A general numerical tool, based on thermal diffusion equation and full-vectorial eigen-mode equation, has been presented for the systematic analysis of graded index channel waveguide fabricated by ion exchange on Er^3...A general numerical tool, based on thermal diffusion equation and full-vectorial eigen-mode equation, has been presented for the systematic analysis of graded index channel waveguide fabricated by ion exchange on Er^3+ doped glass. Finite difference method with full-vectorial formulation (FV-FDM) is applied to solving the full-vectorial modes of graded index channel waveguide for the first time. The coupled difference equations based on magnetic fields in FV-FDM are derived from the Taylor series expansion and accurate formulation of boundary conditions. Hybrid nature of vectorial guided modes for both pump (980 nm) and signal light (1550 nm) are demonstrated by the simulation. Results show that the fabrication parameters of ion exchange, such as channel opening width and time ratio of second step to first step in ion exchange, have large influence on the properties of waveguide. By optimizing the fabrication parameters, maintenance of monomode for signal light and improvement of the gain dynamics can be achieved in Er^3+ doped waveguide amplifier (EDWA) fabricated by ion exchange technique. This theoretical model is significant for the design and fabrication of EDWA with ion exchange technique. Furthermore, a single polarization EDWA, which operates at wavelength from 1528 nm to 1541 nm for HE polarization, is numerically designed.展开更多
Multiple cropping index(MCI)is a very important indicator in crop production and agricultural intensification,which represents the utilizing degree of agriculture resources at time scale and the effective utilization ...Multiple cropping index(MCI)is a very important indicator in crop production and agricultural intensification,which represents the utilizing degree of agriculture resources at time scale and the effective utilization situation of arable land.The objective of this paper is monitoring multiple cropping index of Henan province of China according to the time series of MODIS(Moderate-Resolution Imaging Spectroradiometer)EVI(Enhanced Vegetation Index)after Savitzky-Golay filter processing from the year 2006 to 2011.The results revealed that this method could provide an effective way to monitor multiple cropping index,and the method of no additional authentication data is independent and reliable.The result was accurate and stable,the slope of linear regression of the multiple cropping index between the statistical results and the remote sensing results was 1.0136(R2=0.779).The precision of sample areas validation was 97.91%.Suggesting that the time series MODIS-EVI which after Savitzky-Golay filtering processed,could provide an effective way to extract spatial information of multiple cropping index for management department of agriculture.展开更多
Light propagation in nanoparticle-loaded encapsulants is simulated based on the method of Monte Carlo,referring to the multilayer graded-refractive-index structure for LED encapsulants.And the influence of scattering ...Light propagation in nanoparticle-loaded encapsulants is simulated based on the method of Monte Carlo,referring to the multilayer graded-refractive-index structure for LED encapsulants.And the influence of scattering coefficient on the transmittance is analyzed.The results show that the transmittance decreases with scattering coefficient.For a given number of layers,the encapsulants will yield maximum transmittance if the refractive index value of each layer is optimized.The nanoparticle-loaded encapsulant consists of multiple layers with refractive-index values that gradually decrease.The transmittance will be higher than that of traditional non-graded encapsulants,and will improve light extraction efficiency of LED.展开更多
Graded negative refractive index-based photonic crystal (PC) lenses are designed by gradually modifying the sizes of air holes along the transverse direction for focusing the incident plane wave. To study the tunabi...Graded negative refractive index-based photonic crystal (PC) lenses are designed by gradually modifying the sizes of air holes along the transverse direction for focusing the incident plane wave. To study the tunability of the graded negative index-based PC, we introduce filling factor A, gradually tune the filling factor, and use the finite-difference and time-domain (FDTD) algorithm for numerical calculation. Our calculation results indicate that the focal length and the spot size increase with A increasing. For the same A value, the focal length of a PC with elliptical air holes is the longest, and those of PC with square and rectangular air holes are the shortest. Moreover, when the focal length is greater than 1 ~xm, the focal parameters of the PC are highly insensitive to the variation of A. When the focal length is less than 1 gm, the PC lenses have higher transmittances and all well focus with a beam spot size breaking the diffraction limit. This feature possibly makes the graded negative index-based PC lenses have some new applications in optoelectronic systems.展开更多
Flat lenses are designed by means of graded negative refractive index-based photonic crystals (PCs) constructed using air-holes tuned with different shapes. By gradually modifying the filling factor along the transv...Flat lenses are designed by means of graded negative refractive index-based photonic crystals (PCs) constructed using air-holes tuned with different shapes. By gradually modifying the filling factor along the transverse direction, we obtain the graded negative index-based lenses for the purpose of focusing an incident plane wave. The finite-difference and timedomain (FDTD) algorithm is adopted for numerical calculation. Our calculation results indicate that these lenses can finely focus incident plane waves. Moreover, for the same size of air-holes, the focusing properties of the lens with rectangular air-holes are better than those with the other shaped air-holes. The graded negative index PCs lenses could possibly enable new applications in optoelectronic systems.展开更多
In this study, a reliability index vector formula is proposed for series system with two failure modes in term of the concept of reliability index vector and equivalent failure modes. Firstly, the reliability index ve...In this study, a reliability index vector formula is proposed for series system with two failure modes in term of the concept of reliability index vector and equivalent failure modes. Firstly, the reliability index vector is introduced to determine the correlation coefficient between two failure modes, and then, the reliability index vector of a series system can be obtained. Several numerical cases and an analysis on offshore platform are performed, and the results show that this scheme provided here has better computational accuracy, and its calculation process is simpler for the series systems reliability calculations compared with the other methods. Also this scheme is more convenient for the engineering applications.展开更多
This paper reports that SiO2 is selected to fabricate broadband antireflection (AR) coatings on fused silica substrate by using glancing angle deposition and physical vapour deposition. Through accurate control of t...This paper reports that SiO2 is selected to fabricate broadband antireflection (AR) coatings on fused silica substrate by using glancing angle deposition and physical vapour deposition. Through accurate control of the graded index of the SiO2 layer, transmittance of thc graded broadband AR coating can achieve an average value of 98% across a spectral range of 300-1850 nm. Moreover, a laser-induced damage threshold measurement of the fabricated AR coating is performed by using a one-on-one protocol according to ISOl1254-1, resulting in an average damage threshold of 17.2 J/cm2.展开更多
The 850-nm oxide-confined vertical-cavity surface-emitting lasers with petal-shape holey structures are presented. An area-weighted average refractive index model is given to analyse their effective index profiles, an...The 850-nm oxide-confined vertical-cavity surface-emitting lasers with petal-shape holey structures are presented. An area-weighted average refractive index model is given to analyse their effective index profiles, and the graded index distribution in the holey region is demonstrated. The index step between the optical aperture and the holey region is obtained which is related merely to the etching depth. Four types of holey vertical-cavity surface-emitting lasers with different parameters are fabricated as well as the conventional oxide-confined vertical-cavity surface-emitting laser. Compared with the conventional oxide-confined vertical-cavity surface-emitting laser without etched holes, the holey vertical-cavity surface-emitting laser possesses an improved beam quality due to its graded index distribution, but has a lower output power, higher threshold current and lower slope efficiency. With the hole number increased, the holey vertical-cavity surface-emitting laser can realize the single-mode operation throughout the entire current range, and reduces the beam divergence further. The loss mechanism is used to explain the single-mode characteristic, and the reduced beam divergence is attributed to the shallow etching. High coupling efficiency of 86% to a multi-mode fibre is achieved for the single-mode device in the experiment.展开更多
Let G = (V;E) be a simple connected graph. The sets of vertices and edges of G are denoted by V = V(G) and E = E(G), respectively. In such a simple molecular graph, vertices represent atoms and edges represent bonds. ...Let G = (V;E) be a simple connected graph. The sets of vertices and edges of G are denoted by V = V(G) and E = E(G), respectively. In such a simple molecular graph, vertices represent atoms and edges represent bonds. The Sanskruti index S(G) is a topological index was defined as where Su is the summation of degrees of all neighbors of vertex u in G. The goal of this paper is to compute the Sanskruti index for circumcoronene series of benzenoid.展开更多
We suggest a design method of graded-refractive-index (GRIN) antireflection (AR) coating for s-polarized or p- polarized light at off-normal incidence. The spectrum characteristic of the designed antireflection co...We suggest a design method of graded-refractive-index (GRIN) antireflection (AR) coating for s-polarized or p- polarized light at off-normal incidence. The spectrum characteristic of the designed antireflection coating with a quintic effective refractive-index profile for a given state of polarization has been discussed. In addition, the genetic algorithm was used to optimize the refractive index profile of the GRIN antireflection for reducing the mean reflectance of s- and p-polarizations. The average reflectance loss was reduced to only 0.04% by applying optimized GRIN AR coatings onto BK7 glass over the wavelength range from 400 to 800 nm at the incident angle of θo = 70°.展开更多
During the last decades, air pollution has become a serious environmental hazard. Its impact on public health and safety, as well as on the ecosystem, has been dramatic. Forecasting the levels of air pollution to main...During the last decades, air pollution has become a serious environmental hazard. Its impact on public health and safety, as well as on the ecosystem, has been dramatic. Forecasting the levels of air pollution to maintain the climatic conditions and environmental protection becomes crucial for government authorities to develop strategies for the prevention of pollution. This study aims to evaluate the atmospheric air pollution of the city of Zahleh located in the geographic zone of Bekaa. The study aims to determine a relationship between variations in ambient particulate concentrations during a short time. The data was collected from June 2017 to June 2018. In order to predict the Air Quality Index (AQI), Naïve, Exponential Smoothing, TBATS (a forecasting method to model time series data), and Seasonal Autoregressive Integrated Moving Average (SARIMA) models were implemented. The performance of these models for predicting air quality is measured using the Mean Absolute Error (MAE), the Root Mean Square Error (RMSE), and the Relative Error (RE). SARIMA model is the most accurate in prediction of AQI (RMSE = 38.04, MAE = 22.52 and RE = 0.16). The results reveal that SARIMA can be applied to cities like Zahleh to assess the level of air pollution and to prevent harmful impacts on health. Furthermore, the authorities responsible for controlling the air quality may use this model to measure the level of air pollution in the nearest future and establish a mechanism to identify the high peaks of air pollution.展开更多
Absorption efficiency of graded-index double-clad fiber lasers or amplifiers is analyzed. As ray optics method is no longer valid for graded-index case, the mode analysis method is used. Calculated results show that a...Absorption efficiency of graded-index double-clad fiber lasers or amplifiers is analyzed. As ray optics method is no longer valid for graded-index case, the mode analysis method is used. Calculated results show that absorption efficiency for a graded-index is higher than that for a step-index in symmetric case. In offset core case, the graded-index can achieve the same absorption efficiency with much smaller offset distance. Absorption efficiencies for different graded-index profiles of the inner cladding are compared.展开更多
BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of metastasis.Preoperative chemotherapy is widely recomm...BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of metastasis.Preoperative chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of chemotherapy.However,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative chemotherapy.Body mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour therapies.Several studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with bevacizumab.AIM To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for CRLMs.METHODS A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July 2023.Univariate and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological response.The Kaplan-Meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low BMI.BMI<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour response.RESULTS Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)patients.The rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1.42-14.63,P=0.011],targeted therapy with bevacizumab(OR=3.02,95%CI:1.10-8.33,P=0.033),preoperative carcinoembryonic antigen level<10 ng/mL(OR=3.84,95%CI:1.19-12.44,P=0.025)and severe sinusoidal dilatation(OR=0.17,95%CI:0.03-0.90,P=0.037)were independent predictive factors for complete tumour response.The low BMI group exhibited a significantly longer median PFS than the high BMI group(10.7 mo vs 4.7 mo,P=0.011).CONCLUSION In CRLM patients receiving preoperative chemotherapy,a low BMI may be associated with better tumour response and longer PFS.展开更多
Using the ray theory of light, a simple theoretical model for the power evolution of a propagating light in graded-index-medium is presented. This work can be useful for different engineering applications that utilize...Using the ray theory of light, a simple theoretical model for the power evolution of a propagating light in graded-index-medium is presented. This work can be useful for different engineering applications that utilize graded-index-material, and for further understanding of natural phenomena that depends on light propagation in graded-index-medium.展开更多
BACKGROUND Accurate condition assessment is critical for improving the prognosis of neonatal respiratory distress syndrome(RDS),but current assessment methods for RDS pose a cumulative risk of harm to neonates.Thus,a ...BACKGROUND Accurate condition assessment is critical for improving the prognosis of neonatal respiratory distress syndrome(RDS),but current assessment methods for RDS pose a cumulative risk of harm to neonates.Thus,a less harmful method for assessing the health of neonates with RDS is needed.AIM To analyze the relationships between pulmonary ultrasonography and respiratory distress scores,oxygenation index,and chest X-ray grade of neonatal RDS to identify predictors of neonatal RDS severity.METHODS This retrospective study analyzed the medical information of 73 neonates with RDS admitted to the neonatal intensive care unit of Liupanshui Maternal and Child Care Service Center between April and December 2022.The pulmonary ultrasonography score,respiratory distress score,oxygenation index,and chest Xray grade of each newborn before and after treatment were collected.Spearman correlation analysis was performed to determine the relationships among these values and neonatal RDS severity.RESULTS The pulmonary ultrasonography score,respiratory distress score,oxygenation index,and chest X-ray RDS grade of the neonates were significantly lower after treatment than before treatment(P<0.05).Spearman correlation analysis showed that before and after treatment,the pulmonary ultrasonography score of neonates with RDS was positively correlated with the respiratory distress score,oxygenation index,and chest X-ray grade(ρ=0.429–0.859,P<0.05).Receiver operating characteristic curve analysis indicated that pulmonary ultrasonography screening effectively predicted the severity of neonatal RDS(area under the curve=0.805–1.000,P<0.05).CONCLUSION The pulmonary ultrasonography score was significantly associated with the neonatal RDS score,oxygenation index,and chest X-ray grade.The pulmonary ultrasonography score was an effective predictor of neonatal RDS severity.展开更多
基金supported by the Foundation for Development of Science and Technology of Shanghai (Grant No 022261002)
文摘A general numerical tool, based on thermal diffusion equation and full-vectorial eigen-mode equation, has been presented for the systematic analysis of graded index channel waveguide fabricated by ion exchange on Er^3+ doped glass. Finite difference method with full-vectorial formulation (FV-FDM) is applied to solving the full-vectorial modes of graded index channel waveguide for the first time. The coupled difference equations based on magnetic fields in FV-FDM are derived from the Taylor series expansion and accurate formulation of boundary conditions. Hybrid nature of vectorial guided modes for both pump (980 nm) and signal light (1550 nm) are demonstrated by the simulation. Results show that the fabrication parameters of ion exchange, such as channel opening width and time ratio of second step to first step in ion exchange, have large influence on the properties of waveguide. By optimizing the fabrication parameters, maintenance of monomode for signal light and improvement of the gain dynamics can be achieved in Er^3+ doped waveguide amplifier (EDWA) fabricated by ion exchange technique. This theoretical model is significant for the design and fabrication of EDWA with ion exchange technique. Furthermore, a single polarization EDWA, which operates at wavelength from 1528 nm to 1541 nm for HE polarization, is numerically designed.
基金This work is supported by National Natural Science Foundation of China(Project No.518092509)Science and Technology Service Network Initiative(STS)of the Chinese Academy of Sciences(Project No.KFJ-STS-ZDTP-009)Open Foundation of The Ministry of Water Resources Key Laboratory of Soil and Water Loss Process and Control in the Loess Plateau(Project No.2017004).
文摘Multiple cropping index(MCI)is a very important indicator in crop production and agricultural intensification,which represents the utilizing degree of agriculture resources at time scale and the effective utilization situation of arable land.The objective of this paper is monitoring multiple cropping index of Henan province of China according to the time series of MODIS(Moderate-Resolution Imaging Spectroradiometer)EVI(Enhanced Vegetation Index)after Savitzky-Golay filter processing from the year 2006 to 2011.The results revealed that this method could provide an effective way to monitor multiple cropping index,and the method of no additional authentication data is independent and reliable.The result was accurate and stable,the slope of linear regression of the multiple cropping index between the statistical results and the remote sensing results was 1.0136(R2=0.779).The precision of sample areas validation was 97.91%.Suggesting that the time series MODIS-EVI which after Savitzky-Golay filtering processed,could provide an effective way to extract spatial information of multiple cropping index for management department of agriculture.
基金National High-tech R&D Programof China "863" Program(2006AA03A130)
文摘Light propagation in nanoparticle-loaded encapsulants is simulated based on the method of Monte Carlo,referring to the multilayer graded-refractive-index structure for LED encapsulants.And the influence of scattering coefficient on the transmittance is analyzed.The results show that the transmittance decreases with scattering coefficient.For a given number of layers,the encapsulants will yield maximum transmittance if the refractive index value of each layer is optimized.The nanoparticle-loaded encapsulant consists of multiple layers with refractive-index values that gradually decrease.The transmittance will be higher than that of traditional non-graded encapsulants,and will improve light extraction efficiency of LED.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11079014 and 61077010)
文摘Graded negative refractive index-based photonic crystal (PC) lenses are designed by gradually modifying the sizes of air holes along the transverse direction for focusing the incident plane wave. To study the tunability of the graded negative index-based PC, we introduce filling factor A, gradually tune the filling factor, and use the finite-difference and time-domain (FDTD) algorithm for numerical calculation. Our calculation results indicate that the focal length and the spot size increase with A increasing. For the same A value, the focal length of a PC with elliptical air holes is the longest, and those of PC with square and rectangular air holes are the shortest. Moreover, when the focal length is greater than 1 ~xm, the focal parameters of the PC are highly insensitive to the variation of A. When the focal length is less than 1 gm, the PC lenses have higher transmittances and all well focus with a beam spot size breaking the diffraction limit. This feature possibly makes the graded negative index-based PC lenses have some new applications in optoelectronic systems.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.11079014,61077010,90923036,and 60977041)the 100-Talent Program of the Chinese Academy of Sciences
文摘Flat lenses are designed by means of graded negative refractive index-based photonic crystals (PCs) constructed using air-holes tuned with different shapes. By gradually modifying the filling factor along the transverse direction, we obtain the graded negative index-based lenses for the purpose of focusing an incident plane wave. The finite-difference and timedomain (FDTD) algorithm is adopted for numerical calculation. Our calculation results indicate that these lenses can finely focus incident plane waves. Moreover, for the same size of air-holes, the focusing properties of the lens with rectangular air-holes are better than those with the other shaped air-holes. The graded negative index PCs lenses could possibly enable new applications in optoelectronic systems.
文摘In this study, a reliability index vector formula is proposed for series system with two failure modes in term of the concept of reliability index vector and equivalent failure modes. Firstly, the reliability index vector is introduced to determine the correlation coefficient between two failure modes, and then, the reliability index vector of a series system can be obtained. Several numerical cases and an analysis on offshore platform are performed, and the results show that this scheme provided here has better computational accuracy, and its calculation process is simpler for the series systems reliability calculations compared with the other methods. Also this scheme is more convenient for the engineering applications.
基金Project supported by the National Natural Science Foundation of China (Grant No. 10804060)Higher Educational Science and Technology Program of Shandong Province of China (Grant No. J08LI05)
文摘This paper reports that SiO2 is selected to fabricate broadband antireflection (AR) coatings on fused silica substrate by using glancing angle deposition and physical vapour deposition. Through accurate control of the graded index of the SiO2 layer, transmittance of thc graded broadband AR coating can achieve an average value of 98% across a spectral range of 300-1850 nm. Moreover, a laser-induced damage threshold measurement of the fabricated AR coating is performed by using a one-on-one protocol according to ISOl1254-1, resulting in an average damage threshold of 17.2 J/cm2.
基金supported by the National Key Basic Research Special Foundation of China (Grant No. 2011CB922000)the National Natural Science Foundation of China (Grant Nos. 61025025 and 60838003)the National High Technology Research and Development Program of China (Grant Nos. 2007AA03Z410 and 2007AA03Z408)
文摘The 850-nm oxide-confined vertical-cavity surface-emitting lasers with petal-shape holey structures are presented. An area-weighted average refractive index model is given to analyse their effective index profiles, and the graded index distribution in the holey region is demonstrated. The index step between the optical aperture and the holey region is obtained which is related merely to the etching depth. Four types of holey vertical-cavity surface-emitting lasers with different parameters are fabricated as well as the conventional oxide-confined vertical-cavity surface-emitting laser. Compared with the conventional oxide-confined vertical-cavity surface-emitting laser without etched holes, the holey vertical-cavity surface-emitting laser possesses an improved beam quality due to its graded index distribution, but has a lower output power, higher threshold current and lower slope efficiency. With the hole number increased, the holey vertical-cavity surface-emitting laser can realize the single-mode operation throughout the entire current range, and reduces the beam divergence further. The loss mechanism is used to explain the single-mode characteristic, and the reduced beam divergence is attributed to the shallow etching. High coupling efficiency of 86% to a multi-mode fibre is achieved for the single-mode device in the experiment.
文摘Let G = (V;E) be a simple connected graph. The sets of vertices and edges of G are denoted by V = V(G) and E = E(G), respectively. In such a simple molecular graph, vertices represent atoms and edges represent bonds. The Sanskruti index S(G) is a topological index was defined as where Su is the summation of degrees of all neighbors of vertex u in G. The goal of this paper is to compute the Sanskruti index for circumcoronene series of benzenoid.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.10704079 and 10976030)
文摘We suggest a design method of graded-refractive-index (GRIN) antireflection (AR) coating for s-polarized or p- polarized light at off-normal incidence. The spectrum characteristic of the designed antireflection coating with a quintic effective refractive-index profile for a given state of polarization has been discussed. In addition, the genetic algorithm was used to optimize the refractive index profile of the GRIN antireflection for reducing the mean reflectance of s- and p-polarizations. The average reflectance loss was reduced to only 0.04% by applying optimized GRIN AR coatings onto BK7 glass over the wavelength range from 400 to 800 nm at the incident angle of θo = 70°.
文摘During the last decades, air pollution has become a serious environmental hazard. Its impact on public health and safety, as well as on the ecosystem, has been dramatic. Forecasting the levels of air pollution to maintain the climatic conditions and environmental protection becomes crucial for government authorities to develop strategies for the prevention of pollution. This study aims to evaluate the atmospheric air pollution of the city of Zahleh located in the geographic zone of Bekaa. The study aims to determine a relationship between variations in ambient particulate concentrations during a short time. The data was collected from June 2017 to June 2018. In order to predict the Air Quality Index (AQI), Naïve, Exponential Smoothing, TBATS (a forecasting method to model time series data), and Seasonal Autoregressive Integrated Moving Average (SARIMA) models were implemented. The performance of these models for predicting air quality is measured using the Mean Absolute Error (MAE), the Root Mean Square Error (RMSE), and the Relative Error (RE). SARIMA model is the most accurate in prediction of AQI (RMSE = 38.04, MAE = 22.52 and RE = 0.16). The results reveal that SARIMA can be applied to cities like Zahleh to assess the level of air pollution and to prevent harmful impacts on health. Furthermore, the authorities responsible for controlling the air quality may use this model to measure the level of air pollution in the nearest future and establish a mechanism to identify the high peaks of air pollution.
文摘Absorption efficiency of graded-index double-clad fiber lasers or amplifiers is analyzed. As ray optics method is no longer valid for graded-index case, the mode analysis method is used. Calculated results show that absorption efficiency for a graded-index is higher than that for a step-index in symmetric case. In offset core case, the graded-index can achieve the same absorption efficiency with much smaller offset distance. Absorption efficiencies for different graded-index profiles of the inner cladding are compared.
基金National Natural Science Foundation of China,No.82170618.
文摘BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of metastasis.Preoperative chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of chemotherapy.However,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative chemotherapy.Body mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour therapies.Several studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with bevacizumab.AIM To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for CRLMs.METHODS A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July 2023.Univariate and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological response.The Kaplan-Meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low BMI.BMI<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour response.RESULTS Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)patients.The rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1.42-14.63,P=0.011],targeted therapy with bevacizumab(OR=3.02,95%CI:1.10-8.33,P=0.033),preoperative carcinoembryonic antigen level<10 ng/mL(OR=3.84,95%CI:1.19-12.44,P=0.025)and severe sinusoidal dilatation(OR=0.17,95%CI:0.03-0.90,P=0.037)were independent predictive factors for complete tumour response.The low BMI group exhibited a significantly longer median PFS than the high BMI group(10.7 mo vs 4.7 mo,P=0.011).CONCLUSION In CRLM patients receiving preoperative chemotherapy,a low BMI may be associated with better tumour response and longer PFS.
文摘Using the ray theory of light, a simple theoretical model for the power evolution of a propagating light in graded-index-medium is presented. This work can be useful for different engineering applications that utilize graded-index-material, and for further understanding of natural phenomena that depends on light propagation in graded-index-medium.
基金Guizhou Provincial Science and Technology Department,Technology Achievement Application and Industrialization Plan,Applied Fundamental Research,No.Qianke Synthetic Fruit[2022]004.
文摘BACKGROUND Accurate condition assessment is critical for improving the prognosis of neonatal respiratory distress syndrome(RDS),but current assessment methods for RDS pose a cumulative risk of harm to neonates.Thus,a less harmful method for assessing the health of neonates with RDS is needed.AIM To analyze the relationships between pulmonary ultrasonography and respiratory distress scores,oxygenation index,and chest X-ray grade of neonatal RDS to identify predictors of neonatal RDS severity.METHODS This retrospective study analyzed the medical information of 73 neonates with RDS admitted to the neonatal intensive care unit of Liupanshui Maternal and Child Care Service Center between April and December 2022.The pulmonary ultrasonography score,respiratory distress score,oxygenation index,and chest Xray grade of each newborn before and after treatment were collected.Spearman correlation analysis was performed to determine the relationships among these values and neonatal RDS severity.RESULTS The pulmonary ultrasonography score,respiratory distress score,oxygenation index,and chest X-ray RDS grade of the neonates were significantly lower after treatment than before treatment(P<0.05).Spearman correlation analysis showed that before and after treatment,the pulmonary ultrasonography score of neonates with RDS was positively correlated with the respiratory distress score,oxygenation index,and chest X-ray grade(ρ=0.429–0.859,P<0.05).Receiver operating characteristic curve analysis indicated that pulmonary ultrasonography screening effectively predicted the severity of neonatal RDS(area under the curve=0.805–1.000,P<0.05).CONCLUSION The pulmonary ultrasonography score was significantly associated with the neonatal RDS score,oxygenation index,and chest X-ray grade.The pulmonary ultrasonography score was an effective predictor of neonatal RDS severity.