Objective To study the clinical and histological features of chronic hepatitis B (CHB) with negative hepatitis B e-antigen (HBeAg).Methods A tatal of 743 in-patients with chronic hepatitis B were recruited into the st...Objective To study the clinical and histological features of chronic hepatitis B (CHB) with negative hepatitis B e-antigen (HBeAg).Methods A tatal of 743 in-patients with chronic hepatitis B were recruited into the study and divided into two groups according to the HBeAg status. The correlation among alanine transaminase (ALT) levels, hepatitis B virus (HBV) DNA semiquantification, and the liver histopathological data were dectected.Results Of the 743 successive in-patients, 267 (35.9%) were HBeAg-negative. The HBDAG-negative group had significantly lower serologic HBV DNA levels (63.0% of < 100 pg/ml) vs HBeAg-positive (42.6%, P<0. 001), while more sever inflammation (58. 1% of inflammatory scores of histological activeity index (HAIinf≥9) vs HBeAg-positive group (46.0%, P< 0.001) and severe fibrosis (45.3% of fibrosis scores of histological activity index (HAIfib≥3) vs HBeAg-positive group (27.9%, P < 0. 001 ) of liver histology. In HBeAg-positive patients, increasing ALI levels were significantly associated with high inflammation and fiborsis scores and low HBV DNA levels. However, it was not the case in the HBeAg-negative cases. In HBeAg-positive patients, 91. 3% of them had HAIinf≥9 and 65.7% had HAIfib≥3 with HBV DNA >100 pg/ml, while 8.2% of them had HAIinf≥9 and 12.3% had HAIfib≥3 with HBV DNA<20 pg/ml, indicating an obverse correlation between HBV DNA levels and histology scores.Conclusions As regards clinical and histological background, the chronic HBeAg-negative hepatitis B is a different subpopulation from the HBeAg-positive counterpart.展开更多
文摘Objective To study the clinical and histological features of chronic hepatitis B (CHB) with negative hepatitis B e-antigen (HBeAg).Methods A tatal of 743 in-patients with chronic hepatitis B were recruited into the study and divided into two groups according to the HBeAg status. The correlation among alanine transaminase (ALT) levels, hepatitis B virus (HBV) DNA semiquantification, and the liver histopathological data were dectected.Results Of the 743 successive in-patients, 267 (35.9%) were HBeAg-negative. The HBDAG-negative group had significantly lower serologic HBV DNA levels (63.0% of < 100 pg/ml) vs HBeAg-positive (42.6%, P<0. 001), while more sever inflammation (58. 1% of inflammatory scores of histological activeity index (HAIinf≥9) vs HBeAg-positive group (46.0%, P< 0.001) and severe fibrosis (45.3% of fibrosis scores of histological activity index (HAIfib≥3) vs HBeAg-positive group (27.9%, P < 0. 001 ) of liver histology. In HBeAg-positive patients, increasing ALI levels were significantly associated with high inflammation and fiborsis scores and low HBV DNA levels. However, it was not the case in the HBeAg-negative cases. In HBeAg-positive patients, 91. 3% of them had HAIinf≥9 and 65.7% had HAIfib≥3 with HBV DNA >100 pg/ml, while 8.2% of them had HAIinf≥9 and 12.3% had HAIfib≥3 with HBV DNA<20 pg/ml, indicating an obverse correlation between HBV DNA levels and histology scores.Conclusions As regards clinical and histological background, the chronic HBeAg-negative hepatitis B is a different subpopulation from the HBeAg-positive counterpart.
