We have studied the transport property of the composites （La0.83Sr0.17 MnO3）1-x（ITO）x [ITO=（In2O3）0.95 （SNO2）0.05], which were fabricated by mechanically mixing La0.83Sr0.17MnO3 and ITO grains. A giant positiv...We have studied the transport property of the composites （La0.83Sr0.17 MnO3）1-x（ITO）x [ITO=（In2O3）0.95 （SNO2）0.05], which were fabricated by mechanically mixing La0.83Sr0.17MnO3 and ITO grains. A giant positive magnetoresistance （PMR） has been observed above the Curie temperature Tc for samples with x around 0.40, in addition to the negative magnetoresistanee related to spin-dependent interracial tunnelling below To. For （La0.83Sr0.17MnO3）0.6（ITO）0.4, the magnetoresistive ratio for the PMR can reach 39.3% under a magnetic field H=2.24×10^5A/m. Theoretical analysis suggests that the magnetic-field-induced broadening of the p-n barrier between both kinds of grains and the density of the p-n heterostructures should be responsible for the PMR behaviour.展开更多
Objective： To investigate the methylation status of CpG island in E-cadherin（CDHl）, P16^INK4a（ P16）promoter region ,and to analyze their role in gastrointestinal stromal rumor （GISTs）. Methods： A total of 56 s...Objective： To investigate the methylation status of CpG island in E-cadherin（CDHl）, P16^INK4a（ P16）promoter region ,and to analyze their role in gastrointestinal stromal rumor （GISTs）. Methods： A total of 56 surgically resected GISTs were obtained from January 2003 to December 2005. The routine H＆E-stained sections and CD117, CD34-immunoreactions were reviewed to verify the morphologic diagnosis. Methylation status of the CDH1, P16^INK4a promoter region was analyzed by methylation specific polymerase chain reaction （MSP） from chemically modified DNA after Na-bisulfite treatment. Results： The frequency of CDHlgene methylation was 32% （18 of 56） in GISTs. The rate was 9% （1 of 11）, 21% （4 of 19）, 41.6% （5 of 12）, and 57% （8 of 14） for very low risk, low risk, intermediate risk, and high risk GISTs; P16^INK4a methylation was found in 19 of 56（34%） cases. The rate was 0% （0 of 11）, 16% （3 of 19）, 50% （6 of 12）, and 71% （10 of 14） for very low risk, low risk, intermediate risk, and high risk GISTs. Statistical analysis indicated that of the 56 cases, there was significant association of CDH^INK4a and/or P16^INK4a methylation status with tumor malignant behavior （methylation rate 23/56, 41%, P〈0.01） and site （P〈0.05）. Conclusion： E-cadherin （CDHI） and/or P16^INK4a promoter hypermethylation is strongly associated with risk grade, may be a useful biomarker for GISTs risk assessment, and may shed light on new therapeutic options to treat GISTs展开更多
Among the geotechnical in situ tests,the dynamic penetration test(DPT)is commonly used around the world.However,DPT remains a rough technique and provides only one failure parameter:blow count or cone resistance.This ...Among the geotechnical in situ tests,the dynamic penetration test(DPT)is commonly used around the world.However,DPT remains a rough technique and provides only one failure parameter:blow count or cone resistance.This paper presents an improvement of the dynamic cone penetration test(DCPT)for soil characterisation based on the wave equation theory.Implemented on an instrumented lightweight dynamic penetrometer driving with variable energy,the main process of the test involves the separation and reconstruction of the waves propagating in the rods after each blow and provides a dynamic cone load-penetration(DCLT)curve.An analytical methodology is used to analyse this curve and to estimate additional strength and deformation parameters of the soil:dynamic and pseudo-static cone resistances,deformation modulus and wave velocity.Tests carried out in the laboratory on different specimens(wood,concrete,sand and clay)in an experimental sand pit and in the field demonstrated that the resulting DCLT curve is reproducible,sensitive and reliable to the test conditions(rod length,driving energy,etc.)as well as to the soil properties(nature,density,etc.).Obtained results also showed that the method based on shock polar analysis makes it possible to evaluate mechanical impedance and wave velocity of soils,as demonstrated by the comparisons with cone penetration test(CPT)and shear wave velocity measurements made in the field.This technique improves the method and interpretation of DPT and provides reliable data for shallow foundation design.展开更多
This paper is to establish a nitrogen and phosphorus nutrients cycle-based numerical model of ecological dynamics for Xiamen Bay on the basis of the existing three-dimensional barocline hydrodynamic model. The calcula...This paper is to establish a nitrogen and phosphorus nutrients cycle-based numerical model of ecological dynamics for Xiamen Bay on the basis of the existing three-dimensional barocline hydrodynamic model. The calculation results show that the estuarine district of Jiulongjiang estuary has the highest inorganic nitrogen concentration followed by the West Harbor, which demonstrates that Jiulongjiang River is the main input source of inorganic nitrogen in Xiamen Bay. The West Harbor has relatively high concentration of nutrients caused by the huge land pollution emission and its own poor water exchange capacity; while the distribution rules of phytoplankton biomass correspond with those of phosphates, demonstrating Xiamen Bay＇s phytoplankton controlled by phosphorus; the haloplankton biomass differs slightly, presenting the gradual reduction from the interior part to the exterior part of the bay.展开更多
The neutron yield in the12C(d,n)13N reaction and the proton yield in the12C(d,p)13C reaction have been measured using deuteron beams of energies 0.6-3 MeV.The deuteron beam is delivered from a 4-MeV electrostatic acce...The neutron yield in the12C(d,n)13N reaction and the proton yield in the12C(d,p)13C reaction have been measured using deuteron beams of energies 0.6-3 MeV.The deuteron beam is delivered from a 4-MeV electrostatic accelerator and bombarded on a thick carbon target.The neutrons are detected at 0°,24°,and 48°and the protons at135°in the laboratory frame.Further,the ratio of the neutron yield to the proton yield was calculated.This can be used to effectively recognize the resonances.The resonances are found at 1.4 MeV,1.7 MeV,and 2.5 MeV in the12C(d,p)13C reaction,and at 1.6 MeV and 2.7 MeV in the12C(d,n)13N reaction.The proposed method provides a way to reduce systematic uncertainty and helps confirm more resonances in compound nuclei.展开更多
Amperometric studies have indicated that substance P as well as NMDA stimulates release of NO in rat aortic rings. These data have been confirmed by functional observations of vaso-relaxant action of NMDA within norad...Amperometric studies have indicated that substance P as well as NMDA stimulates release of NO in rat aortic rings. These data have been confirmed by functional observations of vaso-relaxant action of NMDA within noradrenaline pre-contracted aortic rings, supporting the presence of NMDA receptor in rat aortic rings. It is known that the enzyme endothelial NO synthase (eNOS) mediates vasodilatation not only in rats, but also in C57BL6 mice aortic ring, indicating that in this blood vessel NO is the endogenous endothelium-derived vasodilator. In this work, amperometry together with specifically nitrites insensitive micro-biosensors have been applied to examine the effect of NMDA and substance P upon NO release in rat and in two strains of mice aortic rings. The electrochemical data monitored demonstrate that NMDA mediates vascular relaxation via NO in rats but not in mice. These results are supported by functional data, therefore they suggest that NMDA receptors are “not responding” within these experimental conditions in mice aortic rings.展开更多
基金Project supported by the National Natural Science Foundation of China （Grant No 20473038）, the Foundation of High-Tech Project in Jiangsu province, China （Grant No BG-2005401）.
文摘We have studied the transport property of the composites （La0.83Sr0.17 MnO3）1-x（ITO）x [ITO=（In2O3）0.95 （SNO2）0.05], which were fabricated by mechanically mixing La0.83Sr0.17MnO3 and ITO grains. A giant positive magnetoresistance （PMR） has been observed above the Curie temperature Tc for samples with x around 0.40, in addition to the negative magnetoresistanee related to spin-dependent interracial tunnelling below To. For （La0.83Sr0.17MnO3）0.6（ITO）0.4, the magnetoresistive ratio for the PMR can reach 39.3% under a magnetic field H=2.24×10^5A/m. Theoretical analysis suggests that the magnetic-field-induced broadening of the p-n barrier between both kinds of grains and the density of the p-n heterostructures should be responsible for the PMR behaviour.
基金This work was supported by the NaturaScience Foundation of Shanxi Province (No. 2006011122)
文摘Objective： To investigate the methylation status of CpG island in E-cadherin（CDHl）, P16^INK4a（ P16）promoter region ,and to analyze their role in gastrointestinal stromal rumor （GISTs）. Methods： A total of 56 surgically resected GISTs were obtained from January 2003 to December 2005. The routine H＆E-stained sections and CD117, CD34-immunoreactions were reviewed to verify the morphologic diagnosis. Methylation status of the CDH1, P16^INK4a promoter region was analyzed by methylation specific polymerase chain reaction （MSP） from chemically modified DNA after Na-bisulfite treatment. Results： The frequency of CDHlgene methylation was 32% （18 of 56） in GISTs. The rate was 9% （1 of 11）, 21% （4 of 19）, 41.6% （5 of 12）, and 57% （8 of 14） for very low risk, low risk, intermediate risk, and high risk GISTs; P16^INK4a methylation was found in 19 of 56（34%） cases. The rate was 0% （0 of 11）, 16% （3 of 19）, 50% （6 of 12）, and 71% （10 of 14） for very low risk, low risk, intermediate risk, and high risk GISTs. Statistical analysis indicated that of the 56 cases, there was significant association of CDH^INK4a and/or P16^INK4a methylation status with tumor malignant behavior （methylation rate 23/56, 41%, P〈0.01） and site （P〈0.05）. Conclusion： E-cadherin （CDHI） and/or P16^INK4a promoter hypermethylation is strongly associated with risk grade, may be a useful biomarker for GISTs risk assessment, and may shed light on new therapeutic options to treat GISTs
文摘Among the geotechnical in situ tests,the dynamic penetration test(DPT)is commonly used around the world.However,DPT remains a rough technique and provides only one failure parameter:blow count or cone resistance.This paper presents an improvement of the dynamic cone penetration test(DCPT)for soil characterisation based on the wave equation theory.Implemented on an instrumented lightweight dynamic penetrometer driving with variable energy,the main process of the test involves the separation and reconstruction of the waves propagating in the rods after each blow and provides a dynamic cone load-penetration(DCLT)curve.An analytical methodology is used to analyse this curve and to estimate additional strength and deformation parameters of the soil:dynamic and pseudo-static cone resistances,deformation modulus and wave velocity.Tests carried out in the laboratory on different specimens(wood,concrete,sand and clay)in an experimental sand pit and in the field demonstrated that the resulting DCLT curve is reproducible,sensitive and reliable to the test conditions(rod length,driving energy,etc.)as well as to the soil properties(nature,density,etc.).Obtained results also showed that the method based on shock polar analysis makes it possible to evaluate mechanical impedance and wave velocity of soils,as demonstrated by the comparisons with cone penetration test(CPT)and shear wave velocity measurements made in the field.This technique improves the method and interpretation of DPT and provides reliable data for shallow foundation design.
文摘This paper is to establish a nitrogen and phosphorus nutrients cycle-based numerical model of ecological dynamics for Xiamen Bay on the basis of the existing three-dimensional barocline hydrodynamic model. The calculation results show that the estuarine district of Jiulongjiang estuary has the highest inorganic nitrogen concentration followed by the West Harbor, which demonstrates that Jiulongjiang River is the main input source of inorganic nitrogen in Xiamen Bay. The West Harbor has relatively high concentration of nutrients caused by the huge land pollution emission and its own poor water exchange capacity; while the distribution rules of phytoplankton biomass correspond with those of phosphates, demonstrating Xiamen Bay＇s phytoplankton controlled by phosphorus; the haloplankton biomass differs slightly, presenting the gradual reduction from the interior part to the exterior part of the bay.
基金partially supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Nos.XDB16 and XDPB09)the National Natural Science Foundation of China(Nos.11890714 and 11421505)the Key Research Program of Frontier Sciences of the CAS(No.QYZDJ-SSW-SLH002)
文摘The neutron yield in the12C(d,n)13N reaction and the proton yield in the12C(d,p)13C reaction have been measured using deuteron beams of energies 0.6-3 MeV.The deuteron beam is delivered from a 4-MeV electrostatic accelerator and bombarded on a thick carbon target.The neutrons are detected at 0°,24°,and 48°and the protons at135°in the laboratory frame.Further,the ratio of the neutron yield to the proton yield was calculated.This can be used to effectively recognize the resonances.The resonances are found at 1.4 MeV,1.7 MeV,and 2.5 MeV in the12C(d,p)13C reaction,and at 1.6 MeV and 2.7 MeV in the12C(d,n)13N reaction.The proposed method provides a way to reduce systematic uncertainty and helps confirm more resonances in compound nuclei.
文摘Amperometric studies have indicated that substance P as well as NMDA stimulates release of NO in rat aortic rings. These data have been confirmed by functional observations of vaso-relaxant action of NMDA within noradrenaline pre-contracted aortic rings, supporting the presence of NMDA receptor in rat aortic rings. It is known that the enzyme endothelial NO synthase (eNOS) mediates vasodilatation not only in rats, but also in C57BL6 mice aortic ring, indicating that in this blood vessel NO is the endogenous endothelium-derived vasodilator. In this work, amperometry together with specifically nitrites insensitive micro-biosensors have been applied to examine the effect of NMDA and substance P upon NO release in rat and in two strains of mice aortic rings. The electrochemical data monitored demonstrate that NMDA mediates vascular relaxation via NO in rats but not in mice. These results are supported by functional data, therefore they suggest that NMDA receptors are “not responding” within these experimental conditions in mice aortic rings.
