字法分为纳布啡组(n=36)和对照组(n=36)。纳布啡组患者在全身麻醉诱导前10 min静脉注射0.20 mg/kg纳布啡,对照组给予等量生理盐水,比较两组躁动发生率,拔管前(T1)、拔管即刻(T2)、拔管后10 min(T3)、拔管后30 min(T4)的Richmond躁动-镇静评分(RASS)、Ramsay镇静评分,以及术前术后的氧化应激反应和苏醒时间,比较两组恶心呕吐、呼吸抑制、嗜睡、眩晕等不良反应发生情况。结果:与对照组比较,纳布啡组躁动发生率更低,T3、T4时RASS评分均降低,T1、T4时Ramsay镇静评分升高(P <0.05);两组患者术前术后丙二醛(MDA)、脂质过氧化物(LPO)明显下降,超氧化物歧化酶(SOD)明显升高。术后苏醒期,纳布啡组SOD均高于对照组,MDA、LPO低于对照组(P <0.05);两组苏醒时间、恶心呕吐、呼吸抑制、嗜睡、眩晕的不良反应发生率,无统计学差异(P>0.05)。结论:采用纳布啡对行切痂植皮术的烧伤患者有较理想的镇静效果,降低患者全麻苏醒期的躁动,减轻氧化应激反应,且不影响麻醉苏醒时间及不良反应发生率。 展开更多
关键词 纳布啡 切痂植皮术 全身麻醉 苏醒期躁动 氧化应激反应
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重组贻贝粘蛋白联合他克莫司软膏与抗组胺药治疗面部糖皮质激素依赖性 皮炎的疗效及对皮肤屏障指标的影响
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作者 金外淑 陈勇 +1 位作者 周慧 赵莹 《中国美容医学》 CAS 2024年第8期92-95,共4页
目的:研究重组贻贝粘蛋白联合他克莫司软膏、抗组胺药治疗面部糖皮质激素依赖性皮炎(简称面部皮炎)及对皮肤屏障指标的影响。方法:选取2020年4月-2022年12月笔者医院门诊面部皮炎患者131例,采用随机数字表法分为对照组(n=65)与研究组(n=... 目的:研究重组贻贝粘蛋白联合他克莫司软膏、抗组胺药治疗面部糖皮质激素依赖性皮炎(简称面部皮炎)及对皮肤屏障指标的影响。方法:选取2020年4月-2022年12月笔者医院门诊面部皮炎患者131例,采用随机数字表法分为对照组(n=65)与研究组(n=66)。两组均对面部皮炎进行常规处理,对照组给予他克莫司与氯雷他定治疗,研究组在对照组基础上联合重组贻贝粘蛋白治疗,持续治疗4周后,比较两组皮肤屏障指标(表皮皮脂含量、角质层含水量,经表皮水分丢失量)、自觉症状与客观体征积分、疗效、不良反应。结果:治疗后两组表皮皮脂含量、角质层含水量上升,经表皮水分丢失量下降,且研究组表皮皮脂含量、角质层含水量高于对照组,经表皮水分丢失量低于对照组(P<0.05)。治疗4周后两组自觉症状与客观体征积分下降,且研究组积分低于对照组(P<0.05)。研究组总有效率93.94%高于对照组81.54%(P<0.05)。两组总不良反应发生率比较,差异无统计学意义(P>0.05)。结论:重组贻贝粘蛋白联合他克莫司软膏、抗组胺药能有效改善面部皮炎患者临床症状,促进恢复皮肤屏障功能,且无明显严重不良反应发生。 展开更多
关键词 面部皮炎 重组贻贝粘蛋白 抗组胺药 疗效 皮肤屏障 免疫应答
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爆炸荷载下预制节段拼装双层钢管混凝土墩柱的动力响应数值模拟
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作者 李明鸿 刘晏辰 +3 位作者 夏梦涛 宗周红 甘露 陈振健 《东南大学学报(自然科学版)》 EI CAS CSCD 北大核心 2024年第3期647-657,共11页
为提升装配式公路桥梁的抗爆防护能力,提出了一种新型预制节段拼装双层钢管混凝土(PS-CFDST)组合墩柱.基于非线性显式动力分析程序LS-DYNA建立了新型PS-CFDST墩柱在爆炸荷载作用下动力响应分析的精细有限元模型,并通过已有试验结果验证... 为提升装配式公路桥梁的抗爆防护能力,提出了一种新型预制节段拼装双层钢管混凝土(PS-CFDST)组合墩柱.基于非线性显式动力分析程序LS-DYNA建立了新型PS-CFDST墩柱在爆炸荷载作用下动力响应分析的精细有限元模型,并通过已有试验结果验证了模型的准确性.对爆炸荷载作用下PS-CFDST墩柱的动力响应进行数值模拟分析,研究了PS-CFDST墩柱在爆炸荷载作用下的破坏过程、损伤机理和耗能机制.运用参数化分析方法,研究了爆炸距离、节段数量和预应力水平等关键参数对PS-CFDST墩柱动力响应的影响,并在此基础上提出了PS-CFDST墩柱的抗爆设计建议.结果表明:PS-CFDST墩柱除通过材料塑性损伤耗能之外,节段接缝界面滑移耗能机制对耗能贡献可达40%以上;增大墩柱可接近距离是提升墩柱抗爆安全性的有效手段,增大预应力有利于减小柱中最大水平位移和墩底剪切滑移,从而提升PS-CFDST墩柱的抗爆性能. 展开更多
关键词 预制节段拼装墩柱 双层钢管混凝土 数值模拟 爆炸荷载 动力响应 损伤机理
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皮肤试验预测头孢菌素过敏反应的研究进展
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作者 罗俊 刘国萍 +2 位作者 黄舒文 覃福礼 韦坤璇 《抗感染药学》 2024年第2期113-117,共5页
头孢菌素是以7-氨基头孢烷酸(7-amino-cephalosporanic acid)为母核,通过连接不同侧链而形成的一类β-内酰胺类抗菌药物。通过不断迭代研发,头孢菌素在抗菌谱、抗菌作用和药物安全性等方面得到不断优化。然而,在临床使用过程中,头孢菌... 头孢菌素是以7-氨基头孢烷酸(7-amino-cephalosporanic acid)为母核,通过连接不同侧链而形成的一类β-内酰胺类抗菌药物。通过不断迭代研发,头孢菌素在抗菌谱、抗菌作用和药物安全性等方面得到不断优化。然而,在临床使用过程中,头孢菌素仍会出现过敏反应等药物不良反应,国内一直以来都是通过皮肤试验进行预测,但相关研究对皮肤试验的预测和应用价值是存在质疑的。为此,笔者从β-内酰胺类药物致过敏反应的分子机制和影响因素、皮肤试验的经济学价值、国内外头孢菌素的皮肤试验开展现状等方面对相关研究进行了综述,为临床评估皮肤试验对头孢菌素过敏反应的预测价值和应用前景提供参考。 展开更多
关键词 皮肤试验 头孢菌素 过敏反应 研究进展
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托里消毒散通过调控NF-κB信号通路对大鼠皮瓣缺血再灌注损伤的影响 被引量:2
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作者 陈浩 张天琦 +4 位作者 马骁 付秋悦 张杉 严肃 陈刚 《南京中医药大学学报》 CAS CSCD 北大核心 2024年第1期61-67,共7页
目的探讨托里消毒散对大鼠皮瓣缺血再灌注损伤的影响及其潜在机制。方法大鼠随机分为假手术组(Sham组)、模型组(Model组)、托里消毒散高剂量组(MDX-H组)和托里消毒散低剂量组(MDX-L组),每组10只。大鼠背部皮瓣模型构建成功后,立即给予... 目的探讨托里消毒散对大鼠皮瓣缺血再灌注损伤的影响及其潜在机制。方法大鼠随机分为假手术组(Sham组)、模型组(Model组)、托里消毒散高剂量组(MDX-H组)和托里消毒散低剂量组(MDX-L组),每组10只。大鼠背部皮瓣模型构建成功后,立即给予药物灌胃处理,每日1次,连续14 d。观察术后各组大鼠皮瓣变化情况,并于术后第14天测定各组大鼠皮瓣成活率;HE染色观察大鼠皮瓣组织病理学变化;Western blot检测大鼠皮瓣组织p-p65和p-IκBα蛋白表达;ELISA法检测TNF-α、IL-1β、IL-6细胞因子的表达情况;通过Ki67和CD31免疫组化染色观察表皮基底层细胞增殖及血管再生情况。结果与Model组相比,MDX-H组与MDX-L组术后14 d出现少量水肿,有少量炎性液体渗出,脱痂时间提前,皮瓣缺血坏死情况得到明显改善,皮瓣坏死面积显著减少,大鼠皮瓣成活率明显提高(P<0.01)。此外,托里消毒散可明显改善大鼠背部皮瓣缺血再灌注损伤组织病理形态,降低p-p65和p-IκBα蛋白表达(P<0.001),降低血清中TNF-α、IL-1β、IL-6炎性因子水平(P<0.05,P<0.01,P<0.001,P<0.0001)。Ki67和CD31的差异也提示托里消毒散治疗加快了缺血皮瓣损伤后的再上皮化和血管的形成。结论托里消毒散通过调控NF-κB信号通路、加速上皮化和血管生成,发挥改善皮瓣缺血再灌注损伤的作用。 展开更多
关键词 托里消毒散 缺血再灌注损伤 皮瓣 NF-ΚB信号通路 炎症反应
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基于“肠-皮肤轴”理论及肠道菌群的中药治疗痤疮研究进展 被引量:1
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作者 张雨韵 吕亚 +3 位作者 李志成 秦家麟 徐星丽 吴炯 《上海中医药杂志》 CSCD 2024年第1期96-100,共5页
从“肠-皮肤轴”理论及肠道菌群角度综述中药治疗痤疮的研究进展。痤疮是一种临床常见的皮肤疾病,肠道与皮肤在结构、功能等方面存在很多共同点,肠道菌群失衡与肠道和皮肤的病理改变密切相关。中药可以通过影响肠道菌群来调节机体血清... 从“肠-皮肤轴”理论及肠道菌群角度综述中药治疗痤疮的研究进展。痤疮是一种临床常见的皮肤疾病,肠道与皮肤在结构、功能等方面存在很多共同点,肠道菌群失衡与肠道和皮肤的病理改变密切相关。中药可以通过影响肠道菌群来调节机体血清痤疮相关生化指标[P物质(SP)、短链脂肪酸(SCFAs)、雄激素]水平,干预毛囊皮肤微生物定植及毛囊皮脂腺角化,改善局部免疫炎症,从而对痤疮起到治疗作用。 展开更多
关键词 痤疮 肠-皮肤轴 肠道菌群 中药 雄激素 炎症反应 研究进展
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miR-125a-3p靶向FOXM1调控银屑病大鼠皮肤损伤和炎症反应的作用机制
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作者 金曌 刘钟 +4 位作者 彭静 胡荣毅 吴娟 黄琴斯 王飞 《中国免疫学杂志》 CAS CSCD 北大核心 2024年第12期2531-2536,2542,共7页
目的:探究miR-125a-3p对银屑病大鼠皮肤损伤和炎症反应的影响及机制。方法:SD大鼠随机分为对照组、银屑病组、miR-NC组和miR-125a-3p组,对大鼠进行银屑病面积和严重性指数(PASI)评分、Baker评分;ELISA检测皮肤组织IL-6、IL-1β、TNF-α... 目的:探究miR-125a-3p对银屑病大鼠皮肤损伤和炎症反应的影响及机制。方法:SD大鼠随机分为对照组、银屑病组、miR-NC组和miR-125a-3p组,对大鼠进行银屑病面积和严重性指数(PASI)评分、Baker评分;ELISA检测皮肤组织IL-6、IL-1β、TNF-α水平;qRT-PCR检测皮肤组织miR-125a-3p表达;qRT-PCR、Western blot检测皮肤组织叉头盒蛋白M1(FOXM1)mRNA和蛋白表达。分离培养银屑病大鼠角质形成细胞,双荧光素酶报告基因实验验证miR-125a-3p与FOXM1的靶向关系;分别抑制或过表达miR-125a-3p以及过表达miR-125a-3p基础上过表达FOXM1,检测细胞miR-125a-3p、FOXM1mRNA和蛋白表达以及细胞培养上清中IL-6、IL-1β、TNF-α水平,CCK-8法检测细胞活力,流式细胞术检测细胞凋亡率。结果:与对照组比较,银屑病组大鼠皮肤组织miR-125a-3p表达降低,PASI评分、Baker评分、IL-6、IL-1β、TNF-α水平以及FOXM1mRNA和蛋白表达升高(P<0.05);与银屑病组、miR-NC组比较,miR-125a-3p组大鼠皮肤组织miR-125a-3p表达升高,PASI评分、Baker评分、IL-6、IL-1β、TNF-α水平以及FOXM1 mRNA和蛋白表达降低(P<0.05)。miR-125a-3p与FOXM1存在靶向关系。抑制miR-125a-3p表达后,细胞FOXM1 mRNA和蛋白表达、细胞活力以及细胞培养上清中IL-6、IL-1β、TNF-α水平升高,细胞凋亡率降低(P<0.05),过表达miR-125a-3p则作用相反;过表达FOXM1可减弱过表达miR-125a-3p对细胞活力、凋亡率及炎症反应的影响。结论:miR-125a-3p在银屑病大鼠皮损组织中低表达,其过表达可能通过靶向下调FOXM1抑制角质形成细胞增殖并促进其凋亡,改善银屑病大鼠皮肤损伤,减轻炎症反应。 展开更多
关键词 miR-125a-3p 叉头盒蛋白M1 银屑病 皮肤损伤 炎症反应 角质形成细胞
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