Objectives:To examine the effects of the Roy Adaptation Model-based interventions on adaptation in persons with heart failure.Methods:A quasi-experimental study was conducted in Hangzhou,China,from March 2018 to Novem...Objectives:To examine the effects of the Roy Adaptation Model-based interventions on adaptation in persons with heart failure.Methods:A quasi-experimental study was conducted in Hangzhou,China,from March 2018 to November 2019.A convenience sample of 112 participants with heart failure from a multi-campus hospital was enrolled.Participants were allocated into an intervention group(n=55)and a control group(n=57)according to their hospitalized campus.A culturally-tailored care plan intervention based on the Roy Adaptation Model was performed in the intervention group.The control group received bedside patient education and a regular booklet for HF home care before discharge.Heart ultrasound,Minnesota Living with Heart Failure Questionnaire(MLHFQ),a knowledge survey,Self-care Heart failure Index(SCHFI),and Coping and Adaptation Processing Scale-Short Form(CAPS-SF)were used to measure patients’levels of adaptation of physical function,self-concept,role function,and interdependence at baseline and six months after discharge.Results:Ninety-one participants with complete data,43 in the intervention group and 48 in the control group,were included in the analysis for the primary endpoints and showed adaptive improvement trends.Most patients in the intervention group completed 60%or more of the given interventions.At the sixth month after discharge,compared with the control group,the intervention group had improved adaptive behaviors showing higher scores of the MLHFQ(70.90±22.45 vs.54.78±18.04),heart failurerelated knowledge(13.79±2.45 vs.10.73±4.28),SCHFI maintenance(57.67±13.22 vs.50.35±10.88),and CAPS-SF(40.23±4.36 vs.38.27±2.60)at the six-month follow-up(P<0.05).There were no significant differences between the two groups in the scores of left ventricular ejection fraction,scores of SCHFI management and SCHFI confidence subscales(P>0.05).Conclusions:The findings reported evidence of positive adaptation in patients with heart failure,indicating that the Roy Adaptation Model is an effective guide for developing an implemented framework for the nursing practice of the patients.The culturally-tailored care plan intervention is helpful to improve adaptation of patients with heart failure.展开更多
The authors studied 24 cases of refractory prema-ture beats by giving 0.1 adonisidum twice daily withHolter’s monitoring.It was found that adonisidumwas effective in 12 cases (P【0.001),or 50%.In another 8 patients a...The authors studied 24 cases of refractory prema-ture beats by giving 0.1 adonisidum twice daily withHolter’s monitoring.It was found that adonisidumwas effective in 12 cases (P【0.001),or 50%.In another 8 patients adonisidum or mexiletinealone were ineffective for premature beats.However,when these patients were treated with both mexiletineand adonisidum,they responded with no exception(P【0.001).展开更多
According to statistics of Beijing,Tianjin,Shanghai and other hospitals,cardiovascular and cerebrovascular diseasesconstitute the main causes of death(about50%),while many victims have died ofhypertension and coronary...According to statistics of Beijing,Tianjin,Shanghai and other hospitals,cardiovascular and cerebrovascular diseasesconstitute the main causes of death(about50%),while many victims have died ofhypertension and coronary heart disease.Clinical research on the treatment of thesediseases is therefore an urgent task con-fronting our medical workers.展开更多
The clinical benefit of coronary-artery steating performed inconjunction with coronary angioplasty is limited by the risk of thromboticocclusion of the stant as well as hemorrhagic and vascular complications ofintensi...The clinical benefit of coronary-artery steating performed inconjunction with coronary angioplasty is limited by the risk of thromboticocclusion of the stant as well as hemorrhagic and vascular complications ofintensive anticoaguistion.We analysed complications of three patientscaused by improper antithrombotic therapy after coronary artery stanting.Method and Result:Case 1,male,52 years old.The diagnosis is old myocardial infarction(OMI),unstable angina pectoris(UAP).Gianturco-Roubin stent was successfullyimplanted into right coronary artery(RCA).Balloon angioplasty wasperformed in left circumflex artary(LCX).Angiography showed optimal resultafter the procedure.The patient bad acute inferior myocardial infarction onthe same day,and died from ventricular fibrillation on the third day afterthe stenting.Case 2,male,53 years old.The diagnosis is UAP.Two Gianturco-RoubinStents were implanted into left anterior descending artery(LAD)and RCArespectively,angioplasty was done in LCX On the tenth day atfer theprocedure,bloody urine happened.By reducing warfarin dosage be bloodyurine disappeared.Case 3.female.71 years old.the diagnosis is acute anterior myocardialinfarction,UAP.Multilink stent was implanted into LAD,balloon dilatationwas done in RCA.On the day of the stenting,groin regional bleeding andshock happendod.Afterwards.acute anterior,Supralataral MI and acute heartfailure happended.Finally the patient was discharged.DiscussionRecently the success rate of the stent implantation reach at 95%.However,the main complications are stent thrombosis as well as bleeding,vascular access complicalions caused by intensive antithrombotic agent.Inthese three patients,the death of the first case is due to acute stentthrombosis resulted from insufficient antithrombotic therapy.The bloodyurine of second case is caused by too much intensive anticoagulation.Thecomplications of the third case is due to too much intensive antithrombosisat beginning and insufficient antithrombosis at latter.The antithrombosisafter stenting should be monitored by ACT,CT or PTT The antipisteletherapy can largely reduce the stent thrombosis and the incidence of theleeding.展开更多
Cardiac rupture(CR)is a very severe complication and major lethal factor of acutemyocardial infarction(AMI),included free wall rupture,ventricular septal ruptureand papillary muscular rupture.In addition to the genera...Cardiac rupture(CR)is a very severe complication and major lethal factor of acutemyocardial infarction(AMI),included free wall rupture,ventricular septal ruptureand papillary muscular rupture.In addition to the general clinical symptoms therewere some differences.The patients of ventricular septal rupture had cardiogenicshock,severe right ventricular failure and the murmur as the same as gencricventricular septal defect,papillary muscular rupture resulted severe mitralregurgitation,circulation failure and pulmunary-edima,there were rough systolicmurmur locatied in mitrai region,while free wall rupture occured,theconsciousness,breathless and Beau’disease syndrome were presented suddenly,inthe electrocrdiogram showed sinus rhythm,atrioventricular junctional rhythm,ventricilar rhythm,that was electricity-machine disconnection Treatment of cadacrupture is more diffcult prevention is eimportant The patients of acutemyocardial infarction especially initial pass through wall and no angina,no heartfailure in histry must be take care of carefully,inhibit myocadial systole in noinfarction region suitably,by lying in bed,preventing defecate dry,reducing bloodpressure,using β-blacker.Benefit of thrombolysis on following myocardialinfarction was doubtful in reducing cardiac展开更多
The safe and efficacy of diltiazem in ventricular rate control of atrialfibrillation are the major concern to most clinicians in patients with heartfailure.We tested the performance of acute application of diltiazem i...The safe and efficacy of diltiazem in ventricular rate control of atrialfibrillation are the major concern to most clinicians in patients with heartfailure.We tested the performance of acute application of diltiazem inpatients with heart failure and atrial fibrillation or flutter.A total of 280patients were grouped according to the New York heart failureclassification,with class IV in 48 patients.All the patients receiveddiltiazem 10-20mg intravenous injection and/or 10mg/h intravenousinfusion during arrhythmia.After the drag injection or infusion,theventricular rate decreased from 142.09±17.61 to 100.24±17.74 beatper minute(P【0.0001),the systolic blood pressure dropped from135.44+28.14 to 123.52±19.18 mmHg(P【0.001),the diastolic bloodpressure dropped from 84.52±16.04 to 77.26±12.02mmHg(P【0.01).Despite the decrease in blood pressure,no deteriorate symptom wasnoted in all the groups of patients.Our results suggest that the diltiazemis a safe and effective drug to control the ventricular rate during atrialfibrillation or flutter associated with heart failure.展开更多
930077 The aminophyllin and cefatoxin fortreatment pulmonary heart disease of mutual in-fluence.LI Shenqi(李胜岐),et al.2nd ClinColl Dept,China Med Univ,Shenyang 110003.Chin J Tuberd & Respir Dis 1992;15(5):272-27...930077 The aminophyllin and cefatoxin fortreatment pulmonary heart disease of mutual in-fluence.LI Shenqi(李胜岐),et al.2nd ClinColl Dept,China Med Univ,Shenyang 110003.Chin J Tuberd & Respir Dis 1992;15(5):272-273.The serum Aminophyllin(TP)and Cefatoxin(CTX)concentration of the patients with pul-monary heart disease during acute attack weremeasured by HLPC at 2 hrs and 6 hrs after infu-sion.(1)TP and CTX alone were used.(2)TPand CTX were used simultaneously.The resultshowed that the concentrations of TP weremuch higher,but those of CTX were much low-er when CTX and TP simultaneously,at 2 hrsand 6 hrs(P【0.01,P【0.05).The concentra-展开更多
920271 The relationship between plasmacatecholamines and cardiac function in pa-tients with congestive heart failure.ZHAOShuyuan (赵树元),et al.Dept Intern Med,HebeiProv Hosp.Chin Cir J 1991;6(6):484-486.
Chemotherapy-induced complications,particularly lethal cardiovascular diseases,pose significant challenges for cancer survivors.The intertwined adverse effects,brought by cancer and its complication,further complicate...Chemotherapy-induced complications,particularly lethal cardiovascular diseases,pose significant challenges for cancer survivors.The intertwined adverse effects,brought by cancer and its complication,further complicate anticancer therapy and lead to diminished clinical outcomes.Simple supplementation of cardioprotective agents falls short in addressing these challenges.Developing bifunctional co-therapy agents provided another potential solution to consolidate the chemotherapy and reduce cardiac events simultaneously.Drug repurposing was naturally endowed with co-therapeutic potential of two indications,implying a unique chance in the development of bi-functional agents.Herein,we further proposed a novel“trilogy of drug repurposing”strategy that comprises function-based,targetfocused,and scaffold-driven repurposing approaches,aiming to systematically elucidate the advantages of repurposed drugs in rationally developing bi-functional agent.Through function-based repurposing,a cardioprotective agent,carvedilol(CAR),was identified as a potential neddylation inhibitor to suppress lung cancer growth.Employing target-focused SAR studies and scaffold-driven drug design,we synthesized 44 CAR derivatives to achieve a balance between anticancer and cardioprotection.Remarkably,optimal derivative 43 displayed promising bi-functional effects,especially in various self-established heart failure mice models with and without tumor-bearing.Collectively,the present study validated the practicability of the“trilogy of drug repurposing”strategy in the development of bi-functional cotherapy agents.展开更多
OBJECTIVE: This study used gated myocardial perfusion imaging(G-MPI) to assess the clinical value of Xinmailong injection in chronic congestive heart failure(CHF).METHODS: A total of 102 CHF patients were randomly div...OBJECTIVE: This study used gated myocardial perfusion imaging(G-MPI) to assess the clinical value of Xinmailong injection in chronic congestive heart failure(CHF).METHODS: A total of 102 CHF patients were randomly divided into the control group(n=51) and the Xinmailong group(n=51). Patients in the control group were routinely treated. Patients in the Xinmailong group were additionally treated with Xinmailong injection in addition to routine treatment. Before and 3 months after treatment, G-MPI was used to determine changes in the left ventricular ejection fraction(LVEF), left ventricular end-diastolic volume(LVEDV) and left ventricular end-systolic volume(LVESV). Fourteen days after treatment, changes in plasma brain natriuretic peptide(BNP) levels were determined.RESULTS: Before treatment, there were no significant differences in LVEF, LVEDV, LVESV, and BNP levels between the two groups(all P>0.05). After treatment, LVEDV, LVESV, and BNP levels were significantly lower, and LVEF was significantly higher in the Xinmailong group than in the control group(all P<0.05).CONCLUSION: Additional use of Xinmailong injection in addition to routine treatment improves cardiac function of CHF patients. Because of the safety and effectiveness of Xinmailong injection, this therapy should be promoted.展开更多
基金This work was supported by Health Commission of Zhejiang Province(grant number WKJ-ZJ-1925 and 2019ZD034)The authors thank all investigators and participants who participated in the study.
文摘Objectives:To examine the effects of the Roy Adaptation Model-based interventions on adaptation in persons with heart failure.Methods:A quasi-experimental study was conducted in Hangzhou,China,from March 2018 to November 2019.A convenience sample of 112 participants with heart failure from a multi-campus hospital was enrolled.Participants were allocated into an intervention group(n=55)and a control group(n=57)according to their hospitalized campus.A culturally-tailored care plan intervention based on the Roy Adaptation Model was performed in the intervention group.The control group received bedside patient education and a regular booklet for HF home care before discharge.Heart ultrasound,Minnesota Living with Heart Failure Questionnaire(MLHFQ),a knowledge survey,Self-care Heart failure Index(SCHFI),and Coping and Adaptation Processing Scale-Short Form(CAPS-SF)were used to measure patients’levels of adaptation of physical function,self-concept,role function,and interdependence at baseline and six months after discharge.Results:Ninety-one participants with complete data,43 in the intervention group and 48 in the control group,were included in the analysis for the primary endpoints and showed adaptive improvement trends.Most patients in the intervention group completed 60%or more of the given interventions.At the sixth month after discharge,compared with the control group,the intervention group had improved adaptive behaviors showing higher scores of the MLHFQ(70.90±22.45 vs.54.78±18.04),heart failurerelated knowledge(13.79±2.45 vs.10.73±4.28),SCHFI maintenance(57.67±13.22 vs.50.35±10.88),and CAPS-SF(40.23±4.36 vs.38.27±2.60)at the six-month follow-up(P<0.05).There were no significant differences between the two groups in the scores of left ventricular ejection fraction,scores of SCHFI management and SCHFI confidence subscales(P>0.05).Conclusions:The findings reported evidence of positive adaptation in patients with heart failure,indicating that the Roy Adaptation Model is an effective guide for developing an implemented framework for the nursing practice of the patients.The culturally-tailored care plan intervention is helpful to improve adaptation of patients with heart failure.
文摘The authors studied 24 cases of refractory prema-ture beats by giving 0.1 adonisidum twice daily withHolter’s monitoring.It was found that adonisidumwas effective in 12 cases (P【0.001),or 50%.In another 8 patients adonisidum or mexiletinealone were ineffective for premature beats.However,when these patients were treated with both mexiletineand adonisidum,they responded with no exception(P【0.001).
文摘According to statistics of Beijing,Tianjin,Shanghai and other hospitals,cardiovascular and cerebrovascular diseasesconstitute the main causes of death(about50%),while many victims have died ofhypertension and coronary heart disease.Clinical research on the treatment of thesediseases is therefore an urgent task con-fronting our medical workers.
文摘The clinical benefit of coronary-artery steating performed inconjunction with coronary angioplasty is limited by the risk of thromboticocclusion of the stant as well as hemorrhagic and vascular complications ofintensive anticoaguistion.We analysed complications of three patientscaused by improper antithrombotic therapy after coronary artery stanting.Method and Result:Case 1,male,52 years old.The diagnosis is old myocardial infarction(OMI),unstable angina pectoris(UAP).Gianturco-Roubin stent was successfullyimplanted into right coronary artery(RCA).Balloon angioplasty wasperformed in left circumflex artary(LCX).Angiography showed optimal resultafter the procedure.The patient bad acute inferior myocardial infarction onthe same day,and died from ventricular fibrillation on the third day afterthe stenting.Case 2,male,53 years old.The diagnosis is UAP.Two Gianturco-RoubinStents were implanted into left anterior descending artery(LAD)and RCArespectively,angioplasty was done in LCX On the tenth day atfer theprocedure,bloody urine happened.By reducing warfarin dosage be bloodyurine disappeared.Case 3.female.71 years old.the diagnosis is acute anterior myocardialinfarction,UAP.Multilink stent was implanted into LAD,balloon dilatationwas done in RCA.On the day of the stenting,groin regional bleeding andshock happendod.Afterwards.acute anterior,Supralataral MI and acute heartfailure happended.Finally the patient was discharged.DiscussionRecently the success rate of the stent implantation reach at 95%.However,the main complications are stent thrombosis as well as bleeding,vascular access complicalions caused by intensive antithrombotic agent.Inthese three patients,the death of the first case is due to acute stentthrombosis resulted from insufficient antithrombotic therapy.The bloodyurine of second case is caused by too much intensive anticoagulation.Thecomplications of the third case is due to too much intensive antithrombosisat beginning and insufficient antithrombosis at latter.The antithrombosisafter stenting should be monitored by ACT,CT or PTT The antipisteletherapy can largely reduce the stent thrombosis and the incidence of theleeding.
文摘Cardiac rupture(CR)is a very severe complication and major lethal factor of acutemyocardial infarction(AMI),included free wall rupture,ventricular septal ruptureand papillary muscular rupture.In addition to the general clinical symptoms therewere some differences.The patients of ventricular septal rupture had cardiogenicshock,severe right ventricular failure and the murmur as the same as gencricventricular septal defect,papillary muscular rupture resulted severe mitralregurgitation,circulation failure and pulmunary-edima,there were rough systolicmurmur locatied in mitrai region,while free wall rupture occured,theconsciousness,breathless and Beau’disease syndrome were presented suddenly,inthe electrocrdiogram showed sinus rhythm,atrioventricular junctional rhythm,ventricilar rhythm,that was electricity-machine disconnection Treatment of cadacrupture is more diffcult prevention is eimportant The patients of acutemyocardial infarction especially initial pass through wall and no angina,no heartfailure in histry must be take care of carefully,inhibit myocadial systole in noinfarction region suitably,by lying in bed,preventing defecate dry,reducing bloodpressure,using β-blacker.Benefit of thrombolysis on following myocardialinfarction was doubtful in reducing cardiac
文摘The safe and efficacy of diltiazem in ventricular rate control of atrialfibrillation are the major concern to most clinicians in patients with heartfailure.We tested the performance of acute application of diltiazem inpatients with heart failure and atrial fibrillation or flutter.A total of 280patients were grouped according to the New York heart failureclassification,with class IV in 48 patients.All the patients receiveddiltiazem 10-20mg intravenous injection and/or 10mg/h intravenousinfusion during arrhythmia.After the drag injection or infusion,theventricular rate decreased from 142.09±17.61 to 100.24±17.74 beatper minute(P【0.0001),the systolic blood pressure dropped from135.44+28.14 to 123.52±19.18 mmHg(P【0.001),the diastolic bloodpressure dropped from 84.52±16.04 to 77.26±12.02mmHg(P【0.01).Despite the decrease in blood pressure,no deteriorate symptom wasnoted in all the groups of patients.Our results suggest that the diltiazemis a safe and effective drug to control the ventricular rate during atrialfibrillation or flutter associated with heart failure.
文摘930077 The aminophyllin and cefatoxin fortreatment pulmonary heart disease of mutual in-fluence.LI Shenqi(李胜岐),et al.2nd ClinColl Dept,China Med Univ,Shenyang 110003.Chin J Tuberd & Respir Dis 1992;15(5):272-273.The serum Aminophyllin(TP)and Cefatoxin(CTX)concentration of the patients with pul-monary heart disease during acute attack weremeasured by HLPC at 2 hrs and 6 hrs after infu-sion.(1)TP and CTX alone were used.(2)TPand CTX were used simultaneously.The resultshowed that the concentrations of TP weremuch higher,but those of CTX were much low-er when CTX and TP simultaneously,at 2 hrsand 6 hrs(P【0.01,P【0.05).The concentra-
文摘920271 The relationship between plasmacatecholamines and cardiac function in pa-tients with congestive heart failure.ZHAOShuyuan (赵树元),et al.Dept Intern Med,HebeiProv Hosp.Chin Cir J 1991;6(6):484-486.
基金supported by the National Natural Science Foundation of China (Grant Nos. 22177076, 81820108022, 22037002)the Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism (2021 Sci&Tech 03-28, China)+4 种基金Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation (2021KJ03-12, China)the Innovative Research Team of High-level Local Universities in Shanghai (SHSMU-ZDCX20212702, China)the Chinese Special Fund for State Key Laboratory of Bioreactor Engineering(2060204)Innovation Program of Shanghai Municipal Education Commission (2019-01-07-00-10-E00056, 2021-01-07-00-02-E00104, China)the Scientific and Technological Innovation Action Plan of Science and Technology Commission of Shanghai(20JC1411300, China)
文摘Chemotherapy-induced complications,particularly lethal cardiovascular diseases,pose significant challenges for cancer survivors.The intertwined adverse effects,brought by cancer and its complication,further complicate anticancer therapy and lead to diminished clinical outcomes.Simple supplementation of cardioprotective agents falls short in addressing these challenges.Developing bifunctional co-therapy agents provided another potential solution to consolidate the chemotherapy and reduce cardiac events simultaneously.Drug repurposing was naturally endowed with co-therapeutic potential of two indications,implying a unique chance in the development of bi-functional agents.Herein,we further proposed a novel“trilogy of drug repurposing”strategy that comprises function-based,targetfocused,and scaffold-driven repurposing approaches,aiming to systematically elucidate the advantages of repurposed drugs in rationally developing bi-functional agent.Through function-based repurposing,a cardioprotective agent,carvedilol(CAR),was identified as a potential neddylation inhibitor to suppress lung cancer growth.Employing target-focused SAR studies and scaffold-driven drug design,we synthesized 44 CAR derivatives to achieve a balance between anticancer and cardioprotection.Remarkably,optimal derivative 43 displayed promising bi-functional effects,especially in various self-established heart failure mice models with and without tumor-bearing.Collectively,the present study validated the practicability of the“trilogy of drug repurposing”strategy in the development of bi-functional cotherapy agents.
文摘OBJECTIVE: This study used gated myocardial perfusion imaging(G-MPI) to assess the clinical value of Xinmailong injection in chronic congestive heart failure(CHF).METHODS: A total of 102 CHF patients were randomly divided into the control group(n=51) and the Xinmailong group(n=51). Patients in the control group were routinely treated. Patients in the Xinmailong group were additionally treated with Xinmailong injection in addition to routine treatment. Before and 3 months after treatment, G-MPI was used to determine changes in the left ventricular ejection fraction(LVEF), left ventricular end-diastolic volume(LVEDV) and left ventricular end-systolic volume(LVESV). Fourteen days after treatment, changes in plasma brain natriuretic peptide(BNP) levels were determined.RESULTS: Before treatment, there were no significant differences in LVEF, LVEDV, LVESV, and BNP levels between the two groups(all P>0.05). After treatment, LVEDV, LVESV, and BNP levels were significantly lower, and LVEF was significantly higher in the Xinmailong group than in the control group(all P<0.05).CONCLUSION: Additional use of Xinmailong injection in addition to routine treatment improves cardiac function of CHF patients. Because of the safety and effectiveness of Xinmailong injection, this therapy should be promoted.
