Effects of gradient high-field static magnetic fields on diabetic mice

Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.

Hybrid gradient vector fields for path-following guidance

Guidance path-planning and following are two core technologies used for controlling un-manned aerial vehicles(UAVs)in both military and civilian applications.However,only a few approaches treat both the technologies simultaneously.In this study,an innovative hybrid gradient vector fields for path-following guidance(HGVFs-PFG)algorithm is proposed to control fixed-wing UAVs to follow a generated guidance path and oriented target curves in three-dimensional space,which can be any combination of straight lines,arcs,and helixes as motion primitives.The algorithm aids the creation of vector fields(VFs)for these motion primitives as well as the design of an effective switching strategy to ensure that only one VF is activated at any time to ensure that the complex paths are followed completely.The strategies designed in earlier studies have flaws that prevent the UAV from following arcs that make its turning angle too large.The proposed switching strategy solves this problem by introducing the concept of the virtual way-points.Finally,the performance of the HGVFs-PFG algorithm is verified using a reducedorder autopilot and four representative simulation scenarios.The simulation considers the constraints of the aircraft,and its results indicate that the algorithm performs well in following both lateral and longitudinal control,particularly for curved paths.In general,the proposed technical method is practical and competitive.

Conservative Vector Fields and the Intersect Rule

This paper covers the concept of a conservative vector field, and its application in vector physics and Newtonian mechanics. Conservative vector fields are defined as the gradient of a scalar-valued potential function. Gradient fields are irrotational, as in the curl in all conservative vector fields is zero, by Clairaut’s Theorem. Additionally, line integrals in conservative vector fields are path-independent, and line integrals over closed paths are always equal to zero, properties proved by the Gradient Theorem of multivariable calculus. Gradient fields represent conservative forces, and the associated potential function is analogous to potential energy associated with said conservative forces. The Intersect Rule provides a new, unique shortcut for determining if a vector field is conservative and deriving potential functions, by treating the indefinite integral as a set of infinitely many functions which satisfy the integral.

Directional growth behavior of a(Al) dendrites during concentration-gradientcontrolled solidification process in static magnetic field

The large and small sized Cu（solid）/Al（liquid） couples were prepared to investigate the directional growth behavior of primary a（Al） phase during a concentration-gradient-controlled solidification process under various static magnetic fields（SMFs）.The results show that in the large couples,the α（Al） dendrites reveal a directional growth character whether without or with the SMF.However,the 12 T magnetic field induces regular growth,consistent deflection and the decrease of secondary arm spacing of the dendrites.In the small couples,the α（Al） dendrites still reveal a directional growth character to some extent with a SMF of ≤5 T.However,an 8.8 T SMF destroys the directional growth and induces severe random deflections of the dendrites.When the SMF increases to 12 T,the a（Al） dendrites become quite regular despite of the consistent deflection.The directional growth arises from the continuous long-range concentration gradient field built in the melt.The morphological modification is mainly related to the suppression of natural convections and the induction of thermoelectric magnetic convection by the SMF.

Growth Rate of a-Si∶H Film Influenced by Magnetic Field Gradient in MWECR CVD Plasma System

The magnetic field profiles,which are produced by three ways in the deposition chamber and plasma chamber of single coil divergent field MWECR CVD system,are investigated.The magnetic field gradient of these magnetic field profiles is obtained quantitatively by using Lorentz fit.The results indicate that the gradient value of the magnetic field profile near by the substrate,which is produced by a coil current with 137.7A if a SmCo permanent magnet is equipped under the substrate holder,is the largest;when the SmCo permanent magnet is taken away,the larger one is produced by the coil current with 137.7A and the smallest one produced by a coil current with 115.2A.High deposition rate of a-Si∶H film is observed near by the substrate with high magnetic field gradient.But uneven deposition rate along the radius of the sample holder is also found by infrared analysis technology when sample is deposited in magnetic field profile,which is produced by the coil current with 137.7A if the SmCo permanent magnet is equipped under the substrate holder.

Flashover Probability of Wind Turbine Blade and Impact of Strong Electromagnetic Pulse from Lightning Strikes on Wind Turbine Safety

This paper systematically studies the flashover probability of wind turbine blade lightning arrester and the impact of strong electromagnetic pulses on the local and surrounding wind turbines during lightning strikes.The research results indicate that the flashover probability of direct lightning strikes by the wind turbine blade lightning arrester is almost negligible,and the strong electromagnetic pulse of wind turbine blade during lightning strikes has a serious impact on the electronic equipment of the machine,while the impact on the surrounding wind turbine is relatively small.At the same time,the calculation formula for the reflection of lightning current on the carbon brush between the wind turbine hub and the engine compartment during the flashing of the wind turbine blades is provided,and the calculation method for calculating the spatial gradient distribution of electromagnetic field intensity using Biot-Savart Law theorem is applied.The limitations of using wind turbine blades for lightning protection are pointed out,and a technical route for achieving wind turbine lightning safety is proposed,which can be used as a reference for wind turbine lightning protection technicians.

High-gradient magnetic field-controlled migration of solutes and particles and their effects on solidification microstructure:A review

We present a review of the principal developments in the evolution and synergism of solute and particle migration in a liquid melt in high-gradient magnetic fields and we also describe their effects on the solidification microstructure of alloys.Diverse areas relevant to various aspects of theory and applications of high-gradient magnetic field-controlled migration of solutes and particles are surveyed.They include introduction,high-gradient magnetic field effects,migration behavior of solute and particles in high-gradient magnetic fields,microstructure evolution induced by high-gradient magnetic fieldcontrolled migrations of solute and particles,and properties of materials modified by high-gradient magnetic field-tailored microstructure.Selected examples of binary and multiphase alloy systems are presented and examined,with the main focus on the correlation between the high-gradient magnetic field-modified migration and the related solidification microstructure evolution.Particular attention is given to the mechanisms responsible for the microstructure evolution induced by highgradient magnetic fields.

Gravity and gravity gradient changes caused by a point dislocation

In this paper we studied gravitational potential, gravity and its gradient changes, which are caused by a pointdislocation, and gave the concise mathematical deduction with definite physical implication in dealing with thesingular integral at a seismic source. We also analysed the features of the fields of gravity and gravity gradient,gravity-vertical-displacement gradient. The conclusions a re: (1) Gravity and gravit y gradient changes are verysmall with the change of vertical positionl (2) Gravity change is much greater than the gravity gradient changewhich is not so distinct; (3) The gravity change due to redistribution of mass accounts for 10-50 percent of thetotal gravity change caused by dislocation. The signs (positive or negative) of total gravity change and verticaldisplacement are opposite each other at the same point for strike slip and dip slip 1 (4) Gravity-vertical displacement-gradient is not constantl it manifests a variety of patterns for different dislocation modelsl (5) Gravityvertical-displacement-gradient is approximately equal to a pparent gra vit y-- vert ical- displacement -gradient.

Photodetachment of negative ion in a gradient electric field near a metal surface

Based on closed-orbit theory, the photodetachment of H- in a gradient electric field near a metal surface is studied. It is demonstrated that the gradient electric field has a significant influence on the photodetachment of negative ions near a metal surface. With the increase of the gradient of the electric field, the oscillation in the photodetachment cross section becomes strengthened. Besides, in contrast to the photodetachment of H- near a metal surface in a uniform electric field, the oscillating amplitude and the oscillating region in the cross section of a gradient electric field also become enlarged. Therefore, we can use the gradient electric field to control the photodetachment of negative ions near a metal surface. We hope that our results will be useful for understanding the photodetachment of negative ions in the vicinity of surfaces, cavities, and ion traps.

Detection of invisible phonon modes in individual defect-free carbon nanotubes by gradient-field Raman scattering

We provide an effective method to investigate the field gradient effect in nanoconfined plasmon-matter interaction.Aligned ultralong SWNTs without defects were grown on marked substrates, followed by assembling gold nanoparticle clusters around individual nanotubes. The Raman scattering behavior of a nanotube placed in an atomic scale nanogap between adjacent nanoparticles was studied. In addition to the expected plasmon-induced Raman enhancement up to 103,the defect-free D-mode of an individual SWNT induced by gradient field is found for the first time. When the light is confined at atomic scale, gradient field Raman scattering becomes significant and dipole-forbidden phonon modes can be activated by quadrupole Raman tensor variation, indicating breakdown of the Raman selection rules.

Effects of 3.7 T-24.5 T high magnetic fields on tumor-bearing mice

Since high magnetic field（MF） intensity can improve the image quality and reduce magnetic resonance imaging（MRI） acquisition time, the field intensity of MRIs has continued to increase over the past few decades. Although MRIs in most current hospitals are 0.5 T–3 T, there are preclinical studies have been carried out using 9.4 T MRI, and engineers are also putting efforts on building MRIs with even higher MFs. However, the accompanied safety issue of high-field MRIs is an emergent question to address before their clinical applications. In the meantime, the static magnetic field（SMF） has been shown to inhibit tumor growth in previous studies. Here, we investigated both the safety issue and the anti-tumor potentials of 3.7 T–24.5 T SMFs on GIST-T1 gastrointestinal stromal tumor-bearing nude mice. We followed up the mice three weeks after their exposure to high SMF and found that none of the mice died or had severe organ damage, except for slightly decreased food intake, weight gain, and liver function. Moreover, the tumor growth was inhibited by 3.7 T–24.5 T SMFs（up to ～54%）. It is interesting that the effects are more dependent on MF gradient than intensities, and for the same gradient and intensity, mice responded differently to hypogravity and hypergravity conditions. Therefore, our study not only demonstrated the safeness of high SMFs up to 24.5 T on mice but also revealed their anti-tumor potentials in the future.

Effect of Raman-pulse duration related to the magnetic field gradient in high-precision atom gravimeters

The effect of the Raman-pulse duration related to the magnetic field gradient, as a systematic error, is playing an important role on evaluating the performance of high-precision atomic gravimeters. We study this effect with a simplified theoretical model of the time-propagation operator. According to the typical parameters, we find that this effect should be taken into account when the gravimeter reaches an accuracy of 10^-10g, and the larger the pulse duration is, the more obvious the systematic effect will be. Finally, we make a simple discussion on the possibility of testing this effect.

In-situ measurement of magnetic field gradient in a magnetic shield by a spin-exchange relaxation-free magnetometer

A method of measuring in-situ magnetic field gradient is proposed in this paper. The magnetic shield is widely used in the atomic magnetometer. However, there is magnetic field gradient in the magnetic shield, which would lead to additional gradient broadening. It is impossible to use an ex-situ magnetometer to measure magnetic field gradient in the region of a cell, whose length of side is several centimeters. The method demonstrated in this paper can realize the in-situ measurement of the magnetic field gradient inside the cell, which is significant for the spin relaxation study. The magnetic field gradients along the longitudinal axis of the magnetic shield are measured by a spin-exchange relaxation-free （SERF） magnetometer by adding a magnetic field modulation in the probe beam＇s direction. The transmissivity of the cell for the probe beam is always inhomogeneous along the pump beam direction, and the method proposed in this paper is independent of the intensity of the probe beam, which means that the method is independent of the cell＇s transmissivity. This feature makes the method more practical experimentally. Moreover, the AC-Stark shift can seriously degrade and affect the precision of the magnetic field gradient measurement. The AC-Stark shift is suppressed by locking the pump beam to the resonance of potassium＇s D1 line. Furthermore, the residual magnetic fields are measured with σ＋- and σ--polarized pump beams, which can further suppress the effect of the AC-Stark shift. The method of measuring in-situ magnetic field gradient has achieved a magnetic field gradient precision of better than 30 pT/mm.

Full relativistic calculations of the quadrupole and electric field gradients for C_2,N_2,and O_2

In the present work we calculate the energies,quadrupole moments,and electric field gradients（EFGs） of molecules C2,N2,and O2 based on the DIRRCI method with basis aug-cc-pVTZ-DK.We prove that the quadratic force constant k2 is the product of charge and EFG at its equilibrium nuclear distance.The dipole charge distributions for these symmetrical molecules are all in equilibrium,however,the quadrupole charge distributions are far from equilibrium;among these,there is the most remarkable deviation from equilibrium for N2,for its many charges concentrate on two sides of the molecule,which is in agreement with the well-known characteristic of the nitrogen molecule.The relativistic effect is remarkable even for the same period.

Stress Field Analyses of Functionally Gradient Ceramic Tool by FEM

The cutting properties of the functionally gradient ceramic cutting tools relate closely to the gradient distribution. A cutting model of the functionally gradient ceramic tool is firstly designed in the present paper. The optimum of gradient distribution is obtained by way of the FEM analyses.

Effect of gradient magnetic field on physiochemistry functions of rice seedlings

Rice varieties Handao 2,Zhongbai 4,Han-jingzi,and Akihikari were treated with gradi-ent magnetic fileld to study the effect of gradi-ent field on rice.The magnetic field was madeup of 12 plots magnetic plates arranged in eachother south and north pole.The magneticstrength was 0-40 mT.Each four varieties wasput under the magnetic plate 15 cm away,andwent through the magnetic field with the speedof 20 cm/s.The same varieties without thetreatment were used as CK.Both of the seedswere soaked in water for 48 h in room temper-ature,and then sprouted on the porcelain platewith absorbed water paper.When the

The Bipolar Field-Effect Transistor:II.Drift-Diffusion Current Theory(Two-MOS-Gates on Pure-Base)

This paper describes the drift-diffusion theory of the bipolar field-effect transistor （BiFET） with two identical and connected metal-oxide-silicon-gates （MOS-gates） on a thin-pure-base. Analytical solution is obtained by partitioning the two-dimensional transistor into two one-dimensional problems coupled by the parametric sur- face-electric-potential. Total and component output and transfer currents and conductances versus D. C. voltages from the drift-diffusion theory, and their deviations from the electrochemical （quasi-Fermi） potential-gradient theory,are presented over practical ranges of thicknesses of the silicon base and gate oxide. A substantial contri- bution from the longitudinal gradient of the square of the transverse electric field is shown.

Nondestructive Testing and Characterization of Residual Stress Field Using an Ultrasonic Method

To address the difficulty in testing and calibrating the stress gradient in the depth direction of mechanical components, a new technology of nondestructive testing and characterization of the residual stress gradient field by ultrasonic method is proposed based on acoustoelasticity theory. By carrying out theoretical analysis, the sensitivity coefficients of different types of ultrasonic are obtained by taking the low carbon steel（12%C） as a research object. By fixing the interval distance between sending and receiving transducers, the mathematical expressions of the change of stress and the variation of time are established. To design one sending-one receiving and oblique incidence ultrasonic detection probes, according to Snell law, the critically refracted longitudinal wave（LCR wave） is excited at a certain depth of the fixed distance of the tested components. Then, the relationship between the depth of LCR wave detection and the center frequency of the probe in Q235 steel is obtained through experimental study. To detect the stress gradient in the depth direction, a stress gradient LCR wave detection model is established, through which the stress gradient formula is derived by the relationship between center frequency and detecting depth. A C-shaped stress specimen of Q235 steel is designed to conduct stress loading tests, and the stress is measured with the five group probes at different center frequencies. The accuracy of ultrasonic testing is verified by X-ray stress analyzer. The stress value of each specific depth is calculated using the stress gradient formula. Accordingly, the ultrasonic characterization of residual stress field is realized. Characterization results show that the stress gradient distribution is consistent with the simulation in ANSYS. The new technology can be widely applied in the detection of the residual stress gradient field caused by mechanical processing, such as welding and shot peening.

Self-diffusion coefficients of organic solvents in linear and branched high density polyethylene particles measured by PFG NMR

Pulsed field gradient nuclear magnetic resonance （PFG NMR） has been performed to study the diffusion of organic solvents into semicrystalline polyethylene particles. Self-diffusion coefficients in different domains of the sample can be extracted through a bi- exponential fit to the echo intensity attenuation, which allows the precise determination of the tortuosity of the polyethylene particles. Further exploration comes from the measurements with branched polyethylene particles and it was found that the diffusion in polymer phase contributed significantly to the slow component of the exponential decay curve. 2007 Jing Dai Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

Application of empirical mode decomposition in early diagnosis of magnetic memory signal

In order to eliminate noise interference of metal magnetic memory signal in early diagnosis of stress concentration zones and metal defects, the empirical mode decomposition method combined with the magnetic field gradient characteristic was proposed. A compressive force periodically acting upon a casing pipe led to appreciable deformation, and magnetic signals were measured by a magnetic indicator TSC-1M-4. The raw magnetic memory signal was first decomposed into different intrinsic mode functions and a residue, and the magnetic field gradient distribution of the subsequent reconstructed signal was obtained. The experimental results show that the gradient around 350 mm represents the maximum value ignoring the marginal effect, and there is a good correlation between the real maximum field gradient and the stress concentration zone. The wavelet transform associated with envelop analysis also exhibits this gradient characteristic, indicating that the proposed method is effective for early identifying critical zones.