The vehicles with high gravity centre are more prone to roll over. The paper deals with a method of dynamics analysis of fire engines which is an example of these types of vehicle. Algorithms for generating the equati...The vehicles with high gravity centre are more prone to roll over. The paper deals with a method of dynamics analysis of fire engines which is an example of these types of vehicle. Algorithms for generating the equations of motion have been formulated by homogenous transformations and Lagrange's equation. The model presented in this article consists of a system of rigid bodies connected one with another forming an open kinematic chain. Road maneuvers such as a lane change and negotiating a circular track have been presented as the main simulations when a car loses its stability. The method has been verified by comparing numerical results with results obtained by experimental measurements performed during road tests.展开更多
The superfine BaCO3 particles were synthesized by high gravity technology with BaCl·2H2O and Na2CO3 as the raw materials. The changes of particle size and morphology were studied by adding different amount of EDT...The superfine BaCO3 particles were synthesized by high gravity technology with BaCl·2H2O and Na2CO3 as the raw materials. The changes of particle size and morphology were studied by adding different amount of EDTA, and rod-like, near-spherical and cylindrical shape BaCO3 were prepared. The BaCO3 particles were analyzed and characterized by TG/SDAT, SEM, XRD and FT-IR. The results indicated that the crystal transformation temperature and decomposition temperature of BaCO3 had increased because of EDTA addition. With the increase of EDTA amount, the shape of BaCO3 changed from irregular rod-like to near-spherical then to cylindrical shape. All different shape BaCO3 adopts orthorhombic crystal systems.展开更多
Mass production of nanoparticles at low cost has attracted much attention from industrial and academic circles. In this paper, a novel method, the high gravity reactive precipitation (HGRP) technology, of manufacturin...Mass production of nanoparticles at low cost has attracted much attention from industrial and academic circles. In this paper, a novel method, the high gravity reactive precipitation (HGRP) technology, of manufacturing CaCO3 nanoparticles, presently scaled-up to an annual capacity of 10,000 tons, is presented. This paper describes the process principle, the process design and experiments on the syntheses of 15-30 nm CaCO3, 30-50 nm SiO2, 20-30 nm TiO2, 20-60 nm ZnO, 20-30 nm ZnS, 30 nm SrCO3, 40-70 nm BaTiO3, stick-like nano BaCO3 as well as nano-fibrillar aluminum hydroxide measuring 1-10 nm in diameter and 50-300 nm in length, using liquid-liquid, gas-liquid and gas-liquid-solid reactant systems. The advantage of using the HGRP technology is illustrated by comparison to conventional methods.展开更多
Fast chemical reactions involved in nanomaterials synthesis, polymerization, special chemicals production, reactive absorption, etc., are often difficult to control in terms of product quality, process efficiency and ...Fast chemical reactions involved in nanomaterials synthesis, polymerization, special chemicals production, reactive absorption, etc., are often difficult to control in terms of product quality, process efficiency and production consistency. After a theoretical analysis on such processes based on chemical reaction engineering fundamentals, an idea to intensify micromixing (mixing on the molecular scale) and mass transfer and therefore to control the process ideally was proposed. By experimental investigations of mass transfer and micromixing characteristics in the Rotating Packed Bed (RPB, or 'HIGEE' device), we achieved unique intense micromixing. This led us to the invention of using RPB as a reactor for the fabrication of nanoparticles (Chen et al., 2000).展开更多
In this work,we report an innovative route for the synthesis of rare-earth doped calcium molybdate(CaMoO4)nanophosphors by using high gravity rotating packed bed(RPB)technology and paraffin liquid as the solvent.The s...In this work,we report an innovative route for the synthesis of rare-earth doped calcium molybdate(CaMoO4)nanophosphors by using high gravity rotating packed bed(RPB)technology and paraffin liquid as the solvent.The significant intensified mass transfer and micromixing of reactants in the RPB reactor are benefiting for homogeneous doping of rare-earth ions in the host materials,leading to nanophosphors with high quantum efficiency.The use of liquid paraffin as the solvent eliminates the safety risks associated with volatile organic compounds,increasing the potential for clean production of nanophosphors.Under excitation of deep ultraviolet(DUV)light,the CaMoO4:Na+,Eu3+nanophosphors exhibit red emission at peak wavelength of 615 nm and quantum yield of up to 35.01%.The CaMoO4:Na+,Tb3+nanophosphors exhibit green emission at peak wavelength of543 nm with quantum yield of up to 30.66%.The morphologies of the nanophosphors are tunable from nanofibers through nanorods to nanodots and the possible mechanism of controlling the formation of different nanostructures is proposed on the basis of experimental results and theoretical analysis of mesoscience.These nanophosphors are highly dispersible in organic solvents and utilized for fabricating fabrication of flexible,freestanding luminescent films based on silicone resin.We also demonstrate the red LEDs consisting of the hybrid films of CaMoO4:Na+,Eu3+nanoparticles as color-converting phosphors and DUV LEDs as illuminators,offering strong potential for future nanophosphors-basedsolid-state lighting systems.展开更多
A new method of high-gravity combustion synthesis(HGCS)followed by post-treatment(PT)is reported for preparing high-performance high-entropy alloys(HEAs),Cr0.9FeNi2.5V0.2Al0.5 alloy,whereby cheap thermite powder is us...A new method of high-gravity combustion synthesis(HGCS)followed by post-treatment(PT)is reported for preparing high-performance high-entropy alloys(HEAs),Cr0.9FeNi2.5V0.2Al0.5 alloy,whereby cheap thermite powder is used as the raw material.In this process,the HEA melt and the ceramic melt are rapidly formed by a strong exothermic combustion synthesis reaction and completely separated under a high-gravity field.Then,the master alloy is obtained after cooling.Subsequently,the master alloy is sequentially subjected to conventional vacuum arc melting(VAM),homogenization treatment,cold rolling,and annealing treatment to realize a tensile strength,yield strength,and elongation of 1250 MPa,1075 MPa,and 2.9%,respectively.The present method is increasingly attractive due to its low cost of raw materials and the intermediate product obtained without high-temperature heating.Based on the calculation of phase separation kinetics in the high-temperature melt,it is expected that the final alloys with high performance can be prepared directly across master alloys with higher high-gravity coefficients.展开更多
This study investigated the indirect oxidation of nitrobenzene(NB)by hydroxyl radicals(·OH)in a rotating packed bed(RPB)using competitive kinetics method with p-nitrochlorobenzene as a reference compound.The rate...This study investigated the indirect oxidation of nitrobenzene(NB)by hydroxyl radicals(·OH)in a rotating packed bed(RPB)using competitive kinetics method with p-nitrochlorobenzene as a reference compound.The rate constants of NB with·OH are calculated to be between(1.465±0.113)×10^(9)L/(mol·s)and(2.497±0.192)×10^(9)L/(mol·s).The experimental data are fitted by the modified Arrhenius equation,where the activation energy is 4877.74 J/mol,the order of NB concentration,rotation speed,and initial pH is 0.2425,0.1400 and 0.0167,respectively.The ozonation process of NB could be enhanced by RPB,which is especially effective for highly concentrated NB-containing waste-water under alkaline conditions.The high gravity technology can accelerate ozone mass transfer and self-decomposition of ozone to produce more·OH,resulting in an increase in the indirect oxidation rate of NB by·OH and consequently effective degradation of NB in wastewater.展开更多
The novel ceramic/metal composite materials were successfully fabricated by combustion synthesis in high gravity field.In this paper,the Ti-B_(4)C was selected as the main combustion reaction system to obtain TiB_(2)-...The novel ceramic/metal composite materials were successfully fabricated by combustion synthesis in high gravity field.In this paper,the Ti-B_(4)C was selected as the main combustion reaction system to obtain TiB_(2)-TiC ceramic substrate,and the 1Cr18Ni9Ti stainless steel was selected as the metal substrate.It was found that the TiB_(2)-TiC/1Cr18Ni9Ti composite materials exhibited continuously graded composition and hybrid microstructure.The TiC1-x carbides and TiB_(2)platelets decreased gradually in size and volume fraction from the ceramic to stainless steel.Due to the rapid action of thermal explosion as well as the dissolution of the molten stainless steel into TiB_(2)-TiC liquid,the diffusion-controlled concentration gradient from the ceramic liquid to the alloy liquid was observed.Finally,as a result of the rapid sequent solidification of the ceramic liquid and the melt alloy surface,the laminated composite materials were achieved in multilevel,scale-span hybrid microstructure.展开更多
Due to its merits of drought tolerance and high yield,sweet potatoes are widely considered as a potential alterative feedstock for bioethanol production.Very high gravity(VHG)technology is an effective strategy for im...Due to its merits of drought tolerance and high yield,sweet potatoes are widely considered as a potential alterative feedstock for bioethanol production.Very high gravity(VHG)technology is an effective strategy for improving the efficiency of ethanol fermentation from starch materials.However,this technology has rarely been applied to sweet potatoes because of the high viscosity of their liquid mash.To overcome this problem,cellulase was added to reduce the high viscosity,and the optimal dosage and treatment time were 8 U/g(sweet potato powder)and 1 h,respectively.After pretreatment by cellulase,the viscosity of the VHG sweet potato mash(containing 284.2 g/L of carbohydrates)was reduced by 81%.After liquefaction and simultaneous saccharification and fer-mentation(SSF),thefinal ethanol concentration reached 15.5%(v/v),and the total sugar conversion and ethanol yields were 96.5%and 87.8%,respectively.展开更多
The author argues in this document that initial vacuum state values possibly responsible for GW generation in relic conditions in the initial onset of inflation may have a temporary unsqueezed, possibly even coherent ...The author argues in this document that initial vacuum state values possibly responsible for GW generation in relic conditions in the initial onset of inflation may have a temporary unsqueezed, possibly even coherent initial value, which would permit in certain models classical coherent initial gravitational wave states. Furthermore, several arguments pro and con as to if or not initial relic GW should be high frequency will be presented, with the reason given why earlier string models did NOT favor low frequency relic GW from the big bang. What is observed is that large higher dimensions above our 4 Dimensional space time, if recipients of matter-energy from collapse and re birth of the universe are enough to insure low relic GW. The existence of higher dimensions, in itself if the additional dimensions are small and compact will have no capacity to lower the frequency limit values of relic GW, as predicted by Giovannini, et al. in 1995.展开更多
In this study, a classic survey adjustment computation method was used for data obtained in the Inner Mongolia and Ningxia gravimetric networks between September 2013 and April 2015 so as to investigate the variation ...In this study, a classic survey adjustment computation method was used for data obtained in the Inner Mongolia and Ningxia gravimetric networks between September 2013 and April 2015 so as to investigate the variation of gravity before the Alxa Zuoqi M5.8 earthquake. The relationship between gravity variation and the Alxa Zuoqi M5.8 earthquake was analyzed. The results showed that: (1) the severe variation in gravity field at the test sites before the Alxa Zuoqi M5.8 earthquake, as well as the subsequent accelerated rising, might be an earthquake precursor; (2) the Alxa Zuoqi M5.8 earthquake occurred at the turning point where the high-gravity gradient zone changed from the NE direction to NW.展开更多
To study the effect of a strong underwater shock wave on a concrete dam, this research aims to improve hammer impact methods in model tests. Six 1:200 scale models were designed and tested under distributed impact loa...To study the effect of a strong underwater shock wave on a concrete dam, this research aims to improve hammer impact methods in model tests. Six 1:200 scale models were designed and tested under distributed impact loads. A device was deployed for a direct measurement of the impact force at the upstream face of the dams. The model dam bases were anchored to prevent displacement. The experimental results indicate that the top part of the concrete dam is a weak zone, and the impact failure initiates with a fracture on the top of the dam. The peak value of impact stress increases when the second crack appears in the concrete dam from the upstream face to the downstream face. And, the level of the second crack in the dam body is lower as the peak value of impact stress increases. In this study, dynamic analysis was conducted by calculating the results to verify the effectiveness of a device to directly measure the impact force. This method may be used to approximately forecast the damage of concrete dam and may also be useful in other engineering applications.展开更多
This paper reviews our work on the fundamental principles of high gravity controlled precipitation (HGCP) technology, and its applications in the production of drug nanoparticles, which was carried out in a rotating p...This paper reviews our work on the fundamental principles of high gravity controlled precipitation (HGCP) technology, and its applications in the production of drug nanoparticles, which was carried out in a rotating packed bed (RPB). Several kinds of drug nanoparticles with narrow particle size distributions (PSDs) were successfully prepared via HGCP, including the 300-nm Cefuroxime Axetil (CFA) particles, 200–400-nm cephradine particles, 500-nm salbutamol sulfate (SS) particles (100 nm in width), and 850-nm beclomethasone dipropionate (BDP) particles, etc. Compared to drugs available in the current market, all the drug nanoparticles produced by HGCP exhibited advantages in both formulation and drug delivery, thus improving the bioavailability of drugs. HGCP is essentially a platform technology for the preparation of poorly water-soluble drug nanoparticles for oral and injection delivery, and of inhalable drugs for pulmonary delivery. Consequently, HGCP offers potential applications in the pharmaceutical industry due to its cost-effectiveness, efficient processing and the ease of scaling-up.展开更多
基金supported by National Science Centre in Cracow under doctoral research grant 0630/B/T02/2011/40
文摘The vehicles with high gravity centre are more prone to roll over. The paper deals with a method of dynamics analysis of fire engines which is an example of these types of vehicle. Algorithms for generating the equations of motion have been formulated by homogenous transformations and Lagrange's equation. The model presented in this article consists of a system of rigid bodies connected one with another forming an open kinematic chain. Road maneuvers such as a lane change and negotiating a circular track have been presented as the main simulations when a car loses its stability. The method has been verified by comparing numerical results with results obtained by experimental measurements performed during road tests.
基金Supported by the Open Fund of State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials(10zxfk38)
文摘The superfine BaCO3 particles were synthesized by high gravity technology with BaCl·2H2O and Na2CO3 as the raw materials. The changes of particle size and morphology were studied by adding different amount of EDTA, and rod-like, near-spherical and cylindrical shape BaCO3 were prepared. The BaCO3 particles were analyzed and characterized by TG/SDAT, SEM, XRD and FT-IR. The results indicated that the crystal transformation temperature and decomposition temperature of BaCO3 had increased because of EDTA addition. With the increase of EDTA amount, the shape of BaCO3 changed from irregular rod-like to near-spherical then to cylindrical shape. All different shape BaCO3 adopts orthorhombic crystal systems.
基金This work was fnancially supported by National Natural Science Foundation of China(No.20236020 and 50272008)Special Research Fund of Doctoral Subjects of Chinese Universities(No.20010010004)Fok Ying Tung Foundation.
文摘Mass production of nanoparticles at low cost has attracted much attention from industrial and academic circles. In this paper, a novel method, the high gravity reactive precipitation (HGRP) technology, of manufacturing CaCO3 nanoparticles, presently scaled-up to an annual capacity of 10,000 tons, is presented. This paper describes the process principle, the process design and experiments on the syntheses of 15-30 nm CaCO3, 30-50 nm SiO2, 20-30 nm TiO2, 20-60 nm ZnO, 20-30 nm ZnS, 30 nm SrCO3, 40-70 nm BaTiO3, stick-like nano BaCO3 as well as nano-fibrillar aluminum hydroxide measuring 1-10 nm in diameter and 50-300 nm in length, using liquid-liquid, gas-liquid and gas-liquid-solid reactant systems. The advantage of using the HGRP technology is illustrated by comparison to conventional methods.
文摘Fast chemical reactions involved in nanomaterials synthesis, polymerization, special chemicals production, reactive absorption, etc., are often difficult to control in terms of product quality, process efficiency and production consistency. After a theoretical analysis on such processes based on chemical reaction engineering fundamentals, an idea to intensify micromixing (mixing on the molecular scale) and mass transfer and therefore to control the process ideally was proposed. By experimental investigations of mass transfer and micromixing characteristics in the Rotating Packed Bed (RPB, or 'HIGEE' device), we achieved unique intense micromixing. This led us to the invention of using RPB as a reactor for the fabrication of nanoparticles (Chen et al., 2000).
基金financial support from the National Key Research and Development Program of China(2017YFB0404302/2017YFB0404300)National Natural Science Foundation of China(21808009,91934303)the Beijing Natural Science Foundation(2182051)。
文摘In this work,we report an innovative route for the synthesis of rare-earth doped calcium molybdate(CaMoO4)nanophosphors by using high gravity rotating packed bed(RPB)technology and paraffin liquid as the solvent.The significant intensified mass transfer and micromixing of reactants in the RPB reactor are benefiting for homogeneous doping of rare-earth ions in the host materials,leading to nanophosphors with high quantum efficiency.The use of liquid paraffin as the solvent eliminates the safety risks associated with volatile organic compounds,increasing the potential for clean production of nanophosphors.Under excitation of deep ultraviolet(DUV)light,the CaMoO4:Na+,Eu3+nanophosphors exhibit red emission at peak wavelength of 615 nm and quantum yield of up to 35.01%.The CaMoO4:Na+,Tb3+nanophosphors exhibit green emission at peak wavelength of543 nm with quantum yield of up to 30.66%.The morphologies of the nanophosphors are tunable from nanofibers through nanorods to nanodots and the possible mechanism of controlling the formation of different nanostructures is proposed on the basis of experimental results and theoretical analysis of mesoscience.These nanophosphors are highly dispersible in organic solvents and utilized for fabricating fabrication of flexible,freestanding luminescent films based on silicone resin.We also demonstrate the red LEDs consisting of the hybrid films of CaMoO4:Na+,Eu3+nanoparticles as color-converting phosphors and DUV LEDs as illuminators,offering strong potential for future nanophosphors-basedsolid-state lighting systems.
基金the National Natural Science Foundation of China(No.51702332)the Key Research Projects in Gansu Province(No.17YF1GA020)the CAS Key Laboratory of Cryogenics,Technical Institute of Physics and Chemistry(Youth Innovation Fund No.CRYOQN201705).
文摘A new method of high-gravity combustion synthesis(HGCS)followed by post-treatment(PT)is reported for preparing high-performance high-entropy alloys(HEAs),Cr0.9FeNi2.5V0.2Al0.5 alloy,whereby cheap thermite powder is used as the raw material.In this process,the HEA melt and the ceramic melt are rapidly formed by a strong exothermic combustion synthesis reaction and completely separated under a high-gravity field.Then,the master alloy is obtained after cooling.Subsequently,the master alloy is sequentially subjected to conventional vacuum arc melting(VAM),homogenization treatment,cold rolling,and annealing treatment to realize a tensile strength,yield strength,and elongation of 1250 MPa,1075 MPa,and 2.9%,respectively.The present method is increasingly attractive due to its low cost of raw materials and the intermediate product obtained without high-temperature heating.Based on the calculation of phase separation kinetics in the high-temperature melt,it is expected that the final alloys with high performance can be prepared directly across master alloys with higher high-gravity coefficients.
基金the Specialized Research Fund for Sanjin Scholars Program of Shanxi Province(No.201707)Key Research&Development Plan of Shanxi Province(No.201903D321059)+1 种基金Shanxi Scholarship Council of China(No.HGKY2019071)Transformation and Cultivation Projects of Scientific and Technological Achievements of Higher Education Institutions for Shanxi Province(No.2020CG040).
文摘This study investigated the indirect oxidation of nitrobenzene(NB)by hydroxyl radicals(·OH)in a rotating packed bed(RPB)using competitive kinetics method with p-nitrochlorobenzene as a reference compound.The rate constants of NB with·OH are calculated to be between(1.465±0.113)×10^(9)L/(mol·s)and(2.497±0.192)×10^(9)L/(mol·s).The experimental data are fitted by the modified Arrhenius equation,where the activation energy is 4877.74 J/mol,the order of NB concentration,rotation speed,and initial pH is 0.2425,0.1400 and 0.0167,respectively.The ozonation process of NB could be enhanced by RPB,which is especially effective for highly concentrated NB-containing waste-water under alkaline conditions.The high gravity technology can accelerate ozone mass transfer and self-decomposition of ozone to produce more·OH,resulting in an increase in the indirect oxidation rate of NB by·OH and consequently effective degradation of NB in wastewater.
基金sponsored by the National Natural Science Foundation of China(Grant No.51072229).
文摘The novel ceramic/metal composite materials were successfully fabricated by combustion synthesis in high gravity field.In this paper,the Ti-B_(4)C was selected as the main combustion reaction system to obtain TiB_(2)-TiC ceramic substrate,and the 1Cr18Ni9Ti stainless steel was selected as the metal substrate.It was found that the TiB_(2)-TiC/1Cr18Ni9Ti composite materials exhibited continuously graded composition and hybrid microstructure.The TiC1-x carbides and TiB_(2)platelets decreased gradually in size and volume fraction from the ceramic to stainless steel.Due to the rapid action of thermal explosion as well as the dissolution of the molten stainless steel into TiB_(2)-TiC liquid,the diffusion-controlled concentration gradient from the ceramic liquid to the alloy liquid was observed.Finally,as a result of the rapid sequent solidification of the ceramic liquid and the melt alloy surface,the laminated composite materials were achieved in multilevel,scale-span hybrid microstructure.
基金financial support from the National Natural Science Foundation of China(Grant No.20736006)the National Basic Research Program of China(Grant No.2007CB714301)+1 种基金the international collaboration project of MOST(2006DFA62400)Key Projects in the National Science&Technology Pillar Program(No.2007BAD42B02).
文摘Due to its merits of drought tolerance and high yield,sweet potatoes are widely considered as a potential alterative feedstock for bioethanol production.Very high gravity(VHG)technology is an effective strategy for improving the efficiency of ethanol fermentation from starch materials.However,this technology has rarely been applied to sweet potatoes because of the high viscosity of their liquid mash.To overcome this problem,cellulase was added to reduce the high viscosity,and the optimal dosage and treatment time were 8 U/g(sweet potato powder)and 1 h,respectively.After pretreatment by cellulase,the viscosity of the VHG sweet potato mash(containing 284.2 g/L of carbohydrates)was reduced by 81%.After liquefaction and simultaneous saccharification and fer-mentation(SSF),thefinal ethanol concentration reached 15.5%(v/v),and the total sugar conversion and ethanol yields were 96.5%and 87.8%,respectively.
文摘The author argues in this document that initial vacuum state values possibly responsible for GW generation in relic conditions in the initial onset of inflation may have a temporary unsqueezed, possibly even coherent initial value, which would permit in certain models classical coherent initial gravitational wave states. Furthermore, several arguments pro and con as to if or not initial relic GW should be high frequency will be presented, with the reason given why earlier string models did NOT favor low frequency relic GW from the big bang. What is observed is that large higher dimensions above our 4 Dimensional space time, if recipients of matter-energy from collapse and re birth of the universe are enough to insure low relic GW. The existence of higher dimensions, in itself if the additional dimensions are small and compact will have no capacity to lower the frequency limit values of relic GW, as predicted by Giovannini, et al. in 1995.
基金supported by the China Earthquake Administration Earthquake Tracking Task Orientation(2016020202,2016010216,and 2016010220)the“Three Combination”project of the China Earthquake Administration(163201)+2 种基金the National Natural Science Foundation of China(41204058,41474064,and 41374088)the special earthquake research,China Earthquake Administration(201508009-08)the Director,Foundation of Institute of Seismology,China Earthquake Administration(IS201326123)
文摘In this study, a classic survey adjustment computation method was used for data obtained in the Inner Mongolia and Ningxia gravimetric networks between September 2013 and April 2015 so as to investigate the variation of gravity before the Alxa Zuoqi M5.8 earthquake. The relationship between gravity variation and the Alxa Zuoqi M5.8 earthquake was analyzed. The results showed that: (1) the severe variation in gravity field at the test sites before the Alxa Zuoqi M5.8 earthquake, as well as the subsequent accelerated rising, might be an earthquake precursor; (2) the Alxa Zuoqi M5.8 earthquake occurred at the turning point where the high-gravity gradient zone changed from the NE direction to NW.
基金The National Science Foundation of China under Grant No.51121005
文摘To study the effect of a strong underwater shock wave on a concrete dam, this research aims to improve hammer impact methods in model tests. Six 1:200 scale models were designed and tested under distributed impact loads. A device was deployed for a direct measurement of the impact force at the upstream face of the dams. The model dam bases were anchored to prevent displacement. The experimental results indicate that the top part of the concrete dam is a weak zone, and the impact failure initiates with a fracture on the top of the dam. The peak value of impact stress increases when the second crack appears in the concrete dam from the upstream face to the downstream face. And, the level of the second crack in the dam body is lower as the peak value of impact stress increases. In this study, dynamic analysis was conducted by calculating the results to verify the effectiveness of a device to directly measure the impact force. This method may be used to approximately forecast the damage of concrete dam and may also be useful in other engineering applications.
基金"863 Plan" of China(grant no. 2001AA218061, no. 2004AA218042,and no.2006AA030202)the National Natural Science Foundation(NSF) of China (grant no. 20146002,no.20236020,and no.20325621)Nano Materials Technology Pte. Ltd., Singapore
文摘This paper reviews our work on the fundamental principles of high gravity controlled precipitation (HGCP) technology, and its applications in the production of drug nanoparticles, which was carried out in a rotating packed bed (RPB). Several kinds of drug nanoparticles with narrow particle size distributions (PSDs) were successfully prepared via HGCP, including the 300-nm Cefuroxime Axetil (CFA) particles, 200–400-nm cephradine particles, 500-nm salbutamol sulfate (SS) particles (100 nm in width), and 850-nm beclomethasone dipropionate (BDP) particles, etc. Compared to drugs available in the current market, all the drug nanoparticles produced by HGCP exhibited advantages in both formulation and drug delivery, thus improving the bioavailability of drugs. HGCP is essentially a platform technology for the preparation of poorly water-soluble drug nanoparticles for oral and injection delivery, and of inhalable drugs for pulmonary delivery. Consequently, HGCP offers potential applications in the pharmaceutical industry due to its cost-effectiveness, efficient processing and the ease of scaling-up.