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诠释学文本内部循环下的炙甘草汤方义探讨 被引量:6
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作者 张涛 姜丁荣 +2 位作者 张丽丽 杨瑾 张国骏 《河南中医》 2013年第5期636-637,共2页
通过比较《伤寒论》第21条与第177条原文的异同,探讨炙甘草汤的适用证候及配伍意义。基于诠释学文本内部循环方法分析,炙甘草汤药物组成应该分为:桂枝去芍药汤和滋阴养血两部分,其主要功用是"通阳养血"。
关键词 炙甘草汤 桂枝去芍药汤 “胸满” “心动悸” “脉促” “脉结代” 诠释学循环 《伤寒论》 张仲景
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PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells 被引量:8
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作者 Qing Yang Zi-Lian Cui +6 位作者 Qin Wang Xun-Bo Jin Yong Zhao Mu-Wen Wang Wei Song Hua-Wei Qu Wei-Ting Kang 《Asian Journal of Andrology》 SCIE CAS CSCD 2017年第4期453-457,共5页
To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal t... To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. LNCaP cells were divided into a control group and an LNCaP-PlncRNA-I-siRNA experimental group. Normal prostate RWPE-1 cells were divided into an RWPE-1 control group and an RWPE-1-PlncRNA-1 experimental group. After PlncRNA-1 silencing and overexpression, changes in Her-2 and cyclinD1 expression levels were detected both in vivo and in vitro. In prostate cancer tissues, Her-2 and PIncRNA-1 were highly expressed and significantly correlated. In LNCaP cells, the expression of Her-2 and cyclinD1 decreased following the downregulation of PlncRNA-1 as assessed by real-time PCR and Western blotting. In RWPE-1 cells, the expression of Her-2 and cyclinD1 increased following PlncRNA-1 overexpression. Flow cytometry revealed that the proportion of LNCaP cells in G2/M phase was significantly increased after PlncRNA-1 silencing and that the proportion of RWPE-1 cells in G2/M phase was significantly decreased after PlncRNA-1 overexpression. Furthermore, animal experiments validated these results. In conclusion, in prostate cancer, PlncRNA-1 regulates the cell cycle and cyclinD1 levels and can also regulate proliferation and apoptosis in prostate cancer cells through the Her-2 pathway. 展开更多
关键词 APOPTOSIS cell cycle her-2 LNCAP long noncoding RNA PlncRNA-1 prostate cancer
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