A novel slotted helix slow-wave structure (SWS) is proposed to develop a high power, wide-bandwidth, and high reliability millimeter-wave traveling-wave tube (TWT). This novel structure, which has higher heat capa...A novel slotted helix slow-wave structure (SWS) is proposed to develop a high power, wide-bandwidth, and high reliability millimeter-wave traveling-wave tube (TWT). This novel structure, which has higher heat capacity than a conven- tional helix SWS, evolves from conventional helix SWS with three parallel rows of rectangular slots made in the outside of the helix tape. In this paper, the electromagnetic characteristics and the beam-wave interaction of this novel structure operating in the Ka-band are investigated. From our calculations, when the designed beam voltage and beam current are set to be 18.45 kV and 0.2 A, respectively, this novel circuit can produce over 700-W average output power in a frequency range from 27.5 GHz to 32.5 GHz, and the corresponding conversion efficiency values vary from 19% to 21.3%, and the maximum output power is 787 W at 30 GHz.展开更多
Based on the actual vane-loaded tape helix slow wave structure, a new theoretical analytic model for calculating coupling impedance is proposed by Chen Qingyou, et al.(1999)with calculated values of dispersion in good...Based on the actual vane-loaded tape helix slow wave structure, a new theoretical analytic model for calculating coupling impedance is proposed by Chen Qingyou, et al.(1999)with calculated values of dispersion in good agreement with measured ones. In this paper, it is continued to use this model to calculate the coupling impedance of such a structure, and analyze the effects of the propagation power within vane gaps and the helix gap on the coupling impedance.As a result, the theoretical values are found to be in good agreement with the measured ones,with the maximum difference less than ±18%.展开更多
A backward wave amplifier(BWA) in a terahertz regime with a novel slow-wave structure(SWS) composed of multi parallel grating pins inside a rectangular waveguide is analyzed. The multi-pin rectangular waveguide SW...A backward wave amplifier(BWA) in a terahertz regime with a novel slow-wave structure(SWS) composed of multi parallel grating pins inside a rectangular waveguide is analyzed. The multi-pin rectangular waveguide SWS possesses good performance and is compatible with micro-fabrication technologies. The dispersion and interaction impedance of the multipin SWS are presented. The stopbands of the modes cling together in a Brillouim zone. The SWS has a high interaction impedance that is suitable for the interaction of multi cylindrical beams. The design, which is based on three parallel pins supporting the wave–beam interaction with four cylindrical beams, is verified by three-dimensional particle-in-cell simulations. A BWA with the central frequency at 340 GHz is demonstrated, and the output power is more than 100 mW.A tuning frequency range of 15 GHz(333–348 GHz) is obtained with a gain of more than 20 dB.展开更多
A watt-class backward wave oscillator is proposed, using the concise sine waveguide slow-wave structure combined with a pencil electron beam to operate at 220 GHz. Firstly, the dispersion curve of the sine waveguide i...A watt-class backward wave oscillator is proposed, using the concise sine waveguide slow-wave structure combined with a pencil electron beam to operate at 220 GHz. Firstly, the dispersion curve of the sine waveguide is calculated, then, the oscillation frequency and operating voltage of the device are predicted and the circuit transmission loss is calculated. Finally, the particle-in-cell simulation method is used to forecast its radiation performance. The results show that this novel backward wave oscillator can produce over 1-W continuous wave power output in a frequency range from 210 GHz to 230 GHz. Therefore, it will be considered as a very promising high-power millimeter-wave to terahertz-wave radiation source.展开更多
The variational method is applied to calculate the dispersion characteristics of disc-loaded waveguide slow-wave structures. The parameters describing the waveguide discontinuities in disc-loaded waveguide are calcula...The variational method is applied to calculate the dispersion characteristics of disc-loaded waveguide slow-wave structures. The parameters describing the waveguide discontinuities in disc-loaded waveguide are calculated by the variational method. Then the dispersion characteristics of slow-wave structures are obtained using lossless microwave quadrupole theory. Good agreement was observed between results of the Variational method and those of field matching method and high frequency structure simulator. In the case of broad band, results of the variational method are better than those of field matching method.展开更多
This paper investigates the properties of traveling wave-beam interaction in a rectangular helix traveling-wave-tube (TWT) for a solid sheet electron beam. The "hot" dispersion equation is obtained by means of the...This paper investigates the properties of traveling wave-beam interaction in a rectangular helix traveling-wave-tube (TWT) for a solid sheet electron beam. The "hot" dispersion equation is obtained by means of the self-consistent field theory. The small signal analysis,which includes the effects of the beam parameters and slow-wave structure (SWS) parameters,is carried out by theoretical computation. The numerical results show that the bandwidth and the small-signal gain of the rectangular helix TWT increase as the beam current increases;and the beam voltage not obviously influences the small signal gain. Among different rectangular helix structures,the small-signal gain increases as the width of the rectangular helix SWS increases,however,the bandwidth decreases whether structure parameters a and L or ψ and L are fixed or not.In addition,a comparison of the small-signal gain of this structure with a conventional round helix is made.The presented analysis will be useful for the design of the TWT with a rectangular helix circuit.展开更多
In order to solve the problem of using new nozzle is proposed in fire rescue robot. middle or low water pressure to form fine water mist, a Existing water mist nozzles are basically used for high pressure and in large...In order to solve the problem of using new nozzle is proposed in fire rescue robot. middle or low water pressure to form fine water mist, a Existing water mist nozzles are basically used for high pressure and in large size, complex structure and poor low pressure atomization effect in comparison with requirement of snake-like fire rescue robots. On the basis of comprehensive typical spray noz- zles, a direct spiral double helix converging nozzle (DSDHCN) is proposed, which has the advanta- ges of small volume, light weight, simple structure, and convenient installation. To make the spray nozzle have good performance, and meet the requirements of more efficient fire extinguishing, a nu- merical study is carried out to analyze the internal and external full flow field of nozzle. A gas-liquid two-phase flow is applied to simulate the external full flow field of nozzle with VOF model in fluent software. The simulation results show the real situation of water flow out of the atomization nozzle and the water jet trajectory. Some simulations about middle or low water pressure direct spiral double he- lix converging optimized nozzle have been done in 30bar pressure. The simulation results show that the optimized nozzle structure not only makes the spray droplets have a good cone angle, but also have a sufficient axial velocity,which proves the structure rationality of the proposed optimized nozzle.展开更多
Molecular dynamics method is used to study the conformation behavior of a semi-flexible polymer chain confined in a cylinder channel.A novel helix-like structure is found to form during the simulation.Moreover,the det...Molecular dynamics method is used to study the conformation behavior of a semi-flexible polymer chain confined in a cylinder channel.A novel helix-like structure is found to form during the simulation.Moreover,the detailed characteristic parameters and formation probability of these helix-like structures under moderate conditions are investigated.We find that the structure is not a perfect helix,but a bundle of elliptical turns.In addition,we conduct a statistical analysis for the chain monomer distribution along the radial direction.This research contributes to our understanding of the microscopic conformation of polymer chains in confined environments filled with a solvent.展开更多
The title compounds 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid(C11H9Cl N2O2, HL)(1) and [Cu(L)2(H2O)](2) were prepared and structurally characterized by elemental analysis, IR and single-crysta...The title compounds 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid(C11H9Cl N2O2, HL)(1) and [Cu(L)2(H2O)](2) were prepared and structurally characterized by elemental analysis, IR and single-crystal X-ray diffraction. Compound 1(C11H9Cl N2O2) crystallizes in the monoclinic system, space group P21/n with a = 7.249(3), b = 20.515(10), c = 7.249(3),β= 96.30°, V = 1071.6(9) ?3, Z = 4, Mr = 236.65, Dc = 1.467 g/cm3, F(000) = 488, GOOF = 1.029, μ= 0.341 mm-1, the final R = 0.0736 and w R = 0.1966 for 1500 observed reflections with I 〉 2σ(I). Compound 2(C22H18Cl2Cu N4O5) crystallizes in the monoclinic system, space group P21/c with a = 7.2931(6), b = 24.548(2), c = 13.2726(11), β= 99.4040(10)°, V = 2344.2(3) ?3, Z = 4, Mr = 552.84, Dc = 1.566 g/cm3, F(000) = 1124, GOOF = 1.050, μ= 1.201 mm-1, the final R = 0.0376 and w R = 0.1000 for 3626 observed reflections with I 〉 2σ(I). 1 and 2 are connected through hydrogen bonding interactions to generate 2D and 3D supramolecular structures, respectively. Moreover, the preliminary antibacterial activities of 1 and 2 against the gram positive bacteria(S. aureus, C. albicans and B. subtilis) and gram negative bacteria(E. coli and P. aeruginosa) have been tested by using the microdilution method, and the results indicate that 2 is more active than 1 against the tested bacteria.展开更多
The folded double-ridged waveguide structure is presented and its properties used for wide-band traveling-wave tube are investigated. Expressions of dispersion characteristics, normalized phase velocity and interactio...The folded double-ridged waveguide structure is presented and its properties used for wide-band traveling-wave tube are investigated. Expressions of dispersion characteristics, normalized phase velocity and interaction impedance of this structure are derived and numerically calculated. The calculated results using our theory agree well with those obtained by using the 3D electromagnetic simulation software HFSS. Influences of the ridge-loaded area and broad-wall dimensions on the high frequency characteristics of the novel slow-wave structure are discussed. It is shown that the folded double-ridged waveguide structure has a much wider relative passband than the folded waveguide slow-wave structure and a relative passband of 67% could be obtained, indicating that this structure can operate in broad-band frequency ranges of beam-wave interaction. The small signal gain property is investigated for ensuring the improvement of bandwidth. Meanwhile, with comparable dispersion characteristics, the transverse section dimension of this novel structure is much smaller than that of conventional one, which indicates an available way to reduce the weight of traveling-wave tube.展开更多
This paper studies the dispersion characteristics of a modified photonic band-gap slow-wave structure with an open boundary by simulation and experiment. A mode launcher with a wheel radiator and a coupling probe is p...This paper studies the dispersion characteristics of a modified photonic band-gap slow-wave structure with an open boundary by simulation and experiment. A mode launcher with a wheel radiator and a coupling probe is presented to excite a pure TM01-like mode. The cold test and simulation results show that the TM01-like mode is effectively excited and no parasitic modes appear. The dispersion characteristics obtained from the cold test are in good agreement with the calculated results.展开更多
Background:This study was conducted to determine protein molecular structure profiles and quantify the relationship between protein structural features and protein metabolism and bioavailability of blend pel eted prod...Background:This study was conducted to determine protein molecular structure profiles and quantify the relationship between protein structural features and protein metabolism and bioavailability of blend pel eted products(BPP)based on co-products(canola or carinata)from processing with different proportions of pulse pea screenings and lignosulfonate chemical compound.Method:The protein molecular structures were determined using the non-invasive advanced vibrational molecular spectroscopy(ATR-FT/IR)in terms of chemical structure and biofunctional groups of amides(ⅠandⅡ),α-helix andβ-sheet.Results:The results showed that increasing the level of the co-products in BPP significantly increased the spectral intensity of the amide area and amide height.The products exhibited similar protein secondaryα-helix toβ-sheet ratio.The protein molecular structure profiles(amidesⅠandⅡ,α-helix toβ-sheet)were highly associated with protein degradation kinetics and intestinal digestion.In conclusion,the non-invasive vibrational molecular spectroscopy(ATR-FT/IR)could be used to detect inherent structural make-up characteristics in BPP.Conclusion:The molecular structural features related to protein biopolymer were highly associated with protein utilization and metabolism.展开更多
Two 3D Ln-organic coordination frameworks(Ln = Pr3+ for 1 and Er3+ for 2) have been constructed. Single-crystal X-ray diffraction analysis reveals that the two complexes have similar structures and belong to the m...Two 3D Ln-organic coordination frameworks(Ln = Pr3+ for 1 and Er3+ for 2) have been constructed. Single-crystal X-ray diffraction analysis reveals that the two complexes have similar structures and belong to the monoclinic C2/c space group. The trans-μ4-(η2:η1)-(η1:η1) 1,2-pda2- anions link the LnIII centers to generate a 2D network containing helical motif. The dimensionality is extended into a 3D architecture through cis-bis(μ2-η2:η1) 1,2-pda2- anions linking. The geometry of Ln3+ ions is single-capped anti-square prism. Two complexes were characterized by IR spectra and thermogravimetric analysis. The solid fluorescence of 1 and 2 was also investigated at room temperature.展开更多
ERK is involved in multiple cell signaling pathways through its interacting proteins. By </span><i><span style="font-size:12px;font-family:Verdana;">in</span></i> <i><s...ERK is involved in multiple cell signaling pathways through its interacting proteins. By </span><i><span style="font-size:12px;font-family:Verdana;">in</span></i> <i><span style="font-size:12px;font-family:Verdana;">silico</span></i><span style="font-size:12px;font-family:Verdana;"> analysis, earlier we have identified 22 putative ERK interacting proteins namely;ephrin type-B receptor 2 isoform 2 precursor (EPHB2), mitogen-activated protein kinase 1</span></span><span "="" style="font-size:10pt;"> </span><span "="" style="font-size:10pt;"><span style="font-size:12px;font-family:Verdana;">(MAPK1), interleukin-17 receptor D precursor (IL17RD), WD repeat domain containing 83 (WDR83), </span><span style="font-size:12px;font-family:Verdana;">tescalcin (Tesc), mitogen-activated protein kinase kinase kinase 4 (MAPP3K4),</span><span style="font-size:12px;font-family:Verdana;"> kinase suppressor of Ras2 (KSR2), mitogen-activated protein kinase kinase 6 (MAP3K6), UL16 binding protein 2 (ULBP2), UL16 binding protein 1 (ULBP1), dual specificity phosphatase 14 (DUSP14), dual specificity phosphatase 6 (DUSP6), hyaluronan-mediated motility receptor (RHAMM), kinase D interacting substrate of 220</span></span><span "="" style="font-size:10pt;"> </span><span "="" style="font-size:12px;font-family:Verdana;">kDa (KININS220), membrane-associated guanylate kinase (MAGI3), phosphoprotein enriched in astrocytes 15</span><span "="" style="font-size:10pt;"> </span><span "="" style="font-size:12px;font-family:Verdana;">(PEA15), typtophenyl-tRNA synthetase, cytoplasmic (WARS), dual specificity phosphatase 9 (DUSP9), mitogen-activated protein kinase kinase kinase 1</span><span "="" style="font-size:10pt;"> </span><span "="" style="font-size:12px;font-family:Verdana;">(MAP3K1), UL16 binding protein 3 (ULBP3), SLAM family member 7 isoform a precursor (SLAMMF7) and mitogen activated protein kinase kinase kinase 11 (MAP3K11) (</span><span "="" style="font-size:10pt;"><a href="file:///E:/%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2021/0225-wqs-%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89(1)/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89/7-1390595.docx#T1"><b><span color:#943634;"="" style="font-size: 12px;font-family: Verdana;">Table 1</span></b></a></span><span "="" style="font-size:10pt;"><span style="font-size:12px;font-family:Verdana;">). However, prediction of secondary structure and domain/motif present in aforementioned ERK interacting proteins is not studied. In this paper, </span><i><span style="font-size:12px;font-family:Verdana;">in</span></i></span><i><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:12px;font-family:Verdana;" "="">silico</span></i><span "="" style="font-size:12px;font-family:Verdana;"> prediction of secondary structure of ERK interacting proteins was done by SOPMA and motif/domain identification using motif search. Briefly, SOPMA predicted higher random coil and alpha helix percentage in these proteins (</span><span "="" style="font-size:10pt;"><a href="file:///E:/%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2021/0225-wqs-%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89(1)/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89/7-1390595.docx#T2"><b><span color:#943634;"="" style="font-size: 12px;font-family: Verdana;">Table 2</span></b></a></span><span "="" style="font-size:12px;font-family:Verdana;">)</span><span "="" style="font-size:12px;font-family:Verdana;"> and</span><span "="" style="font-size:12px;font-family:Verdana;"> motif scan predicted serine/threonine kinases active site signature and protein kinase ATP binding region in majority of ERK interacting proteins. Moreover, few have commonly dual specificity protein phosphatase family and tyrosine specific protein phosphatase domains (</span><span "="" style="font-size:10pt;"><a href="file:///E:/%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2021/0225-wqs-%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89(1)/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89/7-1390595.docx#T3"><b><span color:#943634;"="" style="font-size: 12px;font-family: Verdana;">Table 3</span></b></a></span><span "="" style="font-size:12px;font-family:Verdana;">). Such study may be helpful to design engineered molecules for regulating ERK dependent pathways in disease condition.展开更多
Protein Secondary Structure Prediction (PSSP) is considered as one of the major challenging tasks in bioinformatics, so many solutions have been proposed to solve that problem via trying to achieve more accurate predi...Protein Secondary Structure Prediction (PSSP) is considered as one of the major challenging tasks in bioinformatics, so many solutions have been proposed to solve that problem via trying to achieve more accurate prediction results. The goal of this paper is to develop and implement an intelligent based system to predict secondary structure of a protein from its primary amino acid sequence by using five models of Neural Network (NN). These models are Feed Forward Neural Network (FNN), Learning Vector Quantization (LVQ), Probabilistic Neural Network (PNN), Convolutional Neural Network (CNN), and CNN Fine Tuning for PSSP. To evaluate our approaches two datasets have been used. The first one contains 114 protein samples, and the second one contains 1845 protein samples.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.61271029)the Natural Science Key Laboratory Foundationthe Natural Science Fund for Distinguished Young Scholars of China(Grant No.61125103)
文摘A novel slotted helix slow-wave structure (SWS) is proposed to develop a high power, wide-bandwidth, and high reliability millimeter-wave traveling-wave tube (TWT). This novel structure, which has higher heat capacity than a conven- tional helix SWS, evolves from conventional helix SWS with three parallel rows of rectangular slots made in the outside of the helix tape. In this paper, the electromagnetic characteristics and the beam-wave interaction of this novel structure operating in the Ka-band are investigated. From our calculations, when the designed beam voltage and beam current are set to be 18.45 kV and 0.2 A, respectively, this novel circuit can produce over 700-W average output power in a frequency range from 27.5 GHz to 32.5 GHz, and the corresponding conversion efficiency values vary from 19% to 21.3%, and the maximum output power is 787 W at 30 GHz.
基金Supported by the National Natural Science Foundation of China under grant no.69901004
文摘Based on the actual vane-loaded tape helix slow wave structure, a new theoretical analytic model for calculating coupling impedance is proposed by Chen Qingyou, et al.(1999)with calculated values of dispersion in good agreement with measured ones. In this paper, it is continued to use this model to calculate the coupling impedance of such a structure, and analyze the effects of the propagation power within vane gaps and the helix gap on the coupling impedance.As a result, the theoretical values are found to be in good agreement with the measured ones,with the maximum difference less than ±18%.
基金Project supported by the National Basic Research Program of China(Grant No.2014CB339801)the National High Technology Research and Development Program of China(Grant No.G060104012AA8122007B)
文摘A backward wave amplifier(BWA) in a terahertz regime with a novel slow-wave structure(SWS) composed of multi parallel grating pins inside a rectangular waveguide is analyzed. The multi-pin rectangular waveguide SWS possesses good performance and is compatible with micro-fabrication technologies. The dispersion and interaction impedance of the multipin SWS are presented. The stopbands of the modes cling together in a Brillouim zone. The SWS has a high interaction impedance that is suitable for the interaction of multi cylindrical beams. The design, which is based on three parallel pins supporting the wave–beam interaction with four cylindrical beams, is verified by three-dimensional particle-in-cell simulations. A BWA with the central frequency at 340 GHz is demonstrated, and the output power is more than 100 mW.A tuning frequency range of 15 GHz(333–348 GHz) is obtained with a gain of more than 20 dB.
基金Project supported by the National Natural Science Foundation for Distinguished Young Scholars of China (Grant No. 61125103)the National Natural Science Foundation of China (Grant Nos. 60971038 and 60971031)the Fundamental Research Funds for the Central Universities,China (Grant No. ZYGX2009Z003)
文摘A watt-class backward wave oscillator is proposed, using the concise sine waveguide slow-wave structure combined with a pencil electron beam to operate at 220 GHz. Firstly, the dispersion curve of the sine waveguide is calculated, then, the oscillation frequency and operating voltage of the device are predicted and the circuit transmission loss is calculated. Finally, the particle-in-cell simulation method is used to forecast its radiation performance. The results show that this novel backward wave oscillator can produce over 1-W continuous wave power output in a frequency range from 210 GHz to 230 GHz. Therefore, it will be considered as a very promising high-power millimeter-wave to terahertz-wave radiation source.
文摘The variational method is applied to calculate the dispersion characteristics of disc-loaded waveguide slow-wave structures. The parameters describing the waveguide discontinuities in disc-loaded waveguide are calculated by the variational method. Then the dispersion characteristics of slow-wave structures are obtained using lossless microwave quadrupole theory. Good agreement was observed between results of the Variational method and those of field matching method and high frequency structure simulator. In the case of broad band, results of the variational method are better than those of field matching method.
基金Project supported in part by the National Natural Science Foundation of China (Grant No 60532010)the Talent Fund of Chinese Education Administration
文摘This paper investigates the properties of traveling wave-beam interaction in a rectangular helix traveling-wave-tube (TWT) for a solid sheet electron beam. The "hot" dispersion equation is obtained by means of the self-consistent field theory. The small signal analysis,which includes the effects of the beam parameters and slow-wave structure (SWS) parameters,is carried out by theoretical computation. The numerical results show that the bandwidth and the small-signal gain of the rectangular helix TWT increase as the beam current increases;and the beam voltage not obviously influences the small signal gain. Among different rectangular helix structures,the small-signal gain increases as the width of the rectangular helix SWS increases,however,the bandwidth decreases whether structure parameters a and L or ψ and L are fixed or not.In addition,a comparison of the small-signal gain of this structure with a conventional round helix is made.The presented analysis will be useful for the design of the TWT with a rectangular helix circuit.
基金Supported by the National Natural Science Foundation of China(No.61105086)Self-Planned Task(SKLRS-2010-MS-12)of State Key Laboratory of Robotics and System(HIT)Hubei Province Natural Science Foundation(No.2010CDB03405)
文摘In order to solve the problem of using new nozzle is proposed in fire rescue robot. middle or low water pressure to form fine water mist, a Existing water mist nozzles are basically used for high pressure and in large size, complex structure and poor low pressure atomization effect in comparison with requirement of snake-like fire rescue robots. On the basis of comprehensive typical spray noz- zles, a direct spiral double helix converging nozzle (DSDHCN) is proposed, which has the advanta- ges of small volume, light weight, simple structure, and convenient installation. To make the spray nozzle have good performance, and meet the requirements of more efficient fire extinguishing, a nu- merical study is carried out to analyze the internal and external full flow field of nozzle. A gas-liquid two-phase flow is applied to simulate the external full flow field of nozzle with VOF model in fluent software. The simulation results show the real situation of water flow out of the atomization nozzle and the water jet trajectory. Some simulations about middle or low water pressure direct spiral double he- lix converging optimized nozzle have been done in 30bar pressure. The simulation results show that the optimized nozzle structure not only makes the spray droplets have a good cone angle, but also have a sufficient axial velocity,which proves the structure rationality of the proposed optimized nozzle.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11504033 and 11404290)the General Research Fund of Hong Kong Research Council of China(Grant No.15301014)
文摘Molecular dynamics method is used to study the conformation behavior of a semi-flexible polymer chain confined in a cylinder channel.A novel helix-like structure is found to form during the simulation.Moreover,the detailed characteristic parameters and formation probability of these helix-like structures under moderate conditions are investigated.We find that the structure is not a perfect helix,but a bundle of elliptical turns.In addition,we conduct a statistical analysis for the chain monomer distribution along the radial direction.This research contributes to our understanding of the microscopic conformation of polymer chains in confined environments filled with a solvent.
基金Supported by the National Natural Science Foundation of China(No.20662007)the Bureau of Education of Jiangxi Province(No.GJJ09064)Jiangxi Science and Technology Support Program(20112BBF60009)
文摘The title compounds 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid(C11H9Cl N2O2, HL)(1) and [Cu(L)2(H2O)](2) were prepared and structurally characterized by elemental analysis, IR and single-crystal X-ray diffraction. Compound 1(C11H9Cl N2O2) crystallizes in the monoclinic system, space group P21/n with a = 7.249(3), b = 20.515(10), c = 7.249(3),β= 96.30°, V = 1071.6(9) ?3, Z = 4, Mr = 236.65, Dc = 1.467 g/cm3, F(000) = 488, GOOF = 1.029, μ= 0.341 mm-1, the final R = 0.0736 and w R = 0.1966 for 1500 observed reflections with I 〉 2σ(I). Compound 2(C22H18Cl2Cu N4O5) crystallizes in the monoclinic system, space group P21/c with a = 7.2931(6), b = 24.548(2), c = 13.2726(11), β= 99.4040(10)°, V = 2344.2(3) ?3, Z = 4, Mr = 552.84, Dc = 1.566 g/cm3, F(000) = 1124, GOOF = 1.050, μ= 1.201 mm-1, the final R = 0.0376 and w R = 0.1000 for 3626 observed reflections with I 〉 2σ(I). 1 and 2 are connected through hydrogen bonding interactions to generate 2D and 3D supramolecular structures, respectively. Moreover, the preliminary antibacterial activities of 1 and 2 against the gram positive bacteria(S. aureus, C. albicans and B. subtilis) and gram negative bacteria(E. coli and P. aeruginosa) have been tested by using the microdilution method, and the results indicate that 2 is more active than 1 against the tested bacteria.
基金Project supported in part by the National Natural Science Foundation of China (Grant No. 60971038)in part by the Fundamental Research Funds for Central Universities,China (Grant No. ZYGX2009Z003)
文摘The folded double-ridged waveguide structure is presented and its properties used for wide-band traveling-wave tube are investigated. Expressions of dispersion characteristics, normalized phase velocity and interaction impedance of this structure are derived and numerically calculated. The calculated results using our theory agree well with those obtained by using the 3D electromagnetic simulation software HFSS. Influences of the ridge-loaded area and broad-wall dimensions on the high frequency characteristics of the novel slow-wave structure are discussed. It is shown that the folded double-ridged waveguide structure has a much wider relative passband than the folded waveguide slow-wave structure and a relative passband of 67% could be obtained, indicating that this structure can operate in broad-band frequency ranges of beam-wave interaction. The small signal gain property is investigated for ensuring the improvement of bandwidth. Meanwhile, with comparable dispersion characteristics, the transverse section dimension of this novel structure is much smaller than that of conventional one, which indicates an available way to reduce the weight of traveling-wave tube.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10975036 and 61071018)the Guangxi Natural Science Foundation,China (Grant No. 2010GXNSFB013049)
文摘This paper studies the dispersion characteristics of a modified photonic band-gap slow-wave structure with an open boundary by simulation and experiment. A mode launcher with a wheel radiator and a coupling probe is presented to excite a pure TM01-like mode. The cold test and simulation results show that the TM01-like mode is effectively excited and no parasitic modes appear. The dispersion characteristics obtained from the cold test are in good agreement with the calculated results.
基金financially supported by the grants from Sask Pulse Growers,Natural Sciences and Engineering Research Council of Canada(NSERC)the Sask Canola,the Ministry of Agriculture Strategic Research Chair ProgramSask Milk.
文摘Background:This study was conducted to determine protein molecular structure profiles and quantify the relationship between protein structural features and protein metabolism and bioavailability of blend pel eted products(BPP)based on co-products(canola or carinata)from processing with different proportions of pulse pea screenings and lignosulfonate chemical compound.Method:The protein molecular structures were determined using the non-invasive advanced vibrational molecular spectroscopy(ATR-FT/IR)in terms of chemical structure and biofunctional groups of amides(ⅠandⅡ),α-helix andβ-sheet.Results:The results showed that increasing the level of the co-products in BPP significantly increased the spectral intensity of the amide area and amide height.The products exhibited similar protein secondaryα-helix toβ-sheet ratio.The protein molecular structure profiles(amidesⅠandⅡ,α-helix toβ-sheet)were highly associated with protein degradation kinetics and intestinal digestion.In conclusion,the non-invasive vibrational molecular spectroscopy(ATR-FT/IR)could be used to detect inherent structural make-up characteristics in BPP.Conclusion:The molecular structural features related to protein biopolymer were highly associated with protein utilization and metabolism.
基金supported by the National Natural Science Foundation of China(21373178)the provincial college students’ innovation and entrepreneurship training program(1238)the Natural Science Foundation of Yanan university(YDZ2013-09)
文摘Two 3D Ln-organic coordination frameworks(Ln = Pr3+ for 1 and Er3+ for 2) have been constructed. Single-crystal X-ray diffraction analysis reveals that the two complexes have similar structures and belong to the monoclinic C2/c space group. The trans-μ4-(η2:η1)-(η1:η1) 1,2-pda2- anions link the LnIII centers to generate a 2D network containing helical motif. The dimensionality is extended into a 3D architecture through cis-bis(μ2-η2:η1) 1,2-pda2- anions linking. The geometry of Ln3+ ions is single-capped anti-square prism. Two complexes were characterized by IR spectra and thermogravimetric analysis. The solid fluorescence of 1 and 2 was also investigated at room temperature.
文摘ERK is involved in multiple cell signaling pathways through its interacting proteins. By </span><i><span style="font-size:12px;font-family:Verdana;">in</span></i> <i><span style="font-size:12px;font-family:Verdana;">silico</span></i><span style="font-size:12px;font-family:Verdana;"> analysis, earlier we have identified 22 putative ERK interacting proteins namely;ephrin type-B receptor 2 isoform 2 precursor (EPHB2), mitogen-activated protein kinase 1</span></span><span "="" style="font-size:10pt;"> </span><span "="" style="font-size:10pt;"><span style="font-size:12px;font-family:Verdana;">(MAPK1), interleukin-17 receptor D precursor (IL17RD), WD repeat domain containing 83 (WDR83), </span><span style="font-size:12px;font-family:Verdana;">tescalcin (Tesc), mitogen-activated protein kinase kinase kinase 4 (MAPP3K4),</span><span style="font-size:12px;font-family:Verdana;"> kinase suppressor of Ras2 (KSR2), mitogen-activated protein kinase kinase 6 (MAP3K6), UL16 binding protein 2 (ULBP2), UL16 binding protein 1 (ULBP1), dual specificity phosphatase 14 (DUSP14), dual specificity phosphatase 6 (DUSP6), hyaluronan-mediated motility receptor (RHAMM), kinase D interacting substrate of 220</span></span><span "="" style="font-size:10pt;"> </span><span "="" style="font-size:12px;font-family:Verdana;">kDa (KININS220), membrane-associated guanylate kinase (MAGI3), phosphoprotein enriched in astrocytes 15</span><span "="" style="font-size:10pt;"> </span><span "="" style="font-size:12px;font-family:Verdana;">(PEA15), typtophenyl-tRNA synthetase, cytoplasmic (WARS), dual specificity phosphatase 9 (DUSP9), mitogen-activated protein kinase kinase kinase 1</span><span "="" style="font-size:10pt;"> </span><span "="" style="font-size:12px;font-family:Verdana;">(MAP3K1), UL16 binding protein 3 (ULBP3), SLAM family member 7 isoform a precursor (SLAMMF7) and mitogen activated protein kinase kinase kinase 11 (MAP3K11) (</span><span "="" style="font-size:10pt;"><a href="file:///E:/%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2021/0225-wqs-%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89(1)/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89/7-1390595.docx#T1"><b><span color:#943634;"="" style="font-size: 12px;font-family: Verdana;">Table 1</span></b></a></span><span "="" style="font-size:10pt;"><span style="font-size:12px;font-family:Verdana;">). However, prediction of secondary structure and domain/motif present in aforementioned ERK interacting proteins is not studied. In this paper, </span><i><span style="font-size:12px;font-family:Verdana;">in</span></i></span><i><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:12px;font-family:Verdana;" "="">silico</span></i><span "="" style="font-size:12px;font-family:Verdana;"> prediction of secondary structure of ERK interacting proteins was done by SOPMA and motif/domain identification using motif search. Briefly, SOPMA predicted higher random coil and alpha helix percentage in these proteins (</span><span "="" style="font-size:10pt;"><a href="file:///E:/%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2021/0225-wqs-%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89(1)/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89/7-1390595.docx#T2"><b><span color:#943634;"="" style="font-size: 12px;font-family: Verdana;">Table 2</span></b></a></span><span "="" style="font-size:12px;font-family:Verdana;">)</span><span "="" style="font-size:12px;font-family:Verdana;"> and</span><span "="" style="font-size:12px;font-family:Verdana;"> motif scan predicted serine/threonine kinases active site signature and protein kinase ATP binding region in majority of ERK interacting proteins. Moreover, few have commonly dual specificity protein phosphatase family and tyrosine specific protein phosphatase domains (</span><span "="" style="font-size:10pt;"><a href="file:///E:/%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2021/0225-wqs-%E5%B7%A5%E4%BD%9C%E8%AE%B0%E5%BD%95/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89(1)/2%E6%9C%88%20WJNS11.1%20%E6%8F%92%E9%A1%B5%E7%A0%81%20%E4%BB%98%E5%96%9C%E4%BB%81%20%EF%BC%887%EF%BC%89/7-1390595.docx#T3"><b><span color:#943634;"="" style="font-size: 12px;font-family: Verdana;">Table 3</span></b></a></span><span "="" style="font-size:12px;font-family:Verdana;">). Such study may be helpful to design engineered molecules for regulating ERK dependent pathways in disease condition.
文摘Protein Secondary Structure Prediction (PSSP) is considered as one of the major challenging tasks in bioinformatics, so many solutions have been proposed to solve that problem via trying to achieve more accurate prediction results. The goal of this paper is to develop and implement an intelligent based system to predict secondary structure of a protein from its primary amino acid sequence by using five models of Neural Network (NN). These models are Feed Forward Neural Network (FNN), Learning Vector Quantization (LVQ), Probabilistic Neural Network (PNN), Convolutional Neural Network (CNN), and CNN Fine Tuning for PSSP. To evaluate our approaches two datasets have been used. The first one contains 114 protein samples, and the second one contains 1845 protein samples.