Long non-coding RNA H19 regulates neurogenesis of induced neural stem cells in a mouse model of closed head injury

Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.

Risk Factors for Geo-Helminthiasis in Children Aged 6 - 36 Months in a Rural Health District in Cameroon

Introduction and Objectives: Soil-Transmitted-Helminthiasis (STH) is a public health problem in Cameroon. The control strategies currently in place, particularly chemoprevention, has shortcomings linked to the target population, which are school-age children. The objective was to determine the prevalence and the risk factors associated with geo-helminthiasis in children aged 0 to 3 years in a rural health district. Method: From December 2020 to May 2021, a descriptive and analytical cross-sectional study of 376 children between 6 and 36 months was carried out in the Akonolinga health district. This was a cluster sampling in 4 health areas. Stool samples were collected and analysed using the mini-FLOTAC method. The results expressed as the number of eggs per gram of stool. A questionnaire on socio-demographic and lifestyle data was administered to the parents. The Chi-squared test was used to measure the association between geo-helminth infection and the data collected. A multivariate analysis using logistic regression was performed (p 0.05). Results: The prevalence of STH was 19.4% (Ascaris lumbricoides: 16% and Trichuris trichiura: 8%). Risk factors were: consumption of contaminated water (AOR = 1.93 [1.03 - 3.6];p = 0.040), early contact of the child with the ground (before age of 4 months) (AOR = 4.9 [2.1 - 11.37];p .001), habit of walking barefoot (AOR = 2.91 [1.1 - 7.97];p = 0.038), and living in a habitat with unpaved ground (AOR = 7.4 [1.55 - 35.7];p = 0.012). Conclusion: The prevalence of STHs in infants was high. Preventive chemotherapy should be extended to this age-group, and other measures intensified.

Factors Associated with Acute Respiratory Infections in Children Aged 0 - 5 Years in the Yénawa District of Cotonou (Benin) in 2023

Introduction: Acute respiratory infections remain one of the main causes of mortality in children aged 0 to 5. This work aimed to study the associated factors with the occurrence of acute respiratory infections in children 0 to 5 years old in Yénawa, Cotonou in 2023. Subjects and Method: It was an analytical cross-sectional study of children aged 0 - 5 years and their mothers in Yénawa, selected by four-degree random sampling. The sampling size, calculated using the Schwartz formula, was 126 children and 126 mothers. The dependent variable was the occurrence of acute respiratory infections. The independent variables were classified into four groups: socio-demographic and economic characteristics, behavioral factors, child-related factors, and environmental factors. Data collected by observation and questionnaire survey were analyzed using STATA version 15 software. Associated factors were investigated by bivariate analysis and multiple logistic regression, at the 5% significance level. Results: A total of 126 children aged 0 - 5 years and 126 mothers were surveyed, aged 23.5 (11 - 36) months and 30 (18 - 48) years respectively. The prevalence of acute respiratory infections was 74.60% (CI95% = 66.89 to 82.30). The associated factors were the mother’s age between 18 and 28 (OR = 10.77;CI95% = 1.89 to 61.27;p = 0.007), the use of charcoal/wood for cooking (OR = 7.36;IC = 1.99 to 27.10;p = 0.003)), children's poor personal hygiene (OR = 8.87;IC = 2.92 to 26.97;p 0.001)), and cohabitation with domestic animals (OR = 7.27;IC = 1.67 to 31.71;p = 0.015). Conclusion: Communicating with mothers about the factors identified will help reduce the prevalence of acute respiratory infections in children aged 0 to 5.

Coverage of Femoral Head at Weight-Bearing Interface of the Hip Joint in Children: An MRI Analysis

Objective: To analyze the features of coverage of femoral head at weight-bearing interface of the hip joints in children. Material and Methods: MRI scans of the hips were performed in 95 normal children aged from 1 to 8 years. Radial scans of the hip joints were performed using FFE sequence. Review the morphological features of weight-bearing interface of the acetabulum and the femoral head. Total covering angle (TCA), acetabular covering angle (ACA) and labral covering angle (LCA) were measured, inter-group comparison and correlation analysis were done. Result: The acetabulum and the femoral head had congruent articulating surface at each weight-bearing position. There was no statistical TCA difference at each position. Average ACA increased, while average LCA decreased from anterior to posterior. TCA correlated with LCA, ACA negatively correlated with LCA. Conclusion: TCA is a good index in indicating stability of the hip joint. Cartilage ossifies slower at posterior than anterior positions. Cartilage acetabulum and the labrum serve as complementary structures that contribute in total stabilizing of the hip joint in development.

Activity of the Fungicide JS399-19 Against Fusarium Head Blight of Wheat and the Risk of Resistance

This report reviews the characteristics of JS399-19, a novel cyanoacrylate fungicide. JS399-19 strongly inhibits the mycelial growth of the fungal plant pathogens of the genus Fusarium and exhibits great potential in controlling Fusarium head blight （FHB） on wheat and other cereals. The mode of action of JS399-19 is evidently different from that of benzimidazole （for example, carbendazim） and other sort of fungicides, making it a possible replacement for carbendazim in China to manage carbendazim-resistant subpopulations of Fusarium graminearum and F. asiaticum. JS399-t9 has excellent protective and curative activity against these pathogens. Incorrect use of this fungicide, however, is likely to select for resistance. Among JS399-19-resistant mutants of F. asiaticum induced in the laboratory, the resistant level of mutants was high and the phenotype of resistance against JS399-19 was conferred by a major gene by genetic analysis. The fitness of laboratory-induced JS399-19-resistant mutants of F. asiaticum was nearly equal to that of their parents. JS399-19 lacks cross resistance with other sort fungicides. To control FHB with JS399-19 and to delay the development of the fungicide-resistance, farmers should use tank mixtures containing JS399-19 and carbendazim, metconazole, tebuconazole, or prothioconazole.

血清TGF-β1、FOXM1 mRNA表达水平与支气管哮喘患儿气道重塑的影响研究

目的探讨血清转化生长因子-β1(TGF-β1)、叉头框蛋白M1(FOXM1)mRNA表达水平与支气管哮喘(BA)患儿气道重塑的影响。方法选取2020年8月至2021年9月我院收治的110例BA患儿作为本次研究对象,依据《儿童支气管哮喘诊断与防治指南(2016年版)》将110例BA患儿分为急性发作组(n=56)和临床缓解组(n=54)。对两组的血清TGF-β1、FOXM1 mRNA、气道重塑相关指标(T/D、WA)、肺功能相关指标(FEV1、FEV1/FVC)水平进行检测并比较。采用Pearson分析急性发作期BA患儿血清TGF-β1、FOXM1 mRNA水平和肺功能及气道重塑指标的相关性。通过多因素Logistic回归分析方法分析影响BA患儿急性发作的因素,建立风险评估模型,经受试者工作特征曲线(ROC)评估模型诊断效能。结果与临床缓解组相比较,急性发作组血清TGF-β1、FOXM1 mRNA水平和T/D、WA水平较高,FEV1、FEV1/FVC水平较低(P<0.05);Pearson分析结果表明,急性发作期BA患儿血清TGF-β1、FOXM1 mRNA水平和FEV1、FEV1/FVC水平呈负相关(r=-0.527、r=-0.496,r=-0.492,r=-0.486,P<0.05),与T/D、WA呈正相关(r=0.434,r=0.511,r=0.515,r=0.524,P<0.05);多因素Logistic回归分析结果显示,血清TGF-β1(P=0.029,OR=11.382)、FOXM1 mRNA(P=0.007,OR=3.200)、T/D(P=0.001,OR=3.019)、WA(P=0.004,OR=2.489)水平是BA患儿急性发作的独立影响因素;ROC曲线分析结果表明,上述四种指标联合检测的AUC值最高,为0.997,灵敏度、特异度分别为96.42%、92.85%。结论BA患儿的血清TGF-β1、FOXM1 mRNA表达水平和气道重塑有紧密关联,血清TGF-β1、FOXM1 mRNA水平的提升可在一定程度上引发气道重塑。同时血清TGF-β1、FOXM1 mRNA水平在评估BA患儿病情严重程度方面具有一定的临床应用价值。

The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children

Post-exposure prophylaxis（PEP） has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children（aged 0-6）. We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure. Thus, we recommend that the Essen regimen should still be used for rabies PEP in preschool children.

Prevalence and Years Lived with Disability for Dental Caries among Children Aged 0-14 Years in China, 1990-2016

The estimate of dental caries among Chinese children at the microscale level using standard methodology remains unclear. In this study, we assessed and analyzed the disease burden of childhood dental caries in China by extracting data from the Global Burden of Disease, Injuries, and Risk Factors Study 2016 （GBD 2016）. In 2016, the number of cases, prevalence, years lived with disability （YLD）, and age-standardized YLD rate of dental caries was 93.0 million, 43.0%, 32,200 person years, and 14.8 per 100,000, respectively. Across 33 provincial units, the disease burden was highest in Hubei （YLD rate 28.6 per 100,000）, lowest in Macao （9.1 per 100,000）, while geographical clustering was not observed. Compared with 1990, the prevalence in 2016 decreased from 46.8% to 43.0%, and the YLD rate decreased from 16.5 per 100,000 to 14.8 per 100,000. Given the slight decrease in dental caries burden, the prevalence and disease burden remained high among Chinese children. Strategies for addressing the spatial inequity of childhood dental caries require geographical targeting.

Factors Influencing Preventive Behaviors of Mothers for Diarrhea in Children Aged 1-5 Years in Buol District, Indonesia

This study aims to determine the factors related with mothers＇ behaviors in preventing diarrhea in children aged 1-5 years inBuol District. This was a cross-sectional survey design with health belief model as the conceptual framework. A total of 300mothers were selected by using purposive sampling method based on criteria. Mothers were interviewed by using astructured questionnaire during October to November 2015. A chi-square （X^2） test was used to determine a significantassociation between independent variables and dependent variable. The finding showed that 68.3% of mothers hadgood behaviors in preventing diarrhea. The factors significantly related to mothers＇ behaviors included perceivedsusceptibility to diarrhea, perceived severity of diarrhea, perceived benefits of diarrhea prevention behaviors, and perceivedbarriers of diarrhea prevention behaviors CP 〈 .01, p 〈 .01, p 〈 .01, and p 〈 .01 respectively）. Further, mothers had highperception to comply with diarrhea prevention behaviors. Those who perceived that diarrhea prevention behaviors werehighly beneficial to their children had good behaviors in preventing diarrhea. However, taking certain actions must considernegative aspects.

Energy Balance-related Behaviors Are Related to Cardiometabolic Parameters and Predict Adiposity in 8-14-year-old Overweight Chinese Children One Year Later

To identify target energy balance-related behaviors（ERBs）,baseline data from 141overweight or obese schoolchildren（aged 8-14years old）was used to predict adiposity[body mass index（BMI）and fat percentage]one year later.The ERBs included a modified Dietary Approach to Stop Hypertension diet score（DASH score）,leisure-time physical activity（PA,days/week）,and leisure screen time（minutes/day）.Several cardiometabolic variables were measured in the fasting state, including systolic blood pressure （SBP）, diastolic blood pressure （DBP）, blood glucose （GLU）, total cholesterol （TC）, triglycerides （TG）, low-density lipoprotein （LDL-C）, and high-density lipoprotein （HDL-C）.

Preventable head and facial injuries by providing free bicycle helmets and education to preschool children in a head start program

The objectives of the study were to determine helmet use rates, incidence rates (IRs) of head and facial injuries for population attributable fraction (PAF) estimation, and to elucidate the magnitude of and changes in PAFs as the result of helmet use changes among preschool children. A study consisting of cross-sectional (survey) and longitudinal (follow-up) component was designed by including a randomly selected group of participants (n = 322) from 10 Head Start sites provided with free bicycle helmets along with a subgroup of prior helmet owners (n = 68) from the other random group (n = 285). All participants received bicycle helmet education. Helmet use surveys were conducted in May (1st Survey) and November 2008 (2nd Survey). The helmet owners were followed up to determine IRs, and incidence rate ratios (IRRs) for head and facial injuries. PAFs were computed using IRs as well as helmet use rates and IRRs. Helmet use rates increased significantly from the 1st to the 2nd Survey. The mean follow-up person-time was 5 months. The IRs for head, face (all portions), and face (upper/mid portions) injuries were higher in non-helmeted than helmeted riders. By using IRs, PAFs for the 3 injuries among the riders in both groups of helmet owners were 77%, 22%, and 32% respectively. The PAFs for each of the above injuries decreased by about 10% as helmet use rates increased. The magnitude of and changes in preventable head and facial injuries following free bicycle helmet distribution and education among helmeted riders was elucidated in this Head Start preschool children population.

Traumatic Isolated Radial Head Dislocation in Children: A Case Report

The isolated dislocation of the radial head is frequently described in the lesion of MONTEGGIA. However it can be a rare isolated pattern of injury in children. Only 81 cases were reported in the literature to our knowledge. The case we report concerns a 13 years old boy, examined 8 days after injury. Because of failure of manual reduction, we performed a surgical management with excellent results after a year of follow-up. We have discussed treatment option and the results obtained.

Expression,Purification and Structural Characterization of Mouse Talin-1 Head Δ139-168

Talin-1 head(hereinafter referred to as TH)is the head structure of talin protein,which contains a four-point-one-protein/ezrin/radixin/moesin(FERM)domain.Its F1 domain contains an unstructured loop of 30 amino acids(139-168),which does not interact with other domains.Because TH doesn’t get the crystal structure and whether the unstructured loop has obvious influence on the TH secondary structure,therefore,the truncated talin-1 headΔ139-168(hereinafter referred to as THΔ)was constructed and its structure and the impact of stability after truncation were analyzed.Molecular biology and structural biology methods were used to construct prokaryotic expression vectors of TH and THΔ,explore and optimize the expression conditions of recombinants,and they were purified by affinity chromatography and FPLC gel filtration chromatography.Finally,a large number of stable,high-purity protein samples were prepared successfully.The physicochemical properties and structural stability of the proteins were investigated by dynamic light scattering and circular dichroism.The results showed that the THΔsecondary structure of the truncated body did not change significantly,the structural stability was enhanced and the resistance to guanidine hydrochloride and high temperature was stronger.

Associations between IL-1RN variable number of tandem repeat, IL-1β (-511) and IL-1β (+3954) gene polymorphisms and urolithiasis in Uighur children of China

Objective:Interleukin-1(IL-1)is a pro-inflammatory cytokine which may be related to urolithiasis.Genetic polymorphisms of the interleukin-1beta(IL-1β)have been proposed as markers for urolithiasis in some areas.Due to the high incidence of urolithiasis in Uighur children(Xinjiang,China)and existence of ethnic difference,our aim is to explore the potential of IL-1 gene polymorphisms and urolithiasis among these children.Methods:Genomic DNA extracted from peripheral blood of 115 patients and 98 controls were used for genotype polymorphisms analyses.IL-1 receptor antagonist(IL-1RN)gene variable number of tandem repeat(VNTR)gene polymorphisms were analyzed by PCR method.PCR-based restriction analysis was done for the IL-1β(-511)and IL-1β(+3954)gene polymorphisms by endonucleases Ava I and Taq I,respectively.The genotype distribution,allele frequencies,carriage rate,and haplotype frequencies were statistically analyzed.Results:No significant differences were observed in genotypic frequencies between pediatric urolithiasis patients and control group for IL-1RN gene(χ^(2)=1.906,p=0.605),IL-1β(-511)gene(χ^(2)=0.105,p=0.949),or IL-1β(+3954)gene(χ^(2)=3.635,p=0.169).There were yet no significant differences of the allele frequencies of IL-1RN VNTR gene(p=0.779),IL-1β(-511)gene(p=0.941),and IL-1β(+3954)gene(p=0.418)in the case and control groups,as well as the carriage rate and haplotype of them(all p>0.05).Conclusions:The associations between IL-1RN VNTR,IL-1β(-511)and IL-1β(+3954)genes polymorphisms and urolithiasis were not significant in Uighur children.The results need to be confirmed in studies with larger population sample size,as well as in other ethnic groups.

The Changes of Baroreflex Sensitivity During Head-up Tilt Test and Its Clinical Significance in the Patients with Vasovagal Syncope

Objective To study thechanges of baroreflex sensitivity (BRS) during head - up tilt test (HUT) in patients with vasovagal syncope (VS), and to examine the relationship between baroreflex sensitivity and neurohormonal factors. Furthermore, to investigate the effects of the changes of BRS on VS. Methods Forty - two patients with unexplained syncope (Among the 42 patients, there were 22 patients with positive HUT and 20 patients with negative HUT respectively) and 20 healthy volunteers (with negative HUT) underwent passive head - up tilt testing, Ante-cubital vein blood samples were taken before and after HUT, or at syncope. The fasting plasma endothelin , serum nitric oxide (NO), serum NE were measured, the BRS was assessed on the basis of the linear regression slope the RR interval versus systolic arterial blood pressure during the increment in blood pressure after intravenous administration of phenylephrine. Results (1) During the syncope, the BRS significantly reduced in HUT(+) group than baseline. At the end of tilt, the level of plasma ET, serum NO in patients with positive HUT significantly increased compared with baseline or normal controls, and the plasma concentration of NE also had the trend of increase. (2) By multiple regression analysis, a significant negative correlation was found between baroreceptor sensitivity and the plasma ET, NO at the end of HUT in patients with positive HUT, but there was no relationship between BRS and NE. Conclusions During the syncope occure, the BRS in patients with VS decreased significantly compared with normal controls. The abnormal plasma ET, NO concen-tration might contribute to the mechanism of VS.

The effect of protective genital care protocol on preventing diaper dermatit development in 0 - 18 month old children using antibiotics

Diaper dermatit is among the widely seen inflamatory skin diseases in neonatals and small 0 - 18 month old children. Control of causative agents as well as providing good genital care may prevent or reduce the risk of the disease. The aim of this study is find out the effect of protective genital care on reducing the diaper dermatit development in 0 - 18 months old inpatient 0 - 18 month old children who are using antibiotic. The study was conducted as prospective half-experimetal using control-experimental groups. Our samples comprise of 0 - 18 month old children admitted at Dokuz Eylul University Practical and Research Hospital, pediatric clinic between January and May 2009, 41 0 - 18 month old children as a control group were not under protective genital care, and 42 0 - 18 month old children as an experimental group were under the protecion and using vaseline. The mothers of the experimental group 0 - 18 month old children were given education. All 0 - 18 month old children were followed-up 3 - 7 days and the collected data were evaluated in computer using Pearson’s chisquare, Fisher’s exact chi-square and Yatest-corrected chi-square tests. The diaper dermatit develop- ment ratio was 34.1% in the control group and 7.1% in the experimental group

深度学习迭代重建算法优化儿童头颅CT图像噪声和图像纹理的可行性

目的评价深度学习迭代重建(DLIR)算法与常规自适应迭代重建(ASIR-V)算法对儿童头颅外伤CT图像噪声和图像纹理的优化程度及图像显示效果的差异。资料与方法回顾性选取2020年12月7—11日首都医科大学附属北京儿童医院影像中心80例儿童头颅CT,扫描方案为低辐射剂量轴扫,电压120 kV,电流150~220 mA。将得到的原始数据重建为5 mm厚层与0.625 mm薄层的脑窗、骨窗图像,分别重建为50%ASIR-V、高权重DLIR图像(DL-H),共8组图像。应用4分制主观评价脑沟脑室、脑灰白质与颅骨显示情况,并统计各组图像的病变数量;客观评价测量基底节层面的灰质和白质的CT值和噪声值,并计算对比噪声比,同时在同层面测量模糊程度指数,比较两种图像重建方法的差异。结果相较于50%ASIR-V图像,2种层厚的DL-H均可以提升脑沟脑室、脑实质显示能力(W=5.5~22.2,P均<0.05),5 mm的50%ASIR-V与0.625 mm的DL-H图像脑沟脑室、脑实质显示能力差异无统计学意义(W=0.9、2.0,P=0.32、0.05)。骨质显示能力方面,所有图像均可以达到满分4.0分。5 mm的50%ASIR-V与DL-H图像均可以在80例患者中发现共35处病变,包括出血病变12处,颅内积气1处,骨折9处,头皮软组织肿胀13处。客观评分方面,DL-H图像噪声低于50%ASIR-V图像(t=21.4~35.7,P均<0.05),0.625 mm的DL-H与5 mm的50%ASIR-V图像噪声及对比噪声比差异无统计学意义(t=1.7~2.2,P均≥0.05)。模糊程度指数显示DL-H优于50%ASIR-V图像(t=6.1、10.0,P均<0.05),0.625 mm的DL-H与5 mm的50%ASIR-V模糊程度指数差异无统计学意义(t=2.6,P=0.28)。结论DLIR可以降低图像噪声,改善图像纹理,整体提升儿童头颅外伤CT图像质量,0.625 mm的DL-H图像质量接近5 mm的50%ASIR-V图像,可以达到诊断要求,使进一步降低儿童头颅外伤的辐射剂量成为可能。

头颈部恶性肿瘤患儿放化疗所致口腔黏膜炎的护理策略

目的通过有效的护理对策降低头颈部肿瘤患儿放化疗所致口腔黏膜炎(OM)的严重程度。方法选取2020年1月—2022年12月北京同仁医院儿科收治头颈部恶性肿瘤放化疗OM患儿,儿童口腔评估指南量表评分为9-16分的中度OM患儿100例,随机分为对照组和干预组,每组各50例,对照组根据医嘱用药,干预组在医嘱用药基础上加用(0-4)℃的0.9%生理盐水指导患儿在进食后、睡前、呕吐后、口腔黏膜炎用药前10分钟,利用双侧颊部运动形成水压涡流含漱,每次含漱口液10-15 mL,漱口≥30 s。干预3天后应用儿童口腔评估指南量表进行比较两组患儿口腔黏膜的严重程度及愈合时间、痛苦程度对比。结果干预组较对照组OM的严重程度明显减轻(χ^(2)=12.398,P=0.00);OM导致的痛苦程度干预组较对照组明显减轻(χ^(2)=5.263,P=0.02);OM愈合时间干预组较对照组明显短(χ^(2)=8.752,P=0.01)。结论儿童头颈部恶性肿瘤放化疗后口腔炎用生理盐水清洁口腔能明显降低OM的严重程度;减轻OM导致的痛苦;提高药物的治疗效果缩短OM的病程,具有临床推广价值。

儿童常见周围性眩晕视频头脉冲结果分析

目的分析儿童常见周围性眩晕的视频头脉冲试验(video head impulse test,vHIT)结果并探讨vHIT的诊断价值。方法回顾性选取2020年1月至2022年3月就诊于苏州大学附属第二医院眩晕诊治中心的儿童常见周围性眩晕患儿78例,根据年龄将患儿分为≤10岁组26例和>10岁组52例,分析其vHIT检查结果。结果78例周围性眩晕患儿中儿童良性阵发性眩晕(benign paroxysmal vertigo of childhood,BPVC)28例,前庭性偏头痛(vestibular mi⁃graine,VM)20例,前庭神经炎(vestibular neuritis,VN)15例,突发性聋伴眩晕(sudden deafness with vertigo,SD)8例,梅尼埃病(Meniere's disease,MD)7例。vHIT检查结果异常47例,其中BPVC14例,VM12例,VN14例,SD3例,MD4例。儿童vHIT检查中出现伪迹的概率更高,最常见的伪迹类型为眨眼,高增益值及追踪震荡,≤10岁组vHIT检查出现伪迹多于>10岁组,差异有统计学意义(P<0.001)。结论儿童周围性眩晕最常见的病因主要为BPVC及VM,vHIT在儿童眩晕的诊断中具有很高的特异性,但出现伪迹的概率较高,检查过程中需注意甄别并防范。

钢板内固定与外架固定治疗儿童BadoⅠ型陈旧性孟氏骨折疗效对比

目的:比较儿童BadoⅠ型陈旧性孟氏骨折尺骨截骨后钢板内固定和外架固定的疗效。方法:收集2015年6月至2022年12月郑州大学第一附属医院收治的儿童BadoⅠ型陈旧性孟氏骨折患儿的资料,患儿均行环状韧带探查联合尺骨截骨术,其中24例尺骨截骨后采用钢板内固定,14例采用外架固定。术前及术后12个月,测量肘关节和前臂活动度,行肘关节Mayo功能评分,记录术后并发症发生情况。结果:两组患儿术后肘关节屈伸、前臂旋转活动度和肘关节Mayo功能评分均高于术前(P<0.05),但是术前术后差值两组比较差异无统计学意义(P>0.05)。钢板内固定组手术时间及出血量均大于外架固定组(P<0.05)。两组患儿肱桡关节再脱位、切口感染和尺骨愈合不良发生率差异无统计学意义(P>0.05)。结论:对于儿童BadoⅠ型陈旧性孟氏骨折,尺骨截骨后钢板内固定和外架固定均有效。