Objective： To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6^° head down bed rest （HDBR）, and the effects of Taikong Yangxin Prescription （太空养心方, TYP...Objective： To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6^° head down bed rest （HDBR）, and the effects of Taikong Yangxin Prescription （太空养心方, TYP） as a countermeasure. Methods： Fourteen healthy male volunteers were randomly divided into a control group and a Chinese medicine （CM） group （7 in each group） by a random digital table based on their body weight. Both groups underwent6^° HDBR for 60 days. Subjects in the CM group received daily TYP pills and subjects in the control group received daily placebo pills. Cardiac systolic and pumping functions were measured by echocardiography before HDBR; on days 20, 42, and 57 of HDBR; and on day 3 of recovery after HDBR （R＋3）. Cardiopulmonary functional reserve and exercise capacity were evaluated before HDBR, on day 29, and on day R＋3 by exercise testing. Results： The heart rate （HR） increased gradually during HDBR. The HR was significantly higher on day 57 than before HDBR in the control group （P〈0.05）, but did not increase significantly in the CM group. The stroke volume/stroke volume index, ejection fraction, and left ventricular fractional shortening tended to decrease over time in the control group, but not in the CM group. These parameters were significantly higher in the CM group than in the control group on day 42 （P〈0.05 or P〈0.01）. Exercise testing showed that maximum 02 consumption （VO2max）, metabolic equivalents, relative 02 consumption （VO2）, 02 pulse, and exercise duration were significantly lower on day 29 than before HDBR in the control group, but not in the CM group. Conclusions： Sixty days of 6^° HDBR induced a reduction in cardiac systolic and pumping functions, and reduced cardiopulmonary functional reserve and exercise capacity. Administration of TYP significantly improved cardiac systolic and pumping functions, and maintained cardiopulmonary functional reserve and exercise capacity.展开更多
目的观察模拟失重对脑认知功能的影响及中药的干预效果。方法 16名志愿者,-6°头低位卧床(head-down bed rest,HDBR)3周前和卧床结束当天起床前各进行一次fMRI实验,包括中性、冲突两种任务模式和事件相关设计。随机分对照组(8人)、...目的观察模拟失重对脑认知功能的影响及中药的干预效果。方法 16名志愿者,-6°头低位卧床(head-down bed rest,HDBR)3周前和卧床结束当天起床前各进行一次fMRI实验,包括中性、冲突两种任务模式和事件相关设计。随机分对照组(8人)、用药组(8人),用药组卧床期间服用自制中药制剂200 mL/d,3周,对照组服用等量安慰剂。结果两组模拟失重前:前扣带回、额叶和丘脑出现显著的激活。模拟失重后(对照组):额叶、前扣带回激活区的范围和信号强度较卧床前显著减少,丘脑激活消失。模拟失重后(用药组):前扣带回出现了显著的激活区,丘脑可见较显著的激活区,右侧额叶额中回小范围激活区。脑激活区范围和信号强度接近模拟失重前状态。结论模拟失重状态对认知功能有明显的影响,中药可以增强相关脑区对认知功能的调控作用。展开更多
目的探讨4 d头低位卧床(head-down bed rest,HDBR)模拟失重对人体运动能力的影响及人工重力联合中等强度运动锻炼的对抗效果。方法 12名健康男性志愿者随机分为2组:对照组(n=6)仅进行4 d HDBR;对抗组(n=6)HDBR期间每天上下午各进行1次30...目的探讨4 d头低位卧床(head-down bed rest,HDBR)模拟失重对人体运动能力的影响及人工重力联合中等强度运动锻炼的对抗效果。方法 12名健康男性志愿者随机分为2组:对照组(n=6)仅进行4 d HDBR;对抗组(n=6)HDBR期间每天上下午各进行1次30 min基于人工重力(足水平2 Gz)的中等强度运动锻炼。HDBR前后对所有志愿者分别进行有氧和无氧运动能力测试。结果 HDBR后对照组递增负荷累计运动应激指数、最大摄氧量、无氧阈及30 s最大负荷运动中的最小无氧功较卧床前均显著下降(P<0.05),无氧功递减率显著升高(P<0.05)而无氧功峰值、平均无氧功均无显著改变;HDBR后对抗组上述各项指标均无显著改变。结论 4 d HDBR可致人体运动能力下降,其中对有氧运动能力影响最大,对无氧运动能力影响较小。基于人工重力的中等强度运动锻炼可有效对抗模拟失重所致的有氧及无氧运动耐力下降。展开更多
基金Supported by the Advance Research Project in Manned Spaceflight(No.010202)the National Natural Science Foundation of China(No.30772694)
文摘Objective： To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6^° head down bed rest （HDBR）, and the effects of Taikong Yangxin Prescription （太空养心方, TYP） as a countermeasure. Methods： Fourteen healthy male volunteers were randomly divided into a control group and a Chinese medicine （CM） group （7 in each group） by a random digital table based on their body weight. Both groups underwent6^° HDBR for 60 days. Subjects in the CM group received daily TYP pills and subjects in the control group received daily placebo pills. Cardiac systolic and pumping functions were measured by echocardiography before HDBR; on days 20, 42, and 57 of HDBR; and on day 3 of recovery after HDBR （R＋3）. Cardiopulmonary functional reserve and exercise capacity were evaluated before HDBR, on day 29, and on day R＋3 by exercise testing. Results： The heart rate （HR） increased gradually during HDBR. The HR was significantly higher on day 57 than before HDBR in the control group （P〈0.05）, but did not increase significantly in the CM group. The stroke volume/stroke volume index, ejection fraction, and left ventricular fractional shortening tended to decrease over time in the control group, but not in the CM group. These parameters were significantly higher in the CM group than in the control group on day 42 （P〈0.05 or P〈0.01）. Exercise testing showed that maximum 02 consumption （VO2max）, metabolic equivalents, relative 02 consumption （VO2）, 02 pulse, and exercise duration were significantly lower on day 29 than before HDBR in the control group, but not in the CM group. Conclusions： Sixty days of 6^° HDBR induced a reduction in cardiac systolic and pumping functions, and reduced cardiopulmonary functional reserve and exercise capacity. Administration of TYP significantly improved cardiac systolic and pumping functions, and maintained cardiopulmonary functional reserve and exercise capacity.
文摘目的观察模拟失重对脑认知功能的影响及中药的干预效果。方法 16名志愿者,-6°头低位卧床(head-down bed rest,HDBR)3周前和卧床结束当天起床前各进行一次fMRI实验,包括中性、冲突两种任务模式和事件相关设计。随机分对照组(8人)、用药组(8人),用药组卧床期间服用自制中药制剂200 mL/d,3周,对照组服用等量安慰剂。结果两组模拟失重前:前扣带回、额叶和丘脑出现显著的激活。模拟失重后(对照组):额叶、前扣带回激活区的范围和信号强度较卧床前显著减少,丘脑激活消失。模拟失重后(用药组):前扣带回出现了显著的激活区,丘脑可见较显著的激活区,右侧额叶额中回小范围激活区。脑激活区范围和信号强度接近模拟失重前状态。结论模拟失重状态对认知功能有明显的影响,中药可以增强相关脑区对认知功能的调控作用。
文摘目的探讨4 d头低位卧床(head-down bed rest,HDBR)模拟失重对人体运动能力的影响及人工重力联合中等强度运动锻炼的对抗效果。方法 12名健康男性志愿者随机分为2组:对照组(n=6)仅进行4 d HDBR;对抗组(n=6)HDBR期间每天上下午各进行1次30 min基于人工重力(足水平2 Gz)的中等强度运动锻炼。HDBR前后对所有志愿者分别进行有氧和无氧运动能力测试。结果 HDBR后对照组递增负荷累计运动应激指数、最大摄氧量、无氧阈及30 s最大负荷运动中的最小无氧功较卧床前均显著下降(P<0.05),无氧功递减率显著升高(P<0.05)而无氧功峰值、平均无氧功均无显著改变;HDBR后对抗组上述各项指标均无显著改变。结论 4 d HDBR可致人体运动能力下降,其中对有氧运动能力影响最大,对无氧运动能力影响较小。基于人工重力的中等强度运动锻炼可有效对抗模拟失重所致的有氧及无氧运动耐力下降。
