Aplastic anemia is a kind of disease mainly manifested by bone marrow failure.Autophagy is very important for cells to adjust the changes and maintain the balance of themselves.Patients with AA suffer from defects in ...Aplastic anemia is a kind of disease mainly manifested by bone marrow failure.Autophagy is very important for cells to adjust the changes and maintain the balance of themselves.Patients with AA suffer from defects in autophagy function,and the level of autophagy is closely related to the pathogenesis of AA.Autophagy may influence the proliferation and differentiation of HSC and their functional,hematopoietic microenvironmental and immune response,thereby mediating the occurrence and development of AA.This review will summarize the role of HSC,hematopoietic microenvironment and immune response in the pathogenesis of AA,and further elaborated the application of autophagy in regulating T cell subsets and the autophagy function of Treg cells in the treatment of AA.展开更多
基金National Natural Science Foundation of China(No.81774080)。
文摘Aplastic anemia is a kind of disease mainly manifested by bone marrow failure.Autophagy is very important for cells to adjust the changes and maintain the balance of themselves.Patients with AA suffer from defects in autophagy function,and the level of autophagy is closely related to the pathogenesis of AA.Autophagy may influence the proliferation and differentiation of HSC and their functional,hematopoietic microenvironmental and immune response,thereby mediating the occurrence and development of AA.This review will summarize the role of HSC,hematopoietic microenvironment and immune response in the pathogenesis of AA,and further elaborated the application of autophagy in regulating T cell subsets and the autophagy function of Treg cells in the treatment of AA.
