120 pearl oysters (Pinctada martensii) were randomly sampled from F1 population, and shell length, shell width, shell height, shell weight and total weight of each sample were measured. Correlation and path analysis...120 pearl oysters (Pinctada martensii) were randomly sampled from F1 population, and shell length, shell width, shell height, shell weight and total weight of each sample were measured. Correlation and path analysis were conducted on the basis of measurement data. The results showed that shell length, shell width, shell height, shell weight and total weight were significantly correlated (P 〈 0.05). Total weight was significantly and positively correlated with shell weight (r = 0.8970), shell height (r = 0.6974), shell width (r = 0.6521) and shell length (r = 0.5486). Shell weight, shell height, shell width and shell length had positive and direct effects on total wet weight, with the values of 0.6356, 0.1872, 0.1814 and 0.0599, respectively. The results indicated that growth traits (shell length, shell width, shell height, shell weight and total wet weigh) of the F1 population could be improved by direct or indirect selection.展开更多
[Objective] This study was tween yield-related traits and yield of conducted to understand the relationship be- Yunmai 52 which is a high-quality high-yield multi-resistant new wheat variety, and make contribution of ...[Objective] This study was tween yield-related traits and yield of conducted to understand the relationship be- Yunmai 52 which is a high-quality high-yield multi-resistant new wheat variety, and make contribution of yield-related traits to the yield of Yunmai 52 clear. [Method] Wheat variety regional trial data in Yunnan Province in 2005-2007 were subjected to correlation analysis and path analysis in the paper. [Result] Correlationanalysis showed that the yield of Yunmai 52 was in- very significant positive correlation with spikelet number per ear, maximum tiller number and grains per ear (r=0.726^**, 0.717^** and 0.695^**, respectively), in signif- icant positive correlation with 1 000-grain weight (r=0.491^*), but in significant nega- tive correlation with sterile spikelet number per ear, and in non-significant correlation with basic seedlings, effective ears and percentage of ear bearing tillers. Partial correlation analysis showed that the yield of Yunmai 52 was in very significant posi- tive correlation with spikelet number per ear (r=0.711^**), significant positive correla- tion with 1 000-grain weight (r=0.641 =), but in non-significant correlation with other 6 traits. Path analysis showed that spikelet number per ear (P=-0.595), maximum tiller number (P=0.462) and t 000-grain weight (P=0.263) had more contribution to yield of Yunmai 52. [Conclusion] Therefore, in extension and application of Yunmal 52 that is a high-quality high-yield multi-resistant new wheat variety, supply of fertilizer and water should be increased in tillering stage and jointing stage, to ensure its characteristics of high tilledng ability and large ear, as well as high 1 000-grain weight, and coordinated development of other yield-related traits is beneficial to im- provement of yield of Yunmai 52.展开更多
Using correlation and path analysis, the genetic correlation between weight traits and morphological traits was determined in the marine gastropod Glossaulax reiniana. A total of 100 G. reiniana individuals from a wil...Using correlation and path analysis, the genetic correlation between weight traits and morphological traits was determined in the marine gastropod Glossaulax reiniana. A total of 100 G. reiniana individuals from a wild population were used. Shell width (X1), shell height (X2), umbo-callus height (X3), body width (X4), operculum length (X5), operculum width (X6), body weight (Y1) and soft-tissue weight (Y2) were measured, and the correlation coefficient matrix calculated. Morphological traits were used as independent variables and weight traits as dependent variables for path coefficient analysis. Path coefficients, correlation indices and determination coefficients were also determined. Results indicate that the correlation coefficients associated with each morphological and weight trait were all highly significant (P〈0.01). After deleting redundant independent variables, the following optimum multiple regression equations were obtained using stepwise multiple regression analysis: Y1=-29.317+0.362X2+0.349X4+ 1.190)(5 for body weight; and Y2=-17.292+0.166X1+0.171X2+0.703X5, for soft-tissue weight. Operculum height had the highest positive direct correlation with both body weight and soft-tissue weight, which was in accordance with the test results obtained from determinate coefficient analysis. The indication of high genetic correlations between weight traits and morphological traits will provide valuable information for G. reiniana breeding programs.展开更多
Hubei Province is one of the critical grain production regions in China with the quantitative cultivated landand good natural condition; it plays an important role in grain security in China. However, owing to rapid e...Hubei Province is one of the critical grain production regions in China with the quantitative cultivated landand good natural condition; it plays an important role in grain security in China. However, owing to rapid economicgrowth, population pressures, anthropogenic activities, and natural disasters, the quality of the cultivated land hassignificantly decreased in recent years and environmental resources are under increasing stress. In order to research onthe mechanism of the change of the cultivated land, this paper analyzes qualitatively the influencing factors of thecultivated land change in Hubei Province from 1978 to 2004, and distinguishes the direct factors from indirect influentones by means of the approach of the path analysis. The result shows that the area of the rent land in the total non-agricultural land, the total population growth and the fixed asset investment are the main factors deciding the change ofthe cultivated land. Meanwhile, the density of the transportation network, the proportion of per capita income of ruralcitizens to that of urban citizens, non-agricultural gross domestic production’s share of the total GDP has a less directeffect but a more indirect influence on the decrease of the cultivated land in Hubei Province. The result means that whilesome factors have less direct influence on the change of the cultivated land, its indirect influence are significant, viceversa. Thus it’s necessary to adopt a comprehensive measurement to protect the cultivated land.展开更多
Correlation power analysis(CPA)combined with genetic algorithms(GA)now achieves greater attack efficiency and can recover all subkeys simultaneously.However,two issues in GA-based CPA still need to be addressed:key de...Correlation power analysis(CPA)combined with genetic algorithms(GA)now achieves greater attack efficiency and can recover all subkeys simultaneously.However,two issues in GA-based CPA still need to be addressed:key degeneration and slow evolution within populations.These challenges significantly hinder key recovery efforts.This paper proposes a screening correlation power analysis framework combined with a genetic algorithm,named SFGA-CPA,to address these issues.SFGA-CPA introduces three operations designed to exploit CPA characteris-tics:propagative operation,constrained crossover,and constrained mutation.Firstly,the propagative operation accelerates population evolution by maximizing the number of correct bytes in each individual.Secondly,the constrained crossover and mutation operations effectively address key degeneration by preventing the compromise of correct bytes.Finally,an intelligent search method is proposed to identify optimal parameters,further improving attack efficiency.Experiments were conducted on both simulated environments and real power traces collected from the SAKURA-G platform.In the case of simulation,SFGA-CPA reduces the number of traces by 27.3%and 60%compared to CPA based on multiple screening methods(MS-CPA)and CPA based on simple GA method(SGA-CPA)when the success rate reaches 90%.Moreover,real experimental results on the SAKURA-G platform demonstrate that our approach outperforms other methods.展开更多
In April of 2006, a base population of the noble scallop Chlamys nobilis was established by collecting parental breeders from the stocks in Wushi, Zhanjiang. In December of 2006, 200 individuals were randomly sampled ...In April of 2006, a base population of the noble scallop Chlamys nobilis was established by collecting parental breeders from the stocks in Wushi, Zhanjiang. In December of 2006, 200 individuals were randomly sampled from the base population and subjected for correlation and path coefficient analysis. It was found that there were statistically significant phenotypic correlations among the traits (P 〈 0.01). Total weight was significantly and positively correlated with the shell length (r = 0.934 3), shell height (r = 0.895 9), shell width (r = 0.899 1 ), muscle weight (r = 0.882 0) and shell weight (r = 0.937 9), respectively. Shell length, shell width, muscle weight, shell height and shell weight had positive and direct effects on the total weight, with values of 0.397 1, 0.321 9, 0.172 1, 0.089 6 and 0.066 9, respectively. Shell length, shell width and muscle weight had higher direct effects on the total weight than shell height and shell weight. A combined evaluation of correlation, direct effects and indirect effects showed that direct selection for shell length, shell width, muscle weight, shell height and shell weight would be effective to improving the total weight. It was concluded that these traits could be regarded as the selection criteria in breeding programs of the species.展开更多
Correlation and path coefficient analyses were conducted for 10 characteristics of 24 pure lines of flue-cured tobacco such as plant height, knot distance, leaf number, the central leaf length and width, ratio of the ...Correlation and path coefficient analyses were conducted for 10 characteristics of 24 pure lines of flue-cured tobacco such as plant height, knot distance, leaf number, the central leaf length and width, ratio of the length to width, stem girth, dates of budding, leaf yield and ratio of the prime-medium tobacco. The leaf number and the central leaf length showed a positive or a strong positive correlation with the yield per plant. And the leaf number and leaf yield per plant showed a strong positive correlation with the ratio of prime-medium tobacco. The results showed that the leaf yield per plant among these characteristics played a major role in determining the ratio of prime-medium tobacco while the others were less related with the ratio. Square sum of deviation method cluster analyses showed that 24 pure lines of flue-cured tobacco were clustered into two groups. Of the pure lines, Line T1706 and Line T1245 had a far relationship with all other lines, and also had a heterosis when crossed with the other lines. Lines Guangdonghuang 1 and R72(3)B-2-1 were closely related.展开更多
Understanding the variation for the expressionof genes in different environments is one of themajor goals in qualitative genetics. In this pa-per, the genetic models for quantitative traitsof endosperm in cereal crops...Understanding the variation for the expressionof genes in different environments is one of themajor goals in qualitative genetics. In this pa-per, the genetic models for quantitative traitsof endosperm in cereal crops were used to eval-uate the seed, cytoplasm and maternal geneticeffects as well as the genotype × environment(GE) interaction effects, and to predict thebreeding value of parents and genotypic corre-lation for nutrient quality traits of indica rice (Oryza sativa L.).展开更多
[Objective] The experiment aimed to study the relation between yield components and yield per plant of double-low hybrid rapeseed and provide reference for breaking yield limitation of rapeseed and culturing new doubl...[Objective] The experiment aimed to study the relation between yield components and yield per plant of double-low hybrid rapeseed and provide reference for breaking yield limitation of rapeseed and culturing new double-low hybrid rapeseed variety. [Method]The yield components and yield per plant of two cross combination of double-low hybrid rapeseed (B02, D04) and Shuza 6 were correlatively analyzed and compared, besides, the path analysis was also carried on to them. [Result] Among B02, D04 and Shuza No.6, effective pod number per plant and seeds per silique, seeds per pod and 1 000-grain weight were all negative correlation. In high yield hybrid, pod number per plant, seeds per pod had more impaction on yield per plant than 1 000-grain weight and the difference was at 0.01 significant level. In the control variety Shuza No.6, the impactions of pod number per plant and seeds per pod on yield per plant were bigger than that of 1 000-grain weight on yield per plant, however, the difference was not significant. [Conclusion] The improvement of effective pod number per plant was an important aim of breeding work of double low rapeseed breeding in Sichuan ecological region.展开更多
This study was designed to analyze the genetic relationship of the morphological traits of the northern japonica hybrid rice. The genetic relationship of the morphological traits of the 100 cultivars combined by the 1...This study was designed to analyze the genetic relationship of the morphological traits of the northern japonica hybrid rice. The genetic relationship of the morphological traits of the 100 cultivars combined by the 10 sterile lines and the 10 restore lines was studied by using the principle component analysis and the SAS and QGA. The results showed that compared with the female parent, most of the morphological traits related closely to their father. The additive genetic effect and the dominant genetic effect appeared significantly, and the former was more significant than the latter. Genetic correlation analysis indicated that high plants or high plants with more leaves were in favor of improving the number and the weight of the spike and producing the hybrid vigor. The important factors influencing the plant type of the northern japonica hybrid rice were the plant height (PH), the angle of the flag leaf (FLA), flag leaf length (FLL), and the weight of the shoots and leaves (SLW), respectively. The morphological traits system of the northern japonica hybrid rice was very complex, and the restore line should be given more importance compared with the sterile line, and PH, FLA, FLL, and SLW should be considered first in the plant type breeding.展开更多
The objective of this study was to estimate genetic parameters of body width(BW)to body length(BL)ratio(BW/BL)and of body weight traits(BWT)in turbot,and to elucidate the genetic mechanism of the two traits during ont...The objective of this study was to estimate genetic parameters of body width(BW)to body length(BL)ratio(BW/BL)and of body weight traits(BWT)in turbot,and to elucidate the genetic mechanism of the two traits during ontogeny by dynamic genetic analysis.From 3 to 27 months,BW,BL and BWT of each communally stocked fish were measured every 3 months.The BW/BL ratio was measured at different sampling ages.A twotrait animal model was used for genetic evaluation of traits.The results showed that the heritability values of BW/BL ratio ranged from 0.2168 to 0.3148,corresponding to moderate heritability.The BWT heritability values ranged from 0.2702 to 0.3479 corresponding to moderate heritability.The heritability of BW/BL ratio was lower than that of BWT,except at 3 months of age.Genetic correlation between BW/BL ratio and BWT decreased throughout the measurement period.Genetic correlations were higher than the phenotypic correlations.The current results for estimating genetic parameters demonstrate that the BW/BL ratio could be used as a phenotypic marker of fast-growing turbot,and the BW/BL ratio and BWT could be improved simultaneously through selective breeding.展开更多
Taking 65 cherry tomato core germplasms as experimental materials,the genetic diversity of seven agronomic traits were analyzed.The correlation between any two of the seven agronomic traits and the genetic relationshi...Taking 65 cherry tomato core germplasms as experimental materials,the genetic diversity of seven agronomic traits were analyzed.The correlation between any two of the seven agronomic traits and the genetic relationships of these germplasms were analyzed based on genotypic values.The genetic diversity indices of the seven agronomic traits were 4.15,4.13,4.16,4.13,4.13,4.13 and 4.01,respectively,showing that the cherry tomato core collection had abundant genetic diversity.The correlation analysis between traits based on genotype effect values showed that leaf length was significantly correlated with leaf width with the correlation coefficient of 0.56.The fruit width was significantly correlated with fruit length with the correlation coefficient of 0.52.The flesh thickness was significantly correlated with fruit length and fruit width with the correlation coefficients of 0.49 and 0.39,respectively.The single fruit weight was significantly correlated with fruit length,fruit width and flesh thickness with the correlation coefficients of 0.44,0.61 and 0.62,respectively.When the genetic distances between core germplasms of cherry tomato were calculated based on the phenotypic values,65 core germplasms of cherry tomato were divided into three groups with the rescaled distance of 10.When the genetic distances between core germplasms of cherry tomato were calculated based on the genotypic values,the 65 core germplasms of cherry tomato were divided into four groups with the rescaled distance of 10.Comparing the 2 clustering results,it could find that genotypic value-based clustering analysis could better clarify the genetic relationship between core germplasms.This study could provide a theoretical basis for the effective utilization of cherry tomato core germplasms.展开更多
Five statistical methods including simple correlation, multiple linear regression, stepwise regression, principal components, and path analysis were used to explore the relationship between leaf water use efficiency ...Five statistical methods including simple correlation, multiple linear regression, stepwise regression, principal components, and path analysis were used to explore the relationship between leaf water use efficiency (WUE) and physiological traits (photosynthesis rate, stomatal conductance, transpiration rate, intercellular CO2 concentration, etc.) of 29 wheat cultivars. The results showed that photosynthesis rate, stomatal conductance, and transpiration rate were the most important leaf WUE parameters under drought condition. Based on the results of statistical analyses, principal component analysis could be the most suitable method to ascertain the relationship between leaf WUE and relative physiological traits. It is reasonable to assume that high leaf WUE wheat could be obtained by selecting breeding materials with high photosynthesis rate, low transpiration rate, and stomatal conductance under dry area.展开更多
[Objectives]This study was conducted to explore the relationship between morphological traits and body mass trait of Lutraria sieboldii.[Methods]110 were randomly selected from 120 2^(nd)-instar L.sieboldii collected ...[Objectives]This study was conducted to explore the relationship between morphological traits and body mass trait of Lutraria sieboldii.[Methods]110 were randomly selected from 120 2^(nd)-instar L.sieboldii collected from the Tieshangang area of Beihai,Guangxi,and 132 were randomly selected from 150 shellfish at the instar of 0.6.Their morphological traits were measured:shell length(SL),shell height(SH),shell width(SW),anterior length(AL),posterior length(PL),nose length(NL)in closed shell state,and maximum open shell width(OS)between two shells in closed shell state,and the body mass trait BM was also measured.Statistical methods such as path analysis and multiple regression were used for data analysis,and the effects of these seven morphological traits on the body mass trait were studied,respectively.The correlation between the tested seven quantitative traits and one body mass trait was all positive,all reaching an extremely significant level(P<0.01).[Results]The body mass trait of the shellfish at the instar of 2 had the highest correlation coefficient with shell length(0.922),that is,shell length had the greatest direct impact on the body mass trait;the path coefficient was 0.700;and the final multiple regression equation established was BM=-124.882+1.189 SL+1.551 SH+1.035 SW+0.119 NL,and the total determination coefficient(R^(2))on body mass was 0.849.The body mass trait of the shellfish at the instar of 0.6 had the highest correlation coefficient with shell length(0.859),that is,shell length had the greatest direct impact on the body mass trait;the path coefficient was 0.494;and the final multiple regression equation established was BM=-1.917+0.111 SL+0.021 NL+0.078 SW+0.032 OS,and the total determination coefficient(R~2)on body mass was 0.828.The multivariate regression variance analysis showed that the regression between the morphological traits and body mass trait of the L.sieboldii at the instars of 2 and 0.6 reached an extremely significant level(P<0.01).[Conclusions]This study provides a scientific basis for the selection of broodstock in the selection and breeding of L.sieboldii.展开更多
<strong>Objective:</strong> To understand the influencing factors of job burnout among nurses in Haikou 3A hospital and explore its direct and indirect effects, so as to provide a scientific basis for the ...<strong>Objective:</strong> To understand the influencing factors of job burnout among nurses in Haikou 3A hospital and explore its direct and indirect effects, so as to provide a scientific basis for the work efficiency of nursing staff. <strong>Methods:</strong> Between November 2, 2015 and November 2015, using multi stage random sampling, self-administered questionnaire survey was conducted among 1049 nursing staff, using the path analysis method to study the effect of direct and indirect factors effect. <strong>Results:</strong> The total score of job burnout of nurses was 38.44 ± 7.55, high occupational burnout was 0.9%, moderate occupational burnout was 66.5%, and low occupational burnout was 32.6%. The scores of job burnout were compared among the nurses with different titles, and less achievement (F = 8.342, P < 0.001) and depersonalization (F = 3.12, P = 0.025) were statistically significant. Nurses’ Job Burnout and job stressors were the first, and the canonical correlation coefficient was 0.4397 (F = 20.54, P < 0.0001), indicating that the more problems existed in patient care, the greater the degree of emotional exhaustion. The first canonical correlation coefficient of job burnout and job satisfaction of nurses was 0.3791 (F = 12.8, P < 0.0001), indicating that the better the family and work balance, the less individualized nurses were. The path analysis results showed that the 4 dimensions of job stressors (management and interpersonal problems) is positive, the direct effect of the strongest (0.219), the total effect of sort of work pressure source of 4 dimensions (0.245) > 5 dimensions of work pressure source (0.125) > title (<span style="white-space:nowrap;"><span style="white-space:nowrap;">−</span></span>0.112) job satisfaction scores (<span style="white-space:nowrap;"><span style="white-space:nowrap;">−</span></span>0.097). <strong>Conclusion:</strong> Job stress, job satisfaction and job title are the factors that affect job burnout. The 4 and the direct and indirect effects of job stressors are the strongest, and measures should be taken to solve these problems.展开更多
In the present study correlation, regression and path analyses were carried out to decide correlations among the agro- nomic traits and their contributions to seed yield per plant in Crambe abyssinica. Partial correla...In the present study correlation, regression and path analyses were carried out to decide correlations among the agro- nomic traits and their contributions to seed yield per plant in Crambe abyssinica. Partial correlation analysis indicated that plant height (X1) was significantly correlated with branching height and the number of first branches (P 2) was significantly correlated with pod number of primary inflorescence (P 3) was significantly correlated with number of secondary branches (P -grain weight (P 4) was significantly correlated with seed yield per plant (P 7) was significantly correlated with seed yield per plant (P -grain weight (P -grain weight (X8) was significantly correlated with seed yield per plant (P -grain weight contributed significantly to seed yield per plant at P 7) and 1000-grain weight (X8) to seed yield per plant (Y) is Y = 0.006 X7 + 1.222 X8 - 7.191. The path coefficient of pod number per plant to seed yield per plant was 0.967 and that of 1000-grain weight was 0.194. The determination coefficient of pod number per plant and 1000-grain weight to seed yield per plant was 0.983 and the determination coefficient of other agronomic traits was 0.130. Coefficient of variance indicated that the length of primary inflorescence showed the greatest variation, followed by seed yield per plant, pod number per plant, number of secondary branches, branching height, pod number of primary inflorescence, number of first branches, seed yield per plot, 1000-grain weight and plant height. It was suggested that seed yield per plant in Crambe might be improved by increasing the pod number per plant through selection or cultivation, but the negative correlation between pod number per plant and 1000-grain weight also needs to be considered.展开更多
Genetic diversity provides the foundation for crop improvement. Genetic variation and associations among Cotton Leaf Curl Disease (CLCuD), fiber and yield related traits were investigated in exotic lines of Gossypium ...Genetic diversity provides the foundation for crop improvement. Genetic variation and associations among Cotton Leaf Curl Disease (CLCuD), fiber and yield related traits were investigated in exotic lines of Gossypium arboreum L. in an experimental field at the Central Cotton Research Institute (CCRI), Multan, Pakistan during the crop season 2011-12. One hundred and nineteen (119) accessions imported from USA through the Pakistan and US “Cotton Productivity Enhancement Program” (CPEP), were evaluated in this study. Various statistical approaches including descriptive statistics, correlation and principal component analysis was performed to evaluate and identify desirable genotypes. Results revealed that seed cotton yield was significantly and positively correlated with boll weight and number of bolls plant-1. Similarly, plant height was also significantly correlated with sympodial branches, lint percentage and micronaire value. Lint percentage showed a highly significant and positive correlation with plant height, sympodial branches and micronaire value. With respect to fiber traits, negative and significant relationships were observed between the micronaire value (MIC) and fiber strength. CLCuD showed no relationship with any of the studied traits, as all the G. arboreum L. lines evaluated were scored resistant to CLCuD. Principal component analysis (PCA) showed that the first four out of 11 components contributed about 65.88% of the total variation having an eigen value greater than 1. Based on PCA, the genotypes GS-4, GS-9, GS-8, GS-55 and GS-50 could be utilized successfully in a future breeding program based on having the highest positive loading factor for staple length (0.135) in PC1 and seed cotton yield (0.625), number of bolls plant-1, boll weight, first sympodial nod, staple length and fiber strength in PC2 respectively.展开更多
There are different degrees of correlation between crop traits. The phenotypic correlation is decomposed into genetic and environmental correlation in quantitative genetics. In this paper,according to stochastic model...There are different degrees of correlation between crop traits. The phenotypic correlation is decomposed into genetic and environmental correlation in quantitative genetics. In this paper,according to stochastic model of variance and covariance analysis,we calculate different genetic components,bring up a decomposition method of genetic correlation coefficient based on NC II mating design,and use examples to show analytic steps and interpret results.展开更多
Sorghum is a staple food crop in Ethiopia and its production is mainly constrained by drought, other environmental factors, and the use of low-yielding, local sorghum varieties. To improve sorghum productivity, it is ...Sorghum is a staple food crop in Ethiopia and its production is mainly constrained by drought, other environmental factors, and the use of low-yielding, local sorghum varieties. To improve sorghum productivity, it is crucial to provide farmers with high yielding, stable sorghum cultivars that are tolerant to drought and other constraints. The stable performance of sorghum varieties in a growing region is critical to obtain a high and stable yield. In the 2012-2014 crop year, 24 genotypes, including standard controls, were evaluated at the national variety trial stage over six main dry lowland sorghum growing sites and two years made 7 environments to evaluate their performance, stability and to quantify Genotype by Environment Interaction (GEI) across moisture stress sorghum growing areas of Ethiopia. Spatial modeling has been used to estimate predicted mean (BLUPs) results and Performance and estimation of environmental correlation, heritability, GEI, and other parameters using the ASReml3-R analysis package. The predicted mean yield of the test genotypes across the environment ranged from 3.45 to 1.56 t<span style="font-family:Verdana;">·</span><span style="font-family:;" "=""><span style="font-family:Verdana;">ha</span><sup><span style="font-family:Verdana;">-1</span></sup><span style="font-family:Verdana;">. Based on the result genotype G13, it could be further promoted because of its yield advantage and other important attributes over the standard checks, but it is the least stable. Based on the analyzed result, two mega environments were formed and Environment 1 (E1) is identified as an ideal environment among the testing environments.</span></span>展开更多
Alzheimer's disease(AD)is affected by genetic factors.Polymorphisms in the glutathione S-transfe rase omega-1(Gsto1)gene have been shown by genetic correlation analyses performed in different ethnic populations to...Alzheimer's disease(AD)is affected by genetic factors.Polymorphisms in the glutathione S-transfe rase omega-1(Gsto1)gene have been shown by genetic correlation analyses performed in different ethnic populations to be genetic risk factors for AD.Gene expression profile data from BXD recombinant inbred mice were used in combination with genetic and bioinformatic analyses to chara cterize the mechanisms underlying regulation of Gstol variation regulation and to identify network membe rs that may contribute to AD risk or progression.Allele-specific assays confirmed that variation in Gstol expression is controlled by cis-expression quantitative trait loci.We found that Gstol mRNA levels were related to several central nervous system traits,such as glial acidic fibrillary protein levels in the caudate putamen,co rtical gray matter volume,and hippocampus mossy fiber pathway volume.We identified 2168 genes whose expression was highly correlated with that of Gsto1.Some genes were enriched for the most common neurodegenerative diseases.Some Gsto1-related genes identified in this study had previously been identified as susceptibility genes for AD,such as APP,Grin2 b,Ide,and Psenen.To evaluate the relationships between Gstol and candidate network members,we transfected astrocytes with Gstol siRNA and assessed the effect on putative downstream effecto rs.We confirmed that knockdown of Gstol had a significant influence on Pa2g4 expression,suggesting that Pa2g4 may be a downstream effector of Gstol,and that both genes intera ct with other genes in a network during AD pathogenesis.展开更多
基金grants of the Guangdong Marine and Fishery Bureau(No.B02068)Guangdong Ocean University(No.E06031).
文摘120 pearl oysters (Pinctada martensii) were randomly sampled from F1 population, and shell length, shell width, shell height, shell weight and total weight of each sample were measured. Correlation and path analysis were conducted on the basis of measurement data. The results showed that shell length, shell width, shell height, shell weight and total weight were significantly correlated (P 〈 0.05). Total weight was significantly and positively correlated with shell weight (r = 0.8970), shell height (r = 0.6974), shell width (r = 0.6521) and shell length (r = 0.5486). Shell weight, shell height, shell width and shell length had positive and direct effects on total wet weight, with the values of 0.6356, 0.1872, 0.1814 and 0.0599, respectively. The results indicated that growth traits (shell length, shell width, shell height, shell weight and total wet weigh) of the F1 population could be improved by direct or indirect selection.
基金Supported by National key R&D Projects(2016YFD0101603)National Planning Project Co-supported by Yunnan Province(2014GA016)Science&Technology Specific Project for Benefiting People in China(2014RA056)~~
文摘[Objective] This study was tween yield-related traits and yield of conducted to understand the relationship be- Yunmai 52 which is a high-quality high-yield multi-resistant new wheat variety, and make contribution of yield-related traits to the yield of Yunmai 52 clear. [Method] Wheat variety regional trial data in Yunnan Province in 2005-2007 were subjected to correlation analysis and path analysis in the paper. [Result] Correlationanalysis showed that the yield of Yunmai 52 was in- very significant positive correlation with spikelet number per ear, maximum tiller number and grains per ear (r=0.726^**, 0.717^** and 0.695^**, respectively), in signif- icant positive correlation with 1 000-grain weight (r=0.491^*), but in significant nega- tive correlation with sterile spikelet number per ear, and in non-significant correlation with basic seedlings, effective ears and percentage of ear bearing tillers. Partial correlation analysis showed that the yield of Yunmai 52 was in very significant posi- tive correlation with spikelet number per ear (r=0.711^**), significant positive correla- tion with 1 000-grain weight (r=0.641 =), but in non-significant correlation with other 6 traits. Path analysis showed that spikelet number per ear (P=-0.595), maximum tiller number (P=0.462) and t 000-grain weight (P=0.263) had more contribution to yield of Yunmai 52. [Conclusion] Therefore, in extension and application of Yunmal 52 that is a high-quality high-yield multi-resistant new wheat variety, supply of fertilizer and water should be increased in tillering stage and jointing stage, to ensure its characteristics of high tilledng ability and large ear, as well as high 1 000-grain weight, and coordinated development of other yield-related traits is beneficial to im- provement of yield of Yunmai 52.
基金Supported by the Modern Agro-Industry Technology Research System(No.CARS-48)
文摘Using correlation and path analysis, the genetic correlation between weight traits and morphological traits was determined in the marine gastropod Glossaulax reiniana. A total of 100 G. reiniana individuals from a wild population were used. Shell width (X1), shell height (X2), umbo-callus height (X3), body width (X4), operculum length (X5), operculum width (X6), body weight (Y1) and soft-tissue weight (Y2) were measured, and the correlation coefficient matrix calculated. Morphological traits were used as independent variables and weight traits as dependent variables for path coefficient analysis. Path coefficients, correlation indices and determination coefficients were also determined. Results indicate that the correlation coefficients associated with each morphological and weight trait were all highly significant (P〈0.01). After deleting redundant independent variables, the following optimum multiple regression equations were obtained using stepwise multiple regression analysis: Y1=-29.317+0.362X2+0.349X4+ 1.190)(5 for body weight; and Y2=-17.292+0.166X1+0.171X2+0.703X5, for soft-tissue weight. Operculum height had the highest positive direct correlation with both body weight and soft-tissue weight, which was in accordance with the test results obtained from determinate coefficient analysis. The indication of high genetic correlations between weight traits and morphological traits will provide valuable information for G. reiniana breeding programs.
基金This paper is supported by National Natural Science Foundation of China (Grant No. 40541001 )Major Program of National Natural Science Foundation of China (Grant No. 40535024)Beijing Municipal Natural Science Foundation (Grant No. 8062020).
文摘Hubei Province is one of the critical grain production regions in China with the quantitative cultivated landand good natural condition; it plays an important role in grain security in China. However, owing to rapid economicgrowth, population pressures, anthropogenic activities, and natural disasters, the quality of the cultivated land hassignificantly decreased in recent years and environmental resources are under increasing stress. In order to research onthe mechanism of the change of the cultivated land, this paper analyzes qualitatively the influencing factors of thecultivated land change in Hubei Province from 1978 to 2004, and distinguishes the direct factors from indirect influentones by means of the approach of the path analysis. The result shows that the area of the rent land in the total non-agricultural land, the total population growth and the fixed asset investment are the main factors deciding the change ofthe cultivated land. Meanwhile, the density of the transportation network, the proportion of per capita income of ruralcitizens to that of urban citizens, non-agricultural gross domestic production’s share of the total GDP has a less directeffect but a more indirect influence on the decrease of the cultivated land in Hubei Province. The result means that whilesome factors have less direct influence on the change of the cultivated land, its indirect influence are significant, viceversa. Thus it’s necessary to adopt a comprehensive measurement to protect the cultivated land.
基金supported by the Hunan Provincial Natrual Science Foundation of China(2022JJ30103)“the 14th Five-Year”Key Disciplines and Application Oriented Special Disciplines of Hunan Province(Xiangjiaotong[2022],351)the Science and Technology Innovation Program of Hunan Province(2016TP1020).
文摘Correlation power analysis(CPA)combined with genetic algorithms(GA)now achieves greater attack efficiency and can recover all subkeys simultaneously.However,two issues in GA-based CPA still need to be addressed:key degeneration and slow evolution within populations.These challenges significantly hinder key recovery efforts.This paper proposes a screening correlation power analysis framework combined with a genetic algorithm,named SFGA-CPA,to address these issues.SFGA-CPA introduces three operations designed to exploit CPA characteris-tics:propagative operation,constrained crossover,and constrained mutation.Firstly,the propagative operation accelerates population evolution by maximizing the number of correct bytes in each individual.Secondly,the constrained crossover and mutation operations effectively address key degeneration by preventing the compromise of correct bytes.Finally,an intelligent search method is proposed to identify optimal parameters,further improving attack efficiency.Experiments were conducted on both simulated environments and real power traces collected from the SAKURA-G platform.In the case of simulation,SFGA-CPA reduces the number of traces by 27.3%and 60%compared to CPA based on multiple screening methods(MS-CPA)and CPA based on simple GA method(SGA-CPA)when the success rate reaches 90%.Moreover,real experimental results on the SAKURA-G platform demonstrate that our approach outperforms other methods.
文摘In April of 2006, a base population of the noble scallop Chlamys nobilis was established by collecting parental breeders from the stocks in Wushi, Zhanjiang. In December of 2006, 200 individuals were randomly sampled from the base population and subjected for correlation and path coefficient analysis. It was found that there were statistically significant phenotypic correlations among the traits (P 〈 0.01). Total weight was significantly and positively correlated with the shell length (r = 0.934 3), shell height (r = 0.895 9), shell width (r = 0.899 1 ), muscle weight (r = 0.882 0) and shell weight (r = 0.937 9), respectively. Shell length, shell width, muscle weight, shell height and shell weight had positive and direct effects on the total weight, with values of 0.397 1, 0.321 9, 0.172 1, 0.089 6 and 0.066 9, respectively. Shell length, shell width and muscle weight had higher direct effects on the total weight than shell height and shell weight. A combined evaluation of correlation, direct effects and indirect effects showed that direct selection for shell length, shell width, muscle weight, shell height and shell weight would be effective to improving the total weight. It was concluded that these traits could be regarded as the selection criteria in breeding programs of the species.
基金Supported by Platform Construction for Germplasm Resources of China Tobacco (2007, 152)
文摘Correlation and path coefficient analyses were conducted for 10 characteristics of 24 pure lines of flue-cured tobacco such as plant height, knot distance, leaf number, the central leaf length and width, ratio of the length to width, stem girth, dates of budding, leaf yield and ratio of the prime-medium tobacco. The leaf number and the central leaf length showed a positive or a strong positive correlation with the yield per plant. And the leaf number and leaf yield per plant showed a strong positive correlation with the ratio of prime-medium tobacco. The results showed that the leaf yield per plant among these characteristics played a major role in determining the ratio of prime-medium tobacco while the others were less related with the ratio. Square sum of deviation method cluster analyses showed that 24 pure lines of flue-cured tobacco were clustered into two groups. Of the pure lines, Line T1706 and Line T1245 had a far relationship with all other lines, and also had a heterosis when crossed with the other lines. Lines Guangdonghuang 1 and R72(3)B-2-1 were closely related.
文摘Understanding the variation for the expressionof genes in different environments is one of themajor goals in qualitative genetics. In this pa-per, the genetic models for quantitative traitsof endosperm in cereal crops were used to eval-uate the seed, cytoplasm and maternal geneticeffects as well as the genotype × environment(GE) interaction effects, and to predict thebreeding value of parents and genotypic corre-lation for nutrient quality traits of indica rice (Oryza sativa L.).
基金Supported by Key Germplasm Project of Sichuan Province during the Eleventh Five-year Plan(2006YZGG-23)~~
文摘[Objective] The experiment aimed to study the relation between yield components and yield per plant of double-low hybrid rapeseed and provide reference for breaking yield limitation of rapeseed and culturing new double-low hybrid rapeseed variety. [Method]The yield components and yield per plant of two cross combination of double-low hybrid rapeseed (B02, D04) and Shuza 6 were correlatively analyzed and compared, besides, the path analysis was also carried on to them. [Result] Among B02, D04 and Shuza No.6, effective pod number per plant and seeds per silique, seeds per pod and 1 000-grain weight were all negative correlation. In high yield hybrid, pod number per plant, seeds per pod had more impaction on yield per plant than 1 000-grain weight and the difference was at 0.01 significant level. In the control variety Shuza No.6, the impactions of pod number per plant and seeds per pod on yield per plant were bigger than that of 1 000-grain weight on yield per plant, however, the difference was not significant. [Conclusion] The improvement of effective pod number per plant was an important aim of breeding work of double low rapeseed breeding in Sichuan ecological region.
基金supported by the National 863 Program of China (2002AA207002)
文摘This study was designed to analyze the genetic relationship of the morphological traits of the northern japonica hybrid rice. The genetic relationship of the morphological traits of the 100 cultivars combined by the 10 sterile lines and the 10 restore lines was studied by using the principle component analysis and the SAS and QGA. The results showed that compared with the female parent, most of the morphological traits related closely to their father. The additive genetic effect and the dominant genetic effect appeared significantly, and the former was more significant than the latter. Genetic correlation analysis indicated that high plants or high plants with more leaves were in favor of improving the number and the weight of the spike and producing the hybrid vigor. The important factors influencing the plant type of the northern japonica hybrid rice were the plant height (PH), the angle of the flag leaf (FLA), flag leaf length (FLL), and the weight of the shoots and leaves (SLW), respectively. The morphological traits system of the northern japonica hybrid rice was very complex, and the restore line should be given more importance compared with the sterile line, and PH, FLA, FLL, and SLW should be considered first in the plant type breeding.
基金The Earmarked Fund for Modern Agro-Industry Technology Research System under contract No.CARS-47-G01the Ao Shan Talents Cultivation Program supported by Qingdao National Laboratory for Marine Science and Technology under contract No.2017ASTCP-OS04+2 种基金the Agricultural Fine Breed Project of Shandong under contract No.2016LZGC031the Chinese Academy of Fishery Sciences Basal Research Fund under contract No.2016HY-JC0302the National Key Research and Development Program under contract No.2018YFD0900102
文摘The objective of this study was to estimate genetic parameters of body width(BW)to body length(BL)ratio(BW/BL)and of body weight traits(BWT)in turbot,and to elucidate the genetic mechanism of the two traits during ontogeny by dynamic genetic analysis.From 3 to 27 months,BW,BL and BWT of each communally stocked fish were measured every 3 months.The BW/BL ratio was measured at different sampling ages.A twotrait animal model was used for genetic evaluation of traits.The results showed that the heritability values of BW/BL ratio ranged from 0.2168 to 0.3148,corresponding to moderate heritability.The BWT heritability values ranged from 0.2702 to 0.3479 corresponding to moderate heritability.The heritability of BW/BL ratio was lower than that of BWT,except at 3 months of age.Genetic correlation between BW/BL ratio and BWT decreased throughout the measurement period.Genetic correlations were higher than the phenotypic correlations.The current results for estimating genetic parameters demonstrate that the BW/BL ratio could be used as a phenotypic marker of fast-growing turbot,and the BW/BL ratio and BWT could be improved simultaneously through selective breeding.
基金Supported by Hainan Provincial Science and Technology Project(ZDYF2018035)
文摘Taking 65 cherry tomato core germplasms as experimental materials,the genetic diversity of seven agronomic traits were analyzed.The correlation between any two of the seven agronomic traits and the genetic relationships of these germplasms were analyzed based on genotypic values.The genetic diversity indices of the seven agronomic traits were 4.15,4.13,4.16,4.13,4.13,4.13 and 4.01,respectively,showing that the cherry tomato core collection had abundant genetic diversity.The correlation analysis between traits based on genotype effect values showed that leaf length was significantly correlated with leaf width with the correlation coefficient of 0.56.The fruit width was significantly correlated with fruit length with the correlation coefficient of 0.52.The flesh thickness was significantly correlated with fruit length and fruit width with the correlation coefficients of 0.49 and 0.39,respectively.The single fruit weight was significantly correlated with fruit length,fruit width and flesh thickness with the correlation coefficients of 0.44,0.61 and 0.62,respectively.When the genetic distances between core germplasms of cherry tomato were calculated based on the phenotypic values,65 core germplasms of cherry tomato were divided into three groups with the rescaled distance of 10.When the genetic distances between core germplasms of cherry tomato were calculated based on the genotypic values,the 65 core germplasms of cherry tomato were divided into four groups with the rescaled distance of 10.Comparing the 2 clustering results,it could find that genotypic value-based clustering analysis could better clarify the genetic relationship between core germplasms.This study could provide a theoretical basis for the effective utilization of cherry tomato core germplasms.
基金supported by the Key Technologies R&D Program of China during the 11th Five-Year Plan period (2008BAD98B03)
文摘Five statistical methods including simple correlation, multiple linear regression, stepwise regression, principal components, and path analysis were used to explore the relationship between leaf water use efficiency (WUE) and physiological traits (photosynthesis rate, stomatal conductance, transpiration rate, intercellular CO2 concentration, etc.) of 29 wheat cultivars. The results showed that photosynthesis rate, stomatal conductance, and transpiration rate were the most important leaf WUE parameters under drought condition. Based on the results of statistical analyses, principal component analysis could be the most suitable method to ascertain the relationship between leaf WUE and relative physiological traits. It is reasonable to assume that high leaf WUE wheat could be obtained by selecting breeding materials with high photosynthesis rate, low transpiration rate, and stomatal conductance under dry area.
基金Supported by Guangxi Key R&D Program(2018AB52002)National Key R&D Program of China(2018YFD0901406)+3 种基金Natural Science Foundation of Guangxi(2018GXNSFAA138197,2021GXNSFAA075008)General Project of National Natural Science Foundation of China(31873042)2021 Key Cultivation Project of Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation(2021ZB02)The Basic Ability Improvement Project for Young and Middle-aged Teachers in Guangxi Universities(2018KY0612)。
文摘[Objectives]This study was conducted to explore the relationship between morphological traits and body mass trait of Lutraria sieboldii.[Methods]110 were randomly selected from 120 2^(nd)-instar L.sieboldii collected from the Tieshangang area of Beihai,Guangxi,and 132 were randomly selected from 150 shellfish at the instar of 0.6.Their morphological traits were measured:shell length(SL),shell height(SH),shell width(SW),anterior length(AL),posterior length(PL),nose length(NL)in closed shell state,and maximum open shell width(OS)between two shells in closed shell state,and the body mass trait BM was also measured.Statistical methods such as path analysis and multiple regression were used for data analysis,and the effects of these seven morphological traits on the body mass trait were studied,respectively.The correlation between the tested seven quantitative traits and one body mass trait was all positive,all reaching an extremely significant level(P<0.01).[Results]The body mass trait of the shellfish at the instar of 2 had the highest correlation coefficient with shell length(0.922),that is,shell length had the greatest direct impact on the body mass trait;the path coefficient was 0.700;and the final multiple regression equation established was BM=-124.882+1.189 SL+1.551 SH+1.035 SW+0.119 NL,and the total determination coefficient(R^(2))on body mass was 0.849.The body mass trait of the shellfish at the instar of 0.6 had the highest correlation coefficient with shell length(0.859),that is,shell length had the greatest direct impact on the body mass trait;the path coefficient was 0.494;and the final multiple regression equation established was BM=-1.917+0.111 SL+0.021 NL+0.078 SW+0.032 OS,and the total determination coefficient(R~2)on body mass was 0.828.The multivariate regression variance analysis showed that the regression between the morphological traits and body mass trait of the L.sieboldii at the instars of 2 and 0.6 reached an extremely significant level(P<0.01).[Conclusions]This study provides a scientific basis for the selection of broodstock in the selection and breeding of L.sieboldii.
文摘<strong>Objective:</strong> To understand the influencing factors of job burnout among nurses in Haikou 3A hospital and explore its direct and indirect effects, so as to provide a scientific basis for the work efficiency of nursing staff. <strong>Methods:</strong> Between November 2, 2015 and November 2015, using multi stage random sampling, self-administered questionnaire survey was conducted among 1049 nursing staff, using the path analysis method to study the effect of direct and indirect factors effect. <strong>Results:</strong> The total score of job burnout of nurses was 38.44 ± 7.55, high occupational burnout was 0.9%, moderate occupational burnout was 66.5%, and low occupational burnout was 32.6%. The scores of job burnout were compared among the nurses with different titles, and less achievement (F = 8.342, P < 0.001) and depersonalization (F = 3.12, P = 0.025) were statistically significant. Nurses’ Job Burnout and job stressors were the first, and the canonical correlation coefficient was 0.4397 (F = 20.54, P < 0.0001), indicating that the more problems existed in patient care, the greater the degree of emotional exhaustion. The first canonical correlation coefficient of job burnout and job satisfaction of nurses was 0.3791 (F = 12.8, P < 0.0001), indicating that the better the family and work balance, the less individualized nurses were. The path analysis results showed that the 4 dimensions of job stressors (management and interpersonal problems) is positive, the direct effect of the strongest (0.219), the total effect of sort of work pressure source of 4 dimensions (0.245) > 5 dimensions of work pressure source (0.125) > title (<span style="white-space:nowrap;"><span style="white-space:nowrap;">−</span></span>0.112) job satisfaction scores (<span style="white-space:nowrap;"><span style="white-space:nowrap;">−</span></span>0.097). <strong>Conclusion:</strong> Job stress, job satisfaction and job title are the factors that affect job burnout. The 4 and the direct and indirect effects of job stressors are the strongest, and measures should be taken to solve these problems.
文摘In the present study correlation, regression and path analyses were carried out to decide correlations among the agro- nomic traits and their contributions to seed yield per plant in Crambe abyssinica. Partial correlation analysis indicated that plant height (X1) was significantly correlated with branching height and the number of first branches (P 2) was significantly correlated with pod number of primary inflorescence (P 3) was significantly correlated with number of secondary branches (P -grain weight (P 4) was significantly correlated with seed yield per plant (P 7) was significantly correlated with seed yield per plant (P -grain weight (P -grain weight (X8) was significantly correlated with seed yield per plant (P -grain weight contributed significantly to seed yield per plant at P 7) and 1000-grain weight (X8) to seed yield per plant (Y) is Y = 0.006 X7 + 1.222 X8 - 7.191. The path coefficient of pod number per plant to seed yield per plant was 0.967 and that of 1000-grain weight was 0.194. The determination coefficient of pod number per plant and 1000-grain weight to seed yield per plant was 0.983 and the determination coefficient of other agronomic traits was 0.130. Coefficient of variance indicated that the length of primary inflorescence showed the greatest variation, followed by seed yield per plant, pod number per plant, number of secondary branches, branching height, pod number of primary inflorescence, number of first branches, seed yield per plot, 1000-grain weight and plant height. It was suggested that seed yield per plant in Crambe might be improved by increasing the pod number per plant through selection or cultivation, but the negative correlation between pod number per plant and 1000-grain weight also needs to be considered.
文摘Genetic diversity provides the foundation for crop improvement. Genetic variation and associations among Cotton Leaf Curl Disease (CLCuD), fiber and yield related traits were investigated in exotic lines of Gossypium arboreum L. in an experimental field at the Central Cotton Research Institute (CCRI), Multan, Pakistan during the crop season 2011-12. One hundred and nineteen (119) accessions imported from USA through the Pakistan and US “Cotton Productivity Enhancement Program” (CPEP), were evaluated in this study. Various statistical approaches including descriptive statistics, correlation and principal component analysis was performed to evaluate and identify desirable genotypes. Results revealed that seed cotton yield was significantly and positively correlated with boll weight and number of bolls plant-1. Similarly, plant height was also significantly correlated with sympodial branches, lint percentage and micronaire value. Lint percentage showed a highly significant and positive correlation with plant height, sympodial branches and micronaire value. With respect to fiber traits, negative and significant relationships were observed between the micronaire value (MIC) and fiber strength. CLCuD showed no relationship with any of the studied traits, as all the G. arboreum L. lines evaluated were scored resistant to CLCuD. Principal component analysis (PCA) showed that the first four out of 11 components contributed about 65.88% of the total variation having an eigen value greater than 1. Based on PCA, the genotypes GS-4, GS-9, GS-8, GS-55 and GS-50 could be utilized successfully in a future breeding program based on having the highest positive loading factor for staple length (0.135) in PC1 and seed cotton yield (0.625), number of bolls plant-1, boll weight, first sympodial nod, staple length and fiber strength in PC2 respectively.
文摘There are different degrees of correlation between crop traits. The phenotypic correlation is decomposed into genetic and environmental correlation in quantitative genetics. In this paper,according to stochastic model of variance and covariance analysis,we calculate different genetic components,bring up a decomposition method of genetic correlation coefficient based on NC II mating design,and use examples to show analytic steps and interpret results.
文摘Sorghum is a staple food crop in Ethiopia and its production is mainly constrained by drought, other environmental factors, and the use of low-yielding, local sorghum varieties. To improve sorghum productivity, it is crucial to provide farmers with high yielding, stable sorghum cultivars that are tolerant to drought and other constraints. The stable performance of sorghum varieties in a growing region is critical to obtain a high and stable yield. In the 2012-2014 crop year, 24 genotypes, including standard controls, were evaluated at the national variety trial stage over six main dry lowland sorghum growing sites and two years made 7 environments to evaluate their performance, stability and to quantify Genotype by Environment Interaction (GEI) across moisture stress sorghum growing areas of Ethiopia. Spatial modeling has been used to estimate predicted mean (BLUPs) results and Performance and estimation of environmental correlation, heritability, GEI, and other parameters using the ASReml3-R analysis package. The predicted mean yield of the test genotypes across the environment ranged from 3.45 to 1.56 t<span style="font-family:Verdana;">·</span><span style="font-family:;" "=""><span style="font-family:Verdana;">ha</span><sup><span style="font-family:Verdana;">-1</span></sup><span style="font-family:Verdana;">. Based on the result genotype G13, it could be further promoted because of its yield advantage and other important attributes over the standard checks, but it is the least stable. Based on the analyzed result, two mega environments were formed and Environment 1 (E1) is identified as an ideal environment among the testing environments.</span></span>
基金the Natural Science Foundation of China,Nos.81200828(to YC),32070998(to GC)the Key Research and Development Program(Social Development)of Jiangsu Province,No.BE2020667(to GC)+1 种基金the Foundation of Jiangsu Province"333 Project High-level Talents",No.BRA2020076(to GC)the Priority Academic Program Development of Jiangsu Higher Education Institutes(PAPD)。
文摘Alzheimer's disease(AD)is affected by genetic factors.Polymorphisms in the glutathione S-transfe rase omega-1(Gsto1)gene have been shown by genetic correlation analyses performed in different ethnic populations to be genetic risk factors for AD.Gene expression profile data from BXD recombinant inbred mice were used in combination with genetic and bioinformatic analyses to chara cterize the mechanisms underlying regulation of Gstol variation regulation and to identify network membe rs that may contribute to AD risk or progression.Allele-specific assays confirmed that variation in Gstol expression is controlled by cis-expression quantitative trait loci.We found that Gstol mRNA levels were related to several central nervous system traits,such as glial acidic fibrillary protein levels in the caudate putamen,co rtical gray matter volume,and hippocampus mossy fiber pathway volume.We identified 2168 genes whose expression was highly correlated with that of Gsto1.Some genes were enriched for the most common neurodegenerative diseases.Some Gsto1-related genes identified in this study had previously been identified as susceptibility genes for AD,such as APP,Grin2 b,Ide,and Psenen.To evaluate the relationships between Gstol and candidate network members,we transfected astrocytes with Gstol siRNA and assessed the effect on putative downstream effecto rs.We confirmed that knockdown of Gstol had a significant influence on Pa2g4 expression,suggesting that Pa2g4 may be a downstream effector of Gstol,and that both genes intera ct with other genes in a network during AD pathogenesis.