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GEOMETRIC DESIGN OF DEPLOYABLE/RETRACTABLE MAST 被引量:1
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作者 杨玉龙 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2006年第4期250-256,共7页
To simplify the complicated design process of deployable/retractable structures, a new design process is developed. The process is divided into three phases: the concept design phase, the model phase and the optimiza... To simplify the complicated design process of deployable/retractable structures, a new design process is developed. The process is divided into three phases: the concept design phase, the model phase and the optimization phase. In each phase, different parameter targets have to be fulfilled. According to three phases, a deployable/retractable mast composed of four right triangle prism modules in the longitudinal direction is designed. It can be deployed and folded simultaneously by the linear movements of sleeve-joints. The deployable and retractable movement of the mast is analyzed and key joint forms are designed. Then bar diameters and joint forms are modified based on mast structural mechanics characteristics in the optimization phase. Finally a 1:1 scaled model mast is built to verify the design and the optimization. Analytical results show that the model mast has the advantages of simple locking mechanism, fewer types of joints and bars, so it can be easily manufactured. 展开更多
关键词 deployable/retractable mast geometric design design process OPTIMIZATION
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基于Altium Designer软件的电子控制技术中电路设计探究
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作者 陈卫群 《价值工程》 2025年第1期90-92,共3页
在正常的电路设计方案中,需要软硬件的互相搭配使用,普通的电路运用收稿方式或简单的办公辅助软件来完成绘制,但在面对复杂情况下的电路,专业的EDA辅助设计软件作用可以显而易见,以该辅助软件设计如SCH(电路原理图)与PCB(印制电路板)文... 在正常的电路设计方案中,需要软硬件的互相搭配使用,普通的电路运用收稿方式或简单的办公辅助软件来完成绘制,但在面对复杂情况下的电路,专业的EDA辅助设计软件作用可以显而易见,以该辅助软件设计如SCH(电路原理图)与PCB(印制电路板)文件方面的工作。电子控制技术中电路随着时代的进步而不断创新,新型器件的不断迭代更新,其中的电路设计也变得复杂且繁琐,传统的电路设计已无法胜任最新电路的完善和使用。此时运用AD16(Altium Designer)这款辅助设计软件进行电路设计就可以事半功倍,AD都是复杂电路设计中的高效工具。 展开更多
关键词 电路设计 EDA 电子控制技术 AD16
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水田动力底盘逆向建模与质心验证——基于Geomagic Design X
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作者 何剑飞 曾志浩 +5 位作者 郭梓游 李贵蓉 钟文能 钟顺 王在满 李庆 《农机化研究》 北大核心 2024年第10期248-253,共6页
针对目前农业机械仿真和优化模型精度不高的问题,提出了一种构建精确模型的逆向建模方法。应用光学扫描仪采集点云数据,基于Geomagic Design X处理点云数据并重构零部件模型,在SolidWorks中完成水田动力底盘的装配。以VP6D-CQ型水田动... 针对目前农业机械仿真和优化模型精度不高的问题,提出了一种构建精确模型的逆向建模方法。应用光学扫描仪采集点云数据,基于Geomagic Design X处理点云数据并重构零部件模型,在SolidWorks中完成水田动力底盘的装配。以VP6D-CQ型水田动力底盘为例,将测得的实际质心位置与所建的模型质心位置进行比较,并对提出的逆向建模方法进行了试验验证以及误差分析。结果表明:总质量、x坐标、y坐标、z坐标的误差值分别为4.55%、3.62%、2.23%、4.81%,误差值均在5%内。此方法可构建准确的三维模型,为后续仿真优化数据精确性奠定了基础,与传统的研发相比较,可缩短农业机械研发周期、降低设计成本。 展开更多
关键词 水田 动力底盘 逆向建模 质心验证 Geomagic design X 数字样机
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App Designer辅助教学方法探索与实践——以软件无线电课程为例
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作者 向新 刘宇峰 +2 位作者 梁源 王瑞 何林远 《中国现代教育装备》 2024年第19期148-151,共4页
软件无线电作为通信学科的必修课程,具有承上启下的重要作用。因课程原理抽象、理论公式复杂,学员在学习过程存在理解掌握难、实践应用难等问题。通过对当前软件无线电教学过程中存在的不足与困难进行分析,提出利用MATLAB App Designer... 软件无线电作为通信学科的必修课程,具有承上启下的重要作用。因课程原理抽象、理论公式复杂,学员在学习过程存在理解掌握难、实践应用难等问题。通过对当前软件无线电教学过程中存在的不足与困难进行分析,提出利用MATLAB App Designer辅助课程教学,从教学准备、课堂互动、自主实验、反馈提升四个方面开展课程教学改革。实践表明,该方法对于提升学员的工程思维、系统思维具有显著效果,同时可以增强学员理论联系实际的能力。 展开更多
关键词 软件无线电 MATLAB App designer 教学方法改革 理实结合
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带线性红利和干扰的复合Poisson-Geometric风险模型的破产问题
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作者 侯致武 乔克林 高磊 《贵州大学学报(自然科学版)》 2024年第6期8-13,共6页
考虑了常利力环境下,包含线性红利、随机干扰和随机保费的复合P-G风险模型。通过应用全期望公式,推导出该模型的Gerber-Shiu函数及破产概率的更新方程。在不考虑分红且保费额和索赔额均服从指数分布时,进一步得到了破产概率所满足的具... 考虑了常利力环境下,包含线性红利、随机干扰和随机保费的复合P-G风险模型。通过应用全期望公式,推导出该模型的Gerber-Shiu函数及破产概率的更新方程。在不考虑分红且保费额和索赔额均服从指数分布时,进一步得到了破产概率所满足的具体微分方程,并求解得到了其解析表达式。通过数值实验,系统分析了多个关键因素对破产概率的具体影响,所得结论与保险公司的实际经营情况相吻合。 展开更多
关键词 复合POISSON-geometric过程 线性红利 GERBER-SHIU函数 破产概率
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第4届全国几何设计与计算学术会议征文通知(CSIAM Geometric Design & Computing 2009)
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《计算机研究与发展》 EI CSCD 北大核心 2008年第12期2086-2086,共1页
关键词 几何设计 CSIAM geometric design Computing 2009 会议
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Data-Driven Structural Design Optimization for Petal-Shaped Auxetics Using Isogeometric Analysis 被引量:9
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作者 Yingjun Wang Zhongyuan Liao +2 位作者 Shengyu Shi Zhenpei Wang Leong Hien Poh 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第2期433-458,共26页
Focusing on the structural optimization of auxetic materials using data-driven methods,a back-propagation neural network(BPNN)based design framework is developed for petal-shaped auxetics using isogeometric analysis.A... Focusing on the structural optimization of auxetic materials using data-driven methods,a back-propagation neural network(BPNN)based design framework is developed for petal-shaped auxetics using isogeometric analysis.Adopting a NURBSbased parametric modelling scheme with a small number of design variables,the highly nonlinear relation between the input geometry variables and the effective material properties is obtained using BPNN-based fitting method,and demonstrated in this work to give high accuracy and efficiency.Such BPNN-based fitting functions also enable an easy analytical sensitivity analysis,in contrast to the generally complex procedures of typical shape and size sensitivity approaches. 展开更多
关键词 DATA-DRIVEN BP neural network petal-shaped auxetics negative Poisson’s ratio structural design isogeometric analysis.
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Alloy design for laser powder bed fusion additive manufacturing:a critical review 被引量:5
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作者 Zhuangzhuang Liu Qihang Zhou +4 位作者 Xiaokang Liang Xiebin Wang Guichuan Li Kim Vanmeensel Jianxin Xie 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第2期29-63,共35页
Metal additive manufacturing(AM)has been extensively studied in recent decades.Despite the significant progress achieved in manufacturing complex shapes and structures,challenges such as severe cracking when using exi... Metal additive manufacturing(AM)has been extensively studied in recent decades.Despite the significant progress achieved in manufacturing complex shapes and structures,challenges such as severe cracking when using existing alloys for laser powder bed fusion(L-PBF)AM have persisted.These challenges arise because commercial alloys are primarily designed for conventional casting or forging processes,overlooking the fast cooling rates,steep temperature gradients and multiple thermal cycles of L-PBF.To address this,there is an urgent need to develop novel alloys specifically tailored for L-PBF technologies.This review provides a comprehensive summary of the strategies employed in alloy design for L-PBF.It aims to guide future research on designing novel alloys dedicated to L-PBF instead of adapting existing alloys.The review begins by discussing the features of the L-PBF processes,focusing on rapid solidification and intrinsic heat treatment.Next,the printability of the four main existing alloys(Fe-,Ni-,Al-and Ti-based alloys)is critically assessed,with a comparison of their conventional weldability.It was found that the weldability criteria are not always applicable in estimating printability.Furthermore,the review presents recent advances in alloy development and associated strategies,categorizing them into crack mitigation-oriented,microstructure manipulation-oriented and machine learning-assisted approaches.Lastly,an outlook and suggestions are given to highlight the issues that need to be addressed in future work. 展开更多
关键词 laser powder bed fusion alloy design PRINTABILITY crack mitigation
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Geometric design of crab-like climbing and walking robots
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作者 David Howard 《Journal of Bionic Engineering》 SCIE EI CSCD 2004年第4期231-240,共10页
This paper considers the geometric design of crab-like walkers and climbers, without decoupling leg design from overall machine design. Crab-like machines represent an important sub-class of multi-legged robots, bein... This paper considers the geometric design of crab-like walkers and climbers, without decoupling leg design from overall machine design. Crab-like machines represent an important sub-class of multi-legged robots, being particularly well suited to crossing difficult terrains. Firstly, the kinematic configurations and constraints are described, which determine the machine’s kinematic characteristics. The influence of the design parameters on the kinematic workspace is discussed. Finally, a two stage design methodology is presented, comprising kinematic design and design optimisation, the latter being based on the use of design maps rather than numerical optimisation. The performance measures considered during design optimisation include kinematic, static and quasi-static measures. 展开更多
关键词 walking machine ROBOT KINEMATICS optimal design 1
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Web Layout Design of Large Cavity Structures Based on Topology Optimization 被引量:1
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作者 Xiaoqiao Yang Jialiang Sun Dongping Jin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2665-2689,共25页
Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas... Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures. 展开更多
关键词 Topology optimization lightweight design web layout design cavity structure
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Design Principles and Mechanistic Understandings of Non-Noble-Metal Bifunctional Electrocatalysts for Zinc-Air Batteries 被引量:2
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作者 Yunnan Gao Ling Liu +10 位作者 Yi Jiang Dexin Yu Xiaomei Zheng Jiayi Wang Jingwei Liu Dan Luo Yongguang Zhang Zhenjia Shi Xin Wang Ya‑Ping Deng Zhongwei Chen 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第9期13-48,共36页
Zinc-air batteries(ZABs)are promising energy storage systems because of high theoretical energy density,safety,low cost,and abundance of zinc.However,the slow multi-step reaction of oxygen and heavy reliance on noble-... Zinc-air batteries(ZABs)are promising energy storage systems because of high theoretical energy density,safety,low cost,and abundance of zinc.However,the slow multi-step reaction of oxygen and heavy reliance on noble-metal catalysts hinder the practical applications of ZABs.Therefore,feasible and advanced non-noble-metal elec-trocatalysts for air cathodes need to be identified to promote the oxygen catalytic reaction.In this review,we initially introduced the advancement of ZABs in the past two decades and provided an overview of key developments in this field.Then,we discussed the work-ing mechanism and the design of bifunctional electrocatalysts from the perspective of morphology design,crystal structure tuning,interface strategy,and atomic engineering.We also included theoretical studies,machine learning,and advanced characterization technologies to provide a comprehensive understanding of the structure-performance relationship of electrocatalysts and the reaction pathways of the oxygen redox reactions.Finally,we discussed the challenges and prospects related to designing advanced non-noble-metal bifunctional electrocatalysts for ZABs. 展开更多
关键词 Zinc-air batteries Bifunctional electrocatalysts design principles Mechanistic understandings
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Analysis of the Relations between Highway Geometric Design and Traffic Safety in Bangladesh,China,and America
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作者 Licai Zhang Kai Hua Fen Xiang 《Frontiers Research of Architecture and Engineering》 2022年第1期19-25,共7页
Transportation plays a critical role in the economic sector in Bangladesh.Since its independence,infrastructure has been developing rapidly,includ-ing land,water,and air transportation.National economy is increasing a... Transportation plays a critical role in the economic sector in Bangladesh.Since its independence,infrastructure has been developing rapidly,includ-ing land,water,and air transportation.National economy is increasing at a relatively high rate,leading to the better-off of people’s lives.As the living standards keep improving,people are more concerned about safety issues in transportation.This article makes an analysis of the status quo of traffic safety in Bangladesh and compares the Bangladeshi code with American code AASHTO from the geometric aspects of horizontal and vertical align-ment,in an effort to provide reference to the highway design in Bangla-desh.Through a reasonable design,the traffic safety will be under control and accident rate as well as economic loss will be minimized. 展开更多
关键词 geometric design Traffic safety HIGHWAY
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Accelerated design of high-performance Mg-Mn-based magnesium alloys based on novel bayesian optimization 被引量:2
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作者 Xiaoxi Mi Lili Dai +4 位作者 Xuerui Jing Jia She Bjørn Holmedal Aitao Tang Fusheng Pan 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第2期750-766,共17页
Magnesium(Mg),being the lightest structural metal,holds immense potential for widespread applications in various fields.The development of high-performance and cost-effective Mg alloys is crucial to further advancing ... Magnesium(Mg),being the lightest structural metal,holds immense potential for widespread applications in various fields.The development of high-performance and cost-effective Mg alloys is crucial to further advancing their commercial utilization.With the rapid advancement of machine learning(ML)technology in recent years,the“data-driven''approach for alloy design has provided new perspectives and opportunities for enhancing the performance of Mg alloys.This paper introduces a novel regression-based Bayesian optimization active learning model(RBOALM)for the development of high-performance Mg-Mn-based wrought alloys.RBOALM employs active learning to automatically explore optimal alloy compositions and process parameters within predefined ranges,facilitating the discovery of superior alloy combinations.This model further integrates pre-established regression models as surrogate functions in Bayesian optimization,significantly enhancing the precision of the design process.Leveraging RBOALM,several new high-performance alloys have been successfully designed and prepared.Notably,after mechanical property testing of the designed alloys,the Mg-2.1Zn-2.0Mn-0.5Sn-0.1Ca alloy demonstrates exceptional mechanical properties,including an ultimate tensile strength of 406 MPa,a yield strength of 287 MPa,and a 23%fracture elongation.Furthermore,the Mg-2.7Mn-0.5Al-0.1Ca alloy exhibits an ultimate tensile strength of 211 MPa,coupled with a remarkable 41%fracture elongation. 展开更多
关键词 Mg-Mn-based alloys HIGH-PERFORMANCE Alloy design Machine learning Bayesian optimization
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THERMO ELASTO—PLASTIC OPTIMUM DESIGN OF CERAMIC—METAL FUNCTIONALLY GRADED MATERIALS-Ⅰ.MICROMECHANICAL AND GEOMETRICAL EFFECTS
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作者 王继辉 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 1997年第4期44-52,共9页
The thermo elasto-plastic optimum design of ceramic-metal functionally graded materials (FGMs)was investigated in this paper. The inelastic properties were first evaluated using micromechanical approaches, then an ela... The thermo elasto-plastic optimum design of ceramic-metal functionally graded materials (FGMs)was investigated in this paper. The inelastic properties were first evaluated using micromechanical approaches, then an elasto-plastic finite element model was used to calculate the thermal stress in the material . The effects of micromechanical approaches, plasticity and graded interlayer thickness on the thermal stress relaxation characteristics and stress distributions were studied. The results show that: (1) the macro elas-to-plastic response given by the mean-field micromechanics and self-consistent micromechanics is nearly the same but the response given by the rule of mixture is different; (2)the thermo elasto-plastic behavior must be considered to realistically evaluate stress reduction, and the elasto-plastic optimum design can get helpful information to determine the graded interlayer thicknesses;and(3) to optimize the microstructure of the graded material achieves reductions in critical stress components and rational stress distributions. 展开更多
关键词 thermo elasto-plasticity optimum design funcitionally graded material (FGM)
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Inverse design of mechanical metamaterial achieving a prescribedconstitutive curve 被引量:1
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作者 Zongliang Du Tanghuai Bian +4 位作者 Xiaoqiang Ren Yibo Jia Shan Tang Tianchen Cui Xu Guo 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2024年第1期16-22,共7页
Besides exhibiting excellent capabilities such as energy absorption,phase-transforming metamaterials offer a vast design space for achieving nonlinear constitutive relations.This is facilitated by switching between di... Besides exhibiting excellent capabilities such as energy absorption,phase-transforming metamaterials offer a vast design space for achieving nonlinear constitutive relations.This is facilitated by switching between different patterns under deformation.However,the related inverse design problem is quite challenging,due to the lack of appropriate mathematical formulation and the convergence issue in the post-buckling analysis of intermediate designs.In this work,periodic unit cells are explicitly described by the moving morphable voids method and effectively analyzed by eliminating the degrees of freedom in void regions.Furthermore,by exploring the Pareto frontiers between error and cost,an inverse design formulation is proposed for unit cells.This formulation aims to achieve a prescribed constitutive curve and is validated through numerical examples and experimental results.The design approach presented here can be extended to the inverse design of other types of mechanical metamaterials with prescribed nonlinear effective properties. 展开更多
关键词 METAMATERIAL Pattern-transformation Constitutive curve Inverse design
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Machine learning for membrane design and discovery 被引量:1
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作者 Haoyu Yin Muzi Xu +4 位作者 Zhiyao Luo Xiaotian Bi Jiali Li Sui Zhang Xiaonan Wang 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第1期54-70,共17页
Membrane technologies are becoming increasingly versatile and helpful today for sustainable development.Machine Learning(ML),an essential branch of artificial intelligence(AI),has substantially impacted the research an... Membrane technologies are becoming increasingly versatile and helpful today for sustainable development.Machine Learning(ML),an essential branch of artificial intelligence(AI),has substantially impacted the research and development norm of new materials for energy and environment.This review provides an overview and perspectives on ML methodologies and their applications in membrane design and dis-covery.A brief overview of membrane technologies isfirst provided with the current bottlenecks and potential solutions.Through an appli-cations-based perspective of AI-aided membrane design and discovery,we further show how ML strategies are applied to the membrane discovery cycle(including membrane material design,membrane application,membrane process design,and knowledge extraction),in various membrane systems,ranging from gas,liquid,and fuel cell separation membranes.Furthermore,the best practices of integrating ML methods and specific application targets in membrane design and discovery are presented with an ideal paradigm proposed.The challenges to be addressed and prospects of AI applications in membrane discovery are also highlighted in the end. 展开更多
关键词 Machine learning Membranes AI for Membrane DATA-DRIVEN design
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Rationally designing electrolyte additives for highly improving cyclability of LiNi_(0.5)Mn_(1.5)O_(4)/Graphite cells 被引量:2
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作者 Zhiyong Xia Kuan Zhou +8 位作者 Xiaoyan Lin Zhangyating Xie Qiurong Chen Xiaoqing Li Jie Cai Suli Li Hai Wang Mengqing Xu Weishan Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第4期266-275,共10页
High voltage is necessary for high energy lithium-ion batteries but difficult to achieve because of the highly deteriorated cyclability of the batteries.A novel strategy is developed to extend cyclability of a high vo... High voltage is necessary for high energy lithium-ion batteries but difficult to achieve because of the highly deteriorated cyclability of the batteries.A novel strategy is developed to extend cyclability of a high voltage lithium-ion battery,LiNi_(0.5)Mn_(1.5)O_(4)/Graphite(LNMO/Graphite)cell,which emphasizes a rational design of an electrolyte additive that can effectively construct protective interphases on anode and cathode and highly eliminate the effect of hydrogen fluoride(HF).5-Trifluoromethylpyridine-trime thyl lithium borate(LTFMP-TMB),is synthesized,featuring with multi-functionalities.Its anion TFMPTMB-tends to be enriched on cathode and can be preferentially oxidized yielding TMB and radical TFMP-.Both TMB and radical TFMP can combine HF and thus eliminate the detrimental effect of HF on cathode,while the TMB dragged on cathode thus takes a preferential oxidation and constructs a protective cathode interphase.On the other hand,LTFMP-TMB is preferentially reduced on anode and constructs a protective anode interphase.Consequently,a small amount of LTFMP-TMB(0.2%)in 1.0 M LiPF6in EC/DEC/EMC(3/2/5,wt%)results in a highly improved cyclability of LNMO/Graphite cell,with the capacity retention enhanced from 52%to 80%after 150 cycles at 0.5 C between 3.5 and 4.8 V.The as-developed strategy provides a model of designing electrolyte additives for improving cyclability of high voltage batteries. 展开更多
关键词 Electrolyte additive design and synthesis CYCLABILITY High voltage batteries Cathode and anode interphases
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Design and Optimization of the Geometric Properties of a Crane Hook
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作者 Niranjan Desai Nuri Zeytinoglu 《World Journal of Engineering and Technology》 2016年第3期391-397,共8页
Cranes are used in many industries to transport heavy loads from one position to another. These loads are fastened to a crane hook which makes it a critical aspect of the crane itself. The purpose of this study is to ... Cranes are used in many industries to transport heavy loads from one position to another. These loads are fastened to a crane hook which makes it a critical aspect of the crane itself. The purpose of this study is to optimize the performance of the crane hook based on stress, geometry, and weight. A single load is considered and multiple cross sections—including square, circular, and trapezoidal—are analyzed. The analysis takes the form of theoretical calculations and finite element analysis through the use of SOLIDWORKS Simulation. The trapezoidal cross section is determined to be the most efficient and the weight and stress of this cross section are optimized by varying the cross sectional parameters. 展开更多
关键词 Crane-Hook geometric Properties
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OptoGPT: A foundation model for inverse design in optical multilayer thin film structures 被引量:2
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作者 Taigao Ma Haozhu Wang L.Jay Guo 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第7期4-16,共13页
Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design... Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design targets,or are difficult to suit for different types of structures,e.g.,designing for different materials at each layer.These methods also cannot accommodate versatile design situations under different angles and polarizations.In addition,how to benefit practical fabrications and manufacturing has not been extensively considered yet.In this work,we introduce OptoGPT(Opto Generative Pretrained Transformer),a decoder-only transformer,to solve all these drawbacks and issues simultaneously. 展开更多
关键词 multilayer thin film structure inverse design foundation models deep learning structural color
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Glucocorticoids-based prodrug design:Current strategies and research progress 被引量:1
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作者 Hongbing Liu Muse Ji +5 位作者 Peifu Xiao Jingxin Gou Tian Yin Haibing He Xing Tang Yu Zhang 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2024年第3期41-78,共38页
Attributing to their broad pharmacological effects encompassing anti-inflammation,antitoxin,and immunosuppression,glucocorticoids(GCs)are extensively utilized in the clinic for the treatment of diverse diseases such a... Attributing to their broad pharmacological effects encompassing anti-inflammation,antitoxin,and immunosuppression,glucocorticoids(GCs)are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus,nephritis,arthritis,ulcerative colitis,asthma,keratitis,macular edema,and leukemia.However,longterm use often causes undesirable side effects,including metabolic disorders-induced Cushing's syndrome(buffalo back,full moon face,hyperglycemia,etc.),osteoporosis,aggravated infection,psychosis,glaucoma,and cataract.These notorious side effects seriously compromise patients'quality of life,especially in patients with chronic diseases.Therefore,glucocorticoid-based advanced drug delivery systems for reducing adverse effects have received extensive attention.Among them,prodrugs have the advantages of low investment,low risk,and high success rate,making them a promising strategy.In this review,we propose the strategies for the design and summarize current research progress of glucocorticoid-based prodrugs in recent decades,including polymer-based prodrugs,dendrimer-based prodrugs,antibody-drug conjugates,peptide-drug conjugates,carbohydrate-based prodrugs,aliphatic acid-based prodrugs and so on.Besides,we also raise issues that need to be focused on during the development of glucocorticoid-based prodrugs.This review is expected to be helpful for the research and development of novel GCs and prodrugs. 展开更多
关键词 GLUCOCORTICOIDS Prodrug design Targeted drug delivery Research progress
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