AIM: To evaluate the hepatic dysfunction in leptospirosis is usually mild and resolved eventually. However,sequential follow-up of liver biochemical data remained lacking..METHODS: The biochemistry data and clinical s...AIM: To evaluate the hepatic dysfunction in leptospirosis is usually mild and resolved eventually. However,sequential follow-up of liver biochemical data remained lacking..METHODS: The biochemistry data and clinical symptoms of 11 sporadic patients were collected and analyzed, focusing on the impacts of leptospirosis upon liver biochemistry tests.RESULTS: The results disclosed that of the 11 cases, 5 or 45% died. The liver biochemistry data in the beginning of the disease course were only mildly elevated.Nevertheless, late exaggerated aspartate transaminase (AST)elevations were noted in three cases who finally died when compared with the typical course. Besides, significant higher AST/alanine transaminase (ALT) ratios (AARs) of the peak levels for transaminase were also noted in the cases who eventually succumbed. The mean±SD of AARs for the survival group and dead group were 5.65±2.27 (n = 5)and 1.86±0.64 (n = 6) respectively (P= 0.006). The ratios of the cases who finally died were all more than 3.0.Conversely, the survival group's ratios were less than 3.0.CONCLUSION: Serial follow-up of transaminase might provide evidence to predict some rare evolutions in leptospirosis. If AST elevated progressively without a concomitant change of ALT, it might indicate an acute disease course with ensuing death. Additionally, AAR is another prognostic parameter for leptospirosis. Once the value was higher than 3.0, a grave prognosis is inevitable.展开更多
目的:观察葛菊醒神方对急性酒精性肝损伤小鼠的保护作用。方法:将健康SPF级昆明小鼠60只,顺应性喂养3 d,随机分为空白组,模型组,阳性药物对照组,葛菊醒神方高、中、低剂量组,每组10只。除空白组外,其他组小鼠灌胃50%乙醇(20 m L/kg),灌...目的:观察葛菊醒神方对急性酒精性肝损伤小鼠的保护作用。方法:将健康SPF级昆明小鼠60只,顺应性喂养3 d,随机分为空白组,模型组,阳性药物对照组,葛菊醒神方高、中、低剂量组,每组10只。除空白组外,其他组小鼠灌胃50%乙醇(20 m L/kg),灌胃乙醇0.5 h后,灌服相应计量药物。观察用药后小鼠嗜睡时间、血清中ALT、AST水平和肝组织形态学改变。结果:与模型组比较,葛菊醒神方缩短酒精性肝损伤小鼠模型嗜睡时间(P<0.01);降低了血清中谷丙转氨酶(AST)和谷草转氨酶(ALT)的活性(P<0.01);病理组织学显示,葛菊醒神方可减轻肝脏脂肪变性,使肝细胞坏死面积减小。结论:葛菊醒神方能明显改善乙醇致酒精性肝损伤。展开更多
基金Supported by the Chang Gung Medical Research Project fund, No. CMRPG 33014
文摘AIM: To evaluate the hepatic dysfunction in leptospirosis is usually mild and resolved eventually. However,sequential follow-up of liver biochemical data remained lacking..METHODS: The biochemistry data and clinical symptoms of 11 sporadic patients were collected and analyzed, focusing on the impacts of leptospirosis upon liver biochemistry tests.RESULTS: The results disclosed that of the 11 cases, 5 or 45% died. The liver biochemistry data in the beginning of the disease course were only mildly elevated.Nevertheless, late exaggerated aspartate transaminase (AST)elevations were noted in three cases who finally died when compared with the typical course. Besides, significant higher AST/alanine transaminase (ALT) ratios (AARs) of the peak levels for transaminase were also noted in the cases who eventually succumbed. The mean±SD of AARs for the survival group and dead group were 5.65±2.27 (n = 5)and 1.86±0.64 (n = 6) respectively (P= 0.006). The ratios of the cases who finally died were all more than 3.0.Conversely, the survival group's ratios were less than 3.0.CONCLUSION: Serial follow-up of transaminase might provide evidence to predict some rare evolutions in leptospirosis. If AST elevated progressively without a concomitant change of ALT, it might indicate an acute disease course with ensuing death. Additionally, AAR is another prognostic parameter for leptospirosis. Once the value was higher than 3.0, a grave prognosis is inevitable.
文摘目的:观察葛菊醒神方对急性酒精性肝损伤小鼠的保护作用。方法:将健康SPF级昆明小鼠60只,顺应性喂养3 d,随机分为空白组,模型组,阳性药物对照组,葛菊醒神方高、中、低剂量组,每组10只。除空白组外,其他组小鼠灌胃50%乙醇(20 m L/kg),灌胃乙醇0.5 h后,灌服相应计量药物。观察用药后小鼠嗜睡时间、血清中ALT、AST水平和肝组织形态学改变。结果:与模型组比较,葛菊醒神方缩短酒精性肝损伤小鼠模型嗜睡时间(P<0.01);降低了血清中谷丙转氨酶(AST)和谷草转氨酶(ALT)的活性(P<0.01);病理组织学显示,葛菊醒神方可减轻肝脏脂肪变性,使肝细胞坏死面积减小。结论:葛菊醒神方能明显改善乙醇致酒精性肝损伤。
