Objective:Glucagon-like peptide-1 receptor imaging,using 68Ga-NOTA-exendin-4 is recently established for detecting insulinomas.Owing to the highly radioactive kidneys in 68Ga-NOTA-exendin-4 PET/CT,we aimed to determin...Objective:Glucagon-like peptide-1 receptor imaging,using 68Ga-NOTA-exendin-4 is recently established for detecting insulinomas.Owing to the highly radioactive kidneys in 68Ga-NOTA-exendin-4 PET/CT,we aimed to determine the effectiveness of Gelofusine in reducing renal uptake of 68Ga-NOTA-exendin-4.Methods:In our randomized controlled study,patients presenting for 68Ga-NOTA-exendin-4 PET/CT who were18 years and with normal renal function were enrolled,and then randomized into intervention group and control group.Patients in intervention group(group 1)underwent infusion of 500mL Gelofusine prior to PET/CT procedures:patients injected with 68Ga-NOTA-exendin-4(group 1a)immediately after 500mL Gelofusine infusion was completed;(group 1b)at the time point that 250 to 300mL Gelofusine infusion was completed;(group 1c)30minutes after completion of 500mL Gelofusine infusion.The control group(group 2)received 500mL 5%glucose saline instead.PET/CT was then performed,and SUVs of the kidneys and insulinomas were measured.Results:A total of 28 patients were recruited.There were 7 patients(14 kidneys)in each subgroup.The age,body weight,BMI,renal function,injected 68Ga-exendin-4 activity,and interval between injection of the tracer and PET/CT scan were not significantly different among the groups(P>.05).The average and maximum SUVs in the kidneys were significantly reduced in patients of intervention group compared with the control subjects(P<.0001),and the renal uptake could be decreased by 57%with Gelofusine pretreatment.No significant difference in the renal radioactivity was found among group 1a,1b,and 1c(P=.071).The uptake of insulinomas was not significantly different between the intervention and control groups.Conclusion:Renal uptake of 68Ga-exendin-4 can be effectively reduced by pretreatment with Gelofusine.Abbreviations:GLP-1R=Glucagon-like peptide-1 receptor;PRRT=peptide receptor radionuclide therapy;PET=positron emission tomography;SUV=standard uptake value.展开更多
Injection pain of propofol remains a common clinical problem. Previous studies demonstrated that propofol injection pain was alleviated by applying nitroglycerin ointment to the skin of injection site, which inspires ...Injection pain of propofol remains a common clinical problem. Previous studies demonstrated that propofol injection pain was alleviated by applying nitroglycerin ointment to the skin of injection site, which inspires us to test whether venous vasodilation induced by fluid preload could alleviate the pain. Different types or volumes of fluid preload were compared. 200 ASA Ⅰ-Ⅱ adult patients were randomly assigned to five groups of 40 each. A 20 G cannula was established on the dorsum or wrist of the hand. When fluid preload given with Plasma-Lyte A 100 m L（P100 group）, 250 m L（P250 group）, 500 m L（P500 group）, 0.9% saline 500 m L（N500 group） or Gelofusine 500 m L（G500 group） was completed within 30 min, respectively, Propofol（0.5 mg/kg, 1%） was injected at a rate of 0.5 m L/s. A blind investigator assessed the pain using a four-point scale. Incidence of pain in P100, P250, and P500 groups was 87.5%, 57.5% and 35%, respectively（P〈0.05）. The median pain intensity score was significantly lower in P500 group than that in P250 and P100 groups（P〈0.05 and P〈0.01, respectively）. Comparison of the effect of different types of solution preload indicated that the highest incidence of pain was in N500 group（62.5%）（N500 vs. P500, P=0.014; N500 vs. G500, P=0.007）. The median pain intensity score in N500 group was higher than that in P500 group（P〈0.05） and G500 group（P〈0.05）. There was no significant difference between P500 and G500 groups. It is suggested that Plasma-Lyte A or Gelofusine preload with 500 m L before propofol injection is effective in alleviating propofol-induced pain.展开更多
基金supported by National Natural Science Foundation of China(81501515).
文摘Objective:Glucagon-like peptide-1 receptor imaging,using 68Ga-NOTA-exendin-4 is recently established for detecting insulinomas.Owing to the highly radioactive kidneys in 68Ga-NOTA-exendin-4 PET/CT,we aimed to determine the effectiveness of Gelofusine in reducing renal uptake of 68Ga-NOTA-exendin-4.Methods:In our randomized controlled study,patients presenting for 68Ga-NOTA-exendin-4 PET/CT who were18 years and with normal renal function were enrolled,and then randomized into intervention group and control group.Patients in intervention group(group 1)underwent infusion of 500mL Gelofusine prior to PET/CT procedures:patients injected with 68Ga-NOTA-exendin-4(group 1a)immediately after 500mL Gelofusine infusion was completed;(group 1b)at the time point that 250 to 300mL Gelofusine infusion was completed;(group 1c)30minutes after completion of 500mL Gelofusine infusion.The control group(group 2)received 500mL 5%glucose saline instead.PET/CT was then performed,and SUVs of the kidneys and insulinomas were measured.Results:A total of 28 patients were recruited.There were 7 patients(14 kidneys)in each subgroup.The age,body weight,BMI,renal function,injected 68Ga-exendin-4 activity,and interval between injection of the tracer and PET/CT scan were not significantly different among the groups(P>.05).The average and maximum SUVs in the kidneys were significantly reduced in patients of intervention group compared with the control subjects(P<.0001),and the renal uptake could be decreased by 57%with Gelofusine pretreatment.No significant difference in the renal radioactivity was found among group 1a,1b,and 1c(P=.071).The uptake of insulinomas was not significantly different between the intervention and control groups.Conclusion:Renal uptake of 68Ga-exendin-4 can be effectively reduced by pretreatment with Gelofusine.Abbreviations:GLP-1R=Glucagon-like peptide-1 receptor;PRRT=peptide receptor radionuclide therapy;PET=positron emission tomography;SUV=standard uptake value.
文摘Injection pain of propofol remains a common clinical problem. Previous studies demonstrated that propofol injection pain was alleviated by applying nitroglycerin ointment to the skin of injection site, which inspires us to test whether venous vasodilation induced by fluid preload could alleviate the pain. Different types or volumes of fluid preload were compared. 200 ASA Ⅰ-Ⅱ adult patients were randomly assigned to five groups of 40 each. A 20 G cannula was established on the dorsum or wrist of the hand. When fluid preload given with Plasma-Lyte A 100 m L（P100 group）, 250 m L（P250 group）, 500 m L（P500 group）, 0.9% saline 500 m L（N500 group） or Gelofusine 500 m L（G500 group） was completed within 30 min, respectively, Propofol（0.5 mg/kg, 1%） was injected at a rate of 0.5 m L/s. A blind investigator assessed the pain using a four-point scale. Incidence of pain in P100, P250, and P500 groups was 87.5%, 57.5% and 35%, respectively（P〈0.05）. The median pain intensity score was significantly lower in P500 group than that in P250 and P100 groups（P〈0.05 and P〈0.01, respectively）. Comparison of the effect of different types of solution preload indicated that the highest incidence of pain was in N500 group（62.5%）（N500 vs. P500, P=0.014; N500 vs. G500, P=0.007）. The median pain intensity score in N500 group was higher than that in P500 group（P〈0.05） and G500 group（P〈0.05）. There was no significant difference between P500 and G500 groups. It is suggested that Plasma-Lyte A or Gelofusine preload with 500 m L before propofol injection is effective in alleviating propofol-induced pain.
