Significant progress has been made in computational imaging(CI),in which deep convolutional neural networks(CNNs)have demonstrated that sparse speckle patterns can be reconstructed.However,due to the limited“local”k...Significant progress has been made in computational imaging(CI),in which deep convolutional neural networks(CNNs)have demonstrated that sparse speckle patterns can be reconstructed.However,due to the limited“local”kernel size of the convolutional operator,for the spatially dense patterns,such as the generic face images,the performance of CNNs is limited.Here,we propose a“non-local”model,termed the Speckle-Transformer(SpT)UNet,for speckle feature extraction of generic face images.It is worth noting that the lightweight SpT UNet reveals a high efficiency and strong comparative performance with Pearson Correlation Coefficient(PCC),and structural similarity measure(SSIM)exceeding 0.989,and 0.950,respectively.展开更多
Dasatinib is a second-generation tyrosine kinase inhibitor (TKI)and it could be used as a second-line treatment for patients with chronic myeloid leukemia (CML).Yinishu,a generic dasatinib made in China,was approved b...Dasatinib is a second-generation tyrosine kinase inhibitor (TKI)and it could be used as a second-line treatment for patients with chronic myeloid leukemia (CML).Yinishu,a generic dasatinib made in China,was approved by the China Food and Drug Administration in 2013 and it costs much less than the patented dasatinib SPRYCEL.The present study aimed to examine the efficacy and safety of Yinishu as a second-line treatment for CML by comparing the baseline clinical characteristics,rates of adverse events and efficacy between Yinishu and SPRYCEL groups. The results showed that there were no significant differences in the rates of optimal response between Yinishu and SPRYCEL for patients who started second-line treatment because of treatment failure.For patients who started second-line treatment because of intolerance of first-line treatment, their levels of BCR-ABL1/ABL1 on the international scale (BCR-ABL^IS)was maintained very low throughout the course of Yinishu treatment.Drug-related adverse events occurred with the same frequency in these two groups.It was confirmed that Yinishu was effective and safe as a second- line treatment for CML patients.Yinishu may be more suitable for patients who are economically unable to pay for the patented dasatinib SPRYCEL.展开更多
In this paper, we report the results of quality control based in pbysicochemical characteriza- tion and impurities determination of three samples of fluconazole drug substances marketed in Morocco. These samples were ...In this paper, we report the results of quality control based in pbysicochemical characteriza- tion and impurities determination of three samples of fluconazole drug substances marketed in Morocco. These samples were supplied by different pharmaceuticals companies. The sample A, as the discovered product, was supplied by Pfizer, while samples B and C (generics), were manufactured by two different Indian industries. Solid-state characterization of the three samples was realized with different physicochemical methods as: X-ray powder diffraction, Fourier-transformation infrared spectroscopy, differential scanning calorimetry. High performance liquid chromatography was used to quantify the impurities in the different samples. The results from the physicochemical methods cited above, showed difference in polymorph structure of the three drug substances. Sample A consisted in pure polymorph II1, sample B consisted in pure polymorph I1, sample C consisted in a mixture of fluconazole Form Ili, form II and the monohydrate. This result was confirmed by differential scanning calorimetry. Also it was demonstrated that solvents used during the re-crystallization step were among the origins of these differences in the structure form. On the other hand, the result of the stability study under humidity and temperature showed that fluconazole polymorphic transformation could be owed to the no compliance with the conditions of storage. The HPLC analysis of these compounds showed the presence of specific展开更多
This paper presents a generalization of the authors' earlier work. In this paper, the two concepts, generic regular decomposition (GRD) and regular-decomposition-unstable (RDU) variety introduced in the authors'...This paper presents a generalization of the authors' earlier work. In this paper, the two concepts, generic regular decomposition (GRD) and regular-decomposition-unstable (RDU) variety introduced in the authors' previous work for generic zero-dimensional systems, are extended to the case where the parametric systems are not necessarily zero-dimensional. An algorithm is provided to compute GRDs and the associated RDU varieties of parametric systems simultaneously on the basis of the algorithm for generic zero-dimensional systems proposed in the authors' previous work. Then the solutions of any parametric system can be represented by the solutions of finitely many regular systems and the decomposition is stable at any parameter value in the complement of the associated RDU variety of the parameter space. The related definitions and the results presented in the authors' previous work are also generalized and a further discussion on RDU varieties is given from an experimental point of view. The new algorithm has been implemented on the basis of DISCOVERER with Maple 16 and experimented with a number of benchmarks from the literature.展开更多
Rock mass classification(RMC) is of critical importance in support design and applications to mining,tunneling and other underground excavations. Although a number of techniques are available, there exists an uncertai...Rock mass classification(RMC) is of critical importance in support design and applications to mining,tunneling and other underground excavations. Although a number of techniques are available, there exists an uncertainty in application to complex underground works. In the present work, a generic rock mass rating(GRMR) system is developed. The proposed GRMR system refers to as most commonly used techniques, and two rock load equations are suggested in terms of GRMR, which are based on the fact that whether all the rock parameters considered by the system have an influence or only few of them are influencing. The GRMR method has been validated with the data obtained from three underground coal mines in India. Then, a semi-empirical model is developed for the GRMR method using artificial neural network(ANN), and it is validated by a comparative analysis of ANN model results with that by analytical GRMR method.展开更多
Objective:Generic drugs provide an opportunity for savings in drug expenditure since they are available at a lower cost and do not affect patients’health.A better understanding of pharmacists’knowledge,attitudes,and...Objective:Generic drugs provide an opportunity for savings in drug expenditure since they are available at a lower cost and do not affect patients’health.A better understanding of pharmacists’knowledge,attitudes,and perception can promote the quality use of generic drugs.The objective of this study was to investigate the knowledge,attitudes,and perception of pharmacists from tertiary hospitals in China regarding generic drugs.Methods:A cross-sectional survey using a postal questionnaire was conducted,which was sent to 200 hospital pharmacists randomly selected from tertiary hospitals in Hubei Province.A total of 125 questionnaires out of 200 were received.Of the respondents,80 were female and 45 were male.Results:The majority of respondents(87.2%)could clearly distinguish between original and generic drugs.Pharmacists agreed that generic drugs were less effective(52.8%)and produced more side effects(52%).Forty-nine respondents thought that generic drug products were not adequately tested.Approximately 78% and 60% of the pharmacists indicated that generic substitution was not feasible for drugs with narrow therapeutic windows and drugs for critical diseases,respectively.Most of them supported the recommendation of generic drugs based on professional judgment.Conclusion:Our study showed that a considerable portion of Chinese hospital pharmacists hold negative perceptions of generic drugs.Interventions to improve pharmacists'knowledge of generic drugs are needed.展开更多
We use Hopf-Lax formula to study local regularity of solution to Hamilton- Jacobi (HJ) equations of multi-dimensional space variables with convex Hamiltonian. Then we give the large time generic form of the solution...We use Hopf-Lax formula to study local regularity of solution to Hamilton- Jacobi (HJ) equations of multi-dimensional space variables with convex Hamiltonian. Then we give the large time generic form of the solution to HJ equation, i.e. for most initial data there exists a constant T 〉 0, which depends only on the Hamiltonian and initial datum, for t 〉 T the solution of the IVP (1.1) is smooth except for ~ smooth n-dimensional hypersurface, across which Du(x, t) is discontinuous. And we show that the hypersurface 1 tends asymptotically to a given hypersurface with rate t-1/4.展开更多
It is well known that calcium channel blockers(CCBs) are the first line of therapy for vasospastic angina(VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from...It is well known that calcium channel blockers(CCBs) are the first line of therapy for vasospastic angina(VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. In both cases, angina recurred upon switching from a brand-name CCB to a generic CCB during follow-up. The patients' condition improved upon switching back to the original CCB. Both cases involved a high severity of VSA, based on the results of spasm provocation testing. These findings suggest that, in some patients with severe VSA, the frequency of angina attacks increases when switching from a brand-name CCB to a generic CCB. Cardiologists should consider this factor when prescribing drugs for angina.展开更多
Calcineurin inhibitors are the cornerstone of solid organ transplant immunosuppression. Tacrolimus has only recently become available in a non-branded formulation, and there is little data on the efficacy and safety o...Calcineurin inhibitors are the cornerstone of solid organ transplant immunosuppression. Tacrolimus has only recently become available in a non-branded formulation, and there is little data on the efficacy and safety of generic tacrolimus, particularly following heart transplant. We performed a retrospective analysis of 21 consecutive patients who were treated with generic tacrolimus following heart transplant and compared rate of biopsy-proven acute cellular rejection to historical controls who were treated with Prograf. No significant difference in biopsy-proven acute cellular rejection was noted between the groups and rates of opportunistic infection and death were comparable. Although limited by the single-center, retrospective design, this preliminary data may be useful to clinicians facing the option of initiating generic tacrolimus following heart transplant.展开更多
In this book new results on controller design techniques for the tracking of generic reference inputs are presented. They allow the design of a controller for an uncertain process, either continuous or discrete-time, ...In this book new results on controller design techniques for the tracking of generic reference inputs are presented. They allow the design of a controller for an uncertain process, either continuous or discrete-time, without zeros, and with measurable state. The controller guarantees that the control system is Type 1 and has the desired constant gain and poles or that the control system tracks, with a specified maximum error and with a specified maximum time constant, a generic reference with bounded derivative (variation in the discrete-time case), also in the presence of a generic disturbance with bounded derivative (variation). In addition, it is considered the case in which the reference is known a priori. The utility and the efficiency of the proposed methods are illustrated with attractive and significant examples of motion control and temperature control. This book is useful for the design of control systems, especially for manufacturing systems, that are versatile, fast, precise and robust.展开更多
《国际功能、残疾与健康分类(international classification of functioning,disability and health,ICF)》由世界卫生组织(WHO)在2001年发布[1],二十多年来,WHO一直致力于ICF在全世界的临床应用,并根据各国反馈推出了ICF的不同版本,包...《国际功能、残疾与健康分类(international classification of functioning,disability and health,ICF)》由世界卫生组织(WHO)在2001年发布[1],二十多年来,WHO一直致力于ICF在全世界的临床应用,并根据各国反馈推出了ICF的不同版本,包括了通用版(ICF generic set,ICF-GS)[2]、核心组合版(ICF core set,ICF-CS)[3]及康复组合版(ICF rehabilitation set,ICF-RS)[4]。展开更多
Recently,generic drug products have played an increasingly important role in the health care system globally,especially in the developing world,as they provide for an effective and more affordable alternative for heal...Recently,generic drug products have played an increasingly important role in the health care system globally,especially in the developing world,as they provide for an effective and more affordable alternative for healthcare professionals.Generic drug products are proven therapeutically equivalent to the corresponding innovator’s product,and hence can be substituted in clinical practice.The objective of generic drug development is to develop a stable and bioequivalent generic drug product with desirable properties in a timely manner.This presentation is intended to summarize three important sequential stages essential for successful generic drug development based on a regulatory experience in reviewing and evaluating the Pharmaceutical Development Section(P2)of the ASEAN Common Technical Dossier(ACTD)of generic drug product applications submitted to the Food and Drug Administration,Thailand[1,2].展开更多
The concept of Fiedler matrices was introduced in [1] by L. Stuart and R.Weaver.In[1], they investigated the factorization of Fiedler matrix into Fiedler matrices and pre-sented some open questions i. e. When is a Fie...The concept of Fiedler matrices was introduced in [1] by L. Stuart and R.Weaver.In[1], they investigated the factorization of Fiedler matrix into Fiedler matrices and pre-sented some open questions i. e. When is a Fiedler matrix factorizable as a product ofFiedler matrices? Are there useful sufficient conditions? If a Fiedler matrix is factorizable,are the factors unique? If not, are the dimensions of the factors unique? In this paper,展开更多
We propose a new description scheme for MPEG-7:Generic-model-based Description Scheme to describe contents of audio, video, text and other sorts of multimedia. It uses a generic model as the description frame, which ...We propose a new description scheme for MPEG-7:Generic-model-based Description Scheme to describe contents of audio, video, text and other sorts of multimedia. It uses a generic model as the description frame, which provides a simple but useful object\|based structure. The main components of the description scheme are generic model, objects and object features. The proposed description scheme is illustrated and exemplified by Extensible Markup Language. It aims at clarity and flexibility to support MPEG\|7 applications such as query and edit. We demonstrate its feasibility and efficiency by presenting applications: Digital Broadcasting and Edit System (DEBS) and Non\|linear Edit System (NLES) that already used the generic structure or will greatly benefit from it.展开更多
基金funding support from the Science and Technology Commission of Shanghai Municipality(Grant No.21DZ1100500)the Shanghai Frontiers Science Center Program(2021-2025 No.20)+2 种基金the Zhangjiang National Innovation Demonstration Zone(Grant No.ZJ2019ZD-005)supported by a fellowship from the China Postdoctoral Science Foundation(2020M671169)the International Postdoctoral Exchange Program from the Administrative Committee of Post-Doctoral Researchers of China([2020]33)。
文摘Significant progress has been made in computational imaging(CI),in which deep convolutional neural networks(CNNs)have demonstrated that sparse speckle patterns can be reconstructed.However,due to the limited“local”kernel size of the convolutional operator,for the spatially dense patterns,such as the generic face images,the performance of CNNs is limited.Here,we propose a“non-local”model,termed the Speckle-Transformer(SpT)UNet,for speckle feature extraction of generic face images.It is worth noting that the lightweight SpT UNet reveals a high efficiency and strong comparative performance with Pearson Correlation Coefficient(PCC),and structural similarity measure(SSIM)exceeding 0.989,and 0.950,respectively.
文摘Dasatinib is a second-generation tyrosine kinase inhibitor (TKI)and it could be used as a second-line treatment for patients with chronic myeloid leukemia (CML).Yinishu,a generic dasatinib made in China,was approved by the China Food and Drug Administration in 2013 and it costs much less than the patented dasatinib SPRYCEL.The present study aimed to examine the efficacy and safety of Yinishu as a second-line treatment for CML by comparing the baseline clinical characteristics,rates of adverse events and efficacy between Yinishu and SPRYCEL groups. The results showed that there were no significant differences in the rates of optimal response between Yinishu and SPRYCEL for patients who started second-line treatment because of treatment failure.For patients who started second-line treatment because of intolerance of first-line treatment, their levels of BCR-ABL1/ABL1 on the international scale (BCR-ABL^IS)was maintained very low throughout the course of Yinishu treatment.Drug-related adverse events occurred with the same frequency in these two groups.It was confirmed that Yinishu was effective and safe as a second- line treatment for CML patients.Yinishu may be more suitable for patients who are economically unable to pay for the patented dasatinib SPRYCEL.
文摘In this paper, we report the results of quality control based in pbysicochemical characteriza- tion and impurities determination of three samples of fluconazole drug substances marketed in Morocco. These samples were supplied by different pharmaceuticals companies. The sample A, as the discovered product, was supplied by Pfizer, while samples B and C (generics), were manufactured by two different Indian industries. Solid-state characterization of the three samples was realized with different physicochemical methods as: X-ray powder diffraction, Fourier-transformation infrared spectroscopy, differential scanning calorimetry. High performance liquid chromatography was used to quantify the impurities in the different samples. The results from the physicochemical methods cited above, showed difference in polymorph structure of the three drug substances. Sample A consisted in pure polymorph II1, sample B consisted in pure polymorph I1, sample C consisted in a mixture of fluconazole Form Ili, form II and the monohydrate. This result was confirmed by differential scanning calorimetry. Also it was demonstrated that solvents used during the re-crystallization step were among the origins of these differences in the structure form. On the other hand, the result of the stability study under humidity and temperature showed that fluconazole polymorphic transformation could be owed to the no compliance with the conditions of storage. The HPLC analysis of these compounds showed the presence of specific
基金supported by by the National Natural Science Foundation of China under Grant Nos.11271034,11290141the Project SYSKF1207 from SKLCS,IOS,the Chinese Academy of Sciences
文摘This paper presents a generalization of the authors' earlier work. In this paper, the two concepts, generic regular decomposition (GRD) and regular-decomposition-unstable (RDU) variety introduced in the authors' previous work for generic zero-dimensional systems, are extended to the case where the parametric systems are not necessarily zero-dimensional. An algorithm is provided to compute GRDs and the associated RDU varieties of parametric systems simultaneously on the basis of the algorithm for generic zero-dimensional systems proposed in the authors' previous work. Then the solutions of any parametric system can be represented by the solutions of finitely many regular systems and the decomposition is stable at any parameter value in the complement of the associated RDU variety of the parameter space. The related definitions and the results presented in the authors' previous work are also generalized and a further discussion on RDU varieties is given from an experimental point of view. The new algorithm has been implemented on the basis of DISCOVERER with Maple 16 and experimented with a number of benchmarks from the literature.
基金an outcome of the Network project(Project No.ESC0303)of CSIR,New Delhi,India
文摘Rock mass classification(RMC) is of critical importance in support design and applications to mining,tunneling and other underground excavations. Although a number of techniques are available, there exists an uncertainty in application to complex underground works. In the present work, a generic rock mass rating(GRMR) system is developed. The proposed GRMR system refers to as most commonly used techniques, and two rock load equations are suggested in terms of GRMR, which are based on the fact that whether all the rock parameters considered by the system have an influence or only few of them are influencing. The GRMR method has been validated with the data obtained from three underground coal mines in India. Then, a semi-empirical model is developed for the GRMR method using artificial neural network(ANN), and it is validated by a comparative analysis of ANN model results with that by analytical GRMR method.
基金supported by the National Natural Science Foundation of China(No.71373089).
文摘Objective:Generic drugs provide an opportunity for savings in drug expenditure since they are available at a lower cost and do not affect patients’health.A better understanding of pharmacists’knowledge,attitudes,and perception can promote the quality use of generic drugs.The objective of this study was to investigate the knowledge,attitudes,and perception of pharmacists from tertiary hospitals in China regarding generic drugs.Methods:A cross-sectional survey using a postal questionnaire was conducted,which was sent to 200 hospital pharmacists randomly selected from tertiary hospitals in Hubei Province.A total of 125 questionnaires out of 200 were received.Of the respondents,80 were female and 45 were male.Results:The majority of respondents(87.2%)could clearly distinguish between original and generic drugs.Pharmacists agreed that generic drugs were less effective(52.8%)and produced more side effects(52%).Forty-nine respondents thought that generic drug products were not adequately tested.Approximately 78% and 60% of the pharmacists indicated that generic substitution was not feasible for drugs with narrow therapeutic windows and drugs for critical diseases,respectively.Most of them supported the recommendation of generic drugs based on professional judgment.Conclusion:Our study showed that a considerable portion of Chinese hospital pharmacists hold negative perceptions of generic drugs.Interventions to improve pharmacists'knowledge of generic drugs are needed.
基金supported by National Natural Science Foundation of China (10871133,11071246 and 11101143)Fundamental Research Funds of the Central Universities (09QL48)
文摘We use Hopf-Lax formula to study local regularity of solution to Hamilton- Jacobi (HJ) equations of multi-dimensional space variables with convex Hamiltonian. Then we give the large time generic form of the solution to HJ equation, i.e. for most initial data there exists a constant T 〉 0, which depends only on the Hamiltonian and initial datum, for t 〉 T the solution of the IVP (1.1) is smooth except for ~ smooth n-dimensional hypersurface, across which Du(x, t) is discontinuous. And we show that the hypersurface 1 tends asymptotically to a given hypersurface with rate t-1/4.
文摘It is well known that calcium channel blockers(CCBs) are the first line of therapy for vasospastic angina(VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. In both cases, angina recurred upon switching from a brand-name CCB to a generic CCB during follow-up. The patients' condition improved upon switching back to the original CCB. Both cases involved a high severity of VSA, based on the results of spasm provocation testing. These findings suggest that, in some patients with severe VSA, the frequency of angina attacks increases when switching from a brand-name CCB to a generic CCB. Cardiologists should consider this factor when prescribing drugs for angina.
文摘Calcineurin inhibitors are the cornerstone of solid organ transplant immunosuppression. Tacrolimus has only recently become available in a non-branded formulation, and there is little data on the efficacy and safety of generic tacrolimus, particularly following heart transplant. We performed a retrospective analysis of 21 consecutive patients who were treated with generic tacrolimus following heart transplant and compared rate of biopsy-proven acute cellular rejection to historical controls who were treated with Prograf. No significant difference in biopsy-proven acute cellular rejection was noted between the groups and rates of opportunistic infection and death were comparable. Although limited by the single-center, retrospective design, this preliminary data may be useful to clinicians facing the option of initiating generic tacrolimus following heart transplant.
文摘In this book new results on controller design techniques for the tracking of generic reference inputs are presented. They allow the design of a controller for an uncertain process, either continuous or discrete-time, without zeros, and with measurable state. The controller guarantees that the control system is Type 1 and has the desired constant gain and poles or that the control system tracks, with a specified maximum error and with a specified maximum time constant, a generic reference with bounded derivative (variation in the discrete-time case), also in the presence of a generic disturbance with bounded derivative (variation). In addition, it is considered the case in which the reference is known a priori. The utility and the efficiency of the proposed methods are illustrated with attractive and significant examples of motion control and temperature control. This book is useful for the design of control systems, especially for manufacturing systems, that are versatile, fast, precise and robust.
文摘Recently,generic drug products have played an increasingly important role in the health care system globally,especially in the developing world,as they provide for an effective and more affordable alternative for healthcare professionals.Generic drug products are proven therapeutically equivalent to the corresponding innovator’s product,and hence can be substituted in clinical practice.The objective of generic drug development is to develop a stable and bioequivalent generic drug product with desirable properties in a timely manner.This presentation is intended to summarize three important sequential stages essential for successful generic drug development based on a regulatory experience in reviewing and evaluating the Pharmaceutical Development Section(P2)of the ASEAN Common Technical Dossier(ACTD)of generic drug product applications submitted to the Food and Drug Administration,Thailand[1,2].
基金This work is supported by the Natural Scientific Research Foundation of Yunnan Province(200A0001--1M)the Scientific Research Foundation of Education Commission of Yunnan Province(9911126)
文摘The concept of Fiedler matrices was introduced in [1] by L. Stuart and R.Weaver.In[1], they investigated the factorization of Fiedler matrix into Fiedler matrices and pre-sented some open questions i. e. When is a Fiedler matrix factorizable as a product ofFiedler matrices? Are there useful sufficient conditions? If a Fiedler matrix is factorizable,are the factors unique? If not, are the dimensions of the factors unique? In this paper,
文摘We propose a new description scheme for MPEG-7:Generic-model-based Description Scheme to describe contents of audio, video, text and other sorts of multimedia. It uses a generic model as the description frame, which provides a simple but useful object\|based structure. The main components of the description scheme are generic model, objects and object features. The proposed description scheme is illustrated and exemplified by Extensible Markup Language. It aims at clarity and flexibility to support MPEG\|7 applications such as query and edit. We demonstrate its feasibility and efficiency by presenting applications: Digital Broadcasting and Edit System (DEBS) and Non\|linear Edit System (NLES) that already used the generic structure or will greatly benefit from it.