On the basis of analyzing the reliability of the organization’ management chain of the large and medium- sized project in the construction period, the paper studies the factors influencing the reliability of the orga...On the basis of analyzing the reliability of the organization’ management chain of the large and medium- sized project in the construction period, the paper studies the factors influencing the reliability of the organi-zation management chain, which, corresponding to four elements of management chain – “Management Loop”, “Management Link”, “Management Chain”, and “Management Network”, can be summarized as project main body, interface management, connection sequence and management model. The paper then re-searches on the specific influencing factors from the above-mentioned four aspects.展开更多
The prognosis of hepatocellular carcinoma(HCC) depends on tumor extension as well as hepatic function.Hepatic functional reserve is recognized as a factor affecting survival in the treatment of HCC;the ChildPugh class...The prognosis of hepatocellular carcinoma(HCC) depends on tumor extension as well as hepatic function.Hepatic functional reserve is recognized as a factor affecting survival in the treatment of HCC;the ChildPugh classif ication system is the most extensively used method for assessing hepatic functional reserve in patients with chronic liver disease,using serum albumin level to achieve accurate assessment of the status of protein metabolism.However,insuff icient attention has been given to the status of amino acid(AA) metabolism in chronic liver disease and HCC.Fischer's ratio is the molar ratio of branched-chain AAs(BCAAs:leucine,valine,isoleucine) to aromatic AAs(phenylalanine,tyrosine) and is important for assessing liver metabolism,hepatic functional reserve and the severity of liver dysfunction.Although this ratio is diff icult to determine in clinical situations,BCAAs/tyrosine molar concentration ratio(BTR) has been proposed as a simpler substitute.BTR correlates with various liver function examinations,including markers of hepatic f ibrosis,hepatic blood flow and hepatocyte function,and can thus be considered as reflecting the degree of hepatic impairment.This manuscript examines the literature to clarify whether BTR can serve as a prognostic factor for treatment of HCC.展开更多
In improving the competitiveness of business organi sa tion in the 21st century, minimising cost and increasing productivity are no lon ger factors that could promise the success. The changes in customer trends whic h...In improving the competitiveness of business organi sa tion in the 21st century, minimising cost and increasing productivity are no lon ger factors that could promise the success. The changes in customer trends whic h focusing more on product or service customising, high quality and short delive ry times are additional crucial factors that organisation should be aware of. T hese factors have direct relations on how the management could utilise the capab ility of its supply chain management (SCM). The importance of SCM in organisati on specifically to manufacturer is to play a vital role in managing the flow of material and information along the chain from suppliers to customers. In a trad itional way, SCM is mainly manage by the production department in organisation b ut with the advancement in information technology, resulted the changes in worki ng environment. One of the ways that could be implemented in decision making p rocess in order to improve the effectiveness and efficiency of the decision is t hrough collaborative environment. Due to this situation, there is a need to rede sign the existing SCM in order to optimise its capability and functionality in t he way to ensure the organisation competitiveness is sustainable. A minor or ma jor alignment to SCM business processes should be done in order to streamline th e flow of information, which could also affect the flow of materials. Factors s uch as SCM operational, structural and even its managerial are among the issues that are critical in redesigning its business process. Each of these factors has its own attributes such as lead-times, complexity, frequency and organisationa l setting that could lead in improving organisational competitiveness. In additi on, by identifying these factors, it would help the management to plan and desig n the collaborative SCM that would effectively correspond to the changes in busi ness and customer trends. The intention of the paper is to promote a list of fa ctors and attributes, which are critical in redesigning an existing SCM in order to shift its environment to become collaborative SCM. By utilising these facto rs and attributes, a model for redesigning SCM into collaborative environment is currently developed by the author and will be used in the next stage of his res earch.展开更多
文摘On the basis of analyzing the reliability of the organization’ management chain of the large and medium- sized project in the construction period, the paper studies the factors influencing the reliability of the organi-zation management chain, which, corresponding to four elements of management chain – “Management Loop”, “Management Link”, “Management Chain”, and “Management Network”, can be summarized as project main body, interface management, connection sequence and management model. The paper then re-searches on the specific influencing factors from the above-mentioned four aspects.
文摘The prognosis of hepatocellular carcinoma(HCC) depends on tumor extension as well as hepatic function.Hepatic functional reserve is recognized as a factor affecting survival in the treatment of HCC;the ChildPugh classif ication system is the most extensively used method for assessing hepatic functional reserve in patients with chronic liver disease,using serum albumin level to achieve accurate assessment of the status of protein metabolism.However,insuff icient attention has been given to the status of amino acid(AA) metabolism in chronic liver disease and HCC.Fischer's ratio is the molar ratio of branched-chain AAs(BCAAs:leucine,valine,isoleucine) to aromatic AAs(phenylalanine,tyrosine) and is important for assessing liver metabolism,hepatic functional reserve and the severity of liver dysfunction.Although this ratio is diff icult to determine in clinical situations,BCAAs/tyrosine molar concentration ratio(BTR) has been proposed as a simpler substitute.BTR correlates with various liver function examinations,including markers of hepatic f ibrosis,hepatic blood flow and hepatocyte function,and can thus be considered as reflecting the degree of hepatic impairment.This manuscript examines the literature to clarify whether BTR can serve as a prognostic factor for treatment of HCC.
文摘In improving the competitiveness of business organi sa tion in the 21st century, minimising cost and increasing productivity are no lon ger factors that could promise the success. The changes in customer trends whic h focusing more on product or service customising, high quality and short delive ry times are additional crucial factors that organisation should be aware of. T hese factors have direct relations on how the management could utilise the capab ility of its supply chain management (SCM). The importance of SCM in organisati on specifically to manufacturer is to play a vital role in managing the flow of material and information along the chain from suppliers to customers. In a trad itional way, SCM is mainly manage by the production department in organisation b ut with the advancement in information technology, resulted the changes in worki ng environment. One of the ways that could be implemented in decision making p rocess in order to improve the effectiveness and efficiency of the decision is t hrough collaborative environment. Due to this situation, there is a need to rede sign the existing SCM in order to optimise its capability and functionality in t he way to ensure the organisation competitiveness is sustainable. A minor or ma jor alignment to SCM business processes should be done in order to streamline th e flow of information, which could also affect the flow of materials. Factors s uch as SCM operational, structural and even its managerial are among the issues that are critical in redesigning its business process. Each of these factors has its own attributes such as lead-times, complexity, frequency and organisationa l setting that could lead in improving organisational competitiveness. In additi on, by identifying these factors, it would help the management to plan and desig n the collaborative SCM that would effectively correspond to the changes in busi ness and customer trends. The intention of the paper is to promote a list of fa ctors and attributes, which are critical in redesigning an existing SCM in order to shift its environment to become collaborative SCM. By utilising these facto rs and attributes, a model for redesigning SCM into collaborative environment is currently developed by the author and will be used in the next stage of his res earch.
文摘目的探讨阿尔茨海默病患者神经丝轻链蛋白(neurofilament light chain,NfL)与临床特点相关性。方法分析2020年6月—2022年12月宁波市第二医院收治的58例阿尔茨海默病患者的临床资料为研究对象。检测58例阿尔茨海默病患者的神经丝轻链蛋白水平。Simoa法检测阿尔茨海默病患者神经丝轻链蛋白水平,探索神经丝轻链蛋白表达与临床因素的关联性。结果58例患者中女性患者33例,NfL水平为(24.93±17.07)pg/ml;男性患者24例,NfL水平为(28.14±17.98)pg/ml,差异无统计学意义。不同文化程度与NfL水平分别为:文盲[(27.87±14.75)pg/ml(7/58)]、小学[(15.22±9.62)pg/ml(7/58)]、初中[(27.95±15.60)pg/ml(14/58)]、高中[(12.84±2.97)pg/ml(4/58)]、中专[(37.35±26.63)pg/ml(7/58)]、大专[(33.79±21.81)pg/ml(5/58)]、大学[(15.22±9.62)pg/ml(7/58)],结果无统计学差异。用相关分析研究NfL和年龄、病程、海马分级,日常生活活动能力评定量表(Activities of Daily Living,ADL)分值,简易精神状态检查表(Mini-Mental State Examination,MMSE)分值,长谷川痴呆量表(Hasegawa Dementia Scale,HDS)分值之间的相关关系,Pearson相关系数(r)表示相关关系的强弱情况。NfL和年龄的r值为0.448,提示NfL和年龄呈正相关。NfL和病程之间的r值为0.045,且P>0.05,说明NfL和病程无相关关系。NfL和海马分级的r值为0.345,说明NfL和海马分级有正相关关系。NfL和ADL分值之间的r值为0.242,P>0.05,说明NfL和ADL分值无相关关系。NfL和MMSE分值的相r值为‒0.099,P>0.05,说明NfL和MMSE分值无相关关系。NfL和HDS分值的r值为‒0.096,P值为0.475>0.05,说明NfL和HDS分值之间没有相关关系。结论阿尔茨海默病患者血清神经丝轻链蛋白水平与患者年龄,磁共振海马分级呈正相关,与性别、文化程度、病程、ADL分值、MMSE分值、HDS分值无相关关系。
