AIM To determine the prevalence of work disability in inflammatory bowel disease(IBD), and to assess risk factors associated with work disability.METHODS For this retrospective cohort study, we retrieved clinical data...AIM To determine the prevalence of work disability in inflammatory bowel disease(IBD), and to assess risk factors associated with work disability.METHODS For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population. Multivariate analyses were performed for work disability(sick leave, partial and full disability) and long-term full work disability(> 80% work disability for > 2 years).RESULTS Prevalence of work disability was higher in Crohn's disease(CD)(29%) and ulcerative colitis(UC)(19%) patients compared to the general Dutch population(7%). In all IBD patients, female sex, a lower education level, and extra-intestinal manifestations, were associated with work disability. In CD patients, an age > 40 years at diagnosis, disease duration > 15 years,smoking, surgical interventions, and anti-TNFα use were associated with work disability. In UC patients, an age > 55 years, and immunomodulator use were associated with work disability. In CD patients, a lower education level(OR = 1.62, 95%CI: 1.02-2.58), and in UC patients, disease complications(OR = 3.39, 95%CI: 1.09-10.58) were associated with long-term full work disability.CONCLUSION The prevalence of work disability in IBD patients is higher than in the general Dutch population. Early assessment of risk factors for work disability is necessary, as work disability is substantial among IBD patients.展开更多
To determine the rational layout parameters of the lateral high drainage roadway(LHDR) serving for two adjacent working faces, a mechanical model of the LHDR under mining influence was established, and the overburden ...To determine the rational layout parameters of the lateral high drainage roadway(LHDR) serving for two adjacent working faces, a mechanical model of the LHDR under mining influence was established, and the overburden fissure, mining-induced stress distribution rules were analyzed. First, the development characteristics of mining-induced overburden fissure and the stress distribution law of the upper section of the working face were analyzed. Second, by analyzing the distribution law of vertical stress at different layers, the lateral distance of the LHDR was determined as 25 m. Third, by analyzing the surrounding rock deformation effect, stress distribution law, and overburden fissure distribution law of the LHDR at the heights of 20, 25, and 30 m away from the roof, the rational horizon of the LHDR was determined to be 25 m. Finally, an example of a LHDR located 25 m above the roof of the No. 2 coal seam and 25 m away from the No. 2-603 working face was presented. Results show that when the No. 2-603 coalface is being mined, the surrounding rocks lag 80 m or even further and the working face tends to be stable. The relative deformations of the roof and floor of the roadway and both of its walls were 583 and 450 mm,respectively. The reduction rate of the roadway section was 21.52%–25.32%. The section of the roadway was sufficient to extract the pressure relief gas in the overburden of the No. 2-605 working face. The average gas concentration and the pure volume at the branch pipeline were 24.8% and 22.3 m^3/min,respectively, showing that the position of high-level boreholes was reasonable.展开更多
The average stress of people in China’s workplace is reaching the peak in recent two years.To improve employee’s positive psychological factors,Spiritual leadership has a good performance in this regard.Based on the...The average stress of people in China’s workplace is reaching the peak in recent two years.To improve employee’s positive psychological factors,Spiritual leadership has a good performance in this regard.Based on the mediating effect of goal self-concordance and self-efficacy,this paper further studies the impact of spiritual leadership on employee’s work engagement.Through the empirical study,the following conclusions are drawn:(1)Spiritual leadership significantly positively affects the employee’s work engagement.(2)Spiritual leadership has a significant positive effect on goal self-concordance and self-efficacy.(3)Goal self-concordance and self-efficacy have significant positive effects on employee’s work engagement.(4)Goal self-concordance and self-efficacy play a partial mediating role in the process of spiritual leadership’s impact on employees’work engagement.This study found the new mediator which partly revealed the mechanism between the effectiveness of Spiritual Leadership and employee’s work engagement.This study may serve as one of the researches for improving the effectiveness of leaders in organizations and promoting the motivation of employees in the workplace.展开更多
Energy methods and the principle of virtual work are commonly used for obtaining solutions of boundary value problems (BVPs) and initial value problems (IVPs) associated with homogeneous, isotropic and non-homogeneous...Energy methods and the principle of virtual work are commonly used for obtaining solutions of boundary value problems (BVPs) and initial value problems (IVPs) associated with homogeneous, isotropic and non-homogeneous, non-isotropic matter without using (or in the absence of) the mathematical models of the BVPs and the IVPs. These methods are also used for deriving mathematical models for BVPs and IVPs associated with isotropic, homogeneous as well as non-homogeneous, non-isotropic continuous matter. In energy methods when applied to IVPs, one constructs energy functional (<i>I</i>) consisting of kinetic energy, strain energy and the potential energy of loads. The first variation of this energy functional (<em>δI</em>) set to zero is a necessary condition for an extremum of <i>I</i>. In this approach one could use <i>δI</i> = 0 directly in constructing computational processes such as the finite element method or could derive Euler’s equations (differential or partial differential equations) from <i>δI</i> = 0, which is also satisfied by a solution obtained from <i>δI</i> = 0. The Euler’s equations obtained from <i>δI</i> = 0 indeed are the mathematical model associated with the energy functional <i>I</i>. In case of BVPs we follow the same approach except in this case, the energy functional <i>I</i> consists of strain energy and the potential energy of loads. In using the principle of virtual work for BVPs and the IVPs, we can also accomplish the same as described above using energy methods. In this paper we investigate consistency and validity of the mathematical models for isotropic, homogeneous and non-isotropic, non-homogeneous continuous matter for BVPs that are derived using energy functional consisting of strain energy and the potential energy of loads. Similar investigation is also presented for IVPs using energy functional consisting of kinetic energy, strain energy and the potential energy of loads. The computational approaches for BVPs and the IVPs designed using energy functional and principle of virtual work, their consistency and validity are also investigated. Classical continuum mechanics (CCM) principles <i>i.e.</i> conservation and balance laws of CCM with consistent constitutive theories and the elements of calculus of variations are employed in the investigations presented in this paper.展开更多
Metropolises in the globalization call nowadays Towns' of jazzmen, jazzwomen and jazz lovers, in a way from which we citizens. Christian Sallenave, sociologist with musical academic and Cities' into question. Jazz a...Metropolises in the globalization call nowadays Towns' of jazzmen, jazzwomen and jazz lovers, in a way from which we citizens. Christian Sallenave, sociologist with musical academic and Cities' into question. Jazz answers with stories and memories can learn a lesson for the future of towns, metropolises and their background, shows through examples of stories of jazz in New Orleans, New York, Paris, Bordeaux and Rome, how this nomad, notable and crossbreeding music contributes to the history of jazz, and world music, and listeners' memories, in "their own way" as towns, cities and their memories can contribute to the prosperity of the metropolises in globalization, through original melting pot works.展开更多
Nowadays, new paradigm of enterprise organization i s constantly changing due to the emergence of the global marketplace, the rise of information technology, and the emphasis of the social developments. This re quires...Nowadays, new paradigm of enterprise organization i s constantly changing due to the emergence of the global marketplace, the rise of information technology, and the emphasis of the social developments. This re quires a more flexible form of organization that are more adaptable to rapid cha nges in business environment such as autonomous work groups (AWGs) in order to achieve higher productivity and effectiveness. AWGs are work units responsib le for the production of goods and the provision of services. They involve team members in making decisions that are traditionally the responsibility of the sup ervisors and managers (Cohen & Bailey, 1997). Team members of AWGs are allowed t o self-regulate their behavior on jobs such as task assignments, methods for ca rrying out the work, and scheduling of activities etc. (Cohen & Ledford, 1994). For example, Motorola achieved a high organizational performance due to the succ essful implementation of AWGs in quality management (Piczak & Hauser, 1996). Xer ox also reported their operational successes based on the team-oriented work gr oups (Wageman, 1997). In recent years many organizations have replaced the traditional layers of manag ement with autonomous team-based work arrangements. Surveys indicated that the adoption of AWGs has soared in responding to the competitive business challenges . Many enterprises are making a deliberate effort to use AWGs to carry out work and operational processes as an alternative for hierarchical approaches (Lawler et al., 1995). There is a growing body of evidence that AWGs are more effective than traditionally managed groups and they contributes to organizational perform ance, such as improvement in operational performance, productivity, quality, cos t savings, employee attitude and behavior, and employee satisfaction (e.g. Pears on, 1992; Cohen & Ledford, 1994; Seers et al. 1995). Given the complexity and cognitive nature of team-based organizations, the mech anisms that the enterprises use in the development of the increasingly sophistic ated models, which can contribute to the effective functioning of AWGs, are extr emely important. The process of developing effective AWGs enables enterprises to inherent built-in intelligence of the organizations so that they will be more able to accommodate to external pressures and changes. The context of this paper is the construction of a dynamics framework and a stra tegic path for autonomous work groups in the technology-oriented manufacturing organization re-design. The framework is a conceptual one drawn from the litera ture survey. The importance of studying autonomous work groups for today’s manuf acturing organizations is claimed. Based on the General System Theory (GST), the characterization of AWGs is addressed. Three-dimensional domains such as t echnical content, service content, and relationship content are identified. A st rategic path is proposed to guide the organizations how the development of AWGs progresses at different levels of maturity that are associated with organization al effectiveness and performance. The utility of the model for AWGs is expected to provide technology-oriented organizations with a strategic path to achieve h igher organizational performance.展开更多
"Safe quality standardization campaigns were conducted in enterprises on wide scale. Larger investment on safety was made. Greater progress in safety-related science and technology was stimulated. Safety training..."Safe quality standardization campaigns were conducted in enterprises on wide scale. Larger investment on safety was made. Greater progress in safety-related science and technology was stimulated. Safety training was enhanced.展开更多
The article introduces ZTE's Softswitch-based NGN solutions. such as the long distance VolP service solution over data back- bone,and local voice and data service solution over MAN.Three application cases are anal...The article introduces ZTE's Softswitch-based NGN solutions. such as the long distance VolP service solution over data back- bone,and local voice and data service solution over MAN.Three application cases are analyzed,and NGN's features in aspects of network architecture,service provision and network management are summarized.展开更多
Softswitch technology integrates the su-periorities of both an intelligence net-work and the Internet, which embodiesits maturity and advancement. With ahierarchical network model, it effectivelysolves problems of evo...Softswitch technology integrates the su-periorities of both an intelligence net-work and the Internet, which embodiesits maturity and advancement. With ahierarchical network model, it effectivelysolves problems of evolution and convergenceof current communication networks. It also fol-展开更多
The Eighth Five-year Plan period wasa fast growing period for Jiangsu’sforeign economic and technical co-operation. Guided by the policy of seizingopportunities, expanding the opening driveand promoting development, ...The Eighth Five-year Plan period wasa fast growing period for Jiangsu’sforeign economic and technical co-operation. Guided by the policy of seizingopportunities, expanding the opening driveand promoting development, all the staff atthe provincial foreign economic front madeevery effort to fulfill the goal of the sus-tained, fast and healthy development in for-展开更多
Editor’s Note:After becoming theleading force in CDMAequipment manufacturingin China, ZTE rolled outits self-developed WCD-MA products that at-tracted much expert at-tention in the MTNETsecond phase single sys- tem t...Editor’s Note:After becoming theleading force in CDMAequipment manufacturingin China, ZTE rolled outits self-developed WCD-MA products that at-tracted much expert at-tention in the MTNETsecond phase single sys- tem testing completed inJune 2003. Thefollowing are the remarks of Ye Weimin,ZTE’s vice president, on ZTE’s strate-gies, advantages and achievements inthe development of WCDMA products.展开更多
In December 1958, the China Council forthe Promotion of InternationalTrade(CCPIT) established its PublicityDepartment. Its task was to take over themagazine China’s Foreign Trade, transferredfrom the Ministry of Fore...In December 1958, the China Council forthe Promotion of InternationalTrade(CCPIT) established its PublicityDepartment. Its task was to take over themagazine China’s Foreign Trade, transferredfrom the Ministry of Foreign Trade. Ms. LuJiyin held the post of department head, and Iwas transferred from the post of the ResearchDepartment Commissioner to that of thePublicity Department Commissioner to assisther in her work. The magazine China’s Foreign Tradewas originally established in 1956 by thePropaganda Section under the General Officeof the Ministry of Foreign Trade. It had twoeditions: Chinese and English, under trialpublication. The magazine, sponsored by theMinistry of Foreign Trade was a trialpublication in nature, so when the task展开更多
During the Ninth Five-Year Planperiod,the major objectives ofstruggle for China’s patent work are:the annual number of patentapplications will reach 100 thousand,of which patent applications
Despite exhaustive search, no drug is in sight for AD. Earlier, we reported that reserpine, an antihypertensive and antipsychotic drug, ameliorates Amyloid beta (Aβ-AD causing peptide) toxicity and confers several po...Despite exhaustive search, no drug is in sight for AD. Earlier, we reported that reserpine, an antihypertensive and antipsychotic drug, ameliorates Amyloid beta (Aβ-AD causing peptide) toxicity and confers several positive enhancements in the C. elegans model system. Here, we evaluate whether reserpine can provide protection against working memory and against AD in the mouse model. Reserpine (0.08 mg) was administered orally on alternate days to the non-Tg and accelerated Aβ deposition (at 2 months of age)and cognitive deficit (4 months of age) developing 5XFAD AD Tg mouse model expressing mutant human APP (3 familial mutations) and human Presenilin1(2 familial mutations) in the neurons, and follow their working memory for 2 months using the spontaneous Y-maze alteration behavioral paradigm. Reserpine enhanced working memory in non-Tg mice and improved the cognitive deficit in the 5XFAD AD Tg mice. Hence, reserpine can be considered for a detailed evaluation in the 3X Tg AD mouse model and a pilot study in AD patients.展开更多
基金Supported by the Netherlands Organisation for Scientific Research,VIDI grant No.016.136.308 to Weersma RKCareer Development grant of the Dutch Digestive Foundation,No.CDG 14-04 to Festen EAM
文摘AIM To determine the prevalence of work disability in inflammatory bowel disease(IBD), and to assess risk factors associated with work disability.METHODS For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population. Multivariate analyses were performed for work disability(sick leave, partial and full disability) and long-term full work disability(> 80% work disability for > 2 years).RESULTS Prevalence of work disability was higher in Crohn's disease(CD)(29%) and ulcerative colitis(UC)(19%) patients compared to the general Dutch population(7%). In all IBD patients, female sex, a lower education level, and extra-intestinal manifestations, were associated with work disability. In CD patients, an age > 40 years at diagnosis, disease duration > 15 years,smoking, surgical interventions, and anti-TNFα use were associated with work disability. In UC patients, an age > 55 years, and immunomodulator use were associated with work disability. In CD patients, a lower education level(OR = 1.62, 95%CI: 1.02-2.58), and in UC patients, disease complications(OR = 3.39, 95%CI: 1.09-10.58) were associated with long-term full work disability.CONCLUSION The prevalence of work disability in IBD patients is higher than in the general Dutch population. Early assessment of risk factors for work disability is necessary, as work disability is substantial among IBD patients.
基金National Key Basic Research Program of China (973 Program) (No. 2015CB251600)the National Natural Science Foundation of China (Nos. 51327007, 51174157, and 51104118) for their support of this project
文摘To determine the rational layout parameters of the lateral high drainage roadway(LHDR) serving for two adjacent working faces, a mechanical model of the LHDR under mining influence was established, and the overburden fissure, mining-induced stress distribution rules were analyzed. First, the development characteristics of mining-induced overburden fissure and the stress distribution law of the upper section of the working face were analyzed. Second, by analyzing the distribution law of vertical stress at different layers, the lateral distance of the LHDR was determined as 25 m. Third, by analyzing the surrounding rock deformation effect, stress distribution law, and overburden fissure distribution law of the LHDR at the heights of 20, 25, and 30 m away from the roof, the rational horizon of the LHDR was determined to be 25 m. Finally, an example of a LHDR located 25 m above the roof of the No. 2 coal seam and 25 m away from the No. 2-603 working face was presented. Results show that when the No. 2-603 coalface is being mined, the surrounding rocks lag 80 m or even further and the working face tends to be stable. The relative deformations of the roof and floor of the roadway and both of its walls were 583 and 450 mm,respectively. The reduction rate of the roadway section was 21.52%–25.32%. The section of the roadway was sufficient to extract the pressure relief gas in the overburden of the No. 2-605 working face. The average gas concentration and the pure volume at the branch pipeline were 24.8% and 22.3 m^3/min,respectively, showing that the position of high-level boreholes was reasonable.
基金Youth Program of National Natural Science Foundation of China(No.71702068).
文摘The average stress of people in China’s workplace is reaching the peak in recent two years.To improve employee’s positive psychological factors,Spiritual leadership has a good performance in this regard.Based on the mediating effect of goal self-concordance and self-efficacy,this paper further studies the impact of spiritual leadership on employee’s work engagement.Through the empirical study,the following conclusions are drawn:(1)Spiritual leadership significantly positively affects the employee’s work engagement.(2)Spiritual leadership has a significant positive effect on goal self-concordance and self-efficacy.(3)Goal self-concordance and self-efficacy have significant positive effects on employee’s work engagement.(4)Goal self-concordance and self-efficacy play a partial mediating role in the process of spiritual leadership’s impact on employees’work engagement.This study found the new mediator which partly revealed the mechanism between the effectiveness of Spiritual Leadership and employee’s work engagement.This study may serve as one of the researches for improving the effectiveness of leaders in organizations and promoting the motivation of employees in the workplace.
文摘Energy methods and the principle of virtual work are commonly used for obtaining solutions of boundary value problems (BVPs) and initial value problems (IVPs) associated with homogeneous, isotropic and non-homogeneous, non-isotropic matter without using (or in the absence of) the mathematical models of the BVPs and the IVPs. These methods are also used for deriving mathematical models for BVPs and IVPs associated with isotropic, homogeneous as well as non-homogeneous, non-isotropic continuous matter. In energy methods when applied to IVPs, one constructs energy functional (<i>I</i>) consisting of kinetic energy, strain energy and the potential energy of loads. The first variation of this energy functional (<em>δI</em>) set to zero is a necessary condition for an extremum of <i>I</i>. In this approach one could use <i>δI</i> = 0 directly in constructing computational processes such as the finite element method or could derive Euler’s equations (differential or partial differential equations) from <i>δI</i> = 0, which is also satisfied by a solution obtained from <i>δI</i> = 0. The Euler’s equations obtained from <i>δI</i> = 0 indeed are the mathematical model associated with the energy functional <i>I</i>. In case of BVPs we follow the same approach except in this case, the energy functional <i>I</i> consists of strain energy and the potential energy of loads. In using the principle of virtual work for BVPs and the IVPs, we can also accomplish the same as described above using energy methods. In this paper we investigate consistency and validity of the mathematical models for isotropic, homogeneous and non-isotropic, non-homogeneous continuous matter for BVPs that are derived using energy functional consisting of strain energy and the potential energy of loads. Similar investigation is also presented for IVPs using energy functional consisting of kinetic energy, strain energy and the potential energy of loads. The computational approaches for BVPs and the IVPs designed using energy functional and principle of virtual work, their consistency and validity are also investigated. Classical continuum mechanics (CCM) principles <i>i.e.</i> conservation and balance laws of CCM with consistent constitutive theories and the elements of calculus of variations are employed in the investigations presented in this paper.
文摘Metropolises in the globalization call nowadays Towns' of jazzmen, jazzwomen and jazz lovers, in a way from which we citizens. Christian Sallenave, sociologist with musical academic and Cities' into question. Jazz answers with stories and memories can learn a lesson for the future of towns, metropolises and their background, shows through examples of stories of jazz in New Orleans, New York, Paris, Bordeaux and Rome, how this nomad, notable and crossbreeding music contributes to the history of jazz, and world music, and listeners' memories, in "their own way" as towns, cities and their memories can contribute to the prosperity of the metropolises in globalization, through original melting pot works.
文摘Nowadays, new paradigm of enterprise organization i s constantly changing due to the emergence of the global marketplace, the rise of information technology, and the emphasis of the social developments. This re quires a more flexible form of organization that are more adaptable to rapid cha nges in business environment such as autonomous work groups (AWGs) in order to achieve higher productivity and effectiveness. AWGs are work units responsib le for the production of goods and the provision of services. They involve team members in making decisions that are traditionally the responsibility of the sup ervisors and managers (Cohen & Bailey, 1997). Team members of AWGs are allowed t o self-regulate their behavior on jobs such as task assignments, methods for ca rrying out the work, and scheduling of activities etc. (Cohen & Ledford, 1994). For example, Motorola achieved a high organizational performance due to the succ essful implementation of AWGs in quality management (Piczak & Hauser, 1996). Xer ox also reported their operational successes based on the team-oriented work gr oups (Wageman, 1997). In recent years many organizations have replaced the traditional layers of manag ement with autonomous team-based work arrangements. Surveys indicated that the adoption of AWGs has soared in responding to the competitive business challenges . Many enterprises are making a deliberate effort to use AWGs to carry out work and operational processes as an alternative for hierarchical approaches (Lawler et al., 1995). There is a growing body of evidence that AWGs are more effective than traditionally managed groups and they contributes to organizational perform ance, such as improvement in operational performance, productivity, quality, cos t savings, employee attitude and behavior, and employee satisfaction (e.g. Pears on, 1992; Cohen & Ledford, 1994; Seers et al. 1995). Given the complexity and cognitive nature of team-based organizations, the mech anisms that the enterprises use in the development of the increasingly sophistic ated models, which can contribute to the effective functioning of AWGs, are extr emely important. The process of developing effective AWGs enables enterprises to inherent built-in intelligence of the organizations so that they will be more able to accommodate to external pressures and changes. The context of this paper is the construction of a dynamics framework and a stra tegic path for autonomous work groups in the technology-oriented manufacturing organization re-design. The framework is a conceptual one drawn from the litera ture survey. The importance of studying autonomous work groups for today’s manuf acturing organizations is claimed. Based on the General System Theory (GST), the characterization of AWGs is addressed. Three-dimensional domains such as t echnical content, service content, and relationship content are identified. A st rategic path is proposed to guide the organizations how the development of AWGs progresses at different levels of maturity that are associated with organization al effectiveness and performance. The utility of the model for AWGs is expected to provide technology-oriented organizations with a strategic path to achieve h igher organizational performance.
文摘"Safe quality standardization campaigns were conducted in enterprises on wide scale. Larger investment on safety was made. Greater progress in safety-related science and technology was stimulated. Safety training was enhanced.
文摘The article introduces ZTE's Softswitch-based NGN solutions. such as the long distance VolP service solution over data back- bone,and local voice and data service solution over MAN.Three application cases are analyzed,and NGN's features in aspects of network architecture,service provision and network management are summarized.
文摘Softswitch technology integrates the su-periorities of both an intelligence net-work and the Internet, which embodiesits maturity and advancement. With ahierarchical network model, it effectivelysolves problems of evolution and convergenceof current communication networks. It also fol-
文摘The Eighth Five-year Plan period wasa fast growing period for Jiangsu’sforeign economic and technical co-operation. Guided by the policy of seizingopportunities, expanding the opening driveand promoting development, all the staff atthe provincial foreign economic front madeevery effort to fulfill the goal of the sus-tained, fast and healthy development in for-
文摘Editor’s Note:After becoming theleading force in CDMAequipment manufacturingin China, ZTE rolled outits self-developed WCD-MA products that at-tracted much expert at-tention in the MTNETsecond phase single sys- tem testing completed inJune 2003. Thefollowing are the remarks of Ye Weimin,ZTE’s vice president, on ZTE’s strate-gies, advantages and achievements inthe development of WCDMA products.
文摘The year 1995 was the10th anniversary of theimplementation of China’sPatent Law.Over the pastdecade,China’s patent workhas made importantachievements.
文摘In December 1958, the China Council forthe Promotion of InternationalTrade(CCPIT) established its PublicityDepartment. Its task was to take over themagazine China’s Foreign Trade, transferredfrom the Ministry of Foreign Trade. Ms. LuJiyin held the post of department head, and Iwas transferred from the post of the ResearchDepartment Commissioner to that of thePublicity Department Commissioner to assisther in her work. The magazine China’s Foreign Tradewas originally established in 1956 by thePropaganda Section under the General Officeof the Ministry of Foreign Trade. It had twoeditions: Chinese and English, under trialpublication. The magazine, sponsored by theMinistry of Foreign Trade was a trialpublication in nature, so when the task
文摘During the Ninth Five-Year Planperiod,the major objectives ofstruggle for China’s patent work are:the annual number of patentapplications will reach 100 thousand,of which patent applications
文摘Despite exhaustive search, no drug is in sight for AD. Earlier, we reported that reserpine, an antihypertensive and antipsychotic drug, ameliorates Amyloid beta (Aβ-AD causing peptide) toxicity and confers several positive enhancements in the C. elegans model system. Here, we evaluate whether reserpine can provide protection against working memory and against AD in the mouse model. Reserpine (0.08 mg) was administered orally on alternate days to the non-Tg and accelerated Aβ deposition (at 2 months of age)and cognitive deficit (4 months of age) developing 5XFAD AD Tg mouse model expressing mutant human APP (3 familial mutations) and human Presenilin1(2 familial mutations) in the neurons, and follow their working memory for 2 months using the spontaneous Y-maze alteration behavioral paradigm. Reserpine enhanced working memory in non-Tg mice and improved the cognitive deficit in the 5XFAD AD Tg mice. Hence, reserpine can be considered for a detailed evaluation in the 3X Tg AD mouse model and a pilot study in AD patients.