The internal structure of the inertial measurement unit(IMU)in active state is easily damaged in the high overload environment.So that the IMU is usually required to be powered within the disappearance of the high ove...The internal structure of the inertial measurement unit(IMU)in active state is easily damaged in the high overload environment.So that the IMU is usually required to be powered within the disappearance of the high overload.In this paper,a mechanical switch is designed to enable the IMU based on the analysis of the impact of high overload on the power-supply circuit.In which,parameters of mechanical switch are determined through theoretical calculation and data analysis.The innovation of the proposed structure lies in that the mechanical switch is triggered through the high overload process and could provide a delay signal for the circuit.After all,the proposed switch is tested through mechanical simulation,impact test and practical test.The experimental results show that the designed mechanical switch can effectively and reliably provide the delay for the circuit and guarantee operation of the IMU under high overload.展开更多
Iron overload can lead to cytotoxicity, and it is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear. We conjectured that iron overload-induced neurotoxicity might be a...Iron overload can lead to cytotoxicity, and it is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear. We conjectured that iron overload-induced neurotoxicity might be associated with oxidative stress and the NF-E2-related factor 2 （Nrf2）/ARE signaling pathway. As an in vitro cellular model of diabetic peripheral neuropathy, PC12 cells ex- posed to high glucose concentration were used in this study. PC12 cells were cultured with ferric ammonium citrate at different concentrations to create iron overload. PC12 cells cultured in ferric ammonium citrate under high glucose concentration had significantly low cell viability, a high rate of apoptosis, and elevated reactive oxygen species and malondialdehyde levels. These changes were dependent on ferric ammonium citrate concentration. Nrf2 mRNA and protein expression in the ferric ammonium citrate groups were inhibited markedly in a dose-dependent manner. All changes could be inhibited by addition of deferoxamine. These results indicate that iron overload aggravates oxidative stress injury in neural cells under high glucose concentration and that the Nrf2/ARE sigfnaling pathway might play an important role in this process.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.61803203).
文摘The internal structure of the inertial measurement unit(IMU)in active state is easily damaged in the high overload environment.So that the IMU is usually required to be powered within the disappearance of the high overload.In this paper,a mechanical switch is designed to enable the IMU based on the analysis of the impact of high overload on the power-supply circuit.In which,parameters of mechanical switch are determined through theoretical calculation and data analysis.The innovation of the proposed structure lies in that the mechanical switch is triggered through the high overload process and could provide a delay signal for the circuit.After all,the proposed switch is tested through mechanical simulation,impact test and practical test.The experimental results show that the designed mechanical switch can effectively and reliably provide the delay for the circuit and guarantee operation of the IMU under high overload.
基金supported by the Natural Science Foundation of Hubei Province,No.2010CDB09001
文摘Iron overload can lead to cytotoxicity, and it is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear. We conjectured that iron overload-induced neurotoxicity might be associated with oxidative stress and the NF-E2-related factor 2 （Nrf2）/ARE signaling pathway. As an in vitro cellular model of diabetic peripheral neuropathy, PC12 cells ex- posed to high glucose concentration were used in this study. PC12 cells were cultured with ferric ammonium citrate at different concentrations to create iron overload. PC12 cells cultured in ferric ammonium citrate under high glucose concentration had significantly low cell viability, a high rate of apoptosis, and elevated reactive oxygen species and malondialdehyde levels. These changes were dependent on ferric ammonium citrate concentration. Nrf2 mRNA and protein expression in the ferric ammonium citrate groups were inhibited markedly in a dose-dependent manner. All changes could be inhibited by addition of deferoxamine. These results indicate that iron overload aggravates oxidative stress injury in neural cells under high glucose concentration and that the Nrf2/ARE sigfnaling pathway might play an important role in this process.
