目的:探讨测定血清肿瘤坏死因子样凋亡微弱诱导剂(serum TNF like weak inducer of apoptosis,sTWEAK)的含量在诊断糖尿病肾病以及评价治疗效果方面的临床意义。方法:将研究对象按诊断标准分为健康对照组40例(健康组,来自体检人群),单纯...目的:探讨测定血清肿瘤坏死因子样凋亡微弱诱导剂(serum TNF like weak inducer of apoptosis,sTWEAK)的含量在诊断糖尿病肾病以及评价治疗效果方面的临床意义。方法:将研究对象按诊断标准分为健康对照组40例(健康组,来自体检人群),单纯2型糖尿病组60例(T2DM组),2型糖尿病合并肾病患者组103例(T2DN组)。另根据肾脏损害程度的Mogensen分级标准,将T2DN组分为3个亚组:正常白蛋白尿组(NAU)、微量白蛋白尿组(MAU)和大量白蛋白尿组(MaAU)。用ELISA法测定上述各组患者血清中sTWEAK的含量。观察T2DN组不同等级2型糖尿病肾病患者sTWEAK含量的动态变化,以及治疗后患者血清sTWEAK含量的恢复情况。结果:在上述各组人群的血清中均可测出不同水平的sTWEAK。T2DN组和T2DM组sTWEAK含量明显低于健康组(P<0.01);T2DN组血清sTWEAK含量明显低于T2DM组(P<0.01)。随着肾脏损害程度的增加,T2DN组患者血清sTWEAK浓度相应降低(P<0.01),治疗后血清sTWEAK浓度较治疗前明显提高(P<0.05)。结论:动态检测血清内sTWEAK含量对于观察2型糖尿病肾病的病情以及评价临床治疗效果具有实际应用价值。展开更多
The main work of this article is to give a nontrivial method to construct pointed semilattice graded weak Hopf algebra from a Clifford monoid S =[Y; Gα. φα,β]by Ore-extensions, and to obtain a co-Frobenius semilat...The main work of this article is to give a nontrivial method to construct pointed semilattice graded weak Hopf algebra from a Clifford monoid S =[Y; Gα. φα,β]by Ore-extensions, and to obtain a co-Frobenius semilattice graded weak Hopf algebra H（S, n, c, x, a, b） through factoring At by a semilattice graded weak Hopf ideal.展开更多
Coupled thermo-mechanical analysis of two bonded functionally graded materials subjected to thermal loads is conducted in this study with the graded finite element method. The thermal-mechanical properties of the bi-m...Coupled thermo-mechanical analysis of two bonded functionally graded materials subjected to thermal loads is conducted in this study with the graded finite element method. The thermal-mechanical properties of the bi-material interfaces are classified based on discontinuity degrees of their material properties and their derivatives at the interfaces. Numerical results indicate that discontinuity exerts remarkable effect on the temperature profile and stress value at the interface of two bonded functionally-graded materials. Under the thermal flux loading conditions, the stronger the interface discontinuity is, the smaller the heat flux is.展开更多
文摘目的:探讨测定血清肿瘤坏死因子样凋亡微弱诱导剂(serum TNF like weak inducer of apoptosis,sTWEAK)的含量在诊断糖尿病肾病以及评价治疗效果方面的临床意义。方法:将研究对象按诊断标准分为健康对照组40例(健康组,来自体检人群),单纯2型糖尿病组60例(T2DM组),2型糖尿病合并肾病患者组103例(T2DN组)。另根据肾脏损害程度的Mogensen分级标准,将T2DN组分为3个亚组:正常白蛋白尿组(NAU)、微量白蛋白尿组(MAU)和大量白蛋白尿组(MaAU)。用ELISA法测定上述各组患者血清中sTWEAK的含量。观察T2DN组不同等级2型糖尿病肾病患者sTWEAK含量的动态变化,以及治疗后患者血清sTWEAK含量的恢复情况。结果:在上述各组人群的血清中均可测出不同水平的sTWEAK。T2DN组和T2DM组sTWEAK含量明显低于健康组(P<0.01);T2DN组血清sTWEAK含量明显低于T2DM组(P<0.01)。随着肾脏损害程度的增加,T2DN组患者血清sTWEAK浓度相应降低(P<0.01),治疗后血清sTWEAK浓度较治疗前明显提高(P<0.05)。结论:动态检测血清内sTWEAK含量对于观察2型糖尿病肾病的病情以及评价临床治疗效果具有实际应用价值。
基金supported by the National Natural Science Foundation of China(11271318,11171296,and J1210038)the Specialized Research Fund for the Doctoral Program of Higher Education of China(20110101110010)the Zhejiang Provincial Natural Science Foundation of China(LZ13A010001)
文摘The main work of this article is to give a nontrivial method to construct pointed semilattice graded weak Hopf algebra from a Clifford monoid S =[Y; Gα. φα,β]by Ore-extensions, and to obtain a co-Frobenius semilattice graded weak Hopf algebra H（S, n, c, x, a, b） through factoring At by a semilattice graded weak Hopf ideal.
基金supported by the National Natural Science Foundation of China(Nos.10902046,11032006and11121202)the Fundamental Research Funds for the Central Universities(lzujbky-2012-2)+1 种基金the Fund of Ministry of Education of the Program of Changjiang Scholars and Innovative Research Team in University(No.IRT0628)the Science Foundation of the Ministry of Education of China for Ph.D.program
文摘Coupled thermo-mechanical analysis of two bonded functionally graded materials subjected to thermal loads is conducted in this study with the graded finite element method. The thermal-mechanical properties of the bi-material interfaces are classified based on discontinuity degrees of their material properties and their derivatives at the interfaces. Numerical results indicate that discontinuity exerts remarkable effect on the temperature profile and stress value at the interface of two bonded functionally-graded materials. Under the thermal flux loading conditions, the stronger the interface discontinuity is, the smaller the heat flux is.
