Early detection and intervention in diabetic gastroparesis:Role of body surface gastric mapping

Diabetic gastrointestinal neuropathy is a diabetes-related complication,associated with a complex interplay of hyperglycemic damage,autoimmune responses,oxidative stress,gastrointestinal hormones,and vascular insufficiency.Patients with diabetes should be monitored and therapeutic intervention introduced to prevent neuropathy due to diabetes prior to“the point of no return”.Determining gastric bioelectrical activity by body surface gastric mapping may be a promising option to monitor diabetic gastrointestinal neuropathy.

A Case of Diabetic Nephropathy with Refractory Gastroparesis and Review of the Literature

Background: Gastroparesis is one of the complications of diabetes mellitus, and long-term gastroparesis seriously affects patients quality of life. Most of the patients can be relieved after lifestyle improvement and medication, but refractory gastroparesis is difficult to relieve, and is still a challenge in clinical treatment. Aim: To report a case of a patient with diabetic nephropathy combined with refractory gastroparesis, and to analyse the mechanism, diagnosis, severity grading, treatment of refractory gastroparesis in conjunction with a review of the literature, and to investigate the causes of recurrent nausea and vomiting in diabetic nephropathy patients with refractory diabetic gastroparesis and the possible effective treatment options. Case Presentation: The patient was hospitalised for recurrent nausea and vomiting and diagnosed with diabetic nephropathy and gastroparesis. Symptoms recurred after medication and peritoneal dialysis, and the patients symptoms were relieved after multifaceted interventions. Conclusion: Diabetic nephropathy and refractory gastroparesis can both manifest as digestive tract symptoms, and in the face of this complex disease, it is necessary to analyse the various etiological factors and take comprehensive treatment measures.

TC4-DT钛合金切削加工参数研究

针对YG8和TiAlN涂层硬质合金两种刀具,通过单因素车削、低速铣削及正交高速铣削加工试验,探究刀具切削工艺参数对TC4-DT钛合金加工件表面粗糙度、表层硬度的影响规律。实验结果表明:钛合金的表面粗糙度随着切削三要素发生变化,切削速度越高,粗糙度越低;进给量越大,粗糙度越大;但随切削深度波动变化。使用TiAlN涂层硬质合金立铣刀进行加工得到的平均表面粗糙度小于YG8硬质合金立铣刀,且加工表面硬度变化更小,更适合用于TC4-DT的铣削加工。

Effectiveness and safety of traditional Chinese medicine decoction for diabetic gastroparesis:A network meta-analysis

BACKGROUND Diabetic gastroparesis(DGP)is a prevalent complication of diabetes that impairs people's quality of life and places a significant financial burden on them.The gastrointestinal symptoms of DGP patients can be improved by several Traditional Chinese Medicine(TCM)decoctions that have been shown to be effective in treating the disease.There are still many unanswered questions regarding the identification of appropriate therapeutic agents for the treatment of DGP in clinical practice.AIM To analyze the efficacy of several TCM decoctions in the treatment of DGP using Bayesian network meta-analysis for reference.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,China National Knowledge Infrastructure,The China Biology Medicine DVD,Wanfang,and CQVIP were searched from inception to September 17,2022,to collect randomized controlled trials(RCTs)about TCM decoctions for DGP.Clinical effects and symptom scores were the primary outcomes.Additionally,we assessed motilin(MOT),somatostatin(SS),gastrin(GAS),gastric emptying rate,gastric emptying time,and adverse drug events as secondary outcomes.RESULTS A total of 67 eligible RCTs involving 4790 DGP patients and 7 TCM decoctions were included.The results of network meta-analysis(NMA)and surface under the cumulative ranking curve showed that with western medicine(WM)as a common control,the Banxia Xiexin Decoction(BXXD)+WM was most effective in clinical effects and enhancing early satiety scores;the Simo decoction(SMD)+WM was most effective in improving nausea and vomiting scores and anorexia scores,bloating scores;the Chaishao Liujunzi Decoction(CSLJD)was most effective in MOT,the Zhishi Xiaopi Decoction(ZSXPD)was most effective in SS and upgrading emptying rate;the Jianpi Xiaozhi Decoction was most effective in GAS;the CSLJD+WM was most effective in improving gastric emptying time.CONCLUSION These NMA results suggest that the BXXD+WM and SMD+WM may be one of the potential optimal treatments.Due to various limitations,further large-sample,double-blind,multi-center randomized RCTs are needed.

Oligo(dT)亲和层析介质的载量比较和机制分析

针对Oligo(d T)亲和层析介质的吸附性能,以poly(A)为模型分子,考察了4种Oligo(d T)亲和层析介质的静态吸附平衡、吸附动力学和动态结合载量(DBC),探讨了载量影响相关机制。结果表明,4种介质的合适吸附条件均为0.6 mol·L-1Na Cl、p H=6~7;Monomix d T20静态吸附容量最大,且poly(A)能扩散至介质微球深层孔内,而Poros Oligo(d T)25、Praesto Jetted (d T)25和Nano Gel d T20等3种介质中poly(A)均主要为表层吸附、静态吸附容量稍低;对于DBC,Nano Gel d T20和Monomix d T20的10%穿透的DBC较高,而Poros Oligo (d T)25和Praesto Jetted (d T)25相对略低。经分析,影响载量的主要因素包含基质种类、微球孔径、配基密度、间隔臂和配基长度等。对于基质种类,聚苯乙烯基质可能孔道结构较为特别。对于微球孔径,应针对不同大小的m RNA分子定制不同孔径的微球,以平衡传质阻力与可及吸附表面积之间的矛盾,从而增大DBC。

Study on mechanism of two related Chinese herbs A.officinarum-Pogostemon in treatment of delayed emptying in diabetic gastroparesis based on network pharmacology

Objective:To explore the potential active components,therapeutic targets and critical path of Alpinia officinarum and Pogostemonis Herba in the treatment of diabetic gastroparesis(DGP)by using network pharmacology.Methods:The main chemical components and corresponding targets genes of A.officinarum-Pogostemonis Herba were screened through TCMSP database retrieval[oral bioavailability(OB)≥30%and drug like(DL)≥0.18].Tgenes of diabetic gastroparesis were screened by the Human Gene Database(GeneCards),and Venny 2.1 software was used to obtained common targets for the active ingredients of A.officinarum-Pogostemonis Herba and DGP.Then,the protein-protein interaction(PPI)network of the common targets was constructed by STRING database and analyzed to performed the core targets.GO function and KEGG pathway enrichment analysis of the common target genes were obtained by using ClusterProfiler R package.Finally,the network diagram of"active ingredient-pathway-target"was used to establish by Cytoscape 3.8 software.Results:Totally 23 ingredients of A.officinarum-Pogostemonis Herba,97 active ingredients targets and 533 DGP related targets,including 46 common targets were selected.The common targets were mainly enriched in the cell constituents such as the nuclear chromatin and mitochondria outer membrane,involved in the biological processes as oxidative stress,apoptosis signal regulation,and molecular functions as enzyme binding,protein phosphatase binding,and cytokine activity.They were also concentrated in the signal pathways such as PI3K/Akt,HIF-1 and MAPK.The network of“active ingredients-targets-pathways”indicated the active components such as quercetin,kaempferol and galangin in A.officinarum-Pogostemonis Herba played an anti-delayed gastric emptying in diabetic gastroparesis by acting on PTGS2,NOS2,BCL2,IL6,VEGFA and other targets to jointly regulate PI3K-Akt,HIF-1 and MAPK pathways.Conclusion:This study initially reveals that the combined treatment of A.officinarum-Pogostemonis Herba for delayed gastric emptying in diabetic gastroparesis is a complex process with multi-components,multi-targets and multi-pathways,and provides a new idea for followup researches.

Gastroparesis after video-assisted thoracic surgery:A case report

BACKGROUND Video-assisted thoracic surgery(VATS)lobectomy is a common treatment for patients with early-stage lung cancer.Some patients can experience slight gastrointestinal discomfort after lobectomy for a moment.Gastroparesis is a gastrointestinal disorder that can be severe;it is associated with an increased risk of aspiration pneumonia and impaired postoperative recovery.Here,we report a rare case of gastroparesis after VATS lobectomy.CASE SUMMARY A 61-year-old man underwent VATS right lower lobectomy uneventfully but had an obstruction of the upper digestive tract 2 d after surgery.Acute gastroparesis was diagnosed after emergency computed tomography and oral iohexol X-ray imaging.After gastrointestinal decompression and administration of prokinetic drugs,the patient’s gastrointestinal symptoms improved.Since perioperative medication was applied according to the recommended dose and there was no evidence of electrolyte imbalance,intraoperative periesophageal vagal nerve injury was the most likely underlying cause of gastroparesis.CONCLUSION Although gastroparesis is a rare perioperative complication following VATS,clinicians should be on the alert when patients complain about gastrointestinal discomfort.When surgeons resect paraesophageal lymph nodes with electrocautery,excessive ambient heat and compression of paraesophageal hematoma might induce vagal nerve dysfunction.

PKGIα通路抑制剂DT-3对胃癌细胞增殖和迁移的影响

目的:探讨PKGIα信号通路特异性抑制剂DT-3对胃癌细胞增殖和迁移的影响。方法:利用生物信息学分析,基于GEO、TCGA、HPA、Kaplan-Meier plotter数据库和GEPIA在线分析网站对PKGI在组织中的表达进行差异分析并探讨PKGI和PKGIα在胃癌患者中的预后情况。采用CCK-8、克隆形成实验检测DT-3对细胞增殖的影响,划痕愈合实验观察DT-3对细胞迁移的影响;Western blot-ting法验证PKGIα的蛋白表达和相关性分析。结果:胃腺癌组织中PKGI mRNA表达增高,在42种胃癌细胞株里有27种能检测到PKGI mRNA的表达,高表达PKGIαmRNA的胃癌组织更具肿瘤侵袭性;免疫组织化学(IHC)结果展示PKGI蛋白表达情况,12例胃癌组织中观察到6例存在中、高强度的细胞质染色阳性反应;PKGI和CDH1的表达呈负相关(r=-0.74,P<0.05);生存分析显示PKGI和PKGIαmRNA高表达对胃腺癌患者的总生存期(OS)有统计学意义(HR>1,logrank P<0.05)。实验结果表明PKGIα蛋白在人胃癌细胞株AGS中的表达增加;DT-3抑制细胞增殖迁移(P<0.05),使NF-κB磷酸化p65表达降低,且PKGI和NF-κB p-p65的表达呈极强正相关(r=0.957,P<0.05)。结论:通过抑制PKGIα信号通路,可以有效抑制胃癌细胞增殖迁移。

基于DT‒SVM优化算法的人体姿态特征提取与识别研究

为确定人体运动行为在空间环境中的表现情况,实现对姿态特征的准确定义,针对基于DT‒SVM优化算法的人体姿态特征提取与识别方法展开研究.利用DT‒SVM优化算法,推荐必要的姿态特征节点,确定人体运动行为所处空间平面.实施对姿态特征的梯度化处理,根据获取到的轮廓节点,计算夹角向量的具体数值,从而求解姿态特征提取与识别的数学表达式,完成基于DT‒SVM优化算法的人体姿态特征提取与识别方法的设计.实验结果表明,上述方法的应用,可同时在X轴、Y轴、Z轴三个方向上,控制人体运动行为,使其偏向角数值均不超过12°,符合精准定义人体姿态特征的实际应用需求.

TC4-DT合金中片状α相的高精度定量分析方法

针对网篮组织片状α相体积分数难以精确定量分析以及粘连α相难分离表征的问题,结合体视学原理,采用随机森林、遗传算法和改进遗传算法对TC4-DT合金网篮组织片状α相进行表征。首先,预处理采集网篮组织图像;然后,利用样本中片状α相和β相特征对随机森林模型进行训练。考虑到传统遗传算法图像分割易陷入局部最优解以及收敛速度过快的问题,本文采用精英选择和轮盘赌结合的方法初始化种群,设计了两段式交叉概率和抛物线型变异概率优化遗传算法。最后,利用Java程序验证随机森林模型并自动定量分析片状α相的体积分数,结合实例定量分析片状α相的特征参数。结果表明:采用改进遗传算法运行时时间缩短60%,且图像处理效果也得到提升;随机森林模型不仅在训练样本中的分类准确率达到99.89%,而且在测试样本中的准确率也达到99.29%。这说明随机森林模型能精确地分离片状α相与β相且具有较好的泛化能力。

基于DTS的注水井吸水剖面解释方法

针对注水井分层注水量诊断技术难题,提出基于分布式光纤温度传感(Distributed Temperature Sensing,DTS)的注水井吸水剖面解释方法。建立考虑微量热效应的注水井温度剖面预测模型,模拟分析注水量、注水时间、储层导热系数等7个因素对温度剖面的影响规律。通过正交试验模拟分析,确定不同因素对注水井温度剖面的影响程度从强到弱分别为注入水温度、注水时间、注水量、井筒半径、储层导热系数、井筒倾斜角度、注水层渗透率,明确影响注水井温度剖面的主控因素为注入水温度、注水时间和注入量。采用模拟退火(Simulated Annealing,SA)算法建立注水井DTS数据反演模型,对一口注水井现场实测DTS数据进行反演,获得较为准确的吸水剖面,单层最大吸水量误差百分比14.25%,平均误差11.09%,验证该反演方法的可靠性。通过DTS数据反演可以实现注水井吸水剖面定量解释,为注水效果评价提供直接依据。

Nutritional therapy for gastroparesis

Gastroparesis is a common postoperative complication of abdominal surgery,mainly manifested by postprandial fullness,early satiety,nausea,vomiting,and bloating.Gastroparesis should be addressed with a comprehensive treatment plan that includes nutritional therapy and medications such as metoclopramide,domperidone,cisapride,and antiemetic drugs.Surgical treatment,such as pyloroplasty or partial gastrectomy,should be considered if the conservative therapy is ineffective.Enteral and parenteral nutrition therapy can promote the recovery of gastrointestinal function,maintain the mucosal integrity and immunity,and reduce complications.Thus,nutrition can play an important role in the treatment of gastroparesis.

基于dv/dt参数提取的变流器IGBT驱动自调节技术

绝缘栅双极晶体管(IGBT)作为轨道交通变流器关键部件,对其驱动的调节可以显著改善dv/dt、开关损耗等影响变流器运行的重要参数。为此提出了一种基于dv/dt参数提取的变流器IGBT驱动自调节技术。首先基于IGBT驱动等效电路建立数学模型,分析了dv/dt、门极电阻、开关损耗三者之间的数学关系。其次以dv/dt参数的限制为主要优化目标,开关损耗的平衡为约束条件,提出一种基于Bang-Bang控制的自调节控制策略从而实现门极电阻主动切换,并在双脉冲测试中整定控制策略重要参数。最后通过有无自调节技术对比试验测试,验证了本技术的有效性。

输水隧洞液-气界面DTS监测方法

输水隧洞的运营状态与其水情息息相关,确定隧洞内液-气界面高度是确保隧洞正常运行的重要前提。基于分布式温度传感(DTS)技术时空连续性、监测便捷性、高空分辨率等特点,提出一种基于DTS技术的输水隧洞液-气界面分布式监测方法及液面高度经验公式,并通过室内模型验证该方法的适用性,分析液面高度、光缆布设角度、加热功率、光缆类型对感测性能的影响。结果表明:DTS液-气界面分布式监测方法配合铜网内加热传感光缆效果最佳,当布设角度为45°、加热时间为2 min,且界面高度处于28 cm及以上时,可以准确反映隧洞内液-气界面高度。

玉米新品种“登海 DT996”选育及栽培技术

玉米新品种“登海DT996”是枣庄市金苗农作物研究所在2015年以Z1302为母本、Z2159为父本杂交选育而成,夏播生育期为107天。该品种具有抗病抗倒、耐密耐涝、高产优质等特点,适宜山东省夏玉米区域种植利用。

基于卡尔曼滤波的电机直驱系统DT自动化控制

为了提高电机直驱系统控制精度,对直驱的双模进行状态和参数的同步,并根据性能指数的限制对扩展态卡尔曼滤波器(SAKF)进行参数的调节,以达到最优的动态特性。研究结果表明:负荷扰动下能够精确地探测到载荷惯性变化,证明了卡尔曼滤波算法是行之有效的。速度正弦指令跟随精度分析,SAKF在惯性扰动下跟踪准确率比其它控制器要高。SAKF控制器可以有效地保证惯性参数的可变特性,改善系统稳健性和抗干扰能力。速度阶跃指令响应特性分析,负载下SAKF有效地抑制惯性扰动对DTPI的干扰,并保持了系统的设计特性。

基于DTS的岩溶洼地渗漏室内试验研究

岩溶洼地是修建水库的理想场所,但岩溶洼地多位于岩溶强发育区,存在岩溶渗漏难题。在各种渗漏监测方法中,分布式光纤温度传感技术(DTS)有着显著优势。通过分析两类光缆在相同渗漏条件下的温度表现规律、不同介质和加热功率下可加热型光缆的温度特征值、可加热型光缆的渗漏感知范围,验证将加热光缆沿PVC管螺旋缠绕工艺提高渗漏感知能力的效果。研究成果可为DTS在岩溶洼地渗漏监测的应用提供参考。

玉米新品种登海DT1819的选育及栽培技术

登海DT1819是枣庄登海德泰种业有限公司与枣庄市农业农机技术推广中心联合于2015年冬在海南育种基地以自选系Z1302为母本、Z1145为父本杂交选育的玉米新品种。2020-2023年3年平均产量690.5 kg/亩,2020年平均产量755.8 kg/亩。2023年通过山东省审定。本文作者介绍了该品种的亲本来源、选育经过、特征特性、产量表现及栽培关键技术等,为登海DT1819的推广提供技术参考。

EMS高级应用软件和DTS培训系统在电网运行与调度员培训中的应用

本文主要介绍EMS高级应用软件和DTS培训系统在电网运行与调度员培训中的应用策略。EMS高级应用软件在电网运行中发挥重要作用,具有监测、控制、优化和安全管理等功能。DTS培训系统则满足调度员培训的需求,通过模拟和实践训练提升其应急处理和团队协作能力。在电网运行与调度员培训的应用策略中,安全管理、运行优化、紧急事件处理和团队协作是关键方面。

微电网孤岛运行工况下DT模型自适应迁移方法

微电网在孤岛运行工况变化情况下,会造成数字孪生(DT)模型迁移时无法准确匹配源域模型,从而导致迁移效率偏低等问题。为此,研究提出微电网孤岛运行工况变化场景下的数字孪生模型自适应迁移方法。通过分析微电网在孤岛运行工况下的运行特点,建立数字孪生模型,利用微电网孤岛运行工况的时变性,匹配计算源域模型,并通过缩小不同微电网孤岛运行工况下的源域数据分布差异,实现数字孪生模型的自适应迁移。实验结果表明,电流负载、实际电流等部分特征数据迁移效果较好,且具有较高迁移效率,验证了所提迁移方法可以适应不同微电网孤岛运行工况,具有较好的实用性。