The design of artificial nucleases and nuclease mimics has attracted extensive attention and made great progress due to their significant scientific meanings and potential application in the field of gene medicine and...The design of artificial nucleases and nuclease mimics has attracted extensive attention and made great progress due to their significant scientific meanings and potential application in the field of gene medicine and molecular biology. This paper reviews recent progress in the investigation of artificial nuclease,including "bifunctional cooperative catalysis","dinuclear synergistic catalysis","metal-free catalysis" ,and especially,the studies of aza-crown ethers as artificial nucleases and their interaction with DNA.展开更多
基金Supported by the National Natural Science Foundation of China (Grant Nos. 20872061 & 20372032)the National Basic Research of China (Grant No. 2007CB925103)
文摘The design of artificial nucleases and nuclease mimics has attracted extensive attention and made great progress due to their significant scientific meanings and potential application in the field of gene medicine and molecular biology. This paper reviews recent progress in the investigation of artificial nuclease,including "bifunctional cooperative catalysis","dinuclear synergistic catalysis","metal-free catalysis" ,and especially,the studies of aza-crown ethers as artificial nucleases and their interaction with DNA.
