Establishment of extensively drug-resistant Pseudomonas aeruginosa pneumonia model in rat

Objective:To establish extensively drug-resistant Pseudomonas aeruginosa(XDR-PA)infection-induced pneumonia model in rats.Methods:Twenty-four male SD rats were randomly divided into blank group,low bacterial group,medium bacterial group,and high bacterial group.The low,medium and high bacterial groups were given intratracheal instillation of 0.1 mL of bacterial suspension(bacterial concentration in turn is 7.5×10^(9),3×10^(10),6×10^(10)CFU/mL),while the blank group were given the same volume of sterile normal saline.After modeling,the general conditions of rats in each group were observed,including mental state,hair,respiration,activity,eating,weight,and the survival curve was drawn.The pathological characteristics of lung tissue and the infiltration of inflammatory cells were observed.Pathogenic identification of each group was carried out by bacterial culture of lung tissue homogenate.Results:The general state of the blank group was normal,and the rats in other groups showed signs of mental depression,bristling,shortness of breath,even oral and nasal bleeding,decreased food intake and activity,and significant weight loss,and different degrees of death within 48 hours,the difference was statistically significant(P<0.05).Pathological results showed that the alveolar structure of rats in the blank group was complete,and the alveolar space was clear without exudation.The lung tissue of the low and medium bacterial groups showed obvious inflammatory cell infiltration,alveolar structure destruction,alveolar septum thickening,interstitial edema,but the pathological damage of the medium group was more severe,with a mortality rate of up to 50%,and the mortality rate of the low bacterial group was 17%.In the high bacterial group,red blood cells,inflammatory cells and a large amount of fibrin-like exudation can be seen in the alveolar space,which has the pathological characteristics of acute respiratory failure,and the mortality rate is as high as 67%.The results of bacterial culture of lung tissue homogenate showed that the blank group had no bacterial colonies,while PA colony growth can be seen in low,medium and high bacterial groups.Conclusion:9 Intratracheal instillation of low bacterial count(0.1 mL of 7.5×10^(9) CFU/mL)XDR-PA bacterial suspension can successfully construct a rat pneumonia model of XDR-PA infection.

Cenozoic tectono-sedimentary characteristics and extension model of the Northwest Sub-basin,South China Sea

Based on the interpretations of three seismic profiles and one wide-angle seismic profile across the Northwest Sub-basin,South China Sea.stratigraphic sequences,deformation characteristics and an extension model for this sub-basin have been worked out.Three tectonic-stratigraphic units are determined.Detailed analyses of extension show that the event occurred mainly during the Paleogene and resulted in the formation of half-grabens or grabens distributed symmetrically around the spreading center.Sediments are characterized by chaotic and discontinuous reflectors,indicating clastic sediments. Farther to the southwest,the sub-basin features mainly continental rifting instead of sea-floor spreading. The rifting would have been controlled by the shape of the massif and developed just along the northern edge of the Zhongsha-Xisha Block,rather than joined the Xisha Trough.After 25 Ma.a southward ridge jump triggered the opening of the Southwest Sub-basin.The NW-directed stress caused by the sea-floor spreading of the Northwest Sub-basin may have prevented the continuous opening of the sub-basin.After that the Northwest Sub-basin experienced thermal cooling and exhibited broad subsidence.The deep crustal structure shown by the velocity model from a wide-angle seismic profile is also symmetrical around the spreading center,which indicates that the Northwest Sub-basin might have opened in a pure shear model.

MECHANICAL PRODUCT EXTENSIVE INTELLIGENT CONCEPTUAL DESIGN

Based on extenics, an extensive functional information model(function-behavioral action-structure-environmental constraint) of the mechanical productintelligent conceptual design is developed, and the mechanism of theoretic structure solutions isproduced, the mapping relations between function-behavior and behavior-structure are analyzed. Themodel is applied to the filling material system's conceptual design to verify validity.

Extension Modeling Strategy of Intelligent Detection in D.huoshanense Photosynthesis Process

Aiming at the limitations of the existing knowledge representations in intelligent detection, a new method of Extension-based Knowledge Representation (EKR) was proposed. The definitions, grammar rules, and storage structure of EKR were presented. An Extension Solving Model (ESM) based on EKR was discussed in detail, including creation of the extension constraint graph, extended inference, calculation of relevant functions and generation of extension set. A knowledge base system based on EKR and ESM was developed, which was applied in extension repository system intelligent design of detection in photosynthesis process of D.huoshanense. More reasonable results were obtained than traditional rule-based system. EKR was feasible in intelligent design to solve the problem of intelligent detection knowledge representations.

EXTENSION OF SEQUENCE STRATIGRAPHIC MODELAND SEQUENCE STRATIGRAPHIC ANALYSIS IN LIMNIC DEPOSITIONAL BASIN

The architectural patterns of sedimentary succession are diverse in different depositionalbasins. The sedimentary architecture and geological condition of such basins asepicontinental sea, intraplate limnic basins, etc., differ cIearly from those of continentalmargin basin. Extension, complement and perfection of sequence stratigraphic models are needed in the studies of various depositional basins based on the classical sequence model. This paper, for this reason,expounds the thought, principles of sequence division, methodology and technology of the study of sequence stratigraphy in epicontinental and limnic basins.

Effect Analysis of Gurson Model Parameters on Crack Extension of Pipeline

Leakage-before-break technique is widely used in high energy pipeline of nuclear plant, for which crack stability of pipeline under complex loading condition is a key issue, and crack growth resistance curve of pipeline material is the important foundation for crack stability analysis. In this paper, ferritic steel A533B is studied, Gurson damage model is used to simulate crack process of contact tension specimen under unitension, and effect of Gurson model parameter on simulation result is discussed. The following results are found during simulation: initial porosity factor is the main parameter, when it increases gradually, unstable crack extension will be observed;however, only initial J toughness is affected by critical porosity factor;the minor parameter is load step control, when it increases, stable and convergent result is obtained. All results in this paper can be used to determine parameters in Gurson mode, which will be foundation for crack extension analysis of pipeline.

Two-Dimensional Lithium-Ion Battery Modeling with Electrolyte and Cathode Extensions

A two-dimensional model for transport and the coupled electric field is applied to simulate a charging lithium-ion cell and investigate the effects of lithium concentration gradients within electrodes on cell performance. The lithium concentration gradients within electrodes are affected by the cell geometry. Two different geometries are investigated: extending the length of the electrolyte past the edges of the electrodes and extending the length of the cathode past the edge of the anode. It is found that the electrolyte extension has little impact on the behavior of the electrodes, although it does increase the effective conductivity of the electrolyte in the edge region. However, the extension of the cathode past the edge of the anode, and the possibility for electrochemical reactions on the flooded electrode edges, are both found to impact the concentration gradients of lithium in electrodes and the current distribution within the electrolyte during charging. It is found that concentration gradients of lithium within electrodes may have stronger impacts on electrolytic current distributions, depending on the level of completeness of cell charge. This is because very different gradients of electric potential are expected from similar electrode gradients of lithium concentrations at different levels of cell charge, especially for the LixC6 cathode investigated in this study. This leads to the prediction of significant electric potential gradients along the electrolyte length during early cell charging, and a reduced risk of lithium deposition on the cathode edge during later cell charging, as seen experimentally by others.

NUMERICAL MODELLING OF LITHOSPHERE EVOLUTION IN THE NORTH CHINA CRATON: THERMAL THINNING VERSUS TECTONIC EXTENSION THINNING

The boundary between lithosphere and asthenosphere essentially represents a thermal boundary (the solidus). Temperature variation across this boundary can lead to the change of lithosphere thickness. In the case of elevated temperatures in a lithospheric layer above 1 200℃, partial melting will begin and the result of that is a thinned lithosphere. The other mechanism that can also thin lithosphere is extension. Stretching during an extension event can result in a thinner and longer lithosphere. The two mechanisms above are the reason why we can alserve large variations in lithosphere thickness spatially across various continents and temporally throughout the geological history.

Estimation of Displacement and Extension due to Reverse Drag of Normal Faults: Forward Method

In the case of reverse drag of normal faulting, the displacement and horizontal extension are determined based on the established equations for the three mechanisms: rigid body, vertical shear and inclined shear. There are three sub-cases of basal detachment for the rigid body model: horizontal detachment, antithetic detachment and synthetic detachment. For the rigid body model, the established equations indicate that the total displacement on the synthetic base (Dt2) is the largest, that on the horizontal base (Dt1) is moderate, and that on the antithetic base (Dt3) is the smallest. On the other hand, the value of (Dt1) is larger than the displacement for the vertical shear (Dt4). The value of (Dt1) is larger than or less than the displacement for the inclined shear (Dt5) depending on the original fault dip δ0, bedding angle θ, and the angle of shear direction β. For all original parameters, the value of Dt5 is less than the value of Dt4. Also, by comparing three rotation mechanisms, we find that the inclined shear produces largest extension, the rigid body model with horizontal detachment produces the smallest extension, and the vertical shear model produces moderate extension.

Calculation of the Standard Model Parameters and Particles Based on a SU(4) Preon Model

This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.

The Effects of Infrastructure Projects on House Prices and Rents:Evidence from the HS2 Extension Cancellation in the UK

This paper uses the HS2 extension cancellation in November 2021 as a quasi-experiment to study its impact on house prices and rents in Leeds.Using a DiD approach on repeat sales and monthly rents,I compare property values near the HS2 station and proposed construction site before and after the announcement.Results show a 3.6%decrease in house prices and a 3.9%decline in rents near the station,while properties near the construction site experienced a 2.4%increase in prices and a 2.1%rise in rents.This is the first paper to analyse the HS2 cancellation effect using panel data methods.

SWAT和WetSpa Extension在罗玉沟流域的应用比较

近年来,运用水文模型来研究流域水文状况越来越普遍,本文以黄土高原丘陵沟壑区第三副区的典型小流域为例,基于SWAT和WetSpa Extension两个模型,从模型的输入数据、模型的参数和模型模拟结果等方面进行比较,以期为该区水沙模拟选择合适水文模型并为将来模型性能的改进提供参考。连续15年的校准验证表明:两个模型都能得到较好的结果,而SWAT模型能应用于水文及泥沙等模拟过程,相对来说功能更全面;WetSpa Extension模型目前仅能提供水文模拟的模块,优点在于模拟时间步长较任意,可进行洪水模拟。

角色建模工具RModeler的设计与实现

提倡在对象技术中基于角色识别对象及其协调关系,然后展开到类模型、接口模型、实体模型,同时对角色模型的形式化定义和表示方法进行了系统地研究,并在此基础上设计和实现了基于RML的可视化角色建模工具RModeler。RModeler目前完成了代码实现和测试工作,并在实际开发中使用,运行良好。RModeler支持业务过程中采用RML语言的建模,具备将RML模型转换为UML模型的功能,采用业界标准数据描述格式XMI来传递和共享建模信息。

Interaction between Downslope and Alongslope Processes on the Margins of Daihai Lake,North China:Implication for Deltaic Sedimentation Models of Lacustrine Rift Basin

Daihai Lake, a modern lacustrine rift basin, located in Inner Mongolia, North China, serves as an important modern analog for understanding deltaic depositional processes in an active rift setting. Two of the deltas （Yuanzigou delta and Bulianghe delta） on the margins of Daihai Lake were surveyed to compare and contrast stacking patterns using aerial photographs, field trenching and sediment sampling. Shallow cores and trench data collected from the margins of Daihai Lake indicate that a variety of depositional processes have been active since Daihai Lake formed. Two 3-D sedimentation models which employ chronostratigraphic correlation technique were generated. The chronostratigraphic sedimentation models predict and represent the architectures and sand-body continuity of sediments. Stratigraphical coincidence of the broad sheeted drifts and channel erosion suggests a coupling between downslope and alongslope processes. Distributary mouth bars are prevalent in the front of deltas on steeper slopes due to the dominance of down-slope flows. On the contrary, the along-slope currents favor the development of distal bar deposits with sheeted sandbodies on gentle depositional slopes. This study provides an insight into the architecture of complex sedimentary facies associated with highlighting key differences between downslope flows and alongslope currents. The distribution of sand within these deltas is of particular interests, with applications in understanding the architecture of hydrocarbon reservoirs formed in lacustrine rift basin.

Mesoscale SST perturbation-induced impacts on climatological precipitation in the Kuroshio-Oyashio extension region,as revealed by the WRF simulations

Mesoscale coupling between perturbations of mesoscale sea surface temperature (SST) and lowlevel winds has been extensively studied using available high-resolution satellite observations. However, the climatological impacts of mesoscale SST perturbations (SST meso ) on the free atmosphere have not been fully understood. In this study, the rectified eff ect of SSTmeso on local climatological precipitation in the Kuroshio- Oyashio Extension (KOE) region is investigated using the Weather Research and Forecasting (WRF) Model;two runs are performed, one forced by low-resolution SST fields (almost no mesoscale signals) and another by additional high-resolution SSTmeso fields extracted from satellite observations. Climatological precipitation response to SST meso is characterized mainly by enhanced precipitation on the warmer flank of three oceanic SST fronts in this region. The results show that the positive correlation between the 10-m wind speed perturbations and SSTmeso is well captured by the WRF model with a reasonable spatial pattern but relatively weak strength. The addition of SSTmeso improves the climatological precipitation simulated by WRF with a better representation of fine-scale structures compared with satellite observations. A closer examination on the underlying mechanism suggests that while the pressure adjustment mechanism can explain the climatological precipitation enhancement along the fronts and the relatively high contribution of the convective precipitation, other factors such as synoptic events should also be taken into consideration to account for the seasonality of the precipitation response.

AN APPLICATION OF EXTENSION THEORY TO THE EVALUATION OF SLOPE STABILITY

The slope stability is affected by multiple factors. Thecomprehensive evaluation of the slope stability is a complicateproblem. The principles of extension theory have been used in thispaper to establish the matter-element model for the evaluation ofslope stability. The quantitative evaluated results have been giventhrough the calculation of the matter-element dependent degree.

Optimal Precursors Triggering the Kuroshio Extension State Transition Obtained by the Conditional Nonlinear Optimal Perturbation Approach

In this study, the initial perturbations that are the easiest to trigger the Kuroshio Extension （KE） transition connecting a basic weak jet state and a strong, fairly stable meandering state, are investigated using a reduced-gravity shallow water ocean model and the CNOP （Conditional Nonlinear Optimal Perturbation） approach. This kind of initial perturbation is called an optimal precursor （OPR）. The spatial structures and evolutionary processes of the OPRs are analyzed in detail. The results show that most of the OPRs are in the form of negative sea surface height （SSH） anomalies mainly located in a narrow band region south of the KE jet, in basic agreement with altimetric observations. These negative SSH anomalies reduce the merid- ional SSH gradient within the KE, thus weakening the strength of the jet. The KE jet then becomes more convoluted, with a high-frequency and large-amplitude variability corresponding to a high eddy kinetic energy level; this gradually strengthens the KE jet through an inverse energy cascade. Eventually, the KE reaches a high-energy state characterized by two well defined and fairly stable anticyclonic meanders. Moreover, sensitivity experiments indicate that the spatial structures of the OPRs are not sensitive to the model parameters and to the optimization times used in the analysis.

XML-based integration data model and schema mappingin multidatabase systems

Multidatabase systems are designed to achieve schema integration and data interoperation among distributed and heterogeneous database systems. But data model heterogeneity and schema heterogeneity make this a challenging task. A multidatabase common data model is firstly introduced based on XML, named XML-based Integration Data Model (XIDM), which is suitable for integrating different types of schemas. Then an approach of schema mappings based on XIDM in multidatabase systems has been presented. The mappings include global mappings, dealing with horizontal and vertical partitioning between global schemas and export schemas, and local mappings, processing the transformation between export schemas and local schemas. Finally, the illustration and implementation of schema mappings in a multidatabase prototype - Panorama system are also discussed. The implementation results demonstrate that the XIDM is an efficient model for managing multiple heterogeneous data sources and the approaches of schema mapping based on XIDM behave very well when integrating relational, object-oriented database systems and other file systems.

Photochemical Process Modeling and Analysis of Ozone Generation

Air pollution in modern city and industrial zones has become a serious public concern in recent years in China. Significance of air quality assessment and emission control strategy design is increasing. Most studies in China focus on particulate matter(PM), especially PM2.5, while few account for photochemical secondary air pollutions represented by ozone(O3). In this paper, a procedure for air quality simulation with comprehensive air quality model with extensions(CAMx) is demonstrated for studying the photochemical process and ozone generation in the troposphere. As a case study, the CAMx photochemical grid model is used to model ozone over southern part of Beijing city in winter, 2011. The input parameters to CAMx include emission sources, meteorology field data, terrain definition, photolysis status, initial and boundary conditions. The simulation results are verified by theoretical analysis of the ozone generation tendency. The simulated variation tendency of domain-wide average value of hourly ozone concentration coincides reasonably well with the theoretical analysis on the atmospheric photochemical process, demonstrating the effectiveness of the procedure. An integrated model system that cooperates with CAMx will be established in our future work.

Numerical modeling of metamorphic core complex formation:Implications for the destruction of the North China Craton

Widespread magmatism, metamorphic core complexes(MCCs), and significant lithospheric thinning occurred during the Mesozoic in the North China Craton(NCC). It has been suggested that the coeval exhumation of MCCs with uniform northwest-southeast shear senses and magmatism probably resulted from a decratonization event during the retreat of the paleo-Pacific Plate. Here we used two-dimensional finite element thermomechanical numerical models to investigate critical parameters controlling the formation of MCCs under far-field extensional stress. We observed three end-member deformation modes: the MCC mode, the symmetric-dome mode, and the pure-shear mode. The MCC mode requires a Moho temperature of ≥700 ℃ and an extensional strain rate of ≥5 × 10^(-16)s^(-1), implying that the lithosphere had already thinned when the MCC was formed in the Mesozoic. Considering that the widespread MCCs have the same northwest-southeast extension direction in the NCC, we suggest that the MCCs are surface expressions of both large-scale extension and craton destruction and that rollback of the paleo-Pacific slab might be the common driving force.