149 elementary school pupils were selected as the subjects for this study, to whom five tracking assessments of their verbal vocabulary knowledge were given over a period of three years. In addition, a latent variable...149 elementary school pupils were selected as the subjects for this study, to whom five tracking assessments of their verbal vocabulary knowledge were given over a period of three years. In addition, a latent variable growth model was adopted to explore grades 1-3 elementary school pupil's developmental trajectory for verbal Chinese vocabulary knowledge. The phonological awareness, homomorphic morpheme awareness, compound morpheme awareness and family socioeconomic status(SES) on the students' verbal vocabulary knowledge were also investigated. The ndings are: 1, grades 1-3 elementary school pupils verbal Chinese vocabulary knowledge developmental trajectory shows a curvilinear form, of which linear development is trended in the first two years, and as of the third year the developmental rate doubles the previous two years, whereas individual di erences are remarkable in both the initial level and the growth rate; 2, awareness of phonetics, homomorphic morphemes and complex morphemes as well as the family socioeconomic status can be referred to for a positive forecast of the students' initial level of verbal vocabulary knowledge; 3, only the awareness of homomorphic morphemes and the family socioeconomic status can be applied to a positive prediction of the students' verbal vocabulary knowledge growth rate..展开更多
Schizotypy,defined as the personality organization underlying schizophrenia and other related mental disorders,is a critical construct for a broad range of scientific disciplines.Because schizotypy can be psychometric...Schizotypy,defined as the personality organization underlying schizophrenia and other related mental disorders,is a critical construct for a broad range of scientific disciplines.Because schizotypy can be psychometrically identified in the general population,investigating schizotypy may provide a unique展开更多
Background:Septic shock has a high incidence and mortality rate in Intensive Care Units(ICUs).Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid ove...Background:Septic shock has a high incidence and mortality rate in Intensive Care Units(ICUs).Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid overload(FO),which is associated with poor clinical outcomes.A single point value of fluid cannot provide enough fluid information.The aim of this study was to investigate the impact of fluid balance(FB)latent trajectories on clinical outcomes in septic patients.Methods:Patients were diagnosed with septic shock during the first 48 h,and sequential fluid data for the first 3 days of ICU admission were included.A group-based trajectory model(GBTM)which is designed to identify groups of individuals following similar developmental trajectories was used to identify latent subgroups of individuals following a similar progression of FB.The primary outcomes were hospital mortality,organ dysfunction,major adverse kidney events(MAKE)and severe respiratory adverse events(SRAE).We used multivariable Cox or logistic regression analysis to assess the association between FB trajectories and clinical outcomes.Results:Nine hundred eighty-six patients met the inclusion criteria and were assigned to GBTM analysis,and three latent FB trajectories were detected.64(6.5%),841(85.3%),and 81(8.2%)patients were identified to have decreased,low,and high FB,respectively.Compared with low FB,high FB was associated with increased hospital mortality[hazard ratio(HR)=1.63,95%CI 1.22–2.17],organ dysfunction[odds ratio(OR)=2.18,95%CI 1.22–3.42],MAKE(OR=1.80,95%CI 1.04–2.63)and SRAE(OR=2.33,95%CI 1.46–3.71),and decreasing FB was significantly associated with decreased MAKE(OR=0.46,95%CI 0.29–0.79)after adjustment for potential covariates.Conclusion:Latent subgroups of septic patients followed a similar FB progression.These latent fluid trajectories were associated with clinical outcomes.The decreasing FB trajectory was associated with a decreased risk of hospital mortality and MAKE.展开更多
Understanding the sensitivity of tidal flats to environmental changes is challenging.Currently,most studies rely on process-based models to systematically explain the morphodynamic evolution of tidal flats.In this stu...Understanding the sensitivity of tidal flats to environmental changes is challenging.Currently,most studies rely on process-based models to systematically explain the morphodynamic evolution of tidal flats.In this study,we proposed an alternative empirical approach to explore tidal flat dynamics using statistical indices based on long-term time series of daily surface elevation development.Surface elevation dynamic(SED)indices focus on the magnitude and period of surface elevation changes,while morphodynamic signature(MDS)indices relate sediment dynamics to environmental drivers.The statistical analyses were applied to an intervention site in the Netherlands to determine the effect of recently constructed groynes on the tidal flat.Using these analyses,we were able to(1)detect a reduction in the daily SED and(2)determine that the changes in the daily SED were predominantly caused by the reduction in wave impact between the groynes rather than the reduction in tidal currents.Overall,the presented results showed that the combination of novel statistical indices provides new insights into the trajectories of tidal flats,ecosystem functioning,and sensitivity to physical drivers(wind and tides).Finally,we suggested how the SED and MDS indices may help to explore the future trajectories and climate resilience of intertidal habitats.展开更多
The present paper examines China＇s biotechnology industry from a global perspective and explores how its development trajectory differs from that of countries that are leaders in biotechnology. We draw on diverse dat...The present paper examines China＇s biotechnology industry from a global perspective and explores how its development trajectory differs from that of countries that are leaders in biotechnology. We draw on diverse data to demonstrate the unique development trajectory of the industry in China. China has benefited through targeted spin-offs of R＆D-oriented foreign direct investment from developed countries driven by the effects of globalization, government-encouraged collaboration between the domestic academia and industry, and the input of overseas returnees. Together with an increasing focus of the government and domestic enterprises on independent innovation, such developments have enabled China to catch up with the global biotechnology industry. However, its small scale and low capacity for commercializing innovations under China ＂s current regulations and other barriers pose challenges for the development of the industry. Suggestions for the sustainable development of China＇s biotechnology industry are presented in this study.展开更多
基金project No.17NDJC120YB of philosophy and social sciences under the planning of Zhejiang provincea Youth Fund research project No.16YJC190002 of humanities and social sciences under the planning of the Ministry of Educationa key research project No.13&ZD188 of the of the National Social Science Fund of China
文摘149 elementary school pupils were selected as the subjects for this study, to whom five tracking assessments of their verbal vocabulary knowledge were given over a period of three years. In addition, a latent variable growth model was adopted to explore grades 1-3 elementary school pupil's developmental trajectory for verbal Chinese vocabulary knowledge. The phonological awareness, homomorphic morpheme awareness, compound morpheme awareness and family socioeconomic status(SES) on the students' verbal vocabulary knowledge were also investigated. The ndings are: 1, grades 1-3 elementary school pupils verbal Chinese vocabulary knowledge developmental trajectory shows a curvilinear form, of which linear development is trended in the first two years, and as of the third year the developmental rate doubles the previous two years, whereas individual di erences are remarkable in both the initial level and the growth rate; 2, awareness of phonetics, homomorphic morphemes and complex morphemes as well as the family socioeconomic status can be referred to for a positive forecast of the students' initial level of verbal vocabulary knowledge; 3, only the awareness of homomorphic morphemes and the family socioeconomic status can be applied to a positive prediction of the students' verbal vocabulary knowledge growth rate..
基金supported by grants from the National Natural Science Foundation of Chinathe Beijing Municipal Science&Technology Commission+2 种基金the Beijing Training Project for Leading Talents in Science and Technologythe CAS Key Laboratory of Mental Healththe CAS/SAFEA International Partnership Program for Creative Research Teams
文摘Schizotypy,defined as the personality organization underlying schizophrenia and other related mental disorders,is a critical construct for a broad range of scientific disciplines.Because schizotypy can be psychometrically identified in the general population,investigating schizotypy may provide a unique
基金supported by the National Science and Technology Supporting Plan of the Ministry of Science and Technology of China(2012BAI11B05)。
文摘Background:Septic shock has a high incidence and mortality rate in Intensive Care Units(ICUs).Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid overload(FO),which is associated with poor clinical outcomes.A single point value of fluid cannot provide enough fluid information.The aim of this study was to investigate the impact of fluid balance(FB)latent trajectories on clinical outcomes in septic patients.Methods:Patients were diagnosed with septic shock during the first 48 h,and sequential fluid data for the first 3 days of ICU admission were included.A group-based trajectory model(GBTM)which is designed to identify groups of individuals following similar developmental trajectories was used to identify latent subgroups of individuals following a similar progression of FB.The primary outcomes were hospital mortality,organ dysfunction,major adverse kidney events(MAKE)and severe respiratory adverse events(SRAE).We used multivariable Cox or logistic regression analysis to assess the association between FB trajectories and clinical outcomes.Results:Nine hundred eighty-six patients met the inclusion criteria and were assigned to GBTM analysis,and three latent FB trajectories were detected.64(6.5%),841(85.3%),and 81(8.2%)patients were identified to have decreased,low,and high FB,respectively.Compared with low FB,high FB was associated with increased hospital mortality[hazard ratio(HR)=1.63,95%CI 1.22–2.17],organ dysfunction[odds ratio(OR)=2.18,95%CI 1.22–3.42],MAKE(OR=1.80,95%CI 1.04–2.63)and SRAE(OR=2.33,95%CI 1.46–3.71),and decreasing FB was significantly associated with decreased MAKE(OR=0.46,95%CI 0.29–0.79)after adjustment for potential covariates.Conclusion:Latent subgroups of septic patients followed a similar FB progression.These latent fluid trajectories were associated with clinical outcomes.The decreasing FB trajectory was associated with a decreased risk of hospital mortality and MAKE.
基金supported by the Royal Netherlands Academy of Arts and Sciences(KNAW)(Grant No.PSA-SA-E-02)the Province of Zeeland,the Netherlands(Grant No.CoE-Buitendijks)。
文摘Understanding the sensitivity of tidal flats to environmental changes is challenging.Currently,most studies rely on process-based models to systematically explain the morphodynamic evolution of tidal flats.In this study,we proposed an alternative empirical approach to explore tidal flat dynamics using statistical indices based on long-term time series of daily surface elevation development.Surface elevation dynamic(SED)indices focus on the magnitude and period of surface elevation changes,while morphodynamic signature(MDS)indices relate sediment dynamics to environmental drivers.The statistical analyses were applied to an intervention site in the Netherlands to determine the effect of recently constructed groynes on the tidal flat.Using these analyses,we were able to(1)detect a reduction in the daily SED and(2)determine that the changes in the daily SED were predominantly caused by the reduction in wave impact between the groynes rather than the reduction in tidal currents.Overall,the presented results showed that the combination of novel statistical indices provides new insights into the trajectories of tidal flats,ecosystem functioning,and sensitivity to physical drivers(wind and tides).Finally,we suggested how the SED and MDS indices may help to explore the future trajectories and climate resilience of intertidal habitats.
基金the financial support from the National Science Foundation of China(No.71003061)the Alexander von Humboldt Foundation(2007-2008)+1 种基金the Special Support Fund for China's Postdoctor Research Fellow(201003090)the Humanities and the Social Sciences Project of the Ministry of Education(09YJC630225)
文摘The present paper examines China＇s biotechnology industry from a global perspective and explores how its development trajectory differs from that of countries that are leaders in biotechnology. We draw on diverse data to demonstrate the unique development trajectory of the industry in China. China has benefited through targeted spin-offs of R＆D-oriented foreign direct investment from developed countries driven by the effects of globalization, government-encouraged collaboration between the domestic academia and industry, and the input of overseas returnees. Together with an increasing focus of the government and domestic enterprises on independent innovation, such developments have enabled China to catch up with the global biotechnology industry. However, its small scale and low capacity for commercializing innovations under China ＂s current regulations and other barriers pose challenges for the development of the industry. Suggestions for the sustainable development of China＇s biotechnology industry are presented in this study.
