Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^...Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^(+)/K^(+)-ATPase participates in Ca^(2+)-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell membrane.Na^(+)/K^(+)-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of cells.Therefo re,it is not surprising that Na^(+)/K^(+)-ATPase dysfunction has emerged as a risk factor for a variety of neurological diseases.However,published studies have so far only elucidated the important roles of Na^(+)/K^(+)-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na^(+)/K^(+)-ATPase affects cell function.Our recent studies revealed that membrane loss of Na^(+)/K^(+)-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's disease.Stabilization of plasma membrane Na^(+)/K^(+)-ATPase with an antibody is a novel strategy to treat these diseases.For this reason,Na^(+)/K^(+)-ATPase acts not only as a simple ion pump but also as a sensor/regulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell migration.Thus,the present review attempts to summarize the novel biological functions of Na^(+)/K^(+)-ATPase and Na^(+)/K^(+)-ATPase-related pathogenesis.The potential for novel strategies to treat Na^(+)/K^(+)-ATPase-related brain diseases will also be discussed.展开更多
Compared to conventional magnetic data,magnetic gradient tensor data contain more high-frequency signal components,which can better describe the features of geological bodies.The directional analytic signal of the mag...Compared to conventional magnetic data,magnetic gradient tensor data contain more high-frequency signal components,which can better describe the features of geological bodies.The directional analytic signal of the magnetic gradient tensor is not easily interfered from the tilting magnetization,but it can infer the range of the fi eld source more accurately.However,the analytic signal strength decays faster with depth,making it diffi cult to identify deep fi eld sources.Balanced-boundary recognition can eff ectively overcome this disadvantage.We present here a balanced-boundary identifi cation technique based on the normalization of three-directional analytic signals from aeromagnetic gradient tensor data.This method can eff ectively prevent the fast attenuation of analytic signals.We also derive an Euler inversion algorithm of three-directional analytic signal derivative.By combining magnetic-anomaly model testing with the traditional magnetic anomaly interpretation method,we show that the boundary-recognition technology based on a magnetic gradient tensor analytic signal has a greater advantage in identifying the boundaries of the geological body and can better refl ect shallow anomalies.The characteristics of the Euler equation based on the magnetic anomaly direction to resolve the signal derivative have better convergence,and the obtained solution is more concentrated,which can obtain the depth and horizontal range information of the geological body more accurately.Applying the above method to the measured magneticanomaly gradient data from Baoding area,more accurate fi eld source information is obtained,which shows the feasibility of applying this method to geological interpretations.展开更多
Blood oxygenation level dependence signal (BOLD) for functional magnetic resonance imaging (FMRI), is the use of blood magnetization depending on the oxygenation state of hemoglobin. Susceptibility gradient can shift ...Blood oxygenation level dependence signal (BOLD) for functional magnetic resonance imaging (FMRI), is the use of blood magnetization depending on the oxygenation state of hemoglobin. Susceptibility gradient can shift and skew k-space trajectories and it leads to echo time shift and BOLD sensitivity change. FMRI can be used to detect the signal, the change of the susceptibility gradient of the signal and the distortion of k space trajectory, resulting in echo time shift and BOLD sensitivity change. Using the percentage signal change (PSC) and calibration function, it can be applied to many different fields, such as age-related research. In this paper, the performance of BOLD signal change correction based on sensitivity gradient was verified by real data group calculation, and methods of further improving the calculation speed were analyzed. This paper also analyzed the performance of correcting the variations of BOLD Signal due to susceptibility gradients with real data set, and identified the computational issues that need to be improved for further research.展开更多
In oil and mineral exploration, gravity gradient tensor data include higher- frequency signals than gravity data, which can be used to delineate small-scale anomalies. However, full-tensor gradiometry （FTG） data are...In oil and mineral exploration, gravity gradient tensor data include higher- frequency signals than gravity data, which can be used to delineate small-scale anomalies. However, full-tensor gradiometry （FTG） data are contaminated by high-frequency random noise. The separation of noise from high-frequency signals is one of the most challenging tasks in processing of gravity gradient tensor data. We first derive the Cartesian equations of gravity gradient tensors under the constraint of the Laplace equation and the expression for the gravitational potential, and then we use the Cartesian equations to fit the measured gradient tensor data by using optimal linear inversion and remove the noise from the measured data. Based on model tests, we confirm that not only this method removes the high- frequency random noise but also enhances the weak anomaly signals masked by the noise. Compared with traditional low-pass filtering methods, this method avoids removing noise by sacrificing resolution. Finally, we apply our method to real gravity gradient tensor data acquired by Bell Geospace for the Vinton Dome at the Texas-Louisiana border.展开更多
A new algorithm, called the adaptive exponent smoothing gradient algorithm (AESGA), is developed from Widrow′s LMS algorithm. It is based on the fact that LMS algorithm has properties of time delaying and low pass ...A new algorithm, called the adaptive exponent smoothing gradient algorithm (AESGA), is developed from Widrow′s LMS algorithm. It is based on the fact that LMS algorithm has properties of time delaying and low pass filtering. This paper shows that the algorithm, on the domain of {Ω 1:α∈(0,1)}×{Ω 2:β(0,∞)} , unbiasedly and asymptotically converges to the Winner solution when the signal is a stationary Gauss stochastic process. The convergent property and the performance misadjustment are analyzed in theory. And calculation method of the algorithm is also suggested. Numerical results given by computer simulations show that the algorithm is effective.展开更多
优化城市道路中的交通信号灯控制是低成本地提升城市交通路网性能的方法之一。该研究提出了一种利用策略梯度(Policy Gradient, PG)强化调优的交通灯控制算法。该算法引入了道路压力项、旅程时间项和黑名单机制项,利用统计方式预测汽车...优化城市道路中的交通信号灯控制是低成本地提升城市交通路网性能的方法之一。该研究提出了一种利用策略梯度(Policy Gradient, PG)强化调优的交通灯控制算法。该算法引入了道路压力项、旅程时间项和黑名单机制项,利用统计方式预测汽车行程轨迹,并采用策略梯度估计的优化算法调整算法中的参数。在数据挖掘国际会议Knowledge Discovery and Data Mining (KDD)组织的算法竞赛KDD Cup 2021城市大脑挑战赛中,获得了冠军的成绩。在该挑战赛提供的城市路网规模复杂车流仿真平台上的实验结果表明,算法具有应用于实际场景的价值。展开更多
Diffusion tensor imaging (DTI) is mainly applied to white matter fiber tracking in human brain, but there is still a debate on how many diffusion gradient directions should be used to get the best results. In this pap...Diffusion tensor imaging (DTI) is mainly applied to white matter fiber tracking in human brain, but there is still a debate on how many diffusion gradient directions should be used to get the best results. In this paper, the performance of 7 protocols corresponding to 6, 9, 12, 15, 20, 25, and 30 noncollinear number of diffusion gradi-ent directions (NDGD) were discussed by com-paring signal-noise ratio (SNR) of tensor- de-rived measurement maps and fractional ani-sotropy (FA) values. All DTI data (eight healthy volunteers) were downloaded from the website of Johns Hopkins Medical Institute Laboratory of Brain Anatomi-cal MRI with permission. FA, apparent diffusion constant mean (ADC-mean), the largest eigen-value (LEV), and eigenvector orientation (EVO) maps associated with LEV of all subjects were calculated derived from tensor in the 7 proto-cols via DTI Studio. A method to estimate the variance was presented to calculate SNR of these tensor-derived maps. Mean ±standard deviation of the SNR and FA values within re-gion of interest (ROI) selected in the white mat-ter were compared among the 7 protocols. The SNR were improved significantly with NDGD increasing from 6 to 20 (P<0.05). From 20 to 30, SNR were improved significantly for LEV and EVO maps (P<0.05), but no significant dif-ferences for FA and ADC-mean maps (P>0.05). There were no significant variances in FA val-ues within ROI between any two protocols (P>0.05). The SNR could be improved with NDGD in-creasing, but an optimum protocol is needed because of clinical limitations.展开更多
Special input signals identification method based on the auxiliary model based multi-innovation stochastic gradient algorithm for Hammerstein output-error system was proposed.The special input signals were used to rea...Special input signals identification method based on the auxiliary model based multi-innovation stochastic gradient algorithm for Hammerstein output-error system was proposed.The special input signals were used to realize the identification and separation of the Hammerstein model.As a result,the identification of the dynamic linear part can be separated from the static nonlinear elements without any redundant adjustable parameters.The auxiliary model based multi-innovation stochastic gradient algorithm was applied to identifying the serial link parameters of the Hammerstein model.The auxiliary model based multi-innovation stochastic gradient algorithm can avoid the influence of noise and improve the identification accuracy by changing the innovation length.The simulation results show the efficiency of the proposed method.展开更多
This work describes a novel adaptive matrix/vector gradient (AMVG) algorithm for design of IIR filters and ARMA signal models. The AMVG algorithm can track to IIR filters and ARMA systems having poles also outside the...This work describes a novel adaptive matrix/vector gradient (AMVG) algorithm for design of IIR filters and ARMA signal models. The AMVG algorithm can track to IIR filters and ARMA systems having poles also outside the unit circle. The time reversed filtering procedure was used to treat the unstable conditions. The SVD-based null space solution was used for the initialization of the AMVG algorithm. We demonstrate the feasibility of the method by designing a digital phase shifter, which adapts to complex frequency carriers in the presence of noise. We implement the half-sample delay filter and describe the envelope detector based on the Hilbert transform filter.展开更多
基金supported by the National Natural Science Foundation of China,No.82173800 (to JB)Shenzhen Science and Technology Program,No.KQTD20200820113040070 (to JB)。
文摘Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^(+)/K^(+)-ATPase participates in Ca^(2+)-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell membrane.Na^(+)/K^(+)-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of cells.Therefo re,it is not surprising that Na^(+)/K^(+)-ATPase dysfunction has emerged as a risk factor for a variety of neurological diseases.However,published studies have so far only elucidated the important roles of Na^(+)/K^(+)-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na^(+)/K^(+)-ATPase affects cell function.Our recent studies revealed that membrane loss of Na^(+)/K^(+)-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's disease.Stabilization of plasma membrane Na^(+)/K^(+)-ATPase with an antibody is a novel strategy to treat these diseases.For this reason,Na^(+)/K^(+)-ATPase acts not only as a simple ion pump but also as a sensor/regulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell migration.Thus,the present review attempts to summarize the novel biological functions of Na^(+)/K^(+)-ATPase and Na^(+)/K^(+)-ATPase-related pathogenesis.The potential for novel strategies to treat Na^(+)/K^(+)-ATPase-related brain diseases will also be discussed.
基金supported by the National Key R&D Program of China (No. 2017YFC0602204)。
文摘Compared to conventional magnetic data,magnetic gradient tensor data contain more high-frequency signal components,which can better describe the features of geological bodies.The directional analytic signal of the magnetic gradient tensor is not easily interfered from the tilting magnetization,but it can infer the range of the fi eld source more accurately.However,the analytic signal strength decays faster with depth,making it diffi cult to identify deep fi eld sources.Balanced-boundary recognition can eff ectively overcome this disadvantage.We present here a balanced-boundary identifi cation technique based on the normalization of three-directional analytic signals from aeromagnetic gradient tensor data.This method can eff ectively prevent the fast attenuation of analytic signals.We also derive an Euler inversion algorithm of three-directional analytic signal derivative.By combining magnetic-anomaly model testing with the traditional magnetic anomaly interpretation method,we show that the boundary-recognition technology based on a magnetic gradient tensor analytic signal has a greater advantage in identifying the boundaries of the geological body and can better refl ect shallow anomalies.The characteristics of the Euler equation based on the magnetic anomaly direction to resolve the signal derivative have better convergence,and the obtained solution is more concentrated,which can obtain the depth and horizontal range information of the geological body more accurately.Applying the above method to the measured magneticanomaly gradient data from Baoding area,more accurate fi eld source information is obtained,which shows the feasibility of applying this method to geological interpretations.
文摘Blood oxygenation level dependence signal (BOLD) for functional magnetic resonance imaging (FMRI), is the use of blood magnetization depending on the oxygenation state of hemoglobin. Susceptibility gradient can shift and skew k-space trajectories and it leads to echo time shift and BOLD sensitivity change. FMRI can be used to detect the signal, the change of the susceptibility gradient of the signal and the distortion of k space trajectory, resulting in echo time shift and BOLD sensitivity change. Using the percentage signal change (PSC) and calibration function, it can be applied to many different fields, such as age-related research. In this paper, the performance of BOLD signal change correction based on sensitivity gradient was verified by real data group calculation, and methods of further improving the calculation speed were analyzed. This paper also analyzed the performance of correcting the variations of BOLD Signal due to susceptibility gradients with real data set, and identified the computational issues that need to be improved for further research.
基金financially supported by the SinoProbe-09-01(201011078)
文摘In oil and mineral exploration, gravity gradient tensor data include higher- frequency signals than gravity data, which can be used to delineate small-scale anomalies. However, full-tensor gradiometry （FTG） data are contaminated by high-frequency random noise. The separation of noise from high-frequency signals is one of the most challenging tasks in processing of gravity gradient tensor data. We first derive the Cartesian equations of gravity gradient tensors under the constraint of the Laplace equation and the expression for the gravitational potential, and then we use the Cartesian equations to fit the measured gradient tensor data by using optimal linear inversion and remove the noise from the measured data. Based on model tests, we confirm that not only this method removes the high- frequency random noise but also enhances the weak anomaly signals masked by the noise. Compared with traditional low-pass filtering methods, this method avoids removing noise by sacrificing resolution. Finally, we apply our method to real gravity gradient tensor data acquired by Bell Geospace for the Vinton Dome at the Texas-Louisiana border.
文摘A new algorithm, called the adaptive exponent smoothing gradient algorithm (AESGA), is developed from Widrow′s LMS algorithm. It is based on the fact that LMS algorithm has properties of time delaying and low pass filtering. This paper shows that the algorithm, on the domain of {Ω 1:α∈(0,1)}×{Ω 2:β(0,∞)} , unbiasedly and asymptotically converges to the Winner solution when the signal is a stationary Gauss stochastic process. The convergent property and the performance misadjustment are analyzed in theory. And calculation method of the algorithm is also suggested. Numerical results given by computer simulations show that the algorithm is effective.
文摘优化城市道路中的交通信号灯控制是低成本地提升城市交通路网性能的方法之一。该研究提出了一种利用策略梯度(Policy Gradient, PG)强化调优的交通灯控制算法。该算法引入了道路压力项、旅程时间项和黑名单机制项,利用统计方式预测汽车行程轨迹,并采用策略梯度估计的优化算法调整算法中的参数。在数据挖掘国际会议Knowledge Discovery and Data Mining (KDD)组织的算法竞赛KDD Cup 2021城市大脑挑战赛中,获得了冠军的成绩。在该挑战赛提供的城市路网规模复杂车流仿真平台上的实验结果表明,算法具有应用于实际场景的价值。
文摘Diffusion tensor imaging (DTI) is mainly applied to white matter fiber tracking in human brain, but there is still a debate on how many diffusion gradient directions should be used to get the best results. In this paper, the performance of 7 protocols corresponding to 6, 9, 12, 15, 20, 25, and 30 noncollinear number of diffusion gradi-ent directions (NDGD) were discussed by com-paring signal-noise ratio (SNR) of tensor- de-rived measurement maps and fractional ani-sotropy (FA) values. All DTI data (eight healthy volunteers) were downloaded from the website of Johns Hopkins Medical Institute Laboratory of Brain Anatomi-cal MRI with permission. FA, apparent diffusion constant mean (ADC-mean), the largest eigen-value (LEV), and eigenvector orientation (EVO) maps associated with LEV of all subjects were calculated derived from tensor in the 7 proto-cols via DTI Studio. A method to estimate the variance was presented to calculate SNR of these tensor-derived maps. Mean ±standard deviation of the SNR and FA values within re-gion of interest (ROI) selected in the white mat-ter were compared among the 7 protocols. The SNR were improved significantly with NDGD increasing from 6 to 20 (P<0.05). From 20 to 30, SNR were improved significantly for LEV and EVO maps (P<0.05), but no significant dif-ferences for FA and ADC-mean maps (P>0.05). There were no significant variances in FA val-ues within ROI between any two protocols (P>0.05). The SNR could be improved with NDGD in-creasing, but an optimum protocol is needed because of clinical limitations.
基金National Natural Science Foundation of China(No.61374044)Shanghai Science Technology Commission,China(Nos.15510722100,16111106300)
文摘Special input signals identification method based on the auxiliary model based multi-innovation stochastic gradient algorithm for Hammerstein output-error system was proposed.The special input signals were used to realize the identification and separation of the Hammerstein model.As a result,the identification of the dynamic linear part can be separated from the static nonlinear elements without any redundant adjustable parameters.The auxiliary model based multi-innovation stochastic gradient algorithm was applied to identifying the serial link parameters of the Hammerstein model.The auxiliary model based multi-innovation stochastic gradient algorithm can avoid the influence of noise and improve the identification accuracy by changing the innovation length.The simulation results show the efficiency of the proposed method.
文摘This work describes a novel adaptive matrix/vector gradient (AMVG) algorithm for design of IIR filters and ARMA signal models. The AMVG algorithm can track to IIR filters and ARMA systems having poles also outside the unit circle. The time reversed filtering procedure was used to treat the unstable conditions. The SVD-based null space solution was used for the initialization of the AMVG algorithm. We demonstrate the feasibility of the method by designing a digital phase shifter, which adapts to complex frequency carriers in the presence of noise. We implement the half-sample delay filter and describe the envelope detector based on the Hilbert transform filter.
