A novel Nd, La：SrF_2 disordered crystal is prepared, and its continuous-wave wavelength tuning operation is performed for the first time. Employing a surface plasmon resonance（SPR） based gold nanobipyramids（G-NBPs...A novel Nd, La：SrF_2 disordered crystal is prepared, and its continuous-wave wavelength tuning operation is performed for the first time. Employing a surface plasmon resonance（SPR） based gold nanobipyramids（G-NBPs） saturable absorber,we obtain a compact diode-pumped passively Q-switched Nd, La：SrF_2 laser. The stable Q-switched pulse operates with the shortest pulse duration of 1.15 μs and the maximum repetition rate of 41 k Hz. The corresponding single pulse energy is 2.24 μJ. The results indicate that G-NBPs could be a promising saturable absorber applied to the diode-pumped solid state lasers（DPSSLs）.展开更多
The temperature monitoring of treated cancer cells is critical in photothermal therapy.Current methods of detecting intracellular temperatures have low accuracy and poor spatial resolution,which limits their applicati...The temperature monitoring of treated cancer cells is critical in photothermal therapy.Current methods of detecting intracellular temperatures have low accuracy and poor spatial resolution,which limits their application to photothermal therapy.Herein,a strategy for targeted recognition and selective capture of MCF-7 breast cancer cells based on fluorescent polymer poly(N-isopropylacrylamide-benzoxadiazole-2-vinyl-4,4-dimethyl azlactone,PNMV)and modified gold nanobipyramids(Au NBPs-PNMV)was developed for temperature sensing during photothermal therapy.A mucin-1 protein aptamer(Apt)was applied to selectively target mucin-1 protein overexpressed on the surfaces of the MCF-7 cells,which can reduce interference by affinity interaction between the Apt and proteins.During photothermal therapy,the significant Au NBPs photothermal effect increases the fluorescence intensity of PNMV with temperature.Irradiation of MCF-7 cells cultured with Au NBPs-PNMV@Apt by an 808 nm laser increases the temperature of the system,while the cells can be inactivated because of the remarkable Au NBPs-PNMV@Apt photothermal effect.The results indicate that variation in the fluorescence of Au NBPs-PNMV@Apt can be applied as thermometers to monitor the intracellular effect of photothermal therapy.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61475089,51432007,and 61422511)
文摘A novel Nd, La：SrF_2 disordered crystal is prepared, and its continuous-wave wavelength tuning operation is performed for the first time. Employing a surface plasmon resonance（SPR） based gold nanobipyramids（G-NBPs） saturable absorber,we obtain a compact diode-pumped passively Q-switched Nd, La：SrF_2 laser. The stable Q-switched pulse operates with the shortest pulse duration of 1.15 μs and the maximum repetition rate of 41 k Hz. The corresponding single pulse energy is 2.24 μJ. The results indicate that G-NBPs could be a promising saturable absorber applied to the diode-pumped solid state lasers（DPSSLs）.
基金the National Natural Science Foundation of China(Nos.22074148,21874138,21635008,21727809)。
文摘The temperature monitoring of treated cancer cells is critical in photothermal therapy.Current methods of detecting intracellular temperatures have low accuracy and poor spatial resolution,which limits their application to photothermal therapy.Herein,a strategy for targeted recognition and selective capture of MCF-7 breast cancer cells based on fluorescent polymer poly(N-isopropylacrylamide-benzoxadiazole-2-vinyl-4,4-dimethyl azlactone,PNMV)and modified gold nanobipyramids(Au NBPs-PNMV)was developed for temperature sensing during photothermal therapy.A mucin-1 protein aptamer(Apt)was applied to selectively target mucin-1 protein overexpressed on the surfaces of the MCF-7 cells,which can reduce interference by affinity interaction between the Apt and proteins.During photothermal therapy,the significant Au NBPs photothermal effect increases the fluorescence intensity of PNMV with temperature.Irradiation of MCF-7 cells cultured with Au NBPs-PNMV@Apt by an 808 nm laser increases the temperature of the system,while the cells can be inactivated because of the remarkable Au NBPs-PNMV@Apt photothermal effect.The results indicate that variation in the fluorescence of Au NBPs-PNMV@Apt can be applied as thermometers to monitor the intracellular effect of photothermal therapy.
