Objective: To observe the efficacy of the inhalation of an aerosonzeo group ~ sueloto^u v / preparation in treating orthotopic lung cancer in mouse models and assess the feasibility, safety, and effectiveness of this...Objective: To observe the efficacy of the inhalation of an aerosonzeo group ~ sueloto^u v / preparation in treating orthotopic lung cancer in mouse models and assess the feasibility, safety, and effectiveness of this administration mode for lung cancer. Methods: Lewis lung carcinoma (LLC) cell strains were administered via intrathoracic injection to establish orthotopic lung cancer mouse models. After the tumor-bearing models were successfully established, as confirmed by computed tomography, the mice were administered by inhalation with an aerosolized GAS preparation (GAS group) or aerosolized normal saline (control group). The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically; meanwhile, the survival and quality of life were compared between these two groups. Results: The aerosolized GAS preparation showed remarkably anti-tumor effect, causing the necrosis of the orthotopic lung cancer cells in tumor-bearing mice. Furthermore, mice in the GAS group had significantly better qualitT of life and longer survival than those in control group. Conclusions: The inhalation of aerosolized GAS preparation may be a feasible, safe and effective solution for lung cancer展开更多
Group A Streptococcus(GAS;Streptococcus pyogenes)is one of the most versatile bacteria among human pathogens.Non-invasive GAS infections can cause common diseases,such as pharyngitis and impetigo.Severe invasive GAS i...Group A Streptococcus(GAS;Streptococcus pyogenes)is one of the most versatile bacteria among human pathogens.Non-invasive GAS infections can cause common diseases,such as pharyngitis and impetigo.Severe invasive GAS infections can lead to rapid progressive and life-threatening manifestations,including necrotizing fasciitis and streptococcal toxic shock syndrome with high mortality rates ranging from 30%to 70%.Therefore,GAS is also known as"killer microbes"or"flesh-eating bacteria".During severe invasive GAS infections,anti-bacterial immunity is impeded by attenuation of the cellular components of innate immune responses.However,this loss of protection is compensated for by interferon-γ-producing immature myeloid cells,which are recruited upon severe invasive GAS infections in mouse models.In this review,we discuss and summarize the current knowledge on the role of interferon-γ-producing myeloid cells and other myeloid cells in the prevention and control of severe invasive GAS infections.展开更多
文摘Objective: To observe the efficacy of the inhalation of an aerosonzeo group ~ sueloto^u v / preparation in treating orthotopic lung cancer in mouse models and assess the feasibility, safety, and effectiveness of this administration mode for lung cancer. Methods: Lewis lung carcinoma (LLC) cell strains were administered via intrathoracic injection to establish orthotopic lung cancer mouse models. After the tumor-bearing models were successfully established, as confirmed by computed tomography, the mice were administered by inhalation with an aerosolized GAS preparation (GAS group) or aerosolized normal saline (control group). The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically; meanwhile, the survival and quality of life were compared between these two groups. Results: The aerosolized GAS preparation showed remarkably anti-tumor effect, causing the necrosis of the orthotopic lung cancer cells in tumor-bearing mice. Furthermore, mice in the GAS group had significantly better qualitT of life and longer survival than those in control group. Conclusions: The inhalation of aerosolized GAS preparation may be a feasible, safe and effective solution for lung cancer
基金supported by the Japan Agency forMedical Research and Development(AMED)[JP20fk0108130(TM)]Japan Society for the Promotion of Science(JSPS)KAKENHI[JP20K08833(TM)]the Takeda Science Foundation(TM).
文摘Group A Streptococcus(GAS;Streptococcus pyogenes)is one of the most versatile bacteria among human pathogens.Non-invasive GAS infections can cause common diseases,such as pharyngitis and impetigo.Severe invasive GAS infections can lead to rapid progressive and life-threatening manifestations,including necrotizing fasciitis and streptococcal toxic shock syndrome with high mortality rates ranging from 30%to 70%.Therefore,GAS is also known as"killer microbes"or"flesh-eating bacteria".During severe invasive GAS infections,anti-bacterial immunity is impeded by attenuation of the cellular components of innate immune responses.However,this loss of protection is compensated for by interferon-γ-producing immature myeloid cells,which are recruited upon severe invasive GAS infections in mouse models.In this review,we discuss and summarize the current knowledge on the role of interferon-γ-producing myeloid cells and other myeloid cells in the prevention and control of severe invasive GAS infections.