Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests

The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong earthquakes.While extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains unclear.This research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active fault.The prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation corridor.The results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)increased.The PGAs of different engineering structures were weakened by the fault rupture zone.Nevertheless,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic vibration.Additionally,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active faults.The findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor.

Investigations of the mechanical response of dummy HTPB propellant grain under ultrahigh acceleration overload conditions using onboard flight-test measurements

In this paper,to study the mechanical responses of a solid propellant subjected to ultrahigh acceleration overload during the gun-launch process,specifically designed projectile flight tests with an onboard measurement system were performed.Two projectiles containing dummy HTPB propellant grains were successfully recovered after the flight tests with an ultrahigh acceleration overload value of 8100 g.The onboard-measured time-resolved axial displacement,contact stress and overload values were successfully obtained and analysed.Uniaxial compression tests of the dummy HTPB propellant used in the gunlaunched tests were carried out at low and intermediate strain rates to characterize the propellant's dynamic properties.A linear viscoelastic constitutive model was employed and applied in finite-element simulations of the projectile-launching process.During the launch process,the dummy propellant grain exhibited large deformation due to the high acceleration overload,possibly leading to friction between the motor case and propellant grain.The calculated contact stress showed good agreement with the experimental results,though discrepancies in the overall displacement of the dummy propellant grain were observed.The dynamic mechanical response process of the dummy propellant grain was analysed in detail.The results can be used to estimate the structural integrity of the analysed dummy propellant grain during the gun-launch process.

MAPOD Analysis in Eddy Current Testing of Flaws Considering Multiple Response Signals and Multiple Flaw Parameters

The reliability of the eddy current testing (ECT) in flaw detection is quantitatively evaluated by theprobability of detection (POD). Precise and efficient modeling of POD gives direction for the implement of ECTon sites to avoid false or missing flaw detection. Traditional POD analysis focuses on single uncertain factor orsingle response signal with limited credibility in engineering. This paper considers multiple response signals andmultiple flaw parameters to perform POD. The flaw length, the flaw depth, the coil impedance, and the magneticflux density are comprehensively studied under various lift-off distances. A finite element model (FEM) of ECT isestablished and verified with experiments to obtain sufficient simulation data for discrete POD modeling. Thecontinuous POD function is then fitted based on the discrete values to show the superiority of integrating multiplefactors. A comparison with conventional POD analysis further demonstrates the higher reliability of ECT flawdetection considering multiple flaw parameters and multiple response signals, especially for small flaws.

Effect of burial depth of a new tunnel on the seismic response of an existing tunnel

Burial depth is a crucial factor affecting the forces and deformation of tunnels during earthquakes.One key issue is a lack of understanding of the effect of a change in the buried depth of a single-side tunnel on the seismic response of a double-tunnel system.In this study,shaking table tests were designed and performed based on a tunnel under construction in Dalian,China.Numerical models were established using the equivalent linear method combined with ABAQUS finite element software to analyze the seismic response of the interacting system.The results showed that the amplification coefficient of the soil acceleration did not change evidently with the burial depth of the new tunnel but decreased as the seismic amplitude increased.In addition,the existing tunnel acceleration,earth pressure,and internal force were hardly affected by the change in the burial depth;for the new tunnel,the acceleration and internal force decreased as the burial depth increased,while the earth pressure increased.This shows that the earth pressure distribution in a double-tunnel system is relatively complex and mainly concentrated on the arch spandrel and arch springing of the relative area.Overall,when the horizontal clearance between the center of the two tunnels was more than twice the sum of the radius of the outer edges of the two tunnels,the change in the burial depth of the new tunnel had little effect on the existing one,and the tunnel structure was deemed safe.These results provide a preliminary understanding and reference for the seismic performance of a double-tunnel system.

Damage degradation mechanism and macro-meso structural response of mudstone after water wetting

The predominant presence of weak interlayers primarily composed of mudstone renders them highly susceptible to a reduction in bearing capacity due to the water-rock weakening effect,significantly impacting the safety of open-pit mining operations.This study focuses on the weak mudstone layers within open-pit mine slopes.The mineral composition of mudstone and the microstructure evolution characteristics before and after water wetting were analyzed by X-ray diffraction(XRD)and scanning electron microscope(SEM).The meso-structure and parameter variation characteristics of mudstone interior space after water-rock interaction were quantified by computed tomography scanning test,and the damage variable characterization method was proposed.Additionally,according to the uniaxial compression test,the degradation characteristics of the macroscopic mechanical behavior of mudstone under different water wetting time were explored,and the elastic modulus and strength attenuation model of mudstone based on mesoscopic damage were established.Finally,building upon the macro-meso structural response characteristics of mudstone,an exploration of the failure characteristics and deterioration mechanism under the influence of water-rock interactions was undertaken.The results show that the water-rock interaction makes the internal defects of mudstone gradually develop and form a fracture network structure,which eventually leads to the deterioration of its macroscopic mechanical properties.The porosity,fractal dimension and damage characteristics of mudstone show an exponential trend with the increase of water wetting time.Moreover,the deterioration mechanism of mudstone after water wetting are postulated to encompass factors such as the hydrophilicity of mineral molecular structures,hydration stress and expansion effects on clay particles,as well as the spatial distribution of microcracks and the phenomenon of fracture adsorption.The outcomes of this research endeavor aim to provide certain reference value for further understanding the water-rock interaction and stability control of mudstone slope.

Pathologic complete response to conversion therapy in hepatocellular carcinoma using patient-derived organoids:A case report

BACKGROUND For primary liver cancer,the key to conversion therapy depends on the effectiveness of drug treatment.Patient-derived tumor organoids have been demonstrated to improve the efficacy of conversion therapy by identifying individualtargeted effective drugs,but their clinical effects in liver cancer remain unknown.CASE SUMMARY We described a patient with hepatocellular carcinoma(HCC)who achieved pathologic complete response(pCR)to conversion therapy guided by the patientderived organoid(PDO)drug sensitivity testing.Despite insufficiency of the remaining liver volume after hepatectomy,the patient obtained tumor reduction after treatment with the PDO-sensitive drugs and successfully underwent radical surgical resection.Postoperatively,pCR was observed.CONCLUSION PDOs contributes to screening sensitive drugs for HCC patients to realize the personalized treatment and improve the conversion therapy efficacy.

Automated Flight Test and System Identification for Rotary Wing Small Aerial Platform Using Frequency Responses Analysis

This paper proposes an autopilot system that can be used to control the small scale rotorcraft during the flight test for linear-frequency-domain system identification. The input frequency-sweep is generated automatically as part of the autopilot control command. Therefore the bandwidth coverage and consistency of the frequency-sweep are guaranteed to produce high quality data for system identification. Beside that, we can set the safety parameters during the flight test （maximum roll/pitch value, minimum altitude, etc.） so the safety of the whole flight test is guaranteed. This autopilot system is validated using hardware in the loop simulator for hover flight condition.

Effect of Lithology and Structure on Seismic Response of Steep Slope in a Shaking Table Test

Studies on landslides by the 2008 Wenchuan earthquake showed that topography was of great importance in amplifying the seismic shaking, and among other factors, lithology and slope structure controlled the spatial occurrence of slope failures. The present study carried out experiments on four rock slopes with steep angle of 60° by means of a shaking table. The recorded Wenchuan earthquake waves were scaled to excite the model slopes. Measurements from accelerometers installed on free surface of the model slope were analyzed, with much effort on timedomain acceleration responses to horizontal components of seismic shaking. It was found that the amplification factor of peak horizontal acceleration, RPHA, was increasing with elevation of each model slope, though the upper and lower halves of the slope exhibited different increasing patterns. As excitation intensity was increased, the drastic deterioration of the inner structure of each slope caused the sudden increase of RPHA in the upper slope part. In addition, the model simulating the soft rock slope produced the larger RPHA than the model simulating the hard rock slope by a maximum factor of 2.6. The layered model slope also produced the larger RPHA than the homogeneous model slope by a maximum factor of 2.7. The upper half of a slope was influenced more seriously by the effect of lithology, while the lower half was influenced more seriously by the effect of slope structure.

Shaking table test and dynamic response prediction on an earthquake-damaged RC building

This paper presents the results from shaking table tests of a one-tenth-scale reinforced concrete (RC) building model.The test model is a protype of a building that was seriously damaged during the 1985 Mexico earthquake.The input ground excitation used during the test was from the records obtained near the site of the prototype building during the 1985 and 1995 Mexico earthquakes.The tests showed that the damage pattern of the test model agreed well with that of the prototype building.Analytical prediction of earthquake response has been conducted for the prototype building using a sophisticated 3-D frame model.The input motion used for the dynamic analysis was the shaking table test measurements with similarity transformation.The comparison of the analytical results and the shaking table test results indicates that the response of the RC building to minor and the moderate earthquakes can be predicated well.However,there is difference between the predication and the actual response to the major earthquake.

High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test

AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods.

Shaking table test of seismic responses of anchor cable and lattice beam reinforced slope

As a combined supporting structure,the anchor cable and lattice beam have a complex interaction with the slope body.In order to investigate the seismic behaviors of the slope reinforced by anchor cable and lattice beam,a largescale shaking table test was carried out on a slope model(geometric scale of 1:20)by applying recorded and artificial seismic waves with different amplitudes.The acceleration and displacement of the slope,the displacement of lattice beam and the axial force of anchor cable were obtained to study the interaction between the slope and the supporting structure.The test results show that:(1)the acceleration responses of the slope at different relative elevations display obvious nonlinear characteristics with increasing of the peak ground acceleration(PGA)of the inputted seismic waves,and the weak intercalated layer has a stronger effect on acceleration amplification at the upper part of the slope than that at the lower part of the slope;(2)the frequency component near the second dominant frequency is significantly magnified by the interaction between the slope and the supporting structure;(3)the anchor cables at the upper part of the slope have larger peak and residual axial forces than that at the lower part of the slope,and the prestress loss of the anchor cable first occurs at the top of the slope and then passes down;(4)the peak and residual displacements inside the slope and on the lattice beam increase with the increase of relative elevation.When the inputted PGA is not greater than 0.5 g,the combined effect of anchor cable and lattice beam is remarkable for stabilizing the middle and lower parts of the potential sliding body.The research results can provide a reference for the seismic design of such slope and the optimization of supporting structure.

Test of frequency characteristic for well and itsresponse to seismic waves

The permeation parameters have been calculated by forefathers on the basis of permeation theory by means of the Slug test (Yin, Zheng, 1992) and the restoration curves of well level. We are interested in oscillation of the well level when we make Slug test. Both the permeation parameters and frequency parameters, i.e., natural period and damping coefficients of well aquifer, have been calculated on the basis of vibration theory by means of the oscillation curves. Not only this has given a new method, but also the different response of well level to seismic waves has been explained by it in theory.

Nonlinear Modeling and Identification of Structural Joint by Response Control Vibration Test

Components of mechanical product are assembled by structural joints,such as bolting,riveting,welding,etc.Structural joints introduce nonlinearity to some engineering structures,and the nonlinearity need to be modeled precisely.To meet serious quality requirements,it is necessary to detect and identify nonlinearity of mechanical products for structural optimization.Modal test to acquire a dynamic response has been applied for decades,which provides reliable results for finite element(FE)model updating.Here response control vibration test for identification of nonlinearity is presented.A nonlinear system can be regarded as linearity for particular steady state response,and classical linear analysis tool is applicable to extract modal data for particular response.First,its applicability is illustrated by some numerical simulations.Subsequently,it is implemented on experimental setup with structural joints by shaking table.The stiffness and damping function dependent of relative displacement are fitted to describe its inherent nonlinearity.The spring and damping forces are identified by harmonic balance method(HBM)to predict output response.Based on the identified results,the procedure is recommended that it allows a reliable measurement of nonlinearity with a certain accuracy.

Permanent deformation response parameters of asphalt mixtures for a new mix-confined repeated load test

The main objective of this work is to propose new mixture response parameters and to compare correlations with rut depths and sensitivity of permanent deformation response parameters based on field extracted cores and lab-mixed duplicates. A new "mix-confined" test is developed and four new parameters for this test are proposed. Correlation coefficients with rut depths and coefficients of variation (sensitivity) are compared between the four new and two existing parameters. Some parameters are recommended to be used for the newly developed test. The results show that, newly developed test can capture the changes of permanent deformation of asphalt mixtures. Only one new parameter (D1 of Stephen Price model) and one existing parameter (flow number, Fn ) have strong correlations with rut depths of asphalt pavements (R2 greater than 0.7) and have relative small sensitivity (coefficient of variation, COV, less than 30%). For polymer modified asphalt mixtures, the parameter D1 rather than Fn should be used. These findings can be used to check the permanent deformation of asphalt mixture during the mix design.

Serious response during tilt-table test in elderly and its prophylactic management

Objective: To evaluate the serious response during tilt-table test (TTT) and its prophylactic management. Method: Seventy-six elderly patients were tested at a tilt angle of 70 degrees for a maximum of 45 min and then subjected to isoprotere- nol-provocative tilt testing. ECG and blood pressure were monitored during the test and patients were kept at normal saline con- dition through a peripheral intravenous duct. Results: Fifty-one of 76 patients were defined as positive including 23 having serious response; 6 of the 23 patients had arteriosclerosis involving internal carotid arteries and 7 cases had bradycardia, two of which were associated with II°-I A-V block and the others with chronic atrial fibrillation. The serious response consisted of cardiac arrest for more than 5 s (6 cases), or serious bradycardia for more than 1 min (7 cases) or serious hypotension for more than 1 min (10 cases). Those with serious response were managed by returning to supine position, thus driving up legs and intravenous atropine, CPR (2 cases with cardiac arrest) and needing oxygen supplementation (11 cases). Only 2 hypotension patients recovered gradually by 10 min after emergency management, while others recovered rapidly with no complications. Conclusion: Although non-invasive, TTT may result in serious response, especially in elderly. Therefore proper patient selection, control of isoproterenol infusion and close observation of vital signs are decisive for a safe consequence.

Shaking Table Tests and Seismic Response of Three-Bucket Jacket Foundations for Offshore Wind Turbines

The seismic response characteristics of three-bucket jacket foundations for offshore wind turbines(OWTs)and the liquefaction of the surrounding soil are particularly important for the development and application of this type of structure for offshore use.Using the shaking table test and three-dimensional finite element analysis,different magnitudes of simulated earthquake waves were used as inputs to the shaking table to model seismic excitations.The resulting changes in the excess pore water pressure and acceleration response of the soil under horizontal earthquake are compared in this paper.Calculations of the anti-liquefaction shear stress and equivalent shearing stress during the earthquake,determination of the areas prone to liquefaction,and identification of the effect of the three-bucket jacket foundation on the soil liquefaction resistance were conducted by developing a soil-structure finite element model.The development law of the soil’s amplification effect on seismic acceleration and the seismic response of the foundation soil under various magnitude earthquake waves were also discussed.Results indicate that liquefying the soil inside the bucket of the foundation is more difficult than that outside the bucket during the excitation of seismic waves due to the large upper load and the restraint of the surrounding hoop.This finding confirms the advantages of the three-bucket jacket foundations in improving the liquefaction resistance of the soil inside the bucket.However,the confinement has a barely noticeable impact on the nearby soil outside the skirt.The phenomenon of soil liquefaction at the bottom of the skirt occurred earlier than that in other positions during the seismic excitation,and the excess pore water pressure slowly dissipated.The acceleration amplification coefficient of the sand outside the bucket increases with depth,but that of the sand inside the bucket is substantially inhibited in the height range of the bucket foundation.This result proves the inhibition effects of the three-bucket jacket foundations on the seismic responses of soils.The liquefied soil layer has a significant effect in absorbing a certain amount of seismic wave energy and reducing the amplification effect.The numerical simulation results are consistent with the phenomenon and data measured during the shaking table test.The current study also verifies the feasibility of the excess pore water pressure ratio and the anti-liquefaction shear stress method for judging soil liquefaction.

A study on dynamic response of slopes under wave action using simulation tests

After the erection of the Three Gorges Dam, the water level of Yangtze River will reach 175 m, and the average wave crest will be up to 1 m. Therefore the wave action cannot be neglected for the slope stability. Through simulation tests, the wave-induced dynamic response of the slope is analyzed. The soil body is taken as linear elastic body when it has a small deformation under the small wave action. Based on tests, the excess pore pressure and slope displacement under the loading in different wave period are analyzed. The ratio of dynamic strength and static strength to the breaking process of the slope is discussed. It is demonstrated that smaller wave period gives rise to a larger strain of the slope under the same stress. At different depth of water, different weakness effect on the stability of the soil slope is observed and the slope has an adaptability to the wave action to some extent.

Thermal Response Test by Improved Test Rig with Heating or Cooling Soil

An improved test rig providing both the heat and cold source was used to perform thermal response test （TRT）, and the line source model was used for data analysis. The principle of determining the temperature difference between the inlet and outlet of test well can keep the heating or cooling rate constant, along with a reduced size of test rig. Among the influencial factors of the line source model, the temperature difference was determined as the most important, which agreed with the test results. When the gravel was taken as the backfill material, the soil thermal conductivities of heating and cooling at the test place were 1.883 W/（m＆#183;K） and 1.754 W/（m＆#183;K）, respectively, and the deviation of TRT between heating and cooling soil was 6.8%. In the case of fine sand, the thermal conductivities of heating and cooling were 1.541 W/（m＆#183;K） and 1.486 W/（m＆#183;K）, respectively, and the corresponding deviation was 6%. It was also concluded that different velocities of water had less influence on TRT than the temperature difference.

Temporal pattern of humoral immune response in mild cases of COVID-19

BACKGROUND Understanding the humoral response pattern of coronavirus disease 2019(COVID-19)is one of the essential factors to better characterize the immune memory of patients,which allows understanding the temporality of reinfection,provides answers about the efficacy and durability of protection against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and consequently helps in global public health and vaccination strategy.Among the patients who became infected with SARS-CoV-2,the majority who did not progress to death were those who developed the mild COVID-19,so understanding the pattern and temporality of the antibody response of these patients is certainly relevant.AIM To investigate the temporal pattern of humoral response of specific immunoglobulin G(IgG)in mild cases of COVID-19.METHODS Blood samples from 191 COVID-19 real-time reverse transcriptase-polymerase chain reaction(RT-qPCR)-positive volunteers from the municipality of Toledo/Paraná/Brazil,underwent two distinct serological tests,enzyme-linked immunosorbent assay,and detection of anti-nucleocapsid IgG.Blood samples and clinicoepidemiological data of the volunteers were collected between November 2020 and February 2021.All assays were performed in duplicate and the manufacturers'recommendations were strictly followed.The data were statistically analyzed using multiple logistic regression;the variables were selected by applying the P<0.05 criterion.RESULTS Serological tests to detect specific IgG were performed on serum samples from volunteers who were diagnosed as being positive by RT-qPCR for COVID-19 or had disease onset in the time interval from less than 1 mo to 7 mo.The time periods when the highest number of participants with detectable IgG was observed were 1,2 and 3 mo.It was observed that 9.42%of participants no longer had detectable IgG antibodies 1 mo only after being infected with SARS-CoV-2 and 1.57%were also IgG negative at less than 1 mo.At 5 mo,3.14%of volunteers were IgG negative,and at 6 or 7 mo,1 volunteer(0.52%)had no detectable IgG.During the period between diagnosis by RT-qPCR/symptoms onset and the date of collection for the study,no statistical significance was observed for any association analyzed.Moreover,considering the age category between 31 and 59 years as the exposed group,the P value was 0.11 for the category 31 to 59 years and 0.32 for the category 60 years or older,showing that in both age categories there was no association between the pair of variables analyzed.Regarding chronic disease,the exposure group consisted of the participants without any comorbidity,so the P value of 0.07 for the category of those with at least one chronic disease showed no association between the two variables.CONCLUSION A temporal pattern of IgG response was not observed,but it is suggested that immunological memory is weak and there is no association between IgG production and age or chronic disease in mild COVID-19.

Changing Virus Response

China optimises anti-COVID-19 measures in response to actual situation and public concern After months of lining up every two to three days to take a nucleic acid test at temporary testing stations dotting the urban landscape,many Chinese residents were pleasantly surprised to learn on 7 December 2022 that they would no longer be required to take the test.