The purpose of this study was to investigate the expression of glutathione stransferase (GST) and its clinical significance in human bladder cancer. GST immunoreactivity was assessed respectively in 49 bladder cancer...The purpose of this study was to investigate the expression of glutathione stransferase (GST) and its clinical significance in human bladder cancer. GST immunoreactivity was assessed respectively in 49 bladder cancers and 30 normal bladder mucosas by avidin biotin peroxidase complex (ABC) techniques. The corelationship of GST expression and clinical and biological feature of bladder cancer was studied. Positive GST was observed in 44 cases of bladder cancer mucosa (89.8%) and in 18 cases of normal bladder mucosa (60%). In 42 cases of stage G\-\{12\} and 7 cases of stage G\-3 cancer patients the positive GST expression rate was 80.9%(34/42) and 100%(7/7) respectively. In 14 cases of recurrent bladder cancer the total positive expression rate was 92.9% (13/14), meanwhile in 19 cases of stage T23 the positive nuclear staining was seen in 10. Higher rate of GST expression was found in bladder cancer than in normal bladder mucosa, which was implied that the resistance to chemotheraputic drugs in bladde r cancer might be related to the expression of GST. GST expression was correlated with tumor grade. Furthermore, increased intranuclear GST expression might be associated with bladder cancer progression.展开更多
文摘The purpose of this study was to investigate the expression of glutathione stransferase (GST) and its clinical significance in human bladder cancer. GST immunoreactivity was assessed respectively in 49 bladder cancers and 30 normal bladder mucosas by avidin biotin peroxidase complex (ABC) techniques. The corelationship of GST expression and clinical and biological feature of bladder cancer was studied. Positive GST was observed in 44 cases of bladder cancer mucosa (89.8%) and in 18 cases of normal bladder mucosa (60%). In 42 cases of stage G\-\{12\} and 7 cases of stage G\-3 cancer patients the positive GST expression rate was 80.9%(34/42) and 100%(7/7) respectively. In 14 cases of recurrent bladder cancer the total positive expression rate was 92.9% (13/14), meanwhile in 19 cases of stage T23 the positive nuclear staining was seen in 10. Higher rate of GST expression was found in bladder cancer than in normal bladder mucosa, which was implied that the resistance to chemotheraputic drugs in bladde r cancer might be related to the expression of GST. GST expression was correlated with tumor grade. Furthermore, increased intranuclear GST expression might be associated with bladder cancer progression.
