A hybrid method combined the reduced Sequential Quadratic Programming(SQP)method with the harmonic balance method has been developed to analyze the characteristics of mode localization and internal resonance of nonlin...A hybrid method combined the reduced Sequential Quadratic Programming(SQP)method with the harmonic balance method has been developed to analyze the characteristics of mode localization and internal resonance of nonlinear bladed disks.With the aid of harmonic balance method,the nonlinear equality constraints for the constrained optimization problem are constructed.The reduced SQP method is then utilized to deal with the original constrained optimization problem.Applying the null space decomposition technique to the harmonic balance algebraic equations results in the vanishing of the nonlinear equality constraints and a simple optimization problem involving only upper and lower bound constraints on the optimization variables is formed and solved.Finally,numerical results are given for several test examples to validity the proposed method.The efficiency of the solution method to trace the family of energy dependent nonlinear modes is illustrated.The localization nonlinear normal modes of bladed disks related to various types of internal resonances are explored.展开更多
Considering the fact that the results of laboratory tests provide useful information about the state of health of patients, determination of reference value is considered an intrinsic part in the development of labora...Considering the fact that the results of laboratory tests provide useful information about the state of health of patients, determination of reference value is considered an intrinsic part in the development of laboratory medi-cine. There are still huge differences in the analytical methods used as well as in the associated reference intervals which could consequently significantly affect the proper assessment of patient health. In a constant effort to increase the quality of patients' care, there are numerous international initiatives for standardiza-tion and/or harmonization of laboratory diagnostics in order to achieve maximum comparability of laboratory test results and improve patient safety. Through the standardization and harmonization processes of analytical methods the ability to create unique reference intervals is achieved. Such reference intervals could be applied globally in all laboratories using methods traceable to the same reference measuring system and analysing the biological samples from the populations with similar socio-demographic and ethnic characteristics. In this review we outlined the results of the harmonization processes in Croatia in the field of population based reference intervals for clinically relevant blood and serum constituents which are in accordance with ongoing activity for worldwide standardization and harmonization based on traceability in laboratory medicine.展开更多
To determine the prevalence of metabolic syndrome (MetS) in Malaysian type 2 diabetic patients using WHO, NCEP ATP III, IDF and the new Harmonized definitions, and the concordance between these definitions. This study...To determine the prevalence of metabolic syndrome (MetS) in Malaysian type 2 diabetic patients using WHO, NCEP ATP III, IDF and the new Harmonized definitions, and the concordance between these definitions. This study involved 313 patients diagnosed with type 2 diabetes mellitus (T2DM) at two Malaysian tertiary hospitals. Socio-demographic data were assessed using a pre-tested interviewer-administered structured questionnaire. Anthropometric measurements were carried out according to standard protocols. Clinical and laboratory characteristics were examined. Kappa (k) statistics were used for the agreement between the four MetS definitions. The overall prevalence rates of MetS (95% CI) were 95.8% (93.6-98.1), 96.1% (94.0-98.3), 84.8% (80.8-88.9) and 97.7% (96.1-99.4) according to the WHO, NCEP ATP III, IDF and the Harmonized definitions, respectively. The Kappa statistics demonstrated a slight to substantial agreement between the definitions (k = 0.179-0.875, p k = 0.875, p hest specificity (100%) in identifying MetS. In conclusion, the new Harmonized criteria established the highest prevalence of MetS among the four definitions applied. There was a very good concordance between the WHO and NCEP ATP III criteria. The extremely high prevalence of MetS observed in type 2 diabetic patients indicates an impending pandemic of CVD risk in Malaysia. Aggressive treatment of MetS components is required to reduce cardiovascular risk in T2DM.展开更多
基金The authors would like to thank the sponsor of the National Natural Science Foundation of China through grant No.11502261the Aeronautical Science Foundation of China under award No.2015ZB04002The sponsor of the Beijing Institute of Technology Research Fund Program for Young Scholars is gratefully acknowledged by the authors.
文摘A hybrid method combined the reduced Sequential Quadratic Programming(SQP)method with the harmonic balance method has been developed to analyze the characteristics of mode localization and internal resonance of nonlinear bladed disks.With the aid of harmonic balance method,the nonlinear equality constraints for the constrained optimization problem are constructed.The reduced SQP method is then utilized to deal with the original constrained optimization problem.Applying the null space decomposition technique to the harmonic balance algebraic equations results in the vanishing of the nonlinear equality constraints and a simple optimization problem involving only upper and lower bound constraints on the optimization variables is formed and solved.Finally,numerical results are given for several test examples to validity the proposed method.The efficiency of the solution method to trace the family of energy dependent nonlinear modes is illustrated.The localization nonlinear normal modes of bladed disks related to various types of internal resonances are explored.
基金Supported by The Ministry of science and technology,Zagreb,Croatia,No.55.3-01-143
文摘Considering the fact that the results of laboratory tests provide useful information about the state of health of patients, determination of reference value is considered an intrinsic part in the development of laboratory medi-cine. There are still huge differences in the analytical methods used as well as in the associated reference intervals which could consequently significantly affect the proper assessment of patient health. In a constant effort to increase the quality of patients' care, there are numerous international initiatives for standardiza-tion and/or harmonization of laboratory diagnostics in order to achieve maximum comparability of laboratory test results and improve patient safety. Through the standardization and harmonization processes of analytical methods the ability to create unique reference intervals is achieved. Such reference intervals could be applied globally in all laboratories using methods traceable to the same reference measuring system and analysing the biological samples from the populations with similar socio-demographic and ethnic characteristics. In this review we outlined the results of the harmonization processes in Croatia in the field of population based reference intervals for clinically relevant blood and serum constituents which are in accordance with ongoing activity for worldwide standardization and harmonization based on traceability in laboratory medicine.
文摘To determine the prevalence of metabolic syndrome (MetS) in Malaysian type 2 diabetic patients using WHO, NCEP ATP III, IDF and the new Harmonized definitions, and the concordance between these definitions. This study involved 313 patients diagnosed with type 2 diabetes mellitus (T2DM) at two Malaysian tertiary hospitals. Socio-demographic data were assessed using a pre-tested interviewer-administered structured questionnaire. Anthropometric measurements were carried out according to standard protocols. Clinical and laboratory characteristics were examined. Kappa (k) statistics were used for the agreement between the four MetS definitions. The overall prevalence rates of MetS (95% CI) were 95.8% (93.6-98.1), 96.1% (94.0-98.3), 84.8% (80.8-88.9) and 97.7% (96.1-99.4) according to the WHO, NCEP ATP III, IDF and the Harmonized definitions, respectively. The Kappa statistics demonstrated a slight to substantial agreement between the definitions (k = 0.179-0.875, p k = 0.875, p hest specificity (100%) in identifying MetS. In conclusion, the new Harmonized criteria established the highest prevalence of MetS among the four definitions applied. There was a very good concordance between the WHO and NCEP ATP III criteria. The extremely high prevalence of MetS observed in type 2 diabetic patients indicates an impending pandemic of CVD risk in Malaysia. Aggressive treatment of MetS components is required to reduce cardiovascular risk in T2DM.
