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Application of 2-D and 3-D Geo-electrical Resistivity Tomography and Geotechnical Soil Evaluation for Engineering Site Investigation:A Case Study of Okerenkoko Primary School,Warri-Southwest,Delta State,Nigeria
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作者 U.Stanley Eze M.Edirin Okiotor +3 位作者 J.E.Ighodalo B.Jennifer Owonaro A.Saleh Saleh A.Sikiru Jamiu 《Advances in Geological and Geotechnical Engineering Research》 2023年第2期1-23,共23页
In the design of building structures,joint efforts must be decided to resolve the depth of competent layers across the intended site to safeguard the durability of civil engineering structures and to avert the disastr... In the design of building structures,joint efforts must be decided to resolve the depth of competent layers across the intended site to safeguard the durability of civil engineering structures and to avert the disastrous consequences of structural failure and collapse.In this study,an integrated methodology that employed DC resistivity tomography involving 2-D and 3-D techniques and geotechnical-soil analysis was used to evaluate subsoil conditions for engineering site investigation at Okerenkoko primary school,in the Warri-southwest area of Delta State,to adduce the phenomena responsible for the visible cracks/structural failure observed in the buildings.The results obtained brought to light the geological structure beneath the subsurface,which consists of four geoelectric layers identified as topsoil,dry/lithified upper sandy layer,wet sand(water-saturated)and peat/clay/sandy clayey soil(highly water-saturated).The deeply-seated peat/clay materials(ρ≤20Ωm)were delineated in the study area to the depths of 17.1 m and 19.8 m from 2-D and 3-D tomography respectively.3-D images presented as horizontal depth slices revealed the dominance of very low resistivity materials i.e.peat/clay/sandy clay within the fourth,fifth and sixth layers at depths ranging from 8.68-12.5 m,12.5-16.9 m and 16.9-21.9 m respectively.The dominance of mechanically unstable peat/clay/sandy clay layers beneath the subsurface,which are highly mobile in response to volumetric changes,is responsible for the noticeable cracks/failure detected on structures within the study site.These observations were validated by a geotechnical test of soil samples in the study area.Atterberg’s limits of the samples revealed plasticity indices of zero.Thus,the soil samples within the depth analyzed were representatives of sandy soil that does not possess any plasticity.The methods justifiably provided relevant information on the subsurface geology beneath the study site and should be appropriated as major tools for engineering site assessment/geotechnical projects. 展开更多
关键词 2D and 3D resistivity tomography Engineering site/structure Atterberg limits Orthogonal lines Radar sounding
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A novel method for determining the resistivity of compressed superconducting materials
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作者 Liling Sun Qi Wu +2 位作者 Shu Cai Yang Ding Ho-kwang Mao 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第4期1-3,共3页
The measurement of resistivity in a compressed material within a diamond anvil cell presents significant challenges.The high-pressure exper-imental setup makes it difficult to directly measure the size changes induced... The measurement of resistivity in a compressed material within a diamond anvil cell presents significant challenges.The high-pressure exper-imental setup makes it difficult to directly measure the size changes induced by pressure in the three crystallographic directions of the sample.In this study,we introduce a novel and effective method that addresses these technical challenges.This method is anticipated to offer a valuable foundation for high-pressure investigations on quantum materials,particularly those with anisotropic layered structures. 展开更多
关键词 resistivity METHOD FOUNDATION
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Characterization of Aquifers in Crystalline and Crystallophyll Basement Zones Using the Electrical Resistivity Method (Trails and Electrical Soundings) in the Gagnoa Region, (Central-Western Côte d’Ivoire)
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作者 Oscar Zahibo Onétié Assoué Kouakou Sylvestre Kouadio +1 位作者 Kotchi Rodrigue Orou Maxime Assa Abe 《International Journal of Geosciences》 CAS 2024年第6期511-523,共13页
Introduction: Located in the central-western part of Côte d’Ivoire, the subsoil of the Gagnoa region is made up of sedimentary volcano formations and granitoids with developed fracturing. This complex Precambria... Introduction: Located in the central-western part of Côte d’Ivoire, the subsoil of the Gagnoa region is made up of sedimentary volcano formations and granitoids with developed fracturing. This complex Precambrian basement contains most of the region’s water resources. This is at the origin of the high failure rate during the various hydrogeological prospecting campaigns. Methodology: The database consists of resistivities from 42 holes and 51 trails drilled as part of the implementation of high-throughput drilling in the study area. The objective of this study is to deepen the knowledge of the fissured basement by interpreting profile curves and electrical soundings. It will be a question of classifying the different types of anomalies obtained on the profiles and their shapes. The orientation of the lineaments observed on the profiles was determined. Results: The interpretation of the geophysical data revealed various anomalies, the main ones being of the CC (Conductor Compartment) and CEDP (Contact between two bearings) types. These types of anomalies are mainly expressed in various forms: the “V”, “W” and “U” shapes. From these anomalies and the appearance of the electrical profiles, lineaments and their orientations were identified with N90-100, N130-140, N170-180 as major orientations. Conclusion: These results could contribute to a better understanding of the fractured environment of the Gagnoa region. 展开更多
关键词 BASEMENT Electrical Profiles Sounding Curves resistivities
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Study on theoretical model for electrical explosion resistivity of Al/Ni reactive multilayer foil
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作者 Zehao Wang Tao Wang +2 位作者 Pengfei Xue Mingyu Li Qingxuan Zeng 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期348-356,共9页
Al/Ni reactive multilayer foil(RMF)possesses excellent comprehensive properties as a promising substitute for traditional Cu bridge.A theoretical resistivity model of Al/Ni RMF was developed to guide the optimization ... Al/Ni reactive multilayer foil(RMF)possesses excellent comprehensive properties as a promising substitute for traditional Cu bridge.A theoretical resistivity model of Al/Ni RMF was developed to guide the optimization of EFIs.Al/Ni RMF with different bilayer thicknesses and bridge dimensions were prepared by MEMS technology and electrical explosion tests were carried out.According to physical and chemical reactions in bridge,the electrical explosion process was divided into 5 stages:heating of condensed bridge,vaporization and diffusion of Al layers,intermetallic combination reaction,intrinsic explosion,ionization of metal gases,which are obviously shown in measured voltage curve.Effects of interface and grain boundary scattering on the resistivity of film metal were considered.Focusing on variations of substance and state,the resistivity was developed as a function of temperature at each stage.Electrical explosion curves were calculated by this model at different bilayer thicknesses,bridge dimensions and capacitor voltages,which showed an excellent agreement with experimental ones. 展开更多
关键词 Al/Ni reactive multilayer foil Electrical explosion resistivity model Phase transition CALCULATION
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Research on geo-electrical resistivity observation system specially used for earthquake monitoring in China 被引量:7
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作者 Jialiu Zhao Lanwei Wang Jiadong Qian 《Earthquake Science》 CSCD 2011年第6期497-511,共15页
This paper deals with the design and development of the observational system of geo-electrical resistivity on the basis of the demands for exploring the temporal variations of electrical properties of Earth media in t... This paper deals with the design and development of the observational system of geo-electrical resistivity on the basis of the demands for exploring the temporal variations of electrical properties of Earth media in the fixed points of the networks, which would be associated with the earthquake preparation. The observation system is characterized by the high accuracy in measurement, long term stability in operation and high level of rejection to the environmental interference. It consists of three main parts, configuration system measurement system, the calibration and inspection system. 展开更多
关键词 geo-electrical resistivity observation system earthquake monitoring configuration system measurement system calibration and inspection system
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The near-room-temperature upsurge of electrical resistivity in Lu-H-N is not superconductivity,but a metal-to-poor-conductor transition 被引量:1
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作者 Di Peng Qiaoshi Zeng +3 位作者 Fujun Lan Zhenfang Xing Yang Ding Ho-kwang Mao 《Matter and Radiation at Extremes》 SCIE EI CSCD 2023年第5期96-98,共3页
The recent report of superconductivity in nitrogen-doped lutetium hydride(Lu-H-N)at 294 K and 1 GPa brought hope for long-sought-after ambient-condition superconductors.However,the failure of scientists worldwide to i... The recent report of superconductivity in nitrogen-doped lutetium hydride(Lu-H-N)at 294 K and 1 GPa brought hope for long-sought-after ambient-condition superconductors.However,the failure of scientists worldwide to independently reproduce these results has cast intense skepticism on this exciting claim.In this work,using a reliable experimental protocol,we synthesized Lu-H-N while minimizing extrinsic influences and reproduced the sudden change in resistance near room temperature.With quantitative comparison of the temperaturedependent resistance between Lu-H-N and the pure lutetium before reaction,we were able to clarify that the drastic resistance change is most likely caused by a metal-to-poor-conductor transition rather than by superconductivity.Herein,we also briefly discuss other issues recently raised in relation to the Lu-H-N system. 展开更多
关键词 resistance SUPERCONDUCTIVITY TRANSITION
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The influence of resistance exercise training prescription variables on skeletal muscle mass,strength,and physical function in healthy adults:An umbrella review 被引量:1
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作者 Jonathan C.Mcleod Brad S.Currier +1 位作者 Caroline V.Lowisz Stuart M.Phillips 《Journal of Sport and Health Science》 SCIE CSCD 2024年第1期47-60,共14页
Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy adults.Methods:Following ... Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy adults.Methods:Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,we systematically searched and screened eligible systematic reviews reporting the effects of differing RT prescription variables on muscle mass(or its proxies),strength,and/or physical function in healthy adults aged>18 years.Results:We identified 44 systematic reviews that met our inclusion criteria.The methodological quality of these reviews was assessed using A Measurement Tool to Assess Systematic Reviews;standardized effectiveness statements were generated.We found that RT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),strength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).RT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted RT-induced increases in muscular strength.We discovered that 2/3 reviews provided some or sufficient evidence that RT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of RT load impacting skeletal muscle mass.There was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of RT prescription variables on physical function.Conclusion:Overall,RT increased muscle mass,strength,and physical function compared to no exercise.RT intensity(load)and weekly frequency impacted RT-induced increases in muscular strength but not muscle hypertrophy.RT volume(number of sets)influenced muscular strength and hypertrophy. 展开更多
关键词 HYPERTROPHY resistance training resistance training prescription variables STRENGTH Umbrella review
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Electrical resistivity change of saturated sand during reliquefaction under hammering loading
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作者 Wang Binghui Xiao Xing +2 位作者 Zhang Lei Wang Liyan Jin Dandan 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2023年第3期613-622,共10页
The electrical resistivity method was verified as an optional technique to monitor the change of mesostructure of saturated soils.To investigate the change laws of resistivity and analyze the reliquefaction meso-mecha... The electrical resistivity method was verified as an optional technique to monitor the change of mesostructure of saturated soils.To investigate the change laws of resistivity and analyze the reliquefaction meso-mechanism during the consecutive liquefaction process,five successive impact liquefaction tests were performed in a one-dimensional cubical chamber.The resistivity variation and excess pore water pressure(EPWP)were measured.The results indicate that the excess pore water pressure experienced four stages:quick increase stage,slow dissipation stage,rapid dissipation stage,and stability stage.Meanwhile,a swift decrease of resistivity emerged before the start of the rapid dissipation stage of EPWP,and then an increasing trend of resistivity is demonstrated with the densification of soil.It is proved that the vertical pore connectivity of liquefied sand is better than its random deposit state,based on a comparative study of porosity calculated from the settlement and resistivity of sand after each test. 展开更多
关键词 SAND reliquefaction resistivity excess pore water pressure MESOSTRUCTURE
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Greatly enhanced corrosion/wear resistances of epoxy coating for Mg alloy through a synergistic effect between functionalized graphene and insulated blocking layer 被引量:1
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作者 Z.Y.Xue X.J.Li +3 位作者 J.H.Chu M.M.Li D.N.Zou L.B.Tong 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第1期332-344,共13页
The poor corrosion and wear resistances of Mg alloys seriously limit their potential applications in various industries.The conventional epoxy coating easily forms many intrinsic defects during the solidification proc... The poor corrosion and wear resistances of Mg alloys seriously limit their potential applications in various industries.The conventional epoxy coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient protection.In the current study,we design a double-layer epoxy composite coating on Mg alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assembly technique.The outer layer is functionalized graphene(FG)in waterborne epoxy resin(WEP)and the inner layer is Ce-based conversion(Ce)film.The FG sheets can be homogeneously dispersed within the epoxy matrix to fill the intrinsic defects and improve the barrier capability.The Ce film connects the outer layer with the substrate,showing the transition effect.The corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of bare Mg alloy,and the wear rate is decreased by~90%.The improved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive medium)and the obstruction of galvanic coupling behavior.The synergistic effect derived from the FG sheet and blocking layer exhibits great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of Mg alloys. 展开更多
关键词 Mg alloy Functionalized graphene Epoxy coating Corrosion/wear resistance Blocking layer
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Evaluation of Factors of Soil Resistivity in the Niger Delta
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作者 Tamunoene K. S. Abam Ferdinand Dumbari Giadom +1 位作者 Robert E. O. Iduma Ifeyinwa L. Nwankwo 《Journal of Geoscience and Environment Protection》 2023年第5期335-348,共14页
Soil conductivity is responsible for its aggressive behavior to metallic objects either in contact or buried in the ground. Rapid deterioration and eventual rupture of pipelines leading ultimately to crude oil spillag... Soil conductivity is responsible for its aggressive behavior to metallic objects either in contact or buried in the ground. Rapid deterioration and eventual rupture of pipelines leading ultimately to crude oil spillages have been of economic as well as environmental concern. Although many factors contribute to soil resistivity, these relationships have hardly been quantitatively expressed. This paper explores the factors affecting soil resistivity firstly by matching the spatial regional distribution with each of the identified factors of influence, including ground elevation soil type, depth to water table and undrained strength. 183 Vertical Electrical Sounding VES with the ABEM SAS 1000, using Schlumberger electrode configuration were carried out along a pipeline route to generate resistivity distribution across a linear alignment that traverses three geomorphic sub-environments in the Niger Delta Region. The apparent resistivity values averaged over depths of 3 m and 10 m were plotted against the co-ordinates using Surfer-16 and overlaid on Google earth Pro to produce a spatial distribution with enhanced location visibility. The results show that apparent resistivity is influenced by depth to water table with lower values in areas of shallow water table occurrence. Furthermore, it is shown that changes in resistivity below the water table are more due to variation in soil type. Within a soil type above the water table, soil resistivity increases monotonically with depth until the depth of probe extends to a different soil horizon. Results of this study provide guidance as to what ground resistivity to expect in different part of the delta as well as provide valuable information to assess the risks to assets either as a means of prioritizing maintenance or of improving design for new installations in the Niger Delta Region. 展开更多
关键词 FACTORS resistivity Aggressivity VES Environment of Deposition
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Fabrication and characterization of NiCr-based films with high resistivity and low temperature coefficient of resistance
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作者 Diaohao Zhai Yongping Chen +1 位作者 Houming Zhai Yi Liu 《Nanotechnology and Precision Engineering》 EI CAS CSCD 2023年第2期33-40,共8页
As a metal alloy,NiCr films have a relatively high resistivity and low temperature coefficient of resistance (TCR) and are widely used in electronic components and sensors.However,the resistivity of pure NiCr is insuf... As a metal alloy,NiCr films have a relatively high resistivity and low temperature coefficient of resistance (TCR) and are widely used in electronic components and sensors.However,the resistivity of pure NiCr is insufficient for high-resistance and highly stable film resistors.In this study,a quaternary NiCrAlSi target (47:33:10:10,wt.%) was successfully used to prepare resistor films with resistivities ranging from 1000 to 10 000μΩcm and TCR within±100 ppm/K.An oxygen flow was introduced during the sputtering process.The films exhibit hightemperature stability at 450℃.The films were analyzed using Auger electron spectroscopy,x-ray diffraction,time-of-flight secondary-ion mass spectrometry,and x-ray photoelectron spectroscopy.The results show that the difference in the oxide proportion of the films caused the differences in resistivity.The near-zero TCR values were considered to be due to the competition between silicon and other metals.This study provides new insights into the electrical properties of NiCr-based films containing Si,which will drive the manufacturing of resistors with high resistivity and zero TCR. 展开更多
关键词 NICR magnetron sputtering resistOR temperature coefficient of resistance ToF-SIMS XPS
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Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance 被引量:2
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作者 Dina Medina-Vera Antonio Jesús López-Gambero +4 位作者 Juan Antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期289-295,共7页
Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the pho... Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein.Among the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug development.The present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease. 展开更多
关键词 Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-PINITOL inositols insulin resistance KINASES PHOSPHORYLATION PI3K/Akt tau
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Study on Geological Genesis and Sedimentary Model of Complex Low Resistivity Reservoir in Offshore Oilfield — A Case of NgIII Formation of X Oilfield in Bohai Sea
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作者 Wentong Zhang Jie Tan +2 位作者 Feiteng Wang Songru Mu Bowei Liu 《Journal of Geoscience and Environment Protection》 2023年第4期157-169,共13页
In order to study the micro genetic mechanism and main geological controlling factors of low resistivity reservoir in NgIII formation of X oilfield in Bohai sea in China, the clay mineral composition, irreducible wate... In order to study the micro genetic mechanism and main geological controlling factors of low resistivity reservoir in NgIII formation of X oilfield in Bohai sea in China, the clay mineral composition, irreducible water saturation, salinity and conductive minerals of low resistivity reservoir were studied by using the data of core, cast thin section and analysis, and compared with normal resistivity reservoir. At the same time, the control effect of sedimentary environment on low resistivity reservoir was discussed. The results show that the additional conductivity of high bound water content and high montmorillonite content in the reservoir together leads to the significant reduction of reservoir resistivity, which is the main microscopic cause of the formation of low resistance, and is mainly controlled by the sedimentary background such as paleoclimate and sedimentary cycle. During the deposition period of NgIII formation, the paleoclimate was dry and cold, and it was at the end of the water advance of the medium-term sedimentary cycle. The hydrodynamic force of the river channel was weak, the carrying capacity of the riverbed was weak, and the river channel swayed frequently, resulting in fine lithologic particle size, high shale content and complex pore structure of the reservoir, resulting in significant reduction of reservoir resistance. The research conclusion would have strong guiding significance for the development of low resistivity reservoirs in this area. 展开更多
关键词 Low Energy Braided River Low resistivity Reservoir Irreducible Water Saturation Clay Minerals PALEOCLIMATE Hydrodynamic Force
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Research and Application of High-Density Resistivity Method in Seawater Intrusion Investigation in Laizhou Bay
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作者 Yuhai HE Hongjin WANG +3 位作者 Zengcai ZHAO Biao WANG Bin ZHANG Xiaodan WANG 《Agricultural Biotechnology》 2023年第6期88-92,共5页
The disaster of seawater intrusion seriously affects people's lives and restricts economic development,so the detection and treatment of seawater intrusion is a long-term task.On the basis of field investigation a... The disaster of seawater intrusion seriously affects people's lives and restricts economic development,so the detection and treatment of seawater intrusion is a long-term task.On the basis of field investigation and water quality analysis,according to the change characteristics of apparent resistivity of groundwater after Cl-reaches 250 mg/L,the theoretical basis for the application of high-density resistivity method was determined,and the characteristic values of apparent resistivity for seawater intrusion interfaces in different geological characteristic regions in Laizhou Bay area were determined by typical profile tests.Combined with water quality investigation and other means,profiles for the high-density resistivity method were arranged,and the interfaces between saline and fresh water were accurately divided. 展开更多
关键词 High-density resistivity method Seawater intrusion Laizhou Bay Characteristic value
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Dissemination of Resistance Integrons and Genes Coding for Blse and Cabapenemases in the Urban Drainage Network in Cote d’Ivoire
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作者 Coulibaly Kalpy Julien Diaby Aboubakar Sidik +8 位作者 Vakou N’dri Sabine M’bengue Gbonon Valérie Carole Claon Jean Stephane Yao Kouamé Eric Gnali Gbohounou Fabrice Yéo Yéfougnini Bagré Issa Djaman Allico Joseph Dosso Mireille 《Advances in Microbiology》 CAS 2024年第5期268-286,共19页
Antibiotic resistance has become a major threat to human health worldwide. Environment, particularly the water environment, has long been overlooked as a player in the antibiotic resistance cycle, although its role re... Antibiotic resistance has become a major threat to human health worldwide. Environment, particularly the water environment, has long been overlooked as a player in the antibiotic resistance cycle, although its role remains unclear. These can provide an ideal setting for the acquisition and dissemination of antibiotic resistance, as they are frequently affected by anthropogenic activities. The objective of this study was to establish a diffusion map of resistance integrons used as genetic markers of resistance associated with antibiotic resistance conferring genes (ARGs). Total DNA extracts from non-cultivable bacterial communities were used for the analyses. These communities were obtained from wastewater samples from 14 sites upstream and downstream of drainage channels or effluents in the cities of Abidjan, Bouaké, and Yamoussoukro. The results obtained correspond to the number of positives among the treated samples (n = 39). Among the genetic markers of dissemination, class 1 integrons were the most evident in 94.8% of samples in Abidjan (93.3%), Bouaké (100%) and Yamoussoukro (91.6%). Class 2 integrons and class 3 integrons were found respectively in 41% and 51% of all samples. Genes coding for β-lactamases and blaTEM was identified in almost all samples at a rate of 97.4%. A co-presence of the three genes blaTEM, blaSHV and blaCTX-M is also remarkable in the sites of the city of Yamoussoukro. Among the genes coding for carbapenemases, only blaKPC 17.94%, blaNDM 30.76% and blaOXA48 38.46% were detected in the samples. 展开更多
关键词 Antibiotic resistance WASTEWATER resistance Integrons (RIs) resistance Genes
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Natural Products and Antiviral Resistance
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作者 Erute Magdalene Adongbede Janak Raj Khatiwada +1 位作者 Rishipal Rastrapal Bansode Leonard Lamont Williams 《Advances in Microbiology》 CAS 2024年第7期366-388,共23页
Viral diseases are minacious with the potential for causing pandemics and treatment is complicated because of their inherent ability to mutate and become resistant to drugs. Antiviral drug resistance is a persistent p... Viral diseases are minacious with the potential for causing pandemics and treatment is complicated because of their inherent ability to mutate and become resistant to drugs. Antiviral drug resistance is a persistent problem that needs continuous attention by scientists, medical professionals, and government agencies. To solve the problem, an in-depth understanding of the intricate interplay between causes of antiviral drug resistance and potential new drugs specifically natural products is imperative in the interest and safety of public health. This review delves into natural product as reservoir for antiviral agents with the peculiar potentials for addressing the complexities associated with multi-drug resistant and emerging viral strains. An evaluation of the mechanisms underlying antiviral drug activity, antiviral drug resistance is addressed, with emphasis on production of broad-spectrum antiviral agents from natural sources. There is a need for continued natural product-based research, identification of new species and novel compounds. 展开更多
关键词 Drug resistance resistance Mechanisms PHYTOCHEMICALS Broad-Spectrum Drugs Antiviral Agents
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Nature’s Pharmacy under Siege: Investigating Antibiotic Resistance Pattern in Endophytic Bacteria of Medicinal Plants
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作者 Bonoshree Sarkar Afroza Sultana +5 位作者 Nabila Nawar Binti Farhana Tasnim Chowdhury Sadia Afrin Mohammad Fahim Taibur Rahman Atiqur Rahman 《Advances in Microbiology》 CAS 2024年第4期183-208,共26页
Antibiotic resistance poses a significant global health threat, necessitating a thorough understanding of its prevalence in various ecological contexts. Medicinal plants, renowned for their therapeutic properties, hos... Antibiotic resistance poses a significant global health threat, necessitating a thorough understanding of its prevalence in various ecological contexts. Medicinal plants, renowned for their therapeutic properties, host endophytic bacteria that produce bioactive compounds. Understanding antibiotic resistance dynamics in these bacteria is vital for human health and antibiotic efficacy preservation. In this study, we investigated antibiotic resistance profiles in endophytic bacteria from five medicinal plants: Thankuni, Neem, Aparajita, Joba, and Snake plant. We isolated and characterized 113 endophytic bacteria, with varying resistance patterns observed against multiple antibiotics. Notably, 53 strains were multidrug-resistant (MDR), with 14 exhibiting extensive drug resistance (XDR). Thankuni-associated bacteria displayed 44% MDR and 11% XDR, while Neem-associated bacteria showed higher resistance (60% MDR, 13% XDR). Aparajita-associated bacteria had lower resistance (22% MDR, 6% XDR), whereas Joba-associated bacteria exhibited substantial resistance (54% MDR, 14% XDR). Snake plant-associated bacteria showed 7% MDR and 4% XDR. Genus-specific distribution revealed Bacillus (47%), Staphylococcus (21%), and Klebsiella (11%) as major contributors to MDR. Our findings highlight diverse drug resistance patterns among plant-associated bacteria and underscore the complexity of antibiotic resistance dynamics in diverse plant environments. Identification of XDR strains emphasizes the severity of the antibiotic resistance problem, warranting further investigation into contributing factors. 展开更多
关键词 Antibiotic resistance Endophytic Bacteria Medicinal Plants Drug resistance
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Identification of watered-out zones in carbonate reservoirs using resistivity curve reconstruction based on reservoir classification
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作者 Fei Wang Lun Zhao +2 位作者 Huiyuan Bian Chengqian Tan Jianxin Li 《Energy Geoscience》 2023年第2期128-134,共7页
The KT-II layer in the Zananor Oilfield,Caspian Basin,Kazakhstan,contains carbonate reservoirs of various types.The complex pore structure of the reservoirs have made it difficult to identify watered-out zones with tr... The KT-II layer in the Zananor Oilfield,Caspian Basin,Kazakhstan,contains carbonate reservoirs of various types.The complex pore structure of the reservoirs have made it difficult to identify watered-out zones with traditional logging interpretation methods.This study classifies the reservoirs on the basis of core analysis and establishes an identification model for watered-out layers in the field to effectively improve the interpretation accuracy.Thin section analysis shows that there are three types of pores in the reservoirs,i.e.,the matrix pore,fracture and dissolution vug.A triple porosity model is used to calculate the porosities of the reservoirs and the results are combined with core analysis to classify the reservoirs into the fractured,matrix pore,fracture-pore as well as composite types.A classification standard is also proposed.There are differences in resistivity logging responses from the reservoirs of different types before and after watering-out.The preewatering-out resistivities are reconstructed using generalized neural network for different types of reservoirs.The watered-out layers can be effectively identified according to the difference in resistivity curves before and after watering-out.The results show that the watered-out layers identified with the method are consistent with measured data,thus serving as a reference for the evaluation of watered-out layers in the study area. 展开更多
关键词 Watered-out zone Reconstructed resistivity Neural network Log evaluation Reservoir classification
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Community-acquired multidrug-resistant pneumonia,bacteraemia,and infective endocarditis:A case report 被引量:1
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作者 Basavaraj Jatteppanavar Arnab Choudhury +1 位作者 Prasan Kumar Panda Mukesh Bairwa 《World Journal of Critical Care Medicine》 2024年第1期85-91,共7页
BACKGROUND The prevalence of multidrug-resistant(MDR)bacteria has increased globally,with extensive drug-resistant(XDR)bacteria posing a threat to patients.CASE SUMMARY This case report describes a young man admitted ... BACKGROUND The prevalence of multidrug-resistant(MDR)bacteria has increased globally,with extensive drug-resistant(XDR)bacteria posing a threat to patients.CASE SUMMARY This case report describes a young man admitted for suspected tropical fever infections who experienced rapid deterioration in health.Despite negative results for tropical fever infections,he had neutrophilic leucocytosis,acute kidney injury,and chest imaging findings suggestive of bilateral consolidations.On day two,he was diagnosed with infective endocarditis with possible rheumatic heart disease and MDR methicillin-resistant Staphylococcus aureus bacteraemia,and communityacquired pneumonia.Despite treatment with broad-spectrum antibiotics,he did not respond and succumbed to death on day five.CONCLUSION This case highlights that clinicians/public should be aware of MDR communityacquired pneumonia,bacteraemia,and endocarditis which ultimately culminate in high rates of morbidity and mortality.Early identification of pathogenic strain and prompt antibiotic treatment are a mainstay for the management and prevention of early fatalities.Simultaneously,route cause analysis of communityacquired MDR/XDR pathogens is a global need. 展开更多
关键词 Antibiotic resistance Community-acquired infections Infective endocarditis Methicillin-resistant staphylococcus aureus Rheumatic heart disease Case report
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Groundwater Potential Mapping in Lapan Gwari Community Using Integrated Remote Sensing and Electrical Resistivity Soundings
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作者 Ayuba Danmangu Mangs Jude Steven Ejepu +5 位作者 Charity Chizaram Nkemkah Solomon Nehemiah Yusuf Adamu Keana Sallau Janet Agati Yakubu Yusuf Ibrahim Williams Midala Wakili 《International Journal of Geosciences》 2023年第8期719-732,共14页
This research aims to address the pressing issue of failed and abandoned wells, causing water scarcity in Lapan Gwari Community, through an improved groundwater exploration approach integrating remote sensing and elec... This research aims to address the pressing issue of failed and abandoned wells, causing water scarcity in Lapan Gwari Community, through an improved groundwater exploration approach integrating remote sensing and electrical resistivity soundings. The study area, located within the Zungeru Sheet 163 SE, spans Latitudes 9°30'00"N to 9°32'00"N and Longitudes 6°28'00" to 6°30'00". The surface geologic, structural, and hydrogeological mapping provided essential insights into the hydrogeological framework. Leveraging SRTM DEM data, thematic maps were created for geomorphology, slope, land use, lineament density, and drainage density. These datasets were then integrated using ArcGIS to develop a preliminary groundwater potential zones map. Further investigations were conducted using Vertical Electrical Sounding (VES) and Electrical Resistivity Imaging (2D VES) surveys at targeted locations identified by the preliminary map. Results show that the study area predominantly consists of crystalline rocks of the Nigerian Basement Complex, primarily comprising schist and granite with minor occurrences of quartz vein intrusions. Surface joint directions indicated a dominant NE-SW trend. The VES data revealed three to four geoelectric layers, encompassing the topsoil (1 to 5 m depth, resistivity: 100 Ωm to 300 Ωm), the weathered layer (in the 3-layer system) or fractured layer (in the 4-layer system), and the fresh basement rock characterized by infinite resistivity. The shallow weathered layers (3 to 30 m thickness) are believed to hold aquiferous potential. Hydrogeological interpretation, facilitated by 2D resistivity models, delineated water horizons trapped within clayey sand and weathered/fractured formations. Notably, the aquifer resistivity range was found to be between 3 - 35 m and 100 - 300 Ωm, signifying a promising aquifer positioned at depths of 40 to 88 m. This aligns with corroborative static water level measurements. Given this, we recommend drilling depths of a minimum of 80 m to ensure the acquisition of sufficient and sustainable water supplies. The final groundwater potential zones map derived from this study is expected to serve as an invaluable guide for prospective groundwater developers and relevant authorities in formulating effective water resource management plans. By effectively tackling water scarcity challenges in Lapan Gwari Community, this integrated approach demonstrates its potential for application in similar regions facing comparable hydrogeological concerns. 展开更多
关键词 Vertical Electrical Sounding Electrical resistivity Imaging Fractured Aquifer Groundwater Exploration
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