The use of ＂bath salts＂ or other new psychoactive substances,otherwise known as ＂legal highs＂,is increasing.Illicit drug use during pregnancy is not uncommon.Nevertheless,literature reporting bath salts and their ...The use of ＂bath salts＂ or other new psychoactive substances,otherwise known as ＂legal highs＂,is increasing.Illicit drug use during pregnancy is not uncommon.Nevertheless,literature reporting bath salts and their effect on pregnancy is scant.Besides,there seems to be no literature about bath salts and conduct of general anesthesia.This case report describes a general anesthetic for the surgical delivery of an infant to a woman under the acute influence of bath salts and methamphetamines.展开更多
Due to the huge amount of increasing data, the requirements of people forelectronic products such as mobile phones, tablets, and notebooks are constantlyimproving. The development and design of various software applic...Due to the huge amount of increasing data, the requirements of people forelectronic products such as mobile phones, tablets, and notebooks are constantlyimproving. The development and design of various software applications attach greatimportance to users’ experiences. The rationalized UI design should allow a user not onlyenjoy the visual design experience of the new product but also operating it morepleasingly. This process is to enhance the attractiveness and performance of the newproduct and thus to promote the active usage and consuming conduct of users. In thispaper, an UI design optimization strategy for general APP in the big data environment isproposed to get better user experience while effectively obtaining information. Anexperimental example of a library APP is designed to optimize the user experience. Theexperimental results show that the user-centered UI design is the core of optimization,and user portrait based on big data platforms is the key to UI design.展开更多
A large amount of genome-wide association study(GWAS)panels together with quantitative-trait locus(QTL)information associated with breeding-targeted traits have been described in wheat(Triticum aestivum L.).However,th...A large amount of genome-wide association study(GWAS)panels together with quantitative-trait locus(QTL)information associated with breeding-targeted traits have been described in wheat(Triticum aestivum L.).However,the application of mapping results from a GWAS panel to conventional wheat breeding remains a challenge.In this study,we first report a general genetic map which was constructed from 44 published linkage maps.It permits the estimation of genetic distances between any two genetic loci with physical map positions,thereby unifying the linkage relationships between QTL,genes,and genomic markers from multiple genetic populations.Second,we describe QTL mapping in a wheat GWAS panel of 688 accessions,identifying 77 QTL associated with 12 yield and grain-quality traits.Because these QTL have known physical map positions,they could be mapped onto the general map.Finally,we present a design approach to wheat breeding by using known QTL information and computer simulation.Potential crosses between parents in the GWAS panel may be evaluated by the relative frequency of the target genotype,trait correlations in simulated progeny populations,and genetic gain of selected progenies.It is possible to simultaneously improve yield and grain quality by suitable parental selection,progeny population size,and progeny selection scheme.Applying the design approach will allow identifying the most promising crosses and selection schemes in advance of the field experiment,increasing predictability and efficiency in wheat breeding.展开更多
EPC general contract project includes design, procurement, construction and other links. The quota design in the design link is the first procedure of EPC general contract project. It is a major measure of cost contro...EPC general contract project includes design, procurement, construction and other links. The quota design in the design link is the first procedure of EPC general contract project. It is a major measure of cost control in the design stage, and also the key to control investment and determine the success or failure of the whole project, playing a crucial role in the whole project. By analyzing the role of quota design in EPC general contract project and related control means and determining the target value from the quota design, the design is constantly improved and optimized in each stage to avoid investment risks and misunderstandings, and the effectiveness of quota design in the whole EPC general contract project is effectively improved to increase its internal application value and comprehensively improve the level of project investment control and management, thereby consolidating the core competitiveness of EPC general contract project in the whole market competition.展开更多
In 1907, aviation pioneer Santos-Dumont had the idea of building a very light airplane. He designed and built the SD 19, the Demoiselle, an aircraft with a 6 meter wing span and a 24 HP engine of his own design. The D...In 1907, aviation pioneer Santos-Dumont had the idea of building a very light airplane. He designed and built the SD 19, the Demoiselle, an aircraft with a 6 meter wing span and a 24 HP engine of his own design. The Demoiselle was very successful in flying and, became very popular and its development continued as SD20, SD21 and SD22 （his last airplane）. The influence of the Demoiselle on design principles of light aircraft and general aviation were studied in this work, using statistical entropy, The designs number 20 and 22 may be considered dominant and influenced the design principles of light aircraft and general aviation.展开更多
Fractional factorial split-plot design has been widely used in many fields due to its advantage of saving experimental cost. The general minimum lower order confounding criterion is usually used as one of the attracti...Fractional factorial split-plot design has been widely used in many fields due to its advantage of saving experimental cost. The general minimum lower order confounding criterion is usually used as one of the attractive design criterion for selecting fractional factorial split-plot design. In this paper, we are interested in the theoretical construction methods of the optimal fractional factorial split-plot designs under the general minimum lower order confounding criterion. We present the theoretical construction methods of optimal fractional factorial split-plot designs under general minimum lower order confounding criterion under several conditions.展开更多
试验旨在优化复合酶协同超声水提醇沉法制备黄精粗多糖(crude polysaccharide of po⁃lygahatous,CPP)的工艺并检测其体外抗氧化活性。试验以质量源于设计(qulity by design,QbD)理念为指导,以黄精多糖得率和含量为指标,应用Box-Behnken...试验旨在优化复合酶协同超声水提醇沉法制备黄精粗多糖(crude polysaccharide of po⁃lygahatous,CPP)的工艺并检测其体外抗氧化活性。试验以质量源于设计(qulity by design,QbD)理念为指导,以黄精多糖得率和含量为指标,应用Box-Behnken响应面设计法(BBD)对CPP制备工艺的关键因素:酶解温度、加酶量、超声时间、醇沉浓度进行优化;以维生素C(Vitamin C,VC)为对照,对CPP进行1,1-二苯基-2-三硝基苯肼(1,1-Diphenyl-2-picrylhydrazyl,DPPH)自由基和羟基(·OH)自由基清除能力的检测,评价CPP体外抗氧化活性。结果表明:CPP最佳制备工艺为酶解温度55℃,复合酶(纤维素酶∶果胶酶=1∶1)用量0.28%,超声时间50 min,醇沉浓度78%;采用该制备工艺,CPP的得率为(28.12±1.43)%,多糖含量为(33.74±1.32)%。不同浓度CPP能够有效清除DPPH自由基和抑制·OH的产生。由此可见,优化的CPP制备工艺稳定可行,且所制得的CPP具有一定的体外抗氧化活性。展开更多
文摘The use of ＂bath salts＂ or other new psychoactive substances,otherwise known as ＂legal highs＂,is increasing.Illicit drug use during pregnancy is not uncommon.Nevertheless,literature reporting bath salts and their effect on pregnancy is scant.Besides,there seems to be no literature about bath salts and conduct of general anesthesia.This case report describes a general anesthetic for the surgical delivery of an infant to a woman under the acute influence of bath salts and methamphetamines.
基金Hunan Provincial Education Science 13th Five-Year Plan (Grant No.XJK016BXX001)Social Science Foundation of Hunan Province (Grant No.17YBA049)+1 种基金Open Foundation for the University Innovation Platform in the HunanProvince, grant number 16K013. This research work is implemented at the 2011Collaborative Innovation Center for Development and Utilization of Finance andEconomics Big Data Property, Universities of Hunan Province. Open project (Grant Nos.20181901CRP03, 20181901CRP04, 20181901CRP05)National Social Science Fund Project: Research on the Impact Mechanism of China’sCapital Space Flow on Regional Economic Development (Project No. 14BJL086).
文摘Due to the huge amount of increasing data, the requirements of people forelectronic products such as mobile phones, tablets, and notebooks are constantlyimproving. The development and design of various software applications attach greatimportance to users’ experiences. The rationalized UI design should allow a user not onlyenjoy the visual design experience of the new product but also operating it morepleasingly. This process is to enhance the attractiveness and performance of the newproduct and thus to promote the active usage and consuming conduct of users. In thispaper, an UI design optimization strategy for general APP in the big data environment isproposed to get better user experience while effectively obtaining information. Anexperimental example of a library APP is designed to optimize the user experience. Theexperimental results show that the user-centered UI design is the core of optimization,and user portrait based on big data platforms is the key to UI design.
基金the Hainan Yazhou Bay Seed Laboratory(B21Y10209 and B22C10212)China Postdoctoral Science Foundation(2022M713433)+1 种基金National Natural Science Foundation of China(31861143003)Innovation Program of Chinese Academy of Agricultural Sciences.
文摘A large amount of genome-wide association study(GWAS)panels together with quantitative-trait locus(QTL)information associated with breeding-targeted traits have been described in wheat(Triticum aestivum L.).However,the application of mapping results from a GWAS panel to conventional wheat breeding remains a challenge.In this study,we first report a general genetic map which was constructed from 44 published linkage maps.It permits the estimation of genetic distances between any two genetic loci with physical map positions,thereby unifying the linkage relationships between QTL,genes,and genomic markers from multiple genetic populations.Second,we describe QTL mapping in a wheat GWAS panel of 688 accessions,identifying 77 QTL associated with 12 yield and grain-quality traits.Because these QTL have known physical map positions,they could be mapped onto the general map.Finally,we present a design approach to wheat breeding by using known QTL information and computer simulation.Potential crosses between parents in the GWAS panel may be evaluated by the relative frequency of the target genotype,trait correlations in simulated progeny populations,and genetic gain of selected progenies.It is possible to simultaneously improve yield and grain quality by suitable parental selection,progeny population size,and progeny selection scheme.Applying the design approach will allow identifying the most promising crosses and selection schemes in advance of the field experiment,increasing predictability and efficiency in wheat breeding.
文摘EPC general contract project includes design, procurement, construction and other links. The quota design in the design link is the first procedure of EPC general contract project. It is a major measure of cost control in the design stage, and also the key to control investment and determine the success or failure of the whole project, playing a crucial role in the whole project. By analyzing the role of quota design in EPC general contract project and related control means and determining the target value from the quota design, the design is constantly improved and optimized in each stage to avoid investment risks and misunderstandings, and the effectiveness of quota design in the whole EPC general contract project is effectively improved to increase its internal application value and comprehensively improve the level of project investment control and management, thereby consolidating the core competitiveness of EPC general contract project in the whole market competition.
文摘In 1907, aviation pioneer Santos-Dumont had the idea of building a very light airplane. He designed and built the SD 19, the Demoiselle, an aircraft with a 6 meter wing span and a 24 HP engine of his own design. The Demoiselle was very successful in flying and, became very popular and its development continued as SD20, SD21 and SD22 （his last airplane）. The influence of the Demoiselle on design principles of light aircraft and general aviation were studied in this work, using statistical entropy, The designs number 20 and 22 may be considered dominant and influenced the design principles of light aircraft and general aviation.
文摘Fractional factorial split-plot design has been widely used in many fields due to its advantage of saving experimental cost. The general minimum lower order confounding criterion is usually used as one of the attractive design criterion for selecting fractional factorial split-plot design. In this paper, we are interested in the theoretical construction methods of the optimal fractional factorial split-plot designs under the general minimum lower order confounding criterion. We present the theoretical construction methods of optimal fractional factorial split-plot designs under general minimum lower order confounding criterion under several conditions.
文摘试验旨在优化复合酶协同超声水提醇沉法制备黄精粗多糖(crude polysaccharide of po⁃lygahatous,CPP)的工艺并检测其体外抗氧化活性。试验以质量源于设计(qulity by design,QbD)理念为指导,以黄精多糖得率和含量为指标,应用Box-Behnken响应面设计法(BBD)对CPP制备工艺的关键因素:酶解温度、加酶量、超声时间、醇沉浓度进行优化;以维生素C(Vitamin C,VC)为对照,对CPP进行1,1-二苯基-2-三硝基苯肼(1,1-Diphenyl-2-picrylhydrazyl,DPPH)自由基和羟基(·OH)自由基清除能力的检测,评价CPP体外抗氧化活性。结果表明:CPP最佳制备工艺为酶解温度55℃,复合酶(纤维素酶∶果胶酶=1∶1)用量0.28%,超声时间50 min,醇沉浓度78%;采用该制备工艺,CPP的得率为(28.12±1.43)%,多糖含量为(33.74±1.32)%。不同浓度CPP能够有效清除DPPH自由基和抑制·OH的产生。由此可见,优化的CPP制备工艺稳定可行,且所制得的CPP具有一定的体外抗氧化活性。
