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Antimicrobial-free knitted fabric as wound dressing and the mechanism of promoting infected wound healing 被引量:2
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作者 ZHANG Huan WAN HuaKun +4 位作者 HU XiuYuan ZHAO QingHua LU JianGuo WANG Dong LU ZhenTan 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2023年第7期2147-2154,共8页
Fibrous biomaterials are widely used in the design and fabrication of antibacterial wound dressings.Two strategies are used to make anti-infective dressings:antibacterial and probiotic therapies,which have potential b... Fibrous biomaterials are widely used in the design and fabrication of antibacterial wound dressings.Two strategies are used to make anti-infective dressings:antibacterial and probiotic therapies,which have potential biotoxicity and other side-effects.Herein,we report a new strategy for fabricating wound dressings to combat infection.Poly(4-methyl-1-pentene)(PMP) fabric can remove bacteria from infectious wounds through dressing changes based on its efficient bacterial adhesion.The maximum adhered count of S.aureus and E.coli on the PMP fabric was 1.63 × 106CFU/cm~2 and 4.77 × 105CFU/cm~2,respectively.In addition,the PMP fabric could inhibit the twitching motility of bacteria,which is beneficial for inhibiting infection.The ability of the PMP fabric to accelerate wound healing was demonstrated in vivo in a rat wound model.After treatment with the PMP fabric dressing,pathogenic bacteria in the wound were removed through dressing change;therefore,the wound exhibited better healing speed than when the commercial dressing was used.The low bacterial concentration effectively stimulated the expression of growth factors and suppressed wound inflammation,thereby accelerating wound healing.PMP fabric has three advantages:(1) it has been approved for use in clinical treatment by the Food and Drug Administration;(2) no antibacterial agent or probiotics were used;(3) the fabric could be manufactured through an industrial production process.These results indicate that the new strategy can be used in the design of new-generation wound dressings for antibacterial applications. 展开更多
关键词 ANTI-INFECTION bacterial adhesion healing mechanism knitted fabric wound dressing
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Autogenous healing mechanism of cement-based materials
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作者 Desheng LI Hao ZHENG +3 位作者 Kang GU Lei LANG Shang SHI Bing CHEN 《Frontiers of Structural and Civil Engineering》 SCIE EI CSCD 2023年第6期948-963,共16页
Autogenous self-healing is the innate and fundamental repair capability of cement-based materials for healing cracks.Many researchers have investigated factors that influence autogenous healing.However,systematic rese... Autogenous self-healing is the innate and fundamental repair capability of cement-based materials for healing cracks.Many researchers have investigated factors that influence autogenous healing.However,systematic research on the autogenous healing mechanism of cement-based materials is lacking.The healing process mainly involves a chemical process,including further hydration of unhydrated cement and carbonation of calcium oxide and calcium hydroxide.Hence,the autogenous healing process is influenced by the material constituents of the cement composite and the ambient environment.In this study,different factors influencing the healing process of cement-based materials were investigated.Scanning electron microscopy and optical microscopy were used to examine the autogenous healing mechanism,and the maximum healing capacity was assessed.Furthermore,detailed theoretical analysis and quantitative detection of autogenous healing were conducted.This study provides a valuable reference for developing an improved healing technique for cement-based composites. 展开更多
关键词 autogenous healing cement-based materials healing mechanism aggregation effect
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Self-healable gels in electrochemical energy storage devices
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作者 Yang Li PeiPei Ding +8 位作者 Yuzhe Gu Sheng Qian Yuncong Pang Lele Wang Jiayang Feng Baoguang Liu Qi Wan Ping Li Zhiwei Liu 《Nano Research》 SCIE EI CSCD 2024年第4期3302-3323,共22页
In the green energy and carbon-neutral technology,electrochemical energy storage devices have received continuously increasing attention recently.However,due to the unavoidable volume expansion/shrinkage of key materi... In the green energy and carbon-neutral technology,electrochemical energy storage devices have received continuously increasing attention recently.However,due to the unavoidable volume expansion/shrinkage of key materials or irreversible mechanical damages during application,the stability of energy storage and delivery as well as the lifetime of these devices are severely shortened,leading to serious performance degradation or even safety issues.Therefore,the utilization of self-healable gels into electrochemical energy storage devices,such as electrodes,binders,and electrolytes,is proven as an effective method to realize long-term stable operation of these devices via the self-repairing of mechanical and electrochemical characteristics.Herein,this review first summarizes the feature and fabrication of different gels,paying special attention to hydrogels,organohydrogels,and ionogels.Then,basic concepts and figure of merit of self-healable gels are analyzed with a detailed discussion at the healing mechanisms,from reversible dynamic bonds to physical molecular diffusion,and to external healing trigger.Then we introduce all the important parts of electrochemical energy storage devices,which could be replaced by healable gels to enhance the durability,including electrodes,binders,and electrolytes.Finally,the critical challenges and future perspectives regarding the future development of healable gels based high-performance electrochemical energy storage devices or electronics are provided. 展开更多
关键词 self-healable gels healing mechanisms ELECTRODES binders gel electrolytes
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Advancing engineered approaches for sustainable wound regeneration and repair:Harnessing the potential of green synthesized silver nanoparticles
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作者 J.Nandhini E.Karthikeyan +6 位作者 E.Elizabeth Rani V.S.Karthikha D.Sakthi Sanjana H.Jeevitha S.Rajeshkumar Vijayan Venugopal A.Priyadharshan 《Engineered Regeneration》 EI 2024年第3期306-325,共20页
Wound healing is a crucial biological process for tissue repair and regeneration,preventing infections and com-plications.There’s been a growing interest in exploring sustainable wound healing strategies in recent ye... Wound healing is a crucial biological process for tissue repair and regeneration,preventing infections and com-plications.There’s been a growing interest in exploring sustainable wound healing strategies in recent years.This review examines the use of green-synthesized silver nanoparticles(AgNPs)in sustainable wound healing strate-gies.It highlights the need for innovative approaches and the challenges posed by infections.The current wound therapies and treatments,highlighting gaps in existing methodologies,are evaluated.This review provides a com-prehensive overview of the current state-of-the-art in green synthesis techniques for the synthesis of AgNPs.The properties and characterization of AgNPs are elucidated,providing insights into their efficacy.The biocompati-bility of AgNPs in wound healing is also explored,emphasizing safety in medical applications.Green synthesized AgNPs incorporated wound dressings are detailed,showcasing their potential in clinical settings.Challenges and future perspectives are discussed,addressing hurdles to widespread implementation.The conclusion consolidates key findings,offering a synthesized perspective on the potential of green-synthesized AgNPs in revolutionizing current knowledge on innovative approaches for sustainable wound healing practices. 展开更多
关键词 Green synthesis Wound healing AGNPS Wound healing mechanism Eco-friendly synthesis
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A fast-healing and high-performance metallosupramolecular elastomer based on pyridine-Cu coordination 被引量:2
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作者 Hui Liu Qiaoqiao Shen +8 位作者 Linjun Zhang Shiyu Gu Yan Peng Qi Wu Hui Xiong Hao Zhang Lijuan Zhao Guangsu Huang Jinrong Wu 《Science China Materials》 SCIE EI CAS CSCD 2022年第7期1943-1951,共9页
Elastomers easily undergo a catastrophic failure as soon as a crack is introduced by mechanical damage.Thus,it is extremely important for elastomers to possess fast healing ability,which enables the quick reparation o... Elastomers easily undergo a catastrophic failure as soon as a crack is introduced by mechanical damage.Thus,it is extremely important for elastomers to possess fast healing ability,which enables the quick reparation of cracks.However,developing elastomers with fast self-healing ability and high mechanical strength is highly challenging.Herein,we fabricate a metallosupramolecular elastomer by facilely introducing pyridine-Cu coordination into a copolymer of ethyl acrylate and vinyl pyridine.Interestingly,the pyridine-Cu coordination has a strong photothermal effect,which readily increases the sample temperature to 60℃ in 30 s under near-infrared light.At this temperature,the sticky reptation modes are activated and thus serve as the driving force for network reorganization and fast self-healing of the metallosupramolecular elastomer.Albeit with a tensile strength of 10 MPa,the scratched and completely fractured samples can be healed within 2 min and 3 h,respectively.Moreover,during the damage and healing processes,the break and reformation of the coordination bonds can be tracked through laser confocal micro-Raman spectroscopy.This provides a microscopic methodology to monitor the bond-level healing kinetics of metallosupramolecular polymers. 展开更多
关键词 metallosupramolecular elastomer photothermal effect molecular dynamics healing mechanism laser confocal micro-Raman
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Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions 被引量:8
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作者 Isabel Andia Michele Abate 《Frontiers of Medicine》 SCIE CAS CSCD 2018年第2期139-152,共14页
Current research on common musculoskeletal problems, including osteoart]cular cona]t]ons, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerge... Current research on common musculoskeletal problems, including osteoart]cular cona]t]ons, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regeneration. Platelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionally leukocytes at injured/pathological tissues mimicking the initial stages of healing. However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients' outcomes show partial improvements. Platelet-rich plasma can be customized to specific conditions by selecting the most appropriate formulation and timing for application or by combining platelet-rich plasma with synergistic or complementary treatments. To achieve this goal, researchers should identify and enhance the main mechanisms of healing. In this review, the interactions between platelet-rich plasma and healing mechanisms were addressed and research opportunities for customized treatment modalities were outlined. The development of combinational platelet-rieh plasma treatments that can be used safely and effectively to manipulate healing mechanisms would be valuable and would provide insights into the processes involved in physiological healing and pathological failure. 展开更多
关键词 regenerative medicine joint conditions muscle injuries platelet rich plasma TENDINOPATHY healing mechanisms
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